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Serum Institute of India

December 08, 2023

18°30′18″N 73°56′44″E / 18.505110°N 73.945453°E / 18.505110; 73.945453 Serum Institute of India (SII) is an Indian biotechnology and biopharmaceuticals company, based in Pune. It is the world's largest manufacturer of vaccines.[4][5] It was founded by Cyrus Poonawalla in 1966[6] and is a part of Cyrus Poonawalla Group.[7]

Serum Institute of India Private Limited
Serum Institute of India
TypePrivate
Industry
Founded1966 (57 years ago) (1966)
FounderCyrus S. Poonawalla (Chairman & MD)
HeadquartersPune, Maharashtra, India
Area served
Worldwide
Key people
Adar Poonawalla (CEO)
Products
Revenue ₹25,646 crore (US$3.2 billion) (FY22)[1]
₹17,562 crore (US$2.2 billion) (FY22)[1]
₹11,116 crore (US$1.4 billion) (FY22)[1]
ParentCyrus Poonawalla Group
SubsidiariesBilthoven Biologicals BV[2]
Vakzine Projekt Management GmbH[3]
Websitewww.seruminstitute.com

Overview edit

The Serum Institute of India was founded in 1966 in the city of Pune, India. The company set out to produce immunobiologicals, which were imported into India at high prices. Among the first products the Serum Institute of India manufactured in large quantities were the tetanus antitoxin, snake antivenom, DPT vaccine, and MMR vaccine. The company's product lines was expanded to include different types of vaccines against bacterial or virus infections, combination vaccines, influenza vaccine, and meningococcal vaccine. Besides vaccine the company also manufactures antisera, blood plasma, and hormone products. As of 2014 the vaccines manufactured by the Serum Institute of India have been used in international vaccination programmes run by the World Health Organization (WHO), UNICEF, and the Pan American Health Organization (PAHO). Today the Serum Institute of India is run by the Poonawalla Group and engages in research, development, and manufacturing.[8]

In 2009, the company began developing an intranasal swine flu vaccine.[9][10] In 2012, the company's first international acquisition was Bilthoven Biologicals, a biopharmaceutical company in Netherlands.[11] In 2016, with support from US-based Mass Biologics of University of Massachusetts Medical School, the Serum Institute of India invented a fast-acting anti-rabies agent, Rabies Human Monoclonal Antibody (RMAb), also known as Rabishield.[12][13]

As of 2023, the company is the world's largest vaccine producer by number of doses produced,[14] manufacturing around 1.9 billion doses of vaccines each year with plans to produce 4 billion doses of vaccines.[15][16] The products developed include tuberculosis vaccine Tubervac (BCG), Poliovac for poliomyelitis, and other vaccinations for the childhood vaccination schedule.[17][18][19]

COVID-19 vaccine development edit

 
A vial of the Oxford-AstraZeneca COVID-19 vaccine that is locally produced in the Serum Institute of India (SII) as "Covishield" COVID-19 vaccine

The company has partnered with the British-Swedish multinational pharmaceutical company AstraZeneca, which is developing AZD1222 (Covishield) in partnership with the University of Oxford.[20] It is reported that Serum Institute of India would provide 100 million (10 crore) doses of the vaccine for India and other low and middle-income countries.[21][22][23] This target was later increased to 1 billion doses by the end of 2021.[24] It is estimated to be priced at ₹225 (around $3) per dose.[25] In September 2020, trials were halted by DCGI after a volunteer in Oxford developed illness following vaccination, but were soon resumed after consent by the British regulators.[26][27][28] In December 2020, the Serum Institute of India sought emergency approval for the vaccine developed with AstraZeneca [29] which was approved a month later.[30] In March 2021, an agreement was reached to supply some doses to the UK.[31]

Serum Institute of India has also reached an agreement with Novavax for the production of Novavax's NVX-CoV2373 (Covovax) vaccine for India and other low and middle-income countries.[32][33] The company will also produce Codagenix's nasally administered COVID-19 vaccine CDX-005[34][35] (tradename COVI-VAC).[36]

The company is also manufacturing Sputnik V vaccine in India in collaboration with Gamaleya Research Institute of Epidemiology and Microbiology after receiving approval from DCGI.[37] On 13 July 2021, RDIF published a press release saying SII is starting the production of Sputnik V doses in September 2021. They intend to produce over 300 million doses of the vaccine in India per year.[38]

Attempted data theft edit

In March 2021, Reuters reported that Chinese state-backed cyber-espionage group Red Apollo targeted the Serum Institute of India's intellectual property for exfiltration.[39]

Other vaccine development edit

R21/Matrix-M malaria vaccine edit

On October 8, 2023, the R21/Matrix-M malaria vaccine received a recommendation for use by the World Health Organization’s Strategic Advisory Group of Experts (SAGE) and the Malaria Policy Advisory Group (MPAG).[40] The vaccine, jointly developed by The University of Oxford[41][42] and the Serum Institute of India in collaboration with Novavax's adjuvant technology, demonstrated notable efficacy along with a positive safety profile. Furthermore, the Serum Institute of India had successfully established production capacity for 100 million doses annually, with plans to double this capacity over the next two years.

The R21/Matrix-MTM malaria vaccine was jointly developed by the Jenner Institute at Oxford University and Serum Institute of India, with support from various organizations including the European and Developing Countries Clinical Trials Partnership (EDCTP), the Wellcome Trust, and the European Investment Bank (EIB). As of now, the vaccine has obtained licenses for use in Ghana, Nigeria, and Burkina Faso.

See also edit

References edit

  1. ^ a b c "Serum Institute of India Private Limited" (PDF). CARE Ratings. Retrieved 3 February 2023.
  2. ^ "Bilthoven Biologicals acquired by Serum Institute of India". www.thepharmaletter.com. Retrieved 10 July 2020.
  3. ^ "Profile". vpm-consult.com. Retrieved 10 July 2020.
  4. ^ "Serum Institute of India Pvt. Ltd.: Private Company Information". bloomberg.com. Retrieved 30 September 2018.
  5. ^ "SERUM INSTITUTE OF INDIA PRIVATE LIMITED - Company, directors and contact details". zaubacorp.com. Retrieved 30 September 2018.
  6. ^ "About Us". Serum Institute of India. Retrieved 8 December 2016.
  7. ^ "Poonawalla Investments AND Industries Private Limited Information - Poonawalla Investments AND Industries Private Limited Company Profile, Poonawalla Investments AND Industries Private Limited News on The Economic Times". The Economic Times. Archived from the original on 8 May 2019. Retrieved 10 July 2020.
  8. ^ Burns, Lawton R. (2014). India's Healthcare Industry: Innovation in Delivery, Financing, and Manufacturing. Cambridge University Press. pp. 488–489. ISBN 9781316021217.
  9. ^ "India developing indigenous swine flu vaccine". The Times of India. Retrieved 1 February 2015.
  10. ^ Kulkarni, Prasad S.; Raut, Sidram K.; Dhere, Rajeev M. (27 October 2014). "A post-marketing surveillance study of a human live-virus pandemic influenza A (H1N1) vaccine (Nasovac ®) in India". Human Vaccines & Immunotherapeutics. 9 (1): 122–124. doi:10.4161/hv.22317. PMC 3667925. PMID 23442586.
  11. ^ Unnikrishnan, C. H. (4 July 2012). "Serum Institute buys Bilthoven Biologicals". Livemint. Retrieved 1 July 2020.
  12. ^ "Fast-acting anti-rabies drug set for India launch - Times of India". The Times of India. 24 February 2016. Retrieved 12 June 2016.
  13. ^ Kulkarni, Prasad S.; Sahai, Ashish; Gunale, Bhagwat; Dhere, Rajeev M (3 March 2017). "Development of a new purified vero cell rabies vaccine (Rabivax-S) at the serum institute of India Pvt Ltd". Expert Review of Vaccines. 16 (4): 303–311. doi:10.1080/14760584.2017.1294068. PMID 28276304. S2CID 3382124.
  14. ^ "Serum Institute to focus on supplying COVID-19 vaccine to India first". Reuters. 23 November 2020. Retrieved 26 November 2020.
  15. ^ Krishnan, Murali (29 September 2020). "Coronavirus vaccine: Why does India's Serum Institute have a head start?". Deutsche Welle. Retrieved 26 November 2020.
  16. ^ Choo, Olivia (16 December 2022). "How this millennial CEO steered the world's largest vaccine maker during the pandemic". CNBC. Retrieved 9 October 2023.
  17. ^ "Serum Institute Tubervac (BCG)". Serum Institute of India. Retrieved 15 June 2020.
  18. ^ "Serum Institute Poliovac". Serum Institute of India. Retrieved 15 June 2020.
  19. ^ "Vaccination Schedule". Vaccination as per the National Immunization schedule by Government of India. Retrieved 15 June 2020.
  20. ^ "AstraZeneca & Serum Institute of India sign licensing deal for 1 million doses of Oxford vaccine". The Economic Times. Retrieved 15 June 2020.
  21. ^ "Covid-19 vaccine: Serum Institute signs up for 100 million doses of vaccines for India, low and middle-income countries". The Financial Express. 7 August 2020.
  22. ^ Banerjee, Shoumojit (7 July 2020). "Oxford COVID-19 vaccine at least 6 months away from launch: Serum Institute CEO". The Hindu.
  23. ^ "Coronavirus (Covid-19) vaccine latest update: Oxford-AstraZeneca corona vaccine production starts; US says 2 billion doses 'ready to go'". The Indian Express. 10 June 2020.
  24. ^ "Indian company aims for a billion Covid vaccines". BBC News. Retrieved 21 March 2021.
  25. ^ "Serum Institute of India to provide Covid-19 vaccines through COVAX at Rs 225 a dose". The Indian Express. 7 August 2020.
  26. ^ Sharma, Milan. "Serum Institute halts coronavirus vaccine trials in India after notice from DCGI over volunteer's illness in UK". India Today. Retrieved 10 September 2020.
  27. ^ "Oxford vaccine trial paused as participant falls ill". BBC News. 9 September 2020. Retrieved 10 September 2020.
  28. ^ Ghosh, Poulomi (12 September 2020). "Serum Institute to resume Covid-19 vaccine trial after DGCI gives nod". Hindustan Times.
  29. ^ "India will have Covid-19 vaccine within days: AIIMS director". Hindustan Times. 31 December 2021. Retrieved 31 December 2020.
  30. ^ Schmall E, Yasir S (3 January 2021). "India Approves Oxford-AstraZeneca Covid-19 Vaccine and 1 Other". The New York Times. Retrieved 3 January 2021.
  31. ^ "Covid vaccine: India shortfall behind UK's supply delay". BBC News. 18 March 2021.
  32. ^ "Serum Institute, Novavax in covid vaccine deal, may produce 100 crore doses". Livemint. 7 August 2020.
  33. ^ "Novavax signs COVID-19 vaccine supply deal with India's Serum Institute". Reuters. 5 August 2020.
  34. ^ "Serum Institute starts manufacturing Codagenix's nasal COVID-19 vaccine". mint. 22 September 2020.
  35. ^ "India's Serum Institute starts manufacturing Codagenix's potential Covid-19 vaccine". Hindustan Times. 22 September 2020.
  36. ^ "Codagenix and Serum Institute of India Announce Commencement of First-in-Human Trial of COVI-VAC, A Single Dose, Intranasal Live Attenuated Vaccine for COVID-19". Codagenix. Retrieved 22 April 2021.
  37. ^ "Serum Institute gets DCGI's nod to manufacture Covid vaccine Sputnik V in India". mint. 4 June 2021.
  38. ^ rdif.ru: press release
  39. ^ Das, Krishna N. (1 March 2021). "Chinese hackers target Indian vaccine makers SII, Bharat Biotech, says security firm". Reuters. Retrieved 1 March 2021.
  40. ^ "What is the new anti-malaria vaccine cleared by WHO all about? Will it work for India?". The Indian Express. 3 October 2023. Retrieved 9 October 2023.
  41. ^ "Oxford R21/Matrix-M™ malaria vaccine receives WHO recommendation for use paving the way for global roll-out | University of Oxford". www.ox.ac.uk. 2 October 2023. Retrieved 9 October 2023.
  42. ^ "Serum Institute Of India. Press Release - 02 October 2023". www.seruminstitute.com.

External links edit

  • Official website

December 08, 2023
serum, institute, india, 505110, 945453, 505110, 945453, indian, biotechnology, biopharmaceuticals, company, based, pune, world, largest, manufacturer, vaccines, founded, cyrus, poonawalla, 1966, part, cyrus, poonawalla, group, private, limitedtypeprivateindus. 18 30 18 N 73 56 44 E 18 505110 N 73 945453 E 18 505110 73 945453 Serum Institute of India SII is an Indian biotechnology and biopharmaceuticals company based in Pune It is the world s largest manufacturer of vaccines 4 5 It was founded by Cyrus Poonawalla in 1966 6 and is a part of Cyrus Poonawalla Group 7 Serum Institute of India Private LimitedSerum Institute of IndiaTypePrivateIndustryBiotechnologyBiopharmaceuticalsFounded1966 57 years ago 1966 FounderCyrus S Poonawalla Chairman amp MD HeadquartersPune Maharashtra IndiaArea servedWorldwideKey peopleAdar Poonawalla CEO ProductsVaccinesbiopharmaceuticalsgeneric drugsover the counter drugsRevenue 25 646 crore US 3 2 billion FY22 1 Operating income 17 562 crore US 2 2 billion FY22 1 Net income 11 116 crore US 1 4 billion FY22 1 ParentCyrus Poonawalla GroupSubsidiariesBilthoven Biologicals BV 2 Vakzine Projekt Management GmbH 3 Websitewww wbr seruminstitute wbr com Contents 1 Overview 2 COVID 19 vaccine development 2 1 Attempted data theft 3 Other vaccine development 3 1 R21 Matrix M malaria vaccine 4 See also 5 References 6 External linksOverview editThe Serum Institute of India was founded in 1966 in the city of Pune India The company set out to produce immunobiologicals which were imported into India at high prices Among the first products the Serum Institute of India manufactured in large quantities were the tetanus antitoxin snake antivenom DPT vaccine and MMR vaccine The company s product lines was expanded to include different types of vaccines against bacterial or virus infections combination vaccines influenza vaccine and meningococcal vaccine Besides vaccine the company also manufactures antisera blood plasma and hormone products As of 2014 the vaccines manufactured by the Serum Institute of India have been used in international vaccination programmes run by the World Health Organization WHO UNICEF and the Pan American Health Organization PAHO Today the Serum Institute of India is run by the Poonawalla Group and engages in research development and manufacturing 8 In 2009 the company began developing an intranasal swine flu vaccine 9 10 In 2012 the company s first international acquisition was Bilthoven Biologicals a biopharmaceutical company in Netherlands 11 In 2016 with support from US based Mass Biologics of University of Massachusetts Medical School the Serum Institute of India invented a fast acting anti rabies agent Rabies Human Monoclonal Antibody RMAb also known as Rabishield 12 13 As of 2023 update the company is the world s largest vaccine producer by number of doses produced 14 manufacturing around 1 9 billion doses of vaccines each year with plans to produce 4 billion doses of vaccines 15 16 The products developed include tuberculosis vaccine Tubervac BCG Poliovac for poliomyelitis and other vaccinations for the childhood vaccination schedule 17 18 19 COVID 19 vaccine development edit nbsp A vial of the Oxford AstraZeneca COVID 19 vaccine that is locally produced in the Serum Institute of India SII as Covishield COVID 19 vaccineThe company has partnered with the British Swedish multinational pharmaceutical company AstraZeneca which is developing AZD1222 Covishield in partnership with the University of Oxford 20 It is reported that Serum Institute of India would provide 100 million 10 crore doses of the vaccine for India and other low and middle income countries 21 22 23 This target was later increased to 1 billion doses by the end of 2021 24 It is estimated to be priced at 225 around 3 per dose 25 In September 2020 trials were halted by DCGI after a volunteer in Oxford developed illness following vaccination but were soon resumed after consent by the British regulators 26 27 28 In December 2020 the Serum Institute of India sought emergency approval for the vaccine developed with AstraZeneca 29 which was approved a month later 30 In March 2021 an agreement was reached to supply some doses to the UK 31 Serum Institute of India has also reached an agreement with Novavax for the production of Novavax s NVX CoV2373 Covovax vaccine for India and other low and middle income countries 32 33 The company will also produce Codagenix s nasally administered COVID 19 vaccine CDX 005 34 35 tradename COVI VAC 36 The company is also manufacturing Sputnik V vaccine in India in collaboration with Gamaleya Research Institute of Epidemiology and Microbiology after receiving approval from DCGI 37 On 13 July 2021 RDIF published a press release saying SII is starting the production of Sputnik V doses in September 2021 They intend to produce over 300 million doses of the vaccine in India per year 38 Attempted data theft edit In March 2021 Reuters reported that Chinese state backed cyber espionage group Red Apollo targeted the Serum Institute of India s intellectual property for exfiltration 39 Other vaccine development editR21 Matrix M malaria vaccine edit On October 8 2023 the R21 Matrix M malaria vaccine received a recommendation for use by the World Health Organization s Strategic Advisory Group of Experts SAGE and the Malaria Policy Advisory Group MPAG 40 The vaccine jointly developed by The University of Oxford 41 42 and the Serum Institute of India in collaboration with Novavax s adjuvant technology demonstrated notable efficacy along with a positive safety profile Furthermore the Serum Institute of India had successfully established production capacity for 100 million doses annually with plans to double this capacity over the next two years The R21 Matrix MTM malaria vaccine was jointly developed by the Jenner Institute at Oxford University and Serum Institute of India with support from various organizations including the European and Developing Countries Clinical Trials Partnership EDCTP the Wellcome Trust and the European Investment Bank EIB As of now the vaccine has obtained licenses for use in Ghana Nigeria and Burkina Faso See also editBharat Biotech Zydus Lifesciences Cadila Pharmaceuticals Biotechnology in IndiaReferences edit a b c Serum Institute of India Private Limited PDF CARE Ratings Retrieved 3 February 2023 Bilthoven Biologicals acquired by Serum Institute of India www thepharmaletter com Retrieved 10 July 2020 Profile vpm consult com Retrieved 10 July 2020 Serum Institute of India Pvt Ltd Private Company Information bloomberg com Retrieved 30 September 2018 SERUM INSTITUTE OF INDIA PRIVATE LIMITED Company directors and contact details zaubacorp com Retrieved 30 September 2018 About Us Serum Institute of India Retrieved 8 December 2016 Poonawalla Investments AND Industries Private Limited Information Poonawalla Investments AND Industries Private Limited Company Profile Poonawalla Investments AND Industries Private Limited News on The Economic Times The Economic Times Archived from the original on 8 May 2019 Retrieved 10 July 2020 Burns Lawton R 2014 India s Healthcare Industry Innovation in Delivery Financing and Manufacturing Cambridge University Press pp 488 489 ISBN 9781316021217 India developing indigenous swine flu vaccine The Times of India Retrieved 1 February 2015 Kulkarni Prasad S Raut Sidram K Dhere Rajeev M 27 October 2014 A post marketing surveillance study of a human live virus pandemic influenza A H1N1 vaccine Nasovac in India Human Vaccines amp Immunotherapeutics 9 1 122 124 doi 10 4161 hv 22317 PMC 3667925 PMID 23442586 Unnikrishnan C H 4 July 2012 Serum Institute buys Bilthoven Biologicals Livemint Retrieved 1 July 2020 Fast acting anti rabies drug set for India launch Times of India The Times of India 24 February 2016 Retrieved 12 June 2016 Kulkarni Prasad S Sahai Ashish Gunale Bhagwat Dhere Rajeev M 3 March 2017 Development of a new purified vero cell rabies vaccine Rabivax S at the serum institute of India Pvt Ltd Expert Review of Vaccines 16 4 303 311 doi 10 1080 14760584 2017 1294068 PMID 28276304 S2CID 3382124 Serum Institute to focus on supplying COVID 19 vaccine to India first Reuters 23 November 2020 Retrieved 26 November 2020 Krishnan Murali 29 September 2020 Coronavirus vaccine Why does India s Serum Institute have a head start Deutsche Welle Retrieved 26 November 2020 Choo Olivia 16 December 2022 How this millennial CEO steered the world s largest vaccine maker during the pandemic CNBC Retrieved 9 October 2023 Serum Institute Tubervac BCG Serum Institute of India Retrieved 15 June 2020 Serum Institute Poliovac Serum Institute of India Retrieved 15 June 2020 Vaccination Schedule Vaccination as per the National Immunization schedule by Government of India Retrieved 15 June 2020 AstraZeneca amp Serum Institute of India sign licensing deal for 1 million doses of Oxford vaccine The Economic Times Retrieved 15 June 2020 Covid 19 vaccine Serum Institute signs up for 100 million doses of vaccines for India low and middle income countries The Financial Express 7 August 2020 Banerjee Shoumojit 7 July 2020 Oxford COVID 19 vaccine at least 6 months away from launch Serum Institute CEO The Hindu Coronavirus Covid 19 vaccine latest update Oxford AstraZeneca corona vaccine production starts US says 2 billion doses ready to go The Indian Express 10 June 2020 Indian company aims for a billion Covid vaccines BBC News Retrieved 21 March 2021 Serum Institute of India to provide Covid 19 vaccines through COVAX at Rs 225 a dose The Indian Express 7 August 2020 Sharma Milan Serum Institute halts coronavirus vaccine trials in India after notice from DCGI over volunteer s illness in UK India Today Retrieved 10 September 2020 Oxford vaccine trial paused as participant falls ill BBC News 9 September 2020 Retrieved 10 September 2020 Ghosh Poulomi 12 September 2020 Serum Institute to resume Covid 19 vaccine trial after DGCI gives nod Hindustan Times India will have Covid 19 vaccine within days AIIMS director Hindustan Times 31 December 2021 Retrieved 31 December 2020 Schmall E Yasir S 3 January 2021 India Approves Oxford AstraZeneca Covid 19 Vaccine and 1 Other The New York Times Retrieved 3 January 2021 Covid vaccine India shortfall behind UK s supply delay BBC News 18 March 2021 Serum Institute Novavax in covid vaccine deal may produce 100 crore doses Livemint 7 August 2020 Novavax signs COVID 19 vaccine supply deal with India s Serum Institute Reuters 5 August 2020 Serum Institute starts manufacturing Codagenix s nasal COVID 19 vaccine mint 22 September 2020 India s Serum Institute starts manufacturing Codagenix s potential Covid 19 vaccine Hindustan Times 22 September 2020 Codagenix and Serum Institute of India Announce Commencement of First in Human Trial of COVI VAC A Single Dose Intranasal Live Attenuated Vaccine for COVID 19 Codagenix Retrieved 22 April 2021 Serum Institute gets DCGI s nod to manufacture Covid vaccine Sputnik V in India mint 4 June 2021 rdif ru press release Das Krishna N 1 March 2021 Chinese hackers target Indian vaccine makers SII Bharat Biotech says security firm Reuters Retrieved 1 March 2021 What is the new anti malaria vaccine cleared by WHO all about Will it work for India The Indian Express 3 October 2023 Retrieved 9 October 2023 Oxford R21 Matrix M malaria vaccine receives WHO recommendation for use paving the way for global roll out University of Oxford www ox ac uk 2 October 2023 Retrieved 9 October 2023 Serum Institute Of India Press Release 02 October 2023 www seruminstitute com External links editOfficial website Retrieved from https en wikipedia org w index php title Serum Institute of India amp oldid 1188399426, wikipedia, wiki, book, books, library,

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