Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transportingchloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000225697 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023259 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
^Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
^ ab"Entrez Gene: SLC26A6 solute carrier family 26, member 6".
^Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.
Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862.
Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771.
Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". J. Biol. Chem. 280 (9): 8564–80. doi:10.1074/jbc.M411703200. PMID 15548529.
Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810. S2CID 26671784.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". J. Gen. Physiol. 127 (5): 511–24. doi:10.1085/jgp.200509392. PMC2151520. PMID 16606687.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Novartis Found. Symp. Novartis Foundation Symposia. 273: 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN9780470016244. PMID 17120764.
slc26a6, solute, carrier, family, member, protein, that, humans, encoded, gene, anion, exchanger, expressed, apical, membrane, kidney, proximal, tubule, apical, membranes, duct, cells, pancreas, villi, duodenum, identifiersaliases, solute, carrier, family, mem. Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene 5 6 7 It is an anion exchanger expressed in the apical membrane of the kidney proximal tubule the apical membranes of the duct cells in the pancreas and the villi of the duodenum 8 SLC26A6IdentifiersAliasesSLC26A6 solute carrier family 26 member 6External IDsOMIM 610068 MGI 2159728 HomoloGene 99903 GeneCards SLC26A6Gene location Human Chr Chromosome 3 human 1 Band3p21 31Start48 625 723 bp 1 End48 635 493 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 F2Start108 730 482 bp 2 End108 742 117 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpopliteal arteryascending aortaoocyterectumstromal cell of endometriumleft coronary arterybody of stomachright coronary arterysecondary oocytecanal of the cervixTop expressed induodenumjejunumileumyolk sacpancreasmuscle tissueskeletal muscle tissuequadriceps femoris musclesecondary oocyteislet of LangerhansMore reference expression dataBioGPSn aGene ontologyMolecular functionPDZ domain binding formate transmembrane transporter activity chloride transmembrane transporter activity anion transmembrane transporter activity sulfate transmembrane transporter activity secondary active sulfate transmembrane transporter activity bicarbonate transmembrane transporter activity formate efflux transmembrane transporter activity oxalate transmembrane transporter activity protein binding efflux transmembrane transporter activity antiporter activity chloride channel activity inorganic anion exchanger activityCellular componentintegral component of membrane membrane intracellular membrane bounded organelle vesicle membrane plasma membrane integral component of plasma membrane chloride channel complex brush border membrane basolateral plasma membrane apical plasma membrane endoplasmic reticulum sperm midpiece cytoplasmic vesicle membrane cytoplasmic vesicle intracellular anatomical structure vesicleBiological processoxalic acid secretion mannitol transport oxalate transport formate transport intracellular pH elevation sulfate transport epithelial fluid transport angiotensin activated signaling pathway regulation of membrane potential regulation of intracellular pH cellular response to fructose stimulus ion transport transepithelial chloride transport protein kinase C signaling anion transport transepithelial transport cellular response to interferon gamma sperm capacitation intestinal absorption chloride transport positive regulation of dipeptide transmembrane transport cellular response to cAMP anion transmembrane transport sulfate transmembrane transport bicarbonate transport transmembrane transport chloride transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez65010171429EnsemblENSG00000225697ENSMUSG00000023259UniProtQ9BXS9Q8CIW6RefSeq mRNA NM 134426NM 001040454NM 001281732NM 001281733NM 022911NM 134263NM 134420RefSeq protein NP 001035544NP 001268661NP 001268662NP 075062NP 599025NP 602298NP 001035544 1NP 599252NP 001395316Location UCSC Chr 3 48 63 48 64 MbChr 9 108 73 108 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene belongs to the solute carrier 26 family whose members encode anion transporter proteins This particular family member encodes a protein involved in transporting chloride oxalate sulfate and bicarbonate Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been described but the full length nature of some of these variants has not been determined 7 Contents 1 Associated diseases 2 See also 3 References 4 Further readingAssociated diseases EditDiseases associated with SLC26A6 include sialolithiasis and urolithiasis 9 See also EditSolute carrier familyReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000225697 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000023259 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lohi H Kujala M Kerkela E Saarialho Kere U Kestila M Kere J Jan 2001 Mapping of five new putative anion transporter genes in human and characterization of SLC26A6 a candidate gene for pancreatic anion exchanger Genomics 70 1 102 12 doi 10 1006 geno 2000 6355 PMID 11087667 Waldegger S Moschen I Ramirez A Smith RJ Ayadi H Lang F Kubisch C Mar 2001 Cloning and characterization of SLC26A6 a novel member of the solute carrier 26 gene family Genomics 72 1 43 50 doi 10 1006 geno 2000 6445 PMID 11247665 a b Entrez Gene SLC26A6 solute carrier family 26 member 6 Wang Zhaohui Tong Wang Snezana Petrovic Biguang Tuo Brigitte Riederer Sharon Barone John N Lorenz Ursula Seidler Peter S Aronson Manoocher Soleimani April 2005 Renal and intestinal transport defects in Slc26a6 null mice American Journal of Physiology Cell Physiology 4 288 4 C957 C965 doi 10 1152 ajpcell 00505 2004 PMID 15574486 S2CID 23214608 SLC26A6 Gene GeneCards S26A6 Protein S26A6 Antibody www genecards org Retrieved 2021 05 06 Further reading EditMarkovich D 2001 Physiological roles and regulation of mammalian sulfate transporters Physiol Rev 81 4 1499 533 doi 10 1152 physrev 2001 81 4 1499 PMID 11581495 S2CID 30942862 Ignatovich O Tomlinson IM Popov AV et al 2000 Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire J Mol Biol 294 2 457 65 doi 10 1006 jmbi 1999 3243 PMID 10610771 Xie Q Welch R Mercado A et al 2002 Molecular characterization of the murine Slc26a6 anion exchanger functional comparison with Slc26a1 Am J Physiol Renal Physiol 283 4 F826 38 doi 10 1152 ajprenal 00079 2002 PMID 12217875 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Chernova MN Jiang L Friedman DJ et al 2005 Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants differences in anion selectivity regulation and electrogenicity J Biol Chem 280 9 8564 80 doi 10 1074 jbc M411703200 PMID 15548529 Kujala M Tienari J Lohi H et al 2006 SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney Nephron Exp Nephrol 101 2 e50 8 doi 10 1159 000086345 PMID 15956810 S2CID 26671784 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Shcheynikov N Wang Y Park M et al 2006 Coupling modes and stoichiometry of Cl HCO3 exchange by slc26a3 and slc26a6 J Gen Physiol 127 5 511 24 doi 10 1085 jgp 200509392 PMC 2151520 PMID 16606687 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Alper SL Stewart AK Chernova MN et al 2007 Anion exchangers in flux functional differences between human and mouse SLC26A6 polypeptides Novartis Found Symp Novartis Foundation Symposia 273 107 19 discussion 119 25 261 4 doi 10 1002 0470029579 ch8 ISBN 9780470016244 PMID 17120764 This article incorporates text from the United States National Library of Medicine which is in the public domain This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https 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