The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
^ abcGRCh38: Ensembl release 89: ENSG00000134910 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032116 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: STT3A, catalytic subunit of the oligosaccharyltransferase complex". Retrieved 2018-07-12.
Further readingedit
Ruiz-Canada C, Kelleher DJ, Gilmore R (January 2009). "Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms". Cell. 136 (2): 272–83. doi:10.1016/j.cell.2008.11.047. PMC2859625. PMID 19167329.
Patel MR, Stadler ME, Deal AM, Kim HS, Shores CG, Zanation AM (May 2011). "STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates". Laryngoscope. 121 (5): 983–9. doi:10.1002/lary.21736. PMID 21520112. S2CID 206198313.
Sigstad E, Paus E, Bjøro T, Berner A, Grøholt KK, Jørgensen LH, Sobrinho-Simões M, Holm R, Warren DJ (April 2012). "The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors". Mod. Pathol. 25 (4): 537–47. doi:10.1038/modpathol.2011.188. PMC3318159. PMID 22157935.
Shrimal S, Ng BG, Losfeld ME, Gilmore R, Freeze HH (November 2013). "Mutations in STT3A and STT3B cause two congenital disorders of glycosylation". Hum. Mol. Genet. 22 (22): 4638–45. doi:10.1093/hmg/ddt312. PMC3888133. PMID 23842455.
Malaby HL, Kobertz WR (August 2014). "The middle X residue influences cotranslational N-glycosylation consensus site skipping". Biochemistry. 53 (30): 4884–93. doi:10.1021/bi500681p. PMC4372077. PMID 25029371.
Ghosh A, Urquhart J, Daly S, Ferguson A, Scotcher D, Morris AA, Clayton-Smith J (May 2017). "Phenotypic Heterogeneity in a Congenital Disorder of Glycosylation Caused by Mutations in STT3A" (PDF). J. Child Neurol. 32 (6): 560–565. doi:10.1177/0883073817696816. PMID 28424003. S2CID 11435676.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
stt3a, catalytic, subunit, oligosaccharyltransferase, complex, stt3a, catalytic, subunit, oligosaccharyltransferase, complex, protein, that, humans, encoded, stt3a, gene, stt3aidentifiersaliasesstt3a, itm1, stt3, catalytic, subunit, oligosaccharyltransferase, . STT3A catalytic subunit of the oligosaccharyltransferase complex is a protein that in humans is encoded by the STT3A gene 5 STT3AIdentifiersAliasesSTT3A ITM1 STT3 A TMC catalytic subunit of the oligosaccharyltransferase complex STT3 oligosaccharyltransferase complex catalytic subunit A CDG1WAR CDG1WADExternal IDsOMIM 601134 MGI 105124 HomoloGene 40617 GeneCards STT3AGene location Human Chr Chromosome 11 human 1 Band11q24 2Start125 591 712 bp 1 End125 625 215 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 A4 9 20 67 cMStart36 640 640 bp 2 End36 678 975 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumbody of pancreasislet of Langerhanscanal of the cervixrectumAchilles tendongallbladderright lobe of thyroid glandleft uterine tubeminor salivary glandsTop expressed inotic placodecumulus cellsacculelacrimal glandsubmandibular glandcalvariaseminal vesiculayolk sacmolarureterMore reference expression dataBioGPSn aGene ontologyMolecular functionoligosaccharyl transferase activity glycosyltransferase activity protein binding transferase activity dolichyl diphosphooligosaccharide protein glycotransferase activity metal ion bindingCellular componentendoplasmic reticulum membrane integral component of membrane endoplasmic reticulum oligosaccharyltransferase complex membrane oligosaccharyltransferase III complexBiological processco translational protein modification protein glycosylation protein N linked glycosylation via asparagine post translational protein modificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez370316430EnsemblENSG00000134910ENSMUSG00000032116UniProtP46977P46978RefSeq mRNA NM 001278503NM 001278504NM 152713NM 008408RefSeq protein NP 001265432NP 001265433NP 689926NP 032434Location UCSC Chr 11 125 59 125 63 MbChr 9 36 64 36 68 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further readingFunction editThe protein encoded by this gene is a catalytic subunit of the N oligosaccharyltransferase OST complex which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins A separate complex containing a similar catalytic subunit with an overlapping function also exists Multiple transcript variants encoding different isoforms have been found for this gene provided by RefSeq Aug 2015 See also editOligosaccharyltransferaseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000134910 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032116 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene STT3A catalytic subunit of the oligosaccharyltransferase complex Retrieved 2018 07 12 Further reading editRuiz Canada C Kelleher DJ Gilmore R January 2009 Cotranslational and posttranslational N glycosylation of polypeptides by distinct mammalian OST isoforms Cell 136 2 272 83 doi 10 1016 j cell 2008 11 047 PMC 2859625 PMID 19167329 Patel MR Stadler ME Deal AM Kim HS Shores CG Zanation AM May 2011 STT3A C1orf24 TFF3 putative markers for characterization of follicular thyroid neoplasms from fine needle aspirates Laryngoscope 121 5 983 9 doi 10 1002 lary 21736 PMID 21520112 S2CID 206198313 Sigstad E Paus E Bjoro T Berner A Groholt KK Jorgensen LH Sobrinho Simoes M Holm R Warren DJ April 2012 The new molecular markers DDIT3 STT3A ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors Mod Pathol 25 4 537 47 doi 10 1038 modpathol 2011 188 PMC 3318159 PMID 22157935 Shrimal S Ng BG Losfeld ME Gilmore R Freeze HH November 2013 Mutations in STT3A and STT3B cause two congenital disorders of glycosylation Hum Mol Genet 22 22 4638 45 doi 10 1093 hmg ddt312 PMC 3888133 PMID 23842455 Malaby HL Kobertz WR August 2014 The middle X residue influences cotranslational N glycosylation consensus site skipping Biochemistry 53 30 4884 93 doi 10 1021 bi500681p PMC 4372077 PMID 25029371 Ghosh A Urquhart J Daly S Ferguson A Scotcher D Morris AA Clayton Smith J May 2017 Phenotypic Heterogeneity in a Congenital Disorder of Glycosylation Caused by Mutations in STT3A PDF J Child Neurol 32 6 560 565 doi 10 1177 0883073817696816 PMID 28424003 S2CID 11435676 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Stt3a catalytic subunit of the oligosaccharyltransferase complex amp oldid 1142720914, wikipedia, wiki, book, books, library,
