SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1[5]).
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000198369 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045671 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wakioka T, Sasaki A, Kato R, et al. (2001). "Spred is a Sprouty-related suppressor of Ras signalling". Nature. 412 (6847): 647–51. Bibcode:2001Natur.412..647W. doi:10.1038/35088082. PMID 11493923. S2CID 4345140.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochem. Biophys. Res. Commun. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nobuhisa I, Kato R, Inoue H, et al. (2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation". J. Exp. Med. 199 (5): 737–42. doi:10.1084/jem.20030830. PMC2213301. PMID 14981116.
Miyoshi K, Wakioka T, Nishinakamura H, et al. (2004). "The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization". Oncogene. 23 (33): 5567–76. doi:10.1038/sj.onc.1207759. PMID 15184877.
Zimmermann J, Jarchau T, Walter U, et al. (2005). "1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain". J. Biomol. NMR. 29 (3): 435–6. doi:10.1023/B:JNMR.0000032526.17586.8c. PMID 15213456. S2CID 37933714.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38. doi:10.1007/s00418-004-0725-6. PMID 15580519. S2CID 24496085.
King JA, Straffon AF, D'Abaco GM, et al. (2005). "Distinct requirements for the Sprouty domain for functional activity of Spred proteins". Biochem. J. 388 (Pt 2): 445–54. doi:10.1042/BJ20041284. PMC1138951. PMID 15683364.
Bundschu K, Knobeloch KP, Ullrich M, et al. (2005). "Gene disruption of Spred-2 causes dwarfism". J. Biol. Chem. 280 (31): 28572–80. doi:10.1074/jbc.M503640200. PMID 15946934.
Yoshida T, Hisamoto T, Akiba J, et al. (2006). "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors". Oncogene. 25 (45): 6056–66. doi:10.1038/sj.onc.1209635. PMID 16652141.
Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.
External linksedit
GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
spred2, sprouty, related, evh1, domain, containing, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2jp2identifiersaliases, spred, sprouty, related, evh1, domain, containing, ns14external, idsomim, . Sprouty related EVH1 domain containing protein 2 is a protein that in humans is encoded by the SPRED2 gene 5 SPRED2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2JP2IdentifiersAliasesSPRED2 Spred 2 sprouty related EVH1 domain containing 2 NS14External IDsOMIM 609292 MGI 2150019 HomoloGene 24918 GeneCards SPRED2Gene location Human Chr Chromosome 2 human 1 Band2p14Start65 310 851 bp 1 End65 432 637 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 A3 1Start19 874 375 bp 2 End19 974 026 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nervepostcentral gyrusprefrontal cortexsuperior frontal gyrusBrodmann area 46dorsolateral prefrontal cortexascending aortacingulate gyrusganglionic eminenceright lungTop expressed inprimitive streakprefrontal cortexcingulate gyrushair follicleprimary motor cortexhippocampus propercerebellar vermisnucleus accumbenssubiculumparotid glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding protein kinase binding protein serine threonine kinase inhibitor activity stem cell factor receptor bindingCellular componentcytoplasm plasma membrane transport vesicle membrane membrane cytoplasmic vesicle cytosolBiological processmulticellular organism development negative regulation of peptidyl threonine phosphorylation regulation of signal transduction fibroblast growth factor receptor signaling pathway regulation of protein deacetylation positive regulation of DNA damage response signal transduction by p53 class mediatorSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez200734114716EnsemblENSG00000198369ENSMUSG00000045671UniProtQ7Z698Q924S7RefSeq mRNA NM 001128210NM 181784NM 033523RefSeq protein NP 001121682NP 861449NP 277058Location UCSC Chr 2 65 31 65 43 MbChr 11 19 87 19 97 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editSPRED2 is a member of the Sprouty see SPRY1 SPRED family of proteins that regulate growth factor induced activation of the MAP kinase cascade see MAPK1 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000198369 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000045671 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene SPRED2 sprouty related EVH1 domain containing 2 Further reading editAndersson B Wentland MA Ricafrente JY et al 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Yu W Andersson B Worley KC et al 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Wakioka T Sasaki A Kato R et al 2001 Spred is a Sprouty related suppressor of Ras signalling Nature 412 6847 647 51 Bibcode 2001Natur 412 647W doi 10 1038 35088082 PMID 11493923 S2CID 4345140 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kato R Nonami A Taketomi T et al 2003 Molecular cloning of mammalian Spred 3 which suppresses tyrosine kinase mediated Erk activation Biochem Biophys Res Commun 302 4 767 72 doi 10 1016 S0006 291X 03 00259 6 PMID 12646235 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Nobuhisa I Kato R Inoue H et al 2004 Spred 2 suppresses aorta gonad mesonephros hematopoiesis by inhibiting MAP kinase activation J Exp Med 199 5 737 42 doi 10 1084 jem 20030830 PMC 2213301 PMID 14981116 Miyoshi K Wakioka T Nishinakamura H et al 2004 The Sprouty related protein Spred inhibits cell motility metastasis and Rho mediated actin reorganization Oncogene 23 33 5567 76 doi 10 1038 sj onc 1207759 PMID 15184877 Zimmermann J Jarchau T Walter U et al 2005 1H 13C and 15N resonance assignment of the human Spred2 EVH1 domain J Biomol NMR 29 3 435 6 doi 10 1023 B JNMR 0000032526 17586 8c PMID 15213456 S2CID 37933714 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Engelhardt CM Bundschu K Messerschmitt M et al 2005 Expression and subcellular localization of Spred proteins in mouse and human tissues Histochem Cell Biol 122 6 527 38 doi 10 1007 s00418 004 0725 6 PMID 15580519 S2CID 24496085 King JA Straffon AF D Abaco GM et al 2005 Distinct requirements for the Sprouty domain for functional activity of Spred proteins Biochem J 388 Pt 2 445 54 doi 10 1042 BJ20041284 PMC 1138951 PMID 15683364 Bundschu K Knobeloch KP Ullrich M et al 2005 Gene disruption of Spred 2 causes dwarfism J Biol Chem 280 31 28572 80 doi 10 1074 jbc M503640200 PMID 15946934 Yoshida T Hisamoto T Akiba J et al 2006 Spreds inhibitors of the Ras ERK signal transduction are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors Oncogene 25 45 6056 66 doi 10 1038 sj onc 1209635 PMID 16652141 Lock P I ST Straffon AF et al 2007 Spred 2 steady state levels are regulated by phosphorylation and Cbl mediated ubiquitination Biochem Biophys Res Commun 351 4 1018 23 doi 10 1016 j bbrc 2006 10 150 PMID 17094949 External links editGeneReviews NIH NCBI UW entry on Legius syndrome SPRED1 Sprouty related EVH1 domain containing protein 1 nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SPRED2 amp oldid 1142675650, wikipedia, wiki, book, books, 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