The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.[5]
SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cells.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000124935 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhao C, Nguyen T, Yusifov T, Glasgow BJ, Lehrer RI (March 1999). "Lipophilins: human peptides homologous to rat prostatein". Biochemical and Biophysical Research Communications. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.
^Lehrer RI, Xu G, Abduragimov A, Dinh NN, Qu XD, Martin D, Glasgow BJ (August 1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Letters. 432 (3): 163–7. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917. S2CID 205880914.
^ ab"Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2".
^Lacroix M (December 2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. 13 (4). Bioscientifica: 1033–67. doi:10.1677/ERC-06-0001. PMID 17158753. S2CID 10708900.
Further readingedit
Culleton J, O'Brien N, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ (March 2007). "Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer". International Journal of Cancer. 120 (5): 1087–92. doi:10.1002/ijc.22471. PMID 17163411. S2CID 20729571.
Sjödin A, Guo D, Lund-Johansen M, Krossnes BK, Lilleng P, Henriksson R, Hedman H (April 2005). "Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas". Acta Neuropathologica. 109 (4): 381–6. doi:10.1007/s00401-004-0972-6. PMID 15668787. S2CID 20395605.
Carter D, Dillon DC, Reynolds LD, Retter MW, Fanger G, Molesh DA, Sleath PR, McNeill PD, Vedvick TS, Reed SG, Persing DH, Houghton RL (February 2003). "Serum antibodies to lipophilin B detected in late stage breast cancer patients". Clinical Cancer Research. 9 (2): 749–54. PMID 12576445.
Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS (May 2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
External linksedit
Microarray study results where SCGB1D2 is significantly up or downregulated
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
scgb1d2, secretoglobin, family, member, protein, that, humans, encoded, gene, identifiersaliases, lipb, lphb, lpnb, secretoglobin, family, member, secretoglobin, family, member, 2external, idsomim, 615061, homologene, 88740, genecards, gene, location, human, c. Secretoglobin family 1D member 2 is a protein that in humans is encoded by the SCGB1D2 gene 3 4 5 SCGB1D2IdentifiersAliasesSCGB1D2 LIPB LPHB LPNB secretoglobin family 1D member 2 secretoglobin family 1D member 2External IDsOMIM 615061 HomoloGene 88740 GeneCards SCGB1D2Gene location Human Chr Chromosome 11 human 1 Band11q12 3Start62 242 239 bp 1 End62 244 812 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tubecorpus epididymislactiferous ductskin of abdomenendometriumminor salivary glandscanal of the cervixanterior pituitarygastrocnemius muscleleft uterine tuben aMore reference expression dataBioGPSMore reference expression dataOrthologsSpeciesHumanMouseEntrez10647n aEnsemblENSG00000124935n aUniProtO95969n aRefSeq mRNA NM 006551n aRefSeq protein NP 006542n aLocation UCSC Chr 11 62 24 62 24 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThe protein encoded by this gene is a member of the lipophilin subfamily part of the uteroglobin superfamily and is an ortholog of prostatein the major secretory glycoprotein of the rat ventral prostate gland Lipophilin gene products are widely expressed in normal tissues especially in endocrine responsive organs Assuming that human lipophilins are the functional counterparts of prostatein they may be transcriptionally regulated by steroid hormones with the ability to bind androgens other steroids and possibly bind and concentrate estramustine a chemotherapeutic agent widely used for prostate cancer Although the gene has been reported to be on chromosome 10 this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2 5 SCGB1D2 expression is high in mammary tissue and is sometimes used for identification and detection of disseminated breast cancer cells 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000124935 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Zhao C Nguyen T Yusifov T Glasgow BJ Lehrer RI March 1999 Lipophilins human peptides homologous to rat prostatein Biochemical and Biophysical Research Communications 256 1 147 55 doi 10 1006 bbrc 1999 0274 PMID 10066439 Lehrer RI Xu G Abduragimov A Dinh NN Qu XD Martin D Glasgow BJ August 1998 Lipophilin a novel heterodimeric protein of human tears FEBS Letters 432 3 163 7 doi 10 1016 S0014 5793 98 00852 7 PMID 9720917 S2CID 205880914 a b Entrez Gene SCGB1D2 secretoglobin family 1D member 2 Lacroix M December 2006 Significance detection and markers of disseminated breast cancer cells Endocrine Related Cancer 13 4 Bioscientifica 1033 67 doi 10 1677 ERC 06 0001 PMID 17158753 S2CID 10708900 Further reading editCulleton J O Brien N Ryan BM Hill AD McDermott E O Higgins N Duffy MJ March 2007 Lipophilin B A gene preferentially expressed in breast tissue and upregulated in breast cancer International Journal of Cancer 120 5 1087 92 doi 10 1002 ijc 22471 PMID 17163411 S2CID 20729571 Sjodin A Guo D Lund Johansen M Krossnes BK Lilleng P Henriksson R Hedman H April 2005 Secretoglobins in the human pituitary high expression of lipophilin B and its down regulation in pituitary adenomas Acta Neuropathologica 109 4 381 6 doi 10 1007 s00401 004 0972 6 PMID 15668787 S2CID 20395605 Carter D Dillon DC Reynolds LD Retter MW Fanger G Molesh DA Sleath PR McNeill PD Vedvick TS Reed SG Persing DH Houghton RL February 2003 Serum antibodies to lipophilin B detected in late stage breast cancer patients Clinical Cancer Research 9 2 749 54 PMID 12576445 Carter D Douglass JF Cornellison CD Retter MW Johnson JC Bennington AA Fleming TP Reed SG Houghton RL Diamond DL Vedvick TS May 2002 Purification and characterization of the mammaglobin lipophilin B complex a promising diagnostic marker for breast cancer Biochemistry 41 21 6714 22 doi 10 1021 bi0159884 PMID 12022875 External links editMicroarray study results where SCGB1D2 is significantly up or downregulated nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SCGB1D2 amp oldid 1214863153, wikipedia, wiki, book, books, library,
