SUPT6H

Transcription elongation factor SPT6 is a protein that in humans is encoded by the SUPT6H gene.^[5][6]

SUPT6H
Identifiers
Aliases	SUPT6H, SPT6, SPT6H, emb-5, SPT6 homolog, histone chaperone, SPT6 homolog, histone chaperone and transcription elongation factor
External IDs	OMIM: 601333 MGI: 107726 HomoloGene: 40661 GeneCards: SUPT6H
Gene location (Human) Chr. Chromosome 17 (human)^[1] Band 17q11.2 Start 28,662,198 bp^[1] End 28,702,679 bp^[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)^[2] Band 11 B5|11 46.74 cM Start 78,097,572 bp^[2] End 78,136,813 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium gastric mucosa anterior pituitary gastrocnemius muscle popliteal artery skin of abdomen body of stomach left lobe of thyroid gland minor salivary gland Top expressed in yolk sac superior frontal gyrus entorhinal cortex cerebellar cortex cumulus cell corneal stroma lip pituitary gland secondary oocyte hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity histone binding protein binding nucleic acid binding nucleosome binding RNA binding Cellular component nucleus nucleoplasm transcription elongation factor complex Biological process chromatin remodeling negative regulation of histone H3-K27 methylation mRNA transport regulation of transcription, DNA-templated regulation of muscle cell differentiation regulation of mRNA export from nucleus regulation of transcription by RNA polymerase II mRNA processing regulation of DNA-templated transcription, elongation transcription, DNA-templated RNA splicing regulation of isotype switching viral process nucleobase-containing compound metabolic process positive regulation of transcription elongation from RNA polymerase II promoter transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter nucleosome organization mRNA transcription by RNA polymerase II regulation of mRNA processing transport blastocyst formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6830 20926 Ensembl ENSG00000109111 ENSMUSG00000002052 UniProt Q7KZ85 Q62383 RefSeq (mRNA) NM_003170 NM_001320755 NM_009297 RefSeq (protein) NP_001307684 NP_003161 NP_033323 Location (UCSC) Chr 17: 28.66 – 28.7 Mb Chr 11: 78.1 – 78.14 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000109111 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002052 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics. 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID 8786132.
6. "Entrez Gene: SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Chiang PW, Stubbs L, Zhang L, Kurnit DM (1998). "Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6". Genomics. 47 (3): 426–8. doi:10.1006/geno.1997.5137. PMID 9480761.
• Wu-Baer F, Lane WS, Gaynor RB (1998). "Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation". J. Mol. Biol. 277 (2): 179–97. doi:10.1006/jmbi.1997.1601. PMID 9514752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Endoh M, Zhu W, Hasegawa J, et al. (2004). "Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro". Mol. Cell. Biol. 24 (8): 3324–36. doi:10.1128/MCB.24.8.3324-3336.2004. PMC 381665. PMID 15060154.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.