SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.[6] It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000113658 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021540 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. S2CID 10124489.
^"Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com
mothers, against, decapentaplegic, homolog, also, known, smad5, protein, that, humans, encoded, smad5, gene, smad5identifiersaliasessmad5, dwfc, madh5, smad, family, member, 5external, idsomim, 603110, 1328787, homologene, 4313, genecards, smad5gene, location,. Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene 5 SMAD5IdentifiersAliasesSMAD5 DWFC JV5 1 MADH5 SMAD family member 5External IDsOMIM 603110 MGI 1328787 HomoloGene 4313 GeneCards SMAD5Gene location Human Chr Chromosome 5 human 1 Band5q31 1Start136 132 845 bp 1 End136 188 747 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 B1 13 30 12 cMStart56 850 823 bp 2 End56 890 190 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incaput epididymislactiferous ductcorpus epididymisnipplegerminal epitheliumsuperficial temporal arteryAchilles tendonendothelial cellurethrasecondary oocyteTop expressed inmaxillary prominencePaneth celluretermedial ganglionic eminencehair follicleleft lung loberenal corpusclecondylemolarendocardial cushionMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding DNA binding transcription factor activity metal ion binding protein binding ubiquitin protein ligase binding DEAD H box RNA helicase binding RNA polymerase II transcription regulatory region sequence specific DNA binding RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specificCellular componentSMAD protein complex transcription regulator complex intracellular anatomical structure nucleoplasm nucleus cytoplasm cytosol protein containing complexBiological processgerm cell development ureteric bud development cardiac muscle contraction regulation of transcription DNA templated SMAD protein signal transduction embryonic pattern specification ossification cellular response to organic cyclic compound cellular response to BMP stimulus BMP signaling pathway transcription DNA templated positive regulation of transcription DNA templated Mullerian duct regression protein phosphorylation cartilage development positive regulation of osteoblast differentiation erythrocyte differentiation bone development transforming growth factor beta receptor signaling pathway signal transduction positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus positive regulation of transcription by RNA polymerase II osteoblast fate commitment negative regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez409017129EnsemblENSG00000113658ENSMUSG00000021540UniProtQ99717P97454RefSeq mRNA NM 005903NM 001001419NM 001001420NM 001164041NM 001164042NM 008541RefSeq protein NP 001001419NP 001001420NP 005894NP 001157513NP 001157514NP 032567Location UCSC Chr 5 136 13 136 19 MbChr 13 56 85 56 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseSMAD5 as its name describes is a homolog of the Drosophila gene Mothers against decapentaplegic based on a tradition of such unusual naming within the gene research community 6 It belongs to the SMAD family of proteins which belong to the TGFb superfamily of modulators Like many other TGFb family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins BMP s The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein SMAD5 is a receptor regulated SMAD R SMAD and is activated by bone morphogenetic protein type 1 receptor kinase It may play a role in the pathway where TGFb is an inhibitor of hematopoietic progenitor cells References edit a b c GRCh38 Ensembl release 89 ENSG00000113658 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021540 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Riggins GJ Thiagalingam S Rozenblum E Weinstein CL Kern SE Hamilton SR Willson JK Markowitz SD Kinzler KW Vogelstein B July 1996 Mad related genes in the human Nat Genet 13 3 347 9 doi 10 1038 ng0796 347 PMID 8673135 S2CID 10124489 Sonic Hedgehog DICER and the Problem With Naming Genes Sep 26 2014 Michael White psmag com nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mothers against decapentaplegic homolog 5 amp oldid 1080349302, wikipedia, wiki, book, books, library,
