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RhoGAP domain

RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.

RhoGAP domain
Structure of Phospholipase A2.[1]
Identifiers
SymbolRhoGAP
PfamPF00620
InterProIPR000198
SMARTRhoGAP
PROSITEPDOC50238
SCOP21rgb / SCOPe / SUPFAM
OPM protein1xa6
CDDcd00159
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1xa6A:291-444 1f7cA:199-355 1am4B:260-408

1grnB:260-408 1ow3A:260-408 1rgp :260-402

1tx4A:260-408 2ngrB:260-408 1pbwB:129-281

Human proteins containing this domain edit

ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6; ARHGAP8; ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1; CENTD2; CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1; FAM13A1; FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158; MYO9A; MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1; RACGAP1P; RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1; SRGAP2; SRGAP3; STARD13; STARD8; SYDE1; SYDE2;

Notes edit

  1. ^ Georgieva DN, Rypniewski W, Gabdoulkhakov A, Genov N, Betzel C (July 2004). "Asp49 phospholipase A(2)-elaidoylamide complex: a new mode of inhibition". Biochem. Biophys. Res. Commun. 319 (4): 1314–21. doi:10.1016/j.bbrc.2004.05.106. PMID 15194511.

References edit

  • Musacchio, A.; Cantley, L. C.; Harrison, S. C. (1996). "Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14373–14378. doi:10.1073/pnas.93.25.14373. PMC 26139. PMID 8962058.
  • Barrett, T.; Xiao, B.; Dodson, E. J.; Dodson, G.; Ludbrook, S. B.; Nurmahomed, K.; Gamblin, S. J.; Musacchio, A.; Smerdon, S. J.; Eccleston, J. F. (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615): 458–461. doi:10.1038/385458a0. PMID 9009196. S2CID 4235645.
  • Gamblin, S. J.; Rittinger, K.; Walker, P. A.; Eccleston, J. F.; Nurmahomed, K.; Owen, D.; Laue, E.; Smerdon, S. J. (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643): 693–697. doi:10.1038/41805. PMID 9262406. S2CID 4415826.
  • Boguski, M. S.; McCormick, F. (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643–654. doi:10.1038/366643a0. PMID 8259209. S2CID 4338237.


rhogap, domain, evolutionary, conserved, protein, domain, gtpase, activating, proteins, towards, cdc42, like, small, gtpases, structure, phospholipase, identifierssymbolrhogappfampf00620interproipr000198smartrhogapprositepdoc50238scop21rgb, scope, supfamopm, p. RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho Rac Cdc42 like small GTPases RhoGAP domainStructure of Phospholipase A2 1 IdentifiersSymbolRhoGAPPfamPF00620InterProIPR000198SMARTRhoGAPPROSITEPDOC50238SCOP21rgb SCOPe SUPFAMOPM protein1xa6CDDcd00159Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryPDB1xa6 A 291 444 1f7c A 199 355 1am4 B 260 408 1grn B 260 408 1ow3 A 260 408 1rgp 260 402 1tx4 A 260 408 2ngr B 260 408 1pbw B 129 281Human proteins containing this domain editABR ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP4 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 BCR BPGAP1 C1 C5orf5 CDGAP CENTD1 CENTD2 CENTD3 CHN1 CHN2 DEPDC1 DEPDC1A DEPDC1B DLC1 FAM13A1 FKSG42 GMIP GRLF1 HMHA1 INPP5B KIAA1688 LOC553158 MYO9A MYO9B OCRL OPHN1 PIK3R1 PIK3R2 PRR5 RACGAP1 RACGAP1P RALBP1 RICH2 RICS SH3BP1 SLIT1 SNX26 SRGAP1 SRGAP2 SRGAP3 STARD13 STARD8 SYDE1 SYDE2 Notes edit Georgieva DN Rypniewski W Gabdoulkhakov A Genov N Betzel C July 2004 Asp49 phospholipase A 2 elaidoylamide complex a new mode of inhibition Biochem Biophys Res Commun 319 4 1314 21 doi 10 1016 j bbrc 2004 05 106 PMID 15194511 References editMusacchio A Cantley L C Harrison S C 1996 Crystal structure of the breakpoint cluster region homology domain from phosphoinositide 3 kinase p85 alpha subunit Proceedings of the National Academy of Sciences of the United States of America 93 25 14373 14378 doi 10 1073 pnas 93 25 14373 PMC 26139 PMID 8962058 Barrett T Xiao B Dodson E J Dodson G Ludbrook S B Nurmahomed K Gamblin S J Musacchio A Smerdon S J Eccleston J F 1997 The structure of the GTPase activating domain from p50rhoGAP Nature 385 6615 458 461 doi 10 1038 385458a0 PMID 9009196 S2CID 4235645 Gamblin S J Rittinger K Walker P A Eccleston J F Nurmahomed K Owen D Laue E Smerdon S J 1997 Crystal structure of a small G protein in complex with the GTPase activating protein rhoGAP Nature 388 6643 693 697 doi 10 1038 41805 PMID 9262406 S2CID 4415826 Boguski M S McCormick F 1993 Proteins regulating Ras and its relatives Nature 366 6456 643 654 doi 10 1038 366643a0 PMID 8259209 S2CID 4338237 nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RhoGAP domain amp oldid 1197389733, wikipedia, wiki, book, books, library,

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