^ abcGRCh38: Ensembl release 89: ENSG00000132872 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024261 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hilbush BS, Morgan JI (Sep 1994). "A third synaptotagmin gene, Syt3, in the mouse". Proc Natl Acad Sci U S A. 91 (17): 8195–9. doi:10.1073/pnas.91.17.8195. PMC44572. PMID 8058779.
Ullrich B, Li C, Zhang JZ, et al. (1995). "Functional properties of multiple synaptotagmins in brain". Neuron. 13 (6): 1281–91. doi:10.1016/0896-6273(94)90415-4. PMID 7993622. S2CID 23856449.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC25443. PMID 10397765.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Ferguson GD, Chen XN, Korenberg JR, Herschman HR (2001). "The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity". J. Biol. Chem. 275 (47): 36920–6. doi:10.1074/jbc.M005801200. PMID 10938284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
External linksedit
Overview of all the structural information available in the PDB for UniProt: Q9H2B2 (Human Synaptotagmin-4) at the PDBe-KB.
This protein-related article is a stub. You can help Wikipedia by expanding it.
syt4, synaptotagmin, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1ugkidentifiersaliases, hst1192, synaptotagmin, 4external, idsomim, 600103, 101759, homologene, 7559, genecards, gene, location, human, ch. Synaptotagmin 4 is a protein that in humans is encoded by the SYT4 gene 5 6 SYT4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1UGKIdentifiersAliasesSYT4 HsT1192 synaptotagmin 4External IDsOMIM 600103 MGI 101759 HomoloGene 7559 GeneCards SYT4Gene location Human Chr Chromosome 18 human 1 Band18q12 3Start43 267 892 bp 1 End43 277 535 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 B1 18 17 75 cMStart31 570 861 bp 2 End31 580 459 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incerebellar vermisendothelial cellcerebellar hemisphereBrodmann area 23Brodmann area 46middle temporal gyrussuperior frontal gyrussuperior vestibular nucleusislet of LangerhansponsTop expressed incerebellar vermisventral tegmental areapineal glanddorsomedial hypothalamic nucleushabenulaventromedial nucleusparaventricular nucleus of hypothalamuslateral hypothalamusbarrel cortexdorsal tegmental nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding clathrin binding phosphatidylserine binding metal ion binding protein binding SNARE binding syntaxin 1 binding syntaxin binding syntaxin 3 binding protein homodimerization activity protein heterodimerization activity calcium dependent phospholipid bindingCellular componentintegral component of membrane intracellular membrane bounded organelle membrane synapse synaptic vesicle membrane cell junction perinuclear region of cytoplasm neuron projection dense core granule cytoplasmic vesicle dendrite Golgi apparatus vesicle axon plasma membrane synaptic vesicle integral component of Golgi membrane integral component of synaptic vesicle membrane secretory granule membrane dense core granule membrane somatodendritic compartment neuronal cell body neuron projection terminus exocytic vesicle astrocyte projection microvesicle glutamatergic synapse integral component of neuronal dense core vesicle membraneBiological processcell differentiation brain development positive regulation of dendrite extension negative regulation of vesicle fusion neurotransmitter secretion exocytosis vesicle fusion calcium ion regulated exocytosis of neurotransmitter memory positive regulation of glutamate secretion regulation of dopamine secretion regulation of endocytosis regulation of vesicle fusion negative regulation of catecholamine secretion positive regulation of calcium ion dependent exocytosis negative regulation of neurotransmitter secretion negative regulation of short term neuronal synaptic plasticity vesicle fusion with vesicle secretory granule maturation negative regulation of protein secretion negative regulation of retrograde trans synaptic signaling by neuropeptide regulation of calcium ion dependent exocytosis negative regulation of calcium ion dependent exocytosis trans synaptic signaling by BDNF modulating synaptic transmission vesicle mediated transport calcium ion regulated exocytosis cellular response to calcium ion regulation of presynaptic dense core granule exocytosis negative regulation of dense core granule exocytosis positive regulation of dense core granule exocytosis negative regulation of synaptic vesicle exocytosisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez686020983EnsemblENSG00000132872ENSMUSG00000024261UniProtQ9H2B2P40749RefSeq mRNA NM 020783NM 009308RefSeq protein NP 065834NP 033334Location UCSC Chr 18 43 27 43 28 MbChr 18 31 57 31 58 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000132872 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024261 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Hilbush BS Morgan JI Sep 1994 A third synaptotagmin gene Syt3 in the mouse Proc Natl Acad Sci U S A 91 17 8195 9 doi 10 1073 pnas 91 17 8195 PMC 44572 PMID 8058779 Entrez Gene SYT4 synaptotagmin IV Further reading editUllrich B Li C Zhang JZ et al 1995 Functional properties of multiple synaptotagmins in brain Neuron 13 6 1281 91 doi 10 1016 0896 6273 94 90415 4 PMID 7993622 S2CID 23856449 Perin MS 1996 Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin Biochemistry 35 43 13808 16 doi 10 1021 bi960853x PMID 8901523 Thomas DM Ferguson GD Herschman HR Elferink LA 1999 Functional and biochemical analysis of the C2 domains of synaptotagmin IV Mol Biol Cell 10 7 2285 95 doi 10 1091 mbc 10 7 2285 PMC 25443 PMID 10397765 Nagase T Kikuno R Ishikawa KI et al 2000 Prediction of the coding sequences of unidentified human genes XVI The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro DNA Res 7 1 65 73 doi 10 1093 dnares 7 1 65 PMID 10718198 Mizutani A Fukuda M Ibata K et al 2000 SYNCRIP a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R interacts with ubiquitous synaptotagmin isoforms J Biol Chem 275 13 9823 31 doi 10 1074 jbc 275 13 9823 PMID 10734137 Ferguson GD Chen XN Korenberg JR Herschman HR 2001 The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity J Biol Chem 275 47 36920 6 doi 10 1074 jbc M005801200 PMID 10938284 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 External links editOverview of all the structural information available in the PDB for UniProt Q9H2B2 Human Synaptotagmin 4 at the PDBe KB nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SYT4 amp oldid 1142789500, wikipedia, wiki, book, books, library,
