The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000147465 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031574 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Stocco DM (May 2002). "Clinical disorders associated with abnormal cholesterol transport: mutations in the steroidogenic acute regulatory protein". Mol. Cell. Endocrinol. 191 (1): 19–25. doi:10.1016/s0303-7207(02)00048-5. PMID 12044915. S2CID 23614656.
Tuckey RC, Headlam MJ, Bose HS, Miller WL (December 2002). "Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR)". J. Biol. Chem. 277 (49): 47123–8. doi:10.1074/jbc.M206965200. PMID 12372832.
Mathieu AP, Lavigne P, LeHoux JG (November 2002). "Molecular modeling and structure-based thermodynamic analysis of the StAR protein". Endocr. Res. 28 (4): 419–23. doi:10.1081/erc-120016817. PMID 12530644. S2CID 25030552.
Tajima K, Dantes A, Yao Z, Sorokina K, Kotsuji F, Seger R, Amsterdam A (May 2003). "Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1". J. Clin. Endocrinol. Metab. 88 (5): 2288–99. doi:10.1210/jc.2002-020913. PMID 12727988.
Kim HJ, Kim JE, Ha M, Kang SS, Kim JT, Park IS, Paek SH, Jung HW, Kim DG, Cho GJ, Choi WS (July 2003). "Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors". Brain Res. 978 (1–2): 245–9. doi:10.1016/s0006-8993(03)02840-3. PMID 12834921. S2CID 32869169.
Kohen P, Castro O, Palomino A, Muñoz A, Christenson LK, Sierralta W, Carvallo P, Strauss JF, Devoto L (July 2003). "The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase". J. Clin. Endocrinol. Metab. 88 (7): 3421–30. doi:10.1210/jc.2002-021916. PMID 12843197.
Sugawara T, Shimizu H, Hoshi N, Nakajima A, Fujimoto S (October 2003). "Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system". J. Biol. Chem. 278 (43): 42487–94. doi:10.1074/jbc.M302291200. PMID 12909641.
Sun HS, Hsiao KY, Hsu CC, Wu MH, Tsai SJ (September 2003). "Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor". Endocrinology. 144 (9): 3934–42. doi:10.1210/en.2003-0289. PMID 12933667.
Li J, Feltzer RE, Dawson KL, Hudson EA, Clark BJ (December 2003). "Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells". J. Biol. Chem. 278 (52): 52355–62. doi:10.1074/jbc.M305232200. PMID 14565954.
This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.
star, gene, steroidogenic, acute, regulatory, protein, protein, that, humans, encoded, star, gene, staravailable, structurespdbortholog, search, pdbe, rcsblist, codes3p0lidentifiersaliasesstar, stard1, steroidogenic, acute, regulatory, proteinexternal, idsomim. Steroidogenic acute regulatory protein is a protein that in humans is encoded by the STAR gene 5 STARAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes3P0LIdentifiersAliasesSTAR STARD1 steroidogenic acute regulatory proteinExternal IDsOMIM 600617 MGI 102760 HomoloGene 297 GeneCards STARGene location Human Chr Chromosome 8 human 1 Band8p11 23Start38 142 700 bp 1 End38 150 992 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 A2 8 14 17 cMStart26 296 583 bp 2 End26 306 010 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright adrenal glandleft adrenal glandleft uterine tubeprefrontal cortexstromal cell of endometriumoocyteendothelial cellhypothalamusskin of abdomenBrodmann area 9Top expressed inadrenal glandplacentaspermatocytetesticleadrenal medullaaortic valvespleenascending aortaovaryseminiferous tubuleMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding cholesterol transfer activity lipid binding cholesterol bindingCellular componentcytosol mitochondrial intermembrane space neuronal cell body mitochondrial crista neuron projection mitochondrionBiological processnegative regulation of neuron apoptotic process cellular response to transforming growth factor beta stimulus estrogen biosynthetic process response to ionizing radiation response to fungicide cellular response to gonadotropin stimulus phenol containing compound metabolic process male gonad development phthalate metabolic process biphenyl metabolic process cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus lipid transport cellular lipid metabolic process response to organic cyclic compound cellular response to follicle stimulating hormone stimulus circadian sleep wake cycle REM sleep response to nutrient insecticide metabolic process glucocorticoid metabolic process diterpenoid metabolic process response to corticosterone response to antibiotic response to steroid hormone cellular response to organic cyclic compound response to nicotine regulation of steroid biosynthetic process response to peptide hormone cholesterol metabolic process cellular response to alkaloid cellular response to cadmium ion cellular response to fibroblast growth factor stimulus response to activity response to organic substance response to gonadotropin cellular response to dexamethasone stimulus response to estrogen cellular response to epinephrine stimulus C21 steroid hormone biosynthetic process positive regulation of neurogenesis brain development positive regulation of gene expression cellular response to metal ion intracellular cholesterol transport response to nutrient levels response to lead ion dibenzo p dioxin metabolic process circadian rhythm cellular response to interferon alpha cellular response to insulin stimulus cellular response to interferon gamma cellular response to antibiotic regulation of neuronal synaptic plasticity response to insecticide response to ethanol response to leptin bile acid biosynthetic process cellular response to lipopolysaccharide response to toxic substance response to herbicide response to hydrogen peroxide testosterone biosynthetic process cellular response to cAMP cellular response to glucose stimulus steroid biosynthetic process organic acid metabolic process positive regulation of bile acid biosynthetic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez677020845EnsemblENSG00000147465ENSMUSG00000031574UniProtP49675P51557RefSeq mRNA NM 000349NM 001007243NM 011485RefSeq protein NP 000340NP 035615Location UCSC Chr 8 38 14 38 15 MbChr 8 26 3 26 31 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editThe protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia CLAH also called lipoid CAH A pseudogene of this gene is located on chromosome 13 provided by RefSeq Jul 2008 References edit a b c GRCh38 Ensembl release 89 ENSG00000147465 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031574 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Steroidogenic acute regulatory protein Retrieved 2018 06 24 Further reading editStocco DM May 2002 Clinical disorders associated with abnormal cholesterol transport mutations in the steroidogenic acute regulatory protein Mol Cell Endocrinol 191 1 19 25 doi 10 1016 s0303 7207 02 00048 5 PMID 12044915 S2CID 23614656 Tuckey RC Headlam MJ Bose HS Miller WL December 2002 Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein StAR J Biol Chem 277 49 47123 8 doi 10 1074 jbc M206965200 PMID 12372832 Mathieu AP Lavigne P LeHoux JG November 2002 Molecular modeling and structure based thermodynamic analysis of the StAR protein Endocr Res 28 4 419 23 doi 10 1081 erc 120016817 PMID 12530644 S2CID 25030552 Tajima K Dantes A Yao Z Sorokina K Kotsuji F Seger R Amsterdam A May 2003 Down regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen activated protein kinase activation and modulation of DAX 1 and steroidogenic factor 1 J Clin Endocrinol Metab 88 5 2288 99 doi 10 1210 jc 2002 020913 PMID 12727988 Kim HJ Kim JE Ha M Kang SS Kim JT Park IS Paek SH Jung HW Kim DG Cho GJ Choi WS July 2003 Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors Brain Res 978 1 2 245 9 doi 10 1016 s0006 8993 03 02840 3 PMID 12834921 S2CID 32869169 Kohen P Castro O Palomino A Munoz A Christenson LK Sierralta W Carvallo P Strauss JF Devoto L July 2003 The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase J Clin Endocrinol Metab 88 7 3421 30 doi 10 1210 jc 2002 021916 PMID 12843197 Sugawara T Shimizu H Hoshi N Nakajima A Fujimoto S October 2003 Steroidogenic acute regulatory protein binding protein cloned by a yeast two hybrid system J Biol Chem 278 43 42487 94 doi 10 1074 jbc M302291200 PMID 12909641 Sun HS Hsiao KY Hsu CC Wu MH Tsai SJ September 2003 Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor Endocrinology 144 9 3934 42 doi 10 1210 en 2003 0289 PMID 12933667 Li J Feltzer RE Dawson KL Hudson EA Clark BJ December 2003 Janus kinase 2 and calcium are required for angiotensin II dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells J Biol Chem 278 52 52355 62 doi 10 1074 jbc M305232200 PMID 14565954 nbsp This article on a gene on human chromosome 8 is a stub You can help Wikipedia by expanding it vte This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title STAR gene amp oldid 1170648706, wikipedia, wiki, book, books, library,
