^Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, et al. (February 2004). "Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators". Journal of Medicinal Chemistry. 47 (4): 993–8. doi:10.1021/jm030336u. PMC2040239. PMID 14761201.
^Jones A, Chen J, Hwang DJ, Miller DD, Dalton JT (January 2009). "Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception". Endocrinology. 150 (1): 385–95. doi:10.1210/en.2008-0674. PMC2630904. PMID 18772237.
drug, investigational, selective, androgen, receptor, modulator, sarm, developed, potential, male, hormonal, contraceptive, binds, androgen, receptor, more, strongly, than, older, drugs, such, andarine, with, animal, studies, showed, both, good, ratio, anaboli. S 23 is an investigational selective androgen receptor modulator SARM developed by GTX Inc as a potential male hormonal contraceptive It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1 7 nM and in animal studies it showed both a good ratio of anabolic to androgenic effects and dose dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment 1 2 S 23Legal statusLegal statusUS Investigational New DrugIdentifiersIUPAC name 2S N 4 cyano 3 trifluoromethylphenyl 3 3 fluoro 4 chlorophenoxy 2 hydroxy 2 methyl propanamideCAS Number1010396 29 8 NPubChem CID24892822DrugBankDB07419 NChemSpider24715019 NUNIIXDK89456WMChemical and physical dataFormulaC 18H 13Cl F 4N 2O 3Molar mass416 76 g mol 13D model JSmol Interactive imageSMILES C C COC1 CC C C C1 Cl F C O NC2 CC C C C2 C N C F F F OInChI InChI 1S C18H13ClF4N2O3 c1 17 27 9 28 12 4 5 14 19 15 20 7 12 16 26 25 11 3 2 10 8 24 13 6 11 18 21 22 23 h2 7 27H 9H2 1H3 H 25 26 t17 m0 s1 NKey SSFVOEAXHZGTRJ KRWDZBQOSA N N N Y what is this verify References edit Marhefka CA Gao W Chung K Kim J He Y Yin D et al February 2004 Design synthesis and biological characterization of metabolically stable selective androgen receptor modulators Journal of Medicinal Chemistry 47 4 993 8 doi 10 1021 jm030336u PMC 2040239 PMID 14761201 Jones A Chen J Hwang DJ Miller DD Dalton JT January 2009 Preclinical characterization of a S N 4 cyano 3 trifluoromethyl phenyl 3 3 fluoro 4 chlorophenoxy 2 hydroxy 2 methyl propanamide a selective androgen receptor modulator for hormonal male contraception Endocrinology 150 1 385 95 doi 10 1210 en 2008 0674 PMC 2630904 PMID 18772237 nbsp This drug article relating to the genito urinary system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title S 23 drug amp oldid 1132201431, wikipedia, wiki, book, books, library,
