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Sodium bicarbonate cotransporter 3

March 08, 2023

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.[5]

SLC4A7
Identifiers
AliasesSLC4A7, NBC2, NBC3, NBCN1, SBC2, SLC4A6, solute carrier family 4 member 7
External IDsOMIM: 603353 MGI: 2443878 HomoloGene: 2680 GeneCards: SLC4A7
Orthologs
SpeciesHumanMouse
Entrez

9497

218756

Ensembl

ENSG00000033867

ENSMUSG00000021733

UniProt

Q9Y6M7

Q8BTY2

RefSeq (mRNA)

NM_001033270

RefSeq (protein)

n/a

Location (UCSC)Chr 3: 27.37 – 27.48 MbChr 14: 14.7 – 14.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000033867 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021733 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7".

Further reading

  • Ishibashi K, Sasaki S, Marumo F (1998). "Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina". Biochem. Biophys. Res. Commun. 246 (2): 535–8. doi:10.1006/bbrc.1998.8658. PMID 9610397.
  • Pushkin A, Abuladze N, Lee I, et al. (1999). "Mapping of the human NBC3 (SLC4A7) gene to chromosome 3p22". Genomics. 57 (2): 321–2. doi:10.1006/geno.1999.5781. PMID 10198178.
  • Pushkin A, Abuladze N, Lee I, et al. (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.
  • Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. doi:10.1152/ajprenal.1999.277.6.F974. PMID 10600945.
  • Park M, Ko SB, Choi JY, et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
  • Loiselle FB, Jaschke P, Casey JR (2004). "Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain". Mol. Membr. Biol. 20 (4): 307–17. doi:10.1080/0968768031000122520. PMID 14578046. S2CID 30980041.
  • Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710. S2CID 16522705.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Reiners J, van Wijk E, Märker T, et al. (2006). "Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2". Hum. Mol. Genet. 14 (24): 3933–43. doi:10.1093/hmg/ddi417. PMID 16301216.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


 

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March 08, 2023
sodium, bicarbonate, cotransporter, protein, which, humans, encoded, slc4a7, gene, slc4a7identifiersaliasesslc4a7, nbc2, nbc3, nbcn1, sbc2, slc4a6, solute, carrier, family, member, 7external, idsomim, 603353, 2443878, homologene, 2680, genecards, slc4a7gene, l. Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene 5 SLC4A7IdentifiersAliasesSLC4A7 NBC2 NBC3 NBCN1 SBC2 SLC4A6 solute carrier family 4 member 7External IDsOMIM 603353 MGI 2443878 HomoloGene 2680 GeneCards SLC4A7Gene location Human Chr Chromosome 3 human 1 Band3p24 1Start27 372 721 bp 1 End27 484 420 bp 1 Gene location Mouse Chr Chromosome 14 mouse 2 Band14 14 A1Start14 702 279 bp 2 End14 799 940 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocyteduodenumAchilles tendonjejunal mucosasecondary oocytelactiferous ductsural nervefrontal poleBrodmann area 23superficial temporal arteryTop expressed induodenumleft colonretinaolfactory epitheliummedial ganglionic eminenceislet of Langerhansuterussoleus musclespermatidsubiculumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioninorganic anion exchanger activity symporter activity anion transmembrane transporter activity sodium bicarbonate symporter activity protein bindingCellular componentintegral component of membrane cell projection membrane plasma membrane synapse stereocilium basolateral plasma membrane apical plasma membrane cytoplasmic vesicle integral component of plasma membraneBiological processsodium ion transport anion transport auditory receptor cell development ion transport inorganic anion transport regulation of intracellular pH bicarbonate transport transmembrane transport anion transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez9497218756EnsemblENSG00000033867ENSMUSG00000021733UniProtQ9Y6M7Q8BTY2RefSeq mRNA NM 001258379NM 001258380NM 003615NM 001321103NM 001321104NM 001321105NM 001321106NM 001321107NM 001321108NM 001033270RefSeq protein NP 001245308NP 001245309NP 001308032NP 001308033NP 001308034NP 001308035NP 001308036NP 001308037NP 003606n aLocation UCSC Chr 3 27 37 27 48 MbChr 14 14 7 14 8 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseSee also EditSolute carrier familyReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000033867 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021733 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene SLC4A7 solute carrier family 4 sodium bicarbonate cotransporter member 7 Further reading EditIshibashi K Sasaki S Marumo F 1998 Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina Biochem Biophys Res Commun 246 2 535 8 doi 10 1006 bbrc 1998 8658 PMID 9610397 Pushkin A Abuladze N Lee I et al 1999 Mapping of the human NBC3 SLC4A7 gene to chromosome 3p22 Genomics 57 2 321 2 doi 10 1006 geno 1999 5781 PMID 10198178 Pushkin A Abuladze N Lee I et al 1999 Cloning tissue distribution genomic organization and functional characterization of NBC3 a new member of the sodium bicarbonate cotransporter family J Biol Chem 274 23 16569 75 doi 10 1074 jbc 274 23 16569 PMID 10347222 Pushkin A Yip KP Clark I et al 2000 NBC3 expression in rabbit collecting duct colocalization with vacuolar H ATPase Am J Physiol 277 6 Pt 2 F974 81 doi 10 1152 ajprenal 1999 277 6 F974 PMID 10600945 Park M Ko SB Choi JY et al 2003 The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3 salvage transporter human Na HCO3 cotransport isoform 3 J Biol Chem 277 52 50503 9 doi 10 1074 jbc M201862200 PMID 12403779 Loiselle FB Jaschke P Casey JR 2004 Structural and functional characterization of the human NBC3 sodium bicarbonate co transporter carboxyl terminal cytoplasmic domain Mol Membr Biol 20 4 307 17 doi 10 1080 0968768031000122520 PMID 14578046 S2CID 30980041 Loiselle FB Morgan PE Alvarez BV Casey JR 2004 Regulation of the human NBC3 Na HCO3 cotransporter by carbonic anhydrase II and PKA Am J Physiol Cell Physiol 286 6 C1423 33 doi 10 1152 ajpcell 00382 2003 PMID 14736710 S2CID 16522705 Brill LM Salomon AR Ficarro SB et al 2004 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry Anal Chem 76 10 2763 72 doi 10 1021 ac035352d PMID 15144186 Jin J Smith FD Stark C et al 2004 Proteomic functional and domain based analysis of in vivo 14 3 3 binding proteins involved in cytoskeletal regulation and cellular organization Curr Biol 14 16 1436 50 doi 10 1016 j cub 2004 07 051 PMID 15324660 S2CID 2371325 Reiners J van Wijk E Marker T et al 2006 Scaffold protein harmonin USH1C provides molecular links between Usher syndrome type 1 and type 2 Hum Mol Genet 14 24 3933 43 doi 10 1093 hmg ddi417 PMID 16301216 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Sodium bicarbonate cotransporter 3 amp oldid 1142699187, wikipedia, wiki, book, books, library,

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