Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000139874 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035431 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (February 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (January 1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 251–5. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC48214. PMID 1346068.
Fujita T, Yamaji Y, Sato M, Murao K, Takahara J (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sciences. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6. PMID 7968260.
Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H (September 1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters. 331 (1–2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. S2CID 22557713.
Le Romancer M, Cherifi Y, Levasseur S, Laigneau JP, Peranzi G, Jais P, Lewin MJ, Reyl-Desmars F (1996). "Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae". Life Sciences. 58 (13): 1091–8. doi:10.1016/0024-3205(96)00063-X. PMID 8622562.
Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, Hinuma S, Kitano K, Fujino M (March 1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG (June 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124. S2CID 24935564.
Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, Cadiot G, Mignon M, Lewin MJ (August 1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. S2CID 23503397.
Ferone D, van Hagen PM, van Koetsveld PM, Zuijderwijk J, Mooy DM, Lichtenauer-Kaligis EG, Colao A, Bogers AJ, Lombardi G, Lamberts SW, Hofland LJ (January 1999). "In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells" (PDF). Endocrinology. 140 (1): 373–80. doi:10.1210/endo.140.1.6398. PMID 9886848.
Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC, Patel YC (January 1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.
Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC (March 2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". The Journal of Biological Chemistry. 275 (11): 7862–9. doi:10.1074/jbc.275.11.7862. PMID 10713101.
Schwärzler A, Kreienkamp HJ, Richter D (March 2000). "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast". The Journal of Biological Chemistry. 275 (13): 9557–62. doi:10.1074/jbc.275.13.9557. PMID 10734105.
Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC (May 2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism. 86 (5): 2161–9. doi:10.1210/jcem.86.5.7489. PMID 11344221.
Klisovic DD, O'Dorisio MS, Katz SE, Sall JW, Balster D, O'Dorisio TM, Craig E, Lubow M (September 2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study". Investigative Ophthalmology & Visual Science. 42 (10): 2193–201. PMID 11527930.
Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, Sinisi AA (September 2001). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica. 26 (3): 175–9. PMID 11753241.
Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, Schindler M, Cole SL, Bussolati G (May 2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.
Zatelli MC, Tagliati F, Piccin D, Taylor JE, Culler MD, Bondanelli M, degli Uberti EC (October 2002). "Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line". Biochemical and Biophysical Research Communications. 297 (4): 828–34. doi:10.1016/S0006-291X(02)02307-0. PMID 12359227.
Ferone D, Pivonello R, Van Hagen PM, Dalm VA, Lichtenauer-Kaligis EG, Waaijers M, Van Koetsveld PM, Mooy DM, Colao A, Minuto F, Lamberts SW, Hofland LJ (November 2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". American Journal of Physiology. Endocrinology and Metabolism. 283 (5): E1056-66. CiteSeerX10.1.1.945.8926. doi:10.1152/ajpendo.00205.2001. PMID 12376335.
Pasquali D, Notaro A, Bonavolonta' G, Vassallo P, Bellastella A, Sinisi AA (November 2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". The Journal of Clinical Endocrinology and Metabolism. 87 (11): 5125–9. doi:10.1210/jc.2002-020790. PMID 12414882.
Dizeyi N, Konrad L, Bjartell A, Wu H, Gadaleanu V, Hansson J, Helboe L, Abrahamsson PA (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urologic Oncology. 7 (3): 91–8. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541.
External linksedit
. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
somatostatin+receptor+type+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
somatostatin, receptor, somatostatin, receptor, type, protein, that, humans, encoded, sstr1, gene, sstr1identifiersaliasessstr1, srif, ss1r, external, idsomim, 182451, 98327, homologene, genecards, sstr1gene, location, human, chromosome, human, band14q21, 1sta. Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene 5 6 SSTR1IdentifiersAliasesSSTR1 SRIF 2 SS 1 R SS1 R SS1R Somatostatin receptor 1External IDsOMIM 182451 MGI 98327 HomoloGene 820 GeneCards SSTR1Gene location Human Chr Chromosome 14 human 1 Band14q21 1Start38 207 904 bp 1 End38 213 067 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 C1 12 25 61 cMStart58 258 558 bp 2 End58 261 230 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumjejunal mucosaBrodmann area 46duodenumprefrontal cortexmiddle temporal gyrusBrodmann area 23dorsolateral prefrontal cortexislet of Langerhanscingulate gyrusTop expressed insuperior frontal gyrusventromedial nucleusprimary motor cortexsubiculumdorsomedial hypothalamic nucleusarcuate nucleuslateral hypothalamusneural tubecerebellar cortexsuprachiasmatic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionG protein coupled receptor activity neuropeptide binding signal transducer activity somatostatin receptor activity peptide bindingCellular componentcytoplasm integral component of membrane membrane plasma membrane neuron projection integral component of plasma membraneBiological processglutamate receptor signaling pathway somatostatin signaling pathway G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger cellular response to estradiol stimulus cerebellum development spermatogenesis response to starvation forebrain development neuropeptide signaling pathway signal transduction negative regulation of cell population proliferation cellular response to leukemia inhibitory factor G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez675120605EnsemblENSG00000139874ENSMUSG00000035431UniProtP30872P30873RefSeq mRNA NM 001049NM 009216RefSeq protein NP 001040NP 033242Location UCSC Chr 14 38 21 38 21 MbChr 12 58 26 58 26 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further reading 5 External linksFunction editSomatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biological effects of somatostatin are probably mediated by a family of G protein coupled receptors that are expressed in a tissue specific manner The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments and is expressed in highest levels in jejunum and stomach 6 See also editSomatostatin receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000139874 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000035431 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yamada Y Stoffel M Espinosa R Xiang KS Seino M Seino S Le Beau MM Bell GI February 1993 Human somatostatin receptor genes localization to human chromosomes 14 17 and 22 and identification of simple tandem repeat polymorphisms Genomics 15 2 449 52 doi 10 1006 geno 1993 1088 PMID 8449518 a b Entrez Gene SSTR1 somatostatin receptor 1 Further reading editYamada Y Post SR Wang K Tager HS Bell GI Seino S January 1992 Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain gastrointestinal tract and kidney Proceedings of the National Academy of Sciences of the United States of America 89 1 251 5 Bibcode 1992PNAS 89 251Y doi 10 1073 pnas 89 1 251 PMC 48214 PMID 1346068 Fujita T Yamaji Y Sato M Murao K Takahara J 1994 Gene expression of somatostatin receptor subtypes SSTR1 and SSTR2 in human lung cancer cell lines Life Sciences 55 23 1797 806 doi 10 1016 0024 3205 94 90090 6 PMID 7968260 Kaupmann K Bruns C Hoyer D Seuwen K Lubbert H September 1993 Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain FEBS Letters 331 1 2 53 9 doi 10 1016 0014 5793 93 80296 7 PMID 8405411 S2CID 22557713 Le Romancer M Cherifi Y Levasseur S Laigneau JP Peranzi G Jais P Lewin MJ Reyl Desmars F 1996 Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae Life Sciences 58 13 1091 8 doi 10 1016 0024 3205 96 00063 X PMID 8622562 Fukusumi S Kitada C Takekawa S Kizawa H Sakamoto J Miyamoto M Hinuma S Kitano K Fujino M March 1997 Identification and characterization of a novel human cortistatin like peptide Biochemical and Biophysical Research Communications 232 1 157 63 doi 10 1006 bbrc 1997 6252 PMID 9125122 de Lecea L Ruiz Lozano P Danielson PE Peelle Kirley J Foye PE Frankel WN Sutcliffe JG June 1997 Cloning mRNA expression and chromosomal mapping of mouse and human preprocortistatin Genomics 42 3 499 506 doi 10 1006 geno 1997 4763 PMID 9205124 S2CID 24935564 Jais P Terris B Ruszniewski P LeRomancer M Reyl Desmars F Vissuzaine C Cadiot G Mignon M Lewin MJ August 1997 Somatostatin receptor subtype gene expression in human endocrine gastroentero pancreatic tumours European Journal of Clinical Investigation 27 8 639 44 doi 10 1046 j 1365 2362 1997 1740719 x PMID 9279525 S2CID 23503397 Ferone D van Hagen PM van Koetsveld PM Zuijderwijk J Mooy DM Lichtenauer Kaligis EG Colao A Bogers AJ Lombardi G Lamberts SW Hofland LJ January 1999 In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells PDF Endocrinology 140 1 373 80 doi 10 1210 endo 140 1 6398 PMID 9886848 Kumar U Sasi R Suresh S Patel A Thangaraju M Metrakos P Patel SC Patel YC January 1999 Subtype selective expression of the five somatostatin receptors hSSTR1 5 in human pancreatic islet cells a quantitative double label immunohistochemical analysis Diabetes 48 1 77 85 doi 10 2337 diabetes 48 1 77 PMID 9892225 Rocheville M Lange DC Kumar U Sasi R Patel RC Patel YC March 2000 Subtypes of the somatostatin receptor assemble as functional homo and heterodimers The Journal of Biological Chemistry 275 11 7862 9 doi 10 1074 jbc 275 11 7862 PMID 10713101 Schwarzler A Kreienkamp HJ Richter D March 2000 Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase binding protein from yeast The Journal of Biological Chemistry 275 13 9557 62 doi 10 1074 jbc 275 13 9557 PMID 10734105 Zatelli MC Tagliati F Taylor JE Rossi R Culler MD degli Uberti EC May 2001 Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt The Journal of Clinical Endocrinology and Metabolism 86 5 2161 9 doi 10 1210 jcem 86 5 7489 PMID 11344221 Klisovic DD O Dorisio MS Katz SE Sall JW Balster D O Dorisio TM Craig E Lubow M September 2001 Somatostatin receptor gene expression in human ocular tissues RT PCR and immunohistochemical study Investigative Ophthalmology amp Visual Science 42 10 2193 201 PMID 11527930 Pasquali D Notaro A Esposito D Vassallo P Bonavolonta G Bellastella A Sinisi AA September 2001 Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves ophthalmopathy Minerva Endocrinologica 26 3 175 9 PMID 11753241 Papotti M Bongiovanni M Volante M Allia E Landolfi S Helboe L Schindler M Cole SL Bussolati G May 2002 Expression of somatostatin receptor types 1 5 in 81 cases of gastrointestinal and pancreatic endocrine tumors A correlative immunohistochemical and reverse transcriptase polymerase chain reaction analysis Virchows Archiv 440 5 461 75 doi 10 1007 s00428 002 0609 x PMID 12021920 S2CID 28584328 Zatelli MC Tagliati F Piccin D Taylor JE Culler MD Bondanelli M degli Uberti EC October 2002 Somatostatin receptor subtype 1 selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line Biochemical and Biophysical Research Communications 297 4 828 34 doi 10 1016 S0006 291X 02 02307 0 PMID 12359227 Ferone D Pivonello R Van Hagen PM Dalm VA Lichtenauer Kaligis EG Waaijers M Van Koetsveld PM Mooy DM Colao A Minuto F Lamberts SW Hofland LJ November 2002 Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes American Journal of Physiology Endocrinology and Metabolism 283 5 E1056 66 CiteSeerX 10 1 1 945 8926 doi 10 1152 ajpendo 00205 2001 PMID 12376335 Pasquali D Notaro A Bonavolonta G Vassallo P Bellastella A Sinisi AA November 2002 Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves disease The Journal of Clinical Endocrinology and Metabolism 87 11 5125 9 doi 10 1210 jc 2002 020790 PMID 12414882 Dizeyi N Konrad L Bjartell A Wu H Gadaleanu V Hansson J Helboe L Abrahamsson PA 2002 Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines Urologic Oncology 7 3 91 8 doi 10 1016 S1078 1439 01 00173 9 PMID 12474541 External links edit Somatostatin Receptors sst1 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2016 03 03 Retrieved 2008 12 09 somatostatin receptor type 1 at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Somatostatin receptor 1 amp oldid 1208159429, wikipedia, wiki, book, books, library,
