Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[7][6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000185985 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036790 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
^ abAruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
^ ab"Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".
Further readingedit
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.
slitrk2, slit, ntrk, like, protein, protein, that, humans, encoded, gene, identifiersaliases, cxorf2, slitl1, slit, ntrk, like, family, member, cxorf1, tmem257external, idsomim, 300561, 2679449, homologene, 13054, genecards, gene, location, human, chromosome, . SLIT and NTRK like protein 2 is a protein that in humans is encoded by the SLITRK2 gene 5 6 7 SLITRK2IdentifiersAliasesSLITRK2 CXorf2 SLITL1 SLIT and NTRK like family member 2 CXorf1 TMEM257External IDsOMIM 300561 MGI 2679449 HomoloGene 13054 GeneCards SLITRK2Gene location Human Chr X chromosome human 1 BandXq27 3Start145 817 829 bp 1 End145 829 856 bp 1 Gene location Mouse Chr X chromosome mouse 2 BandX X A7 1Start65 692 924 bp 2 End65 704 999 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ininternal globus palliduscaudate nucleusnucleus accumbensganglionic eminencemiddle temporal gyrusamygdalaputamendorsolateral prefrontal cortexBrodmann area 9prefrontal cortexTop expressed intrigeminal ganglionsubstantia nigraRegion I of hippocampus properdentate gyrussubiculumprimary motor cortexhabenulaolfactory tuberclehippocampus propercerebellar vermisMore reference expression dataBioGPSMore reference expression dataOrthologsSpeciesHumanMouseEntrez84631245450EnsemblENSG00000185985ENSMUSG00000036790UniProtQ9H156Q810C0RefSeq mRNA NM 001144003NM 001144004NM 001144005NM 001144006NM 001144007NM 001144008NM 001144009NM 001144010NM 032539NM 001161431NM 198863RefSeq protein NP 001137475NP 001137476NP 001137477NP 001137478NP 001137480NP 001137481NP 001137482NP 115928NP 001154903NP 942563Location UCSC Chr X 145 82 145 83 MbChr X 65 69 65 7 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editMembers of the SLITRK family such as SLITRK2 are integral membrane proteins with 2 N terminal leucine rich repeat LRR domains similar to those of SLIT proteins see SLIT1 MIM 603742 Most SLITRKs including SLITRK2 also have C terminal regions that share homology with neurotrophin receptors see NTRK1 MIM 191315 SLITRKs are expressed predominantly in neural tissues and have neurite modulating activity 7 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000185985 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000036790 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nagase T Nakayama M Nakajima D Kikuno R Ohara O April 2001 Prediction of the coding sequences of unidentified human genes XX The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Research 8 2 85 95 doi 10 1093 dnares 8 2 85 PMID 11347906 a b Aruga J Yokota N Mikoshiba K October 2003 Human SLITRK family genes genomic organization and expression profiling in normal brain and brain tumor tissue Gene 315 87 94 doi 10 1016 S0378 1119 03 00715 7 PMID 14557068 a b Entrez Gene SLITRK2 SLIT and NTRK like family member 2 Further reading editBonaldo MF Lennon G Soares MB September 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Research 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SLITRK2 amp oldid 1079532285, wikipedia, wiki, book, books, library,
