S100A14

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.^[5]

S100A14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M0R
Identifiers
Aliases	S100A14, BCMP84, S100A15, S100 calcium binding protein A14
External IDs	OMIM: 607986 MGI: 1913416 HomoloGene: 10781 GeneCards: S100A14
Gene location (Human) Chr. Chromosome 1 (human)^[1] Band 1q21.3 Start 153,614,255 bp^[1] End 153,616,986 bp^[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)^[2] Band 3|3 F1 Start 90,434,163 bp^[2] End 90,436,144 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen oral cavity body of tongue gums rectum vulva human penis nipple cervix epithelium hair follicle Top expressed in esophagus lip skin of abdomen epidermis hair follicle skin of back pyloric antrum mucous cell of stomach left colon belly cord More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding chemokine receptor binding calcium ion binding Cellular component cell junction perinuclear region of cytoplasm extracellular exosome cytoplasm cytosol nuclear body plasma membrane Biological process positive regulation of monocyte chemotaxis response to lipopolysaccharide calcium ion homeostasis apoptotic process toll-like receptor 4 signaling pathway defense response to bacterium positive regulation of granulocyte chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57402 66166 Ensembl ENSG00000189334 ENSMUSG00000042306 UniProt Q9HCY8 Q9D2Q8 RefSeq (mRNA) NM_020672 NM_001163525 NM_001163526 NM_025393 RefSeq (protein) NP_065723 NP_001156997 NP_001156998 NP_079669 Location (UCSC) Chr 1: 153.61 – 153.62 Mb Chr 3: 90.43 – 90.44 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.^[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000189334 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042306 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: S100 calcium binding protein A14".
6. Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi:10.3892/or_00000604. PMID 19956863.
7. Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.

Further reading

• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
• Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (Jul 2008). "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15". Journal of Immunology. 181 (2): 1499–1506. doi:10.4049/jimmunol.181.2.1499. PMC 2435511. PMID 18606705.
• Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S (Aug 2009). "Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients". International Journal of Immunogenetics. 36 (4): 217–22. doi:10.1111/j.1744-313X.2009.00858.x. PMID 19601998. S2CID 38130688.
• Jin Q, Chen H, Luo A, Ding F, Liu Z (2011). "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)". PLOS ONE. 6 (4): e19375. Bibcode:2011PLoSO...619375J. doi:10.1371/journal.pone.0019375. PMC 3084824. PMID 21559403.
• Büchau AS, Hassan M, Kukova G, Lewerenz V, Kellermann S, Würthner JU, Wolf R, Walz M, Gallo RL, Ruzicka T (Nov 2007). "S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4". The Journal of Investigative Dermatology. 127 (11): 2596–604. doi:10.1038/sj.jid.5700946. PMID 17625598.
• Sapkota D, Costea DE, Blø M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO (Mar 2012). "S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest". Oral Oncology. 48 (3): 219–25. doi:10.1016/j.oraloncology.2011.10.001. PMID 22032898.
• Boeshans KM, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser TC, Yuspa SH, Ahvazi B (May 2006). "Purification, crystallization and preliminary X-ray diffraction of human S100A15". Acta Crystallographica Section F. 62 (Pt 5): 467–470. doi:10.1107/S1744309106012838. PMC 2219979. PMID 16682778.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.