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SSR-180,575

January 01, 1970

SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.[1][2][3][4]

SSR-180,575
Clinical data
ATC code
  • None
Identifiers
  • 7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide
CAS Number
  • 220448-02-2 Y
PubChem CID
  • 9930560
ChemSpider
  • 8106191
UNII
  • 4K8W47WK2L
CompTox Dashboard (EPA)
  • DTXSID10433007
Chemical and physical data
FormulaC21H19ClN4O2
Molar mass394.86 g·mol−1
3D model (JSmol)
  • Interactive image
  • Cn2c3cc(Cl)ccc3c1c2c(=O)n(nc1CC(=O)N(C)C)-c4ccccc4
  • InChI=1S/C21H19ClN4O2/c1-24(2)18(27)12-16-19-15-10-9-13(22)11-17(15)25(3)20(19)21(28)26(23-16)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3
  • Key:HJSQVJOROCIILI-UHFFFAOYSA-N
 NY (what is this?)  (verify)

See also edit

References edit

  1. ^ Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. (June 2002). "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1067–78. doi:10.1124/jpet.301.3.1067. PMID 12023539. S2CID 16732360.
  2. ^ Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, et al. (September 2003). "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics. 306 (3): 828–37. doi:10.1124/jpet.103.052068. PMID 12928523. S2CID 1101660.
  3. ^ Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Séguélas MH, Leducq N, et al. (August 2004). "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology. 15 (8): 2152–60. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.
  4. ^ Veenman L, Gavish M (June 2006). "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics. 110 (3): 503–24. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.



 

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

January 01, 1970
drug, which, acts, selective, agonist, peripheral, benzodiazepine, receptor, also, known, mitochondrial, translocator, protein, tspo, been, shown, have, neuroprotective, cardioprotective, effects, stimulate, steroidogenesis, pregnenolone, brain, which, linked,. SSR 180 575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor also known as the mitochondrial 18 kDa translocator protein or TSPO It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain which may be linked to its neuroprotective action 1 2 3 4 SSR 180 575Clinical dataATC codeNoneIdentifiersIUPAC name 7 Chloro N N 5 trimethyl 4 oxo 3 phenyl 3 5 dihydro 4H pyridazino 4 5 b indole 1 acetamideCAS Number220448 02 2 YPubChem CID9930560ChemSpider8106191UNII4K8W47WK2LCompTox Dashboard EPA DTXSID10433007Chemical and physical dataFormulaC 21H 19Cl N 4O 2Molar mass394 86 g mol 13D model JSmol Interactive imageSMILES Cn2c3cc Cl ccc3c1c2c O n nc1CC O N C C c4ccccc4InChI InChI 1S C21H19ClN4O2 c1 24 2 18 27 12 16 19 15 10 9 13 22 11 17 15 25 3 20 19 21 28 26 23 16 14 7 5 4 6 8 14 h4 11H 12H2 1 3H3Key HJSQVJOROCIILI UHFFFAOYSA N N Y what is this verify See also editEmapunilReferences edit Ferzaz B Brault E Bourliaud G Robert JP Poughon G Claustre Y et al June 2002 SSR180575 7 chloro N N 5 trimethyl 4 oxo 3 phenyl 3 5 dihydro 4H pyridazino 4 5 b indole 1 acetamide a peripheral benzodiazepine receptor ligand promotes neuronal survival and repair The Journal of Pharmacology and Experimental Therapeutics 301 3 1067 78 doi 10 1124 jpet 301 3 1067 PMID 12023539 S2CID 16732360 Leducq N Bono F Sulpice T Vin V Janiak P Fur GL et al September 2003 Role of peripheral benzodiazepine receptors in mitochondrial cellular and cardiac damage induced by oxidative stress and ischemia reperfusion The Journal of Pharmacology and Experimental Therapeutics 306 3 828 37 doi 10 1124 jpet 103 052068 PMID 12928523 S2CID 1101660 Kunduzova OR Escourrou G De La Farge F Salvayre R Seguelas MH Leducq N et al August 2004 Involvement of peripheral benzodiazepine receptor in the oxidative stress death signaling pathways and renal injury induced by ischemia reperfusion Journal of the American Society of Nephrology 15 8 2152 60 doi 10 1097 01 ASN 0000133563 41148 74 PMID 15284300 Veenman L Gavish M June 2006 The peripheral type benzodiazepine receptor and the cardiovascular system Implications for drug development Pharmacology amp Therapeutics 110 3 503 24 doi 10 1016 j pharmthera 2005 09 007 PMID 16337685 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SSR 180 575 amp oldid 1198967754, wikipedia, wiki, book, books, library,

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