SR-16435 is a drug which acts as a potent partial agonist at both the μ-opioid receptor and nociceptin receptor. In animal studies it was found to be a potent analgesic, with results suggestive of reduced development of tolerance and increased activity against neuropathic pain compared to classic μ-selective agonists.[1][2][3]
^Khroyan TV, Zaveri NT, Polgar WE, Orduna J, Olsen C, Jiang F, Toll L (February 2007). "SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice". The Journal of Pharmacology and Experimental Therapeutics. 320 (2): 934–43. doi:10.1124/jpet.106.111997. PMID 17132815. S2CID 2920534.
^Spagnolo B, Calo G, Polgar WE, Jiang F, Olsen CM, Berzetei-Gurske I, et al. (February 2008). "Activities of mixed NOP and mu-opioid receptor ligands". British Journal of Pharmacology. 153 (3): 609–19. doi:10.1038/sj.bjp.0707598. PMC2241792. PMID 18059322.
^Sukhtankar DD, Zaveri NT, Husbands SM, Ko MC (July 2013). "Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain". The Journal of Pharmacology and Experimental Therapeutics. 346 (1): 11–22. doi:10.1124/jpet.113.203984. PMC3684842. PMID 23652222.
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16435, drug, which, acts, potent, partial, agonist, both, opioid, receptor, nociceptin, receptor, animal, studies, found, potent, analgesic, with, results, suggestive, reduced, development, tolerance, increased, activity, against, neuropathic, pain, compared, . SR 16435 is a drug which acts as a potent partial agonist at both the m opioid receptor and nociceptin receptor In animal studies it was found to be a potent analgesic with results suggestive of reduced development of tolerance and increased activity against neuropathic pain compared to classic m selective agonists 1 2 3 SR 16435IdentifiersIUPAC name 1 1 9 bicyclo 3 3 1 nonanyl piperidin 4 yl 3H indol 2 oneCAS Number857262 16 9PubChem CID11461888Chemical and physical dataFormulaC 22H 30N 2OMolar mass338 495 g mol 13D model JSmol Interactive imageSMILES C1CC2CCCC C1 C2N3CCC CC3 N4C O CC5 CC CC C54InChI InChI 1S C22H30N2O c25 21 15 18 5 1 2 10 20 18 24 21 19 11 13 23 14 12 19 22 16 6 3 7 17 22 9 4 8 16 h1 2 5 10 16 17 19 22H 3 4 6 9 11 15H2Key XVFXJQGBDPFCRF UHFFFAOYSA NSee also EditCebranopadol Brorphine J 113 397 SR 17018References Edit Khroyan TV Zaveri NT Polgar WE Orduna J Olsen C Jiang F Toll L February 2007 SR 16435 1 1 bicyclo 3 3 1 nonan 9 yl piperidin 4 yl indolin 2 one a novel mixed nociceptin orphanin FQ mu opioid receptor partial agonist analgesic and rewarding properties in mice The Journal of Pharmacology and Experimental Therapeutics 320 2 934 43 doi 10 1124 jpet 106 111997 PMID 17132815 S2CID 2920534 Spagnolo B Calo G Polgar WE Jiang F Olsen CM Berzetei Gurske I et al February 2008 Activities of mixed NOP and mu opioid receptor ligands British Journal of Pharmacology 153 3 609 19 doi 10 1038 sj bjp 0707598 PMC 2241792 PMID 18059322 Sukhtankar DD Zaveri NT Husbands SM Ko MC July 2013 Effects of spinally administered bifunctional nociceptin orphanin FQ peptide receptor m opioid receptor ligands in mouse models of neuropathic and inflammatory pain The Journal of Pharmacology and Experimental Therapeutics 346 1 11 22 doi 10 1124 jpet 113 203984 PMC 3684842 PMID 23652222 This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SR 16435 amp oldid 1127581826, wikipedia, wiki, book, books, library,
