The protein encoded by this gene is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multiaminoacyl-tRNA synthetase complex (mARS). Pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.[7] As an inflammatory cytokine, AIMp1/p43 has demonstrated the ability to skew T-helper polarization in the direction of Th-1, and its homozygous deletion leads to a hyper-polarized Th-2 phenotype.
^ abcGRCh38: Ensembl release 89: ENSG00000164022 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028029 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kao J, Houck K, Fan Y, Haehnel I, Libutti SK, Kayton ML, Grikscheit T, Chabot J, Nowygrod R, Greenberg S, et al. (Nov 1994). "Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II". J Biol Chem. 269 (40): 25106–19. doi:10.1016/S0021-9258(17)31505-3. PMID 7929199.
^Kao J, Fan YG, Haehnel I, Brett J, Greenberg S, Clauss M, Kayton M, Houck K, Kisiel W, Seljelid R, et al. (May 1994). "A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response". J Biol Chem. 269 (13): 9774–82. doi:10.1016/S0021-9258(17)36950-8. PMID 7545917.
^ ab"Entrez Gene: SCYE1 small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)".
^Lee YS, Han Jung Min, Son Sung Hwa, Choi Jin Woo, Jeon Eun Ju, Bae Suk-Chul, Park Young In, Kim Sunghoon (Jul 2008). "AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2". Biochem. Biophys. Res. Commun. 371 (3). United States: 395–400. doi:10.1016/j.bbrc.2008.04.099. PMID 18448069.
Further readingedit
Kao J, Ryan J, Brett G, et al. (1992). "Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms". J. Biol. Chem. 267 (28): 20239–47. doi:10.1016/S0021-9258(19)88692-1. PMID 1400342.
Quevillon S, Agou F, Robinson JC, Mirande M (1998). "The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine". J. Biol. Chem. 272 (51): 32573–9. doi:10.1074/jbc.272.51.32573. PMID 9405472. S2CID 34057814.
Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
Park SG, Jung KH, Lee JS, et al. (1999). "Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase". J. Biol. Chem. 274 (24): 16673–6. doi:10.1074/jbc.274.24.16673. PMID 10358004. S2CID 25940947.
Kim Y, Shin J, Li R, et al. (2000). "A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases". J. Biol. Chem. 275 (35): 27062–8. doi:10.1074/jbc.C000216200. PMID 10852899.
Renault L, Kerjan P, Pasqualato S, et al. (2001). "Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry". EMBO J. 20 (3): 570–8. doi:10.1093/emboj/20.3.570. PMC133484. PMID 11157763.
Shalak V, Kaminska M, Mitnacht-Kraus R, et al. (2001). "The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component". J. Biol. Chem. 276 (26): 23769–76. doi:10.1074/jbc.M100489200. PMID 11306575. S2CID 20768076.
Chang SY, Park SG, Kim S, Kang CY (2002). "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation". J. Biol. Chem. 277 (10): 8388–94. doi:10.1074/jbc.M108792200. PMID 11741979.
Battersby S, Boddy SC, Critchley HO, Jabbour HN (2002). "Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2)". J. Clin. Endocrinol. Metab. 87 (8): 3928–35. doi:10.1210/jcem.87.8.8719. PMID 12161535.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Park H, Park SG, Kim J, et al. (2003). "Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43". Cytokine. 20 (4): 148–53. doi:10.1006/cyto.2002.1992. PMID 12543078. S2CID 31844938.
Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Lett. 542 (1–3): 119–24. doi:10.1016/S0014-5793(03)00362-4. PMID 12729910. S2CID 39222196.
Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782. S2CID 41006480.
Wolfe CL, Warrington JA, Davis S, et al. (2004). "Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII". Protein Sci. 12 (10): 2282–90. doi:10.1110/ps.03147903. PMC2366922. PMID 14500886.
Mueller CA, Schluesener HJ, Conrad S, et al. (2004). "Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II". J. Neurotrauma. 20 (10): 1007–15. doi:10.1089/089771503770195858. PMID 14588117.
Murray JC, Symonds P, Ward W, et al. (2004). "Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism". J. Immunol. 172 (1): 274–81. doi:10.4049/jimmunol.172.1.274. PMID 14688335. S2CID 7939914.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Murray JC, Heng YM, Symonds P, et al. (2004). "Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis". J. Leukoc. Biol. 75 (5): 772–6. doi:10.1189/jlb.1003487. PMID 14982944. S2CID 31089927.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
scye1, aminoacyl, trna, synthetase, complex, interacting, multifunctional, protein, protein, that, humans, encoded, aimp1, gene, aimp1available, structurespdbortholog, search, pdbe, rcsblist, codes1e7z, 1euj, 1fl0, 4r3zidentifiersaliasesaimp1, emap2, emapii, h. Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene 5 6 7 AIMP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1E7Z 1EUJ 1FL0 4R3ZIdentifiersAliasesAIMP1 EMAP2 EMAPII HLD3 SCYE1 p43 aminoacyl tRNA synthetase complex interacting multifunctional protein 1External IDsOMIM 603605 MGI 102774 HomoloGene 31260 GeneCards AIMP1Gene location Human Chr Chromosome 4 human 1 Band4q24Start106 315 544 bp 1 End106 349 456 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 G3Start132 366 242 bp 2 End132 390 131 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonrectumthoracic diaphragmendometriummonocytegastrocnemius muscleislet of Langerhanssmooth muscle tissuecervix epitheliumascending aortaTop expressed insomitemaxillary prominenceprimitive streakhair follicleplantaris musclerenal corpuscleextensor digitorum longus musclemedullary collecting ductquadriceps femoris muscletriceps brachii muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein homodimerization activity protein binding RNA binding GTPase binding tRNA binding cytokine activityCellular componentGolgi apparatus membrane aminoacyl tRNA synthetase multienzyme complex transport vesicle extracellular region cell surface endoplasmic reticulum cytoplasmic vesicle nucleus methionyl glutamyl tRNA synthetase complex extracellular space cytoplasm cytosolBiological processblood vessel morphogenesis protein biosynthesis cell cell signaling negative regulation of endothelial cell proliferation chemotaxis cell adhesion defense response to virus response to wounding angiogenesis glucose metabolic process leukocyte migration signal transduction apoptotic process tRNA aminoacylation for protein translation inflammatory response carbohydrate metabolic process regulation of signaling receptor activity positive regulation of glucagon secretionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez925513722EnsemblENSG00000164022ENSMUSG00000028029UniProtQ12904P31230RefSeq mRNA NM 004757NM 001142415NM 001142416NM 007926NM 001368626RefSeq protein NP 001135887NP 001135888NP 004748NP 001355555NP 031952Location UCSC Chr 4 106 32 106 35 MbChr 3 132 37 132 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene is a cytokine that may be induced by apoptosis and is also released from professional antigen presenting cells such as dendritic cells The release of this cytokine renders the tumor associated vasculature sensitive to tumor necrosis factor The precursor of SCYE1 pro SCYE1 is identical to the p43 subunit which is associated with the multiaminoacyl tRNA synthetase complex mARS Pro SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells 7 As an inflammatory cytokine AIMp1 p43 has demonstrated the ability to skew T helper polarization in the direction of Th 1 and its homozygous deletion leads to a hyper polarized Th 2 phenotype Interactions editSCYE1 has been shown to interact with SMURF2 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000164022 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028029 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kao J Houck K Fan Y Haehnel I Libutti SK Kayton ML Grikscheit T Chabot J Nowygrod R Greenberg S et al Nov 1994 Characterization of a novel tumor derived cytokine Endothelial monocyte activating polypeptide II J Biol Chem 269 40 25106 19 doi 10 1016 S0021 9258 17 31505 3 PMID 7929199 Kao J Fan YG Haehnel I Brett J Greenberg S Clauss M Kayton M Houck K Kisiel W Seljelid R et al May 1994 A peptide derived from the amino terminus of endothelial monocyte activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions defines an apparently novel cellular interaction site and induces an acute inflammatory response J Biol Chem 269 13 9774 82 doi 10 1016 S0021 9258 17 36950 8 PMID 7545917 a b Entrez Gene SCYE1 small inducible cytokine subfamily E member 1 endothelial monocyte activating Lee YS Han Jung Min Son Sung Hwa Choi Jin Woo Jeon Eun Ju Bae Suk Chul Park Young In Kim Sunghoon Jul 2008 AIMP1 p43 downregulates TGF beta signaling via stabilization of smurf2 Biochem Biophys Res Commun 371 3 United States 395 400 doi 10 1016 j bbrc 2008 04 099 PMID 18448069 Further reading editKao J Ryan J Brett G et al 1992 Endothelial monocyte activating polypeptide II A novel tumor derived polypeptide that activates host response mechanisms J Biol Chem 267 28 20239 47 doi 10 1016 S0021 9258 19 88692 1 PMID 1400342 Quevillon S Agou F Robinson JC Mirande M 1998 The p43 component of the mammalian multi synthetase complex is likely to be the precursor of the endothelial monocyte activating polypeptide II cytokine J Biol Chem 272 51 32573 9 doi 10 1074 jbc 272 51 32573 PMID 9405472 S2CID 34057814 Quevillon S Robinson JC Berthonneau E et al 1999 Macromolecular assemblage of aminoacyl tRNA synthetases identification of protein protein interactions and characterization of a core protein J Mol Biol 285 1 183 95 doi 10 1006 jmbi 1998 2316 PMID 9878398 Park SG Jung KH Lee JS et al 1999 Precursor of pro apoptotic cytokine modulates aminoacylation activity of tRNA synthetase J Biol Chem 274 24 16673 6 doi 10 1074 jbc 274 24 16673 PMID 10358004 S2CID 25940947 Kim Y Shin J Li R et al 2000 A novel anti tumor cytokine contains an RNA binding motif present in aminoacyl tRNA synthetases J Biol Chem 275 35 27062 8 doi 10 1074 jbc C000216200 PMID 10852899 Renault L Kerjan P Pasqualato S et al 2001 Structure of the EMAPII domain of human aminoacyl tRNA synthetase complex reveals evolutionary dimer mimicry EMBO J 20 3 570 8 doi 10 1093 emboj 20 3 570 PMC 133484 PMID 11157763 Shalak V Kaminska M Mitnacht Kraus R et al 2001 The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43 proEMAPII component J Biol Chem 276 26 23769 76 doi 10 1074 jbc M100489200 PMID 11306575 S2CID 20768076 Chang SY Park SG Kim S Kang CY 2002 Interaction of the C terminal domain of p43 and the alpha subunit of ATP synthase Its functional implication in endothelial cell proliferation J Biol Chem 277 10 8388 94 doi 10 1074 jbc M108792200 PMID 11741979 Battersby S Boddy SC Critchley HO Jabbour HN 2002 Expression and localization of endothelial monocyte activating polypeptide II in the human endometrium across the menstrual cycle regulation of expression by prostaglandin E 2 J Clin Endocrinol Metab 87 8 3928 35 doi 10 1210 jcem 87 8 8719 PMID 12161535 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Park H Park SG Kim J et al 2003 Signaling pathways for TNF production induced by human aminoacyl tRNA synthetase associating factor p43 Cytokine 20 4 148 53 doi 10 1006 cyto 2002 1992 PMID 12543078 S2CID 31844938 Ahn HC Kim S Lee BJ 2003 Solution structure and p43 binding of the p38 leucine zipper motif coiled coil interactions mediate the association between p38 and p43 FEBS Lett 542 1 3 119 24 doi 10 1016 S0014 5793 03 00362 4 PMID 12729910 S2CID 39222196 Kim MJ Park BJ Kang YS et al 2003 Downregulation of FUSE binding protein and c myc by tRNA synthetase cofactor p38 is required for lung cell differentiation Nat Genet 34 3 330 6 doi 10 1038 ng1182 PMID 12819782 S2CID 41006480 Wolfe CL Warrington JA Davis S et al 2004 Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43 EMAPII Protein Sci 12 10 2282 90 doi 10 1110 ps 03147903 PMC 2366922 PMID 14500886 Mueller CA Schluesener HJ Conrad S et al 2004 Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II J Neurotrauma 20 10 1007 15 doi 10 1089 089771503770195858 PMID 14588117 Murray JC Symonds P Ward W et al 2004 Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte activating polypeptide II dependent mechanism J Immunol 172 1 274 81 doi 10 4049 jimmunol 172 1 274 PMID 14688335 S2CID 7939914 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 S2CID 21903526 Murray JC Heng YM Symonds P et al 2004 Endothelial monocyte activating polypeptide II EMAP II a novel inducer of lymphocyte apoptosis J Leukoc Biol 75 5 772 6 doi 10 1189 jlb 1003487 PMID 14982944 S2CID 31089927 nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SCYE1 amp oldid 1191520565, wikipedia, wiki, book, books, library,
