SUV39H2

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.^[5][6]

SUV39H2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R3A
Identifiers
Aliases	SUV39H2, KMT1B, suppressor of variegation 3-9 homolog 2, SUV39H2 histone lysine methyltransferase
External IDs	OMIM: 606503 MGI: 1890396 HomoloGene: 32548 GeneCards: SUV39H2
Gene location (Human) Chr. Chromosome 10 (human)^[1] Band 10p13 Start 14,878,820 bp^[1] End 14,904,315 bp^[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)^[2] Band 2 A1|2 1.95 cM Start 3,456,852 bp^[2] End 3,476,068 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte ganglionic eminence stromal cell of endometrium islet of Langerhans rectum Achilles tendon appendix Brodmann area 23 tibia Top expressed in secondary oocyte spermatid primitive streak abdominal wall medial ganglionic eminence otic placode maxillary prominence cumulus cell somite seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity histone methyltransferase activity (H3-K9 specific) transcription cis-regulatory region binding metal ion binding protein binding histone-lysine N-methyltransferase activity zinc ion binding S-adenosyl-L-methionine binding Cellular component chromosome nucleoplasm chromatin chromosome, centromeric region nucleus Biological process chromatin remodeling cell differentiation regulation of transcription, DNA-templated rhythmic process histone H3-K9 dimethylation negative regulation of circadian rhythm negative regulation of transcription by RNA polymerase II transcription, DNA-templated histone H3-K9 trimethylation methylation histone lysine methylation cell cycle negative regulation of transcription, DNA-templated cellular response to hypoxia chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79723 64707 Ensembl ENSG00000152455 ENSMUSG00000026646 UniProt Q9H5I1 Q9EQQ0 RefSeq (mRNA) NM_001193424 NM_001193425 NM_001193426 NM_001193427 NM_024670 NM_022724 RefSeq (protein) NP_001180353 NP_001180354 NP_001180355 NP_001180356 NP_078946 NP_073561 Location (UCSC) Chr 10: 14.88 – 14.9 Mb Chr 2: 3.46 – 3.48 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000152455 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026646 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol. 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.
6. "Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–9. doi:10.1038/35020506. PMID 10949293. S2CID 205008015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells". EMBO J. 23 (3): 605–15. doi:10.1038/sj.emboj.7600074. PMC 1271807. PMID 14765126.
• Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene. 23 (30): 5242–51. doi:10.1038/sj.onc.1207660. PMID 15107829.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis. 27 (11): 2217–22. doi:10.1093/carcin/bgl084. PMID 16774942.