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Ruth Sonntag Nussenzweig (20 June 1928 – 1 April 2018[1]) was an Austrian-Brazilian immunologist specializing in the development of malaria vaccines. In a career spanning over 60 years, she was primarily affiliated with New York University (NYU). She served as C.V. Starr Professor of Medical and Molecular Parasitology at Langone Medical Center, Research Professor at the NYU Department of Pathology, and finally Professor Emerita of Microbiology and Pathology at the NYU Department of Microbiology.[2]
Dr. Nussenzweig was born Ruth Sonntag in Vienna, Austria, to a secular Jewish family in which both of her parents were physicians.[3] In 1939, after the Anschluss, the Sonntags fled to São Paulo, Brazil. While attending the University of São Paulo School of Medicine, she became involved in leftist politics and met Victor Nussenzweig, her future husband and lifelong research partner.[4] After receiving her M.D., Nussenzweig moved to Paris for a research fellowship. In 1963, she did further graduate work at the NYU laboratory of immunologist Zoltán Óváry.
In 1965, the Nussenzweigs returned to São Paulo, and found that working conditions had become untenable since the 1964 military coup; many of their friends and colleagues had been jailed by the regime, and Victor was singled out for questioning by the School's new military administration. Through the intervention of Baruj Benacerraf, both Nussenzweigs obtained Assistant Professorships at NYU, and moved permanently to the United States. Dr. Nussenzweig returned briefly to Brazil to defend her doctoral thesis, earning her Ph.D. from the University of São Paulo in 1968.[4]
Dr. Nussenzweig's family includes multiple people who have made significant contributions to research and academia, including husband Victor, Professor Emeritus at the NYU School of Medicine; son Michel C. Nussenzweig, Professor of Medicine at The Rockefeller University; daughter Sonia Nussenzweig-Hotimsky, Professor of Anthropology at the Foundation School of Sociology and Politics in São Paulo; and son Andre Nussenzweig, Distinguished Investigator at the National Institutes of Health.[5]
Research work
In 1967, Dr. Nussenzweig demonstrated that mice could acquire immunity to the Plasmodium berghei parasite. She did so by exposing the mice to P. bergheisporozoites that had been inactivated by X-rayirradiation.[6]
Major publications
Huang, Jing; Li, Xiangming; Coelho-Dos-Reis, Jordana G A; Zhang, Min; Mitchell, Robert; Nogueira, Raquel Tayar; Tsao, Tiffany; Noe, Amy R; Ayala, Ramses; Sahi, Vincent; Gutierrez, Gabriel M; Nussenzweig, Victor; Wilson, James M; Nardin, Elizabeth H; Nussenzweig, Ruth S; Tsuji, Moriya. "Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria." Journal of Immunological Methods. 2015 Sep;:42-50
Teixeira, Lais H; Tararam, Cibele A; Lasaro, Marcio O; Camacho, Ariane G A; Ersching, Jonatan; Leal, Monica T; Herrera, Socrates; Bruna-Romero, Oscar; Soares, Irene S; Nussenzweig, Ruth S; Ertl, Hildegund C J; Nussenzweig, Victor; Rodrigues, Mauricio M. "Immunogenicity of a Prime-Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents. Infection and Immunity. 2014 Feb;82(2):793-807
Mishra, Satish; Nussenzweig, Ruth S; Nussenzweig, Victor. "Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity." Journal of Immunological Methods. 2012 Mar;377(1-2):47-52
Camacho, Ariane Guglielmi Ariza; Teixeira, Lais Helena; Bargieri, Daniel Youssef; Boscardin, Silvia Beatriz; Soares, Irene da Silva; Nussenzweig, Ruth Sonntag; Nussenzweig, Victor; Rodrigues, Mauricio Martins. "TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium." Memórias do Instituto Oswaldo Cruz. 2011 Aug;106 Suppl 1:167-171
Mishra, Satish; Rai, Urvashi; Shiratsuchi, Takayuki; Li, Xiangming; Vanloubbeeck, Yannick; Cohen, Joe; Nussenzweig, Ruth S; Winzeler, Elizabeth A; Tsuji, Moriya; Nussenzweig, Victor. "Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites." Vaccine. 2011 Oct 6;29(43):7335-7342
^"Ruth Nussenzweig, precursora no estudo da vacina contra a malária, morre aos 89". Folha de São Paulo. 2018-04-02. Retrieved 2018-04-03.
^"Ruth S. Nussenzweig". NYU Langone Health. Retrieved 11 October 2017.
^Genzlinger, Neil (12 April 2018). "Ruth Nussenzweig, Who Pursued Malaria Vaccine, Dies at 89". The New York Times. p. A29. Retrieved 16 April 2018.
^ abCatanzaro, Michele. "A Fresh Start, Back in Brazil, at 85". Science. Retrieved 2018-04-03.
^"A Fresh Start, Back in Brazil, at 85". Science | AAAS. 2013-06-25. Retrieved 2017-02-14.
^Nussenzweig, Ruth; J. Vanderberg; H. Most; C. Orton (14 October 1967). "Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei". Nature. 216 (5111): 160–162. Bibcode:1967Natur.216..160N. doi:10.1038/216160a0. PMID 6057225. S2CID 4283134. Retrieved 2016-03-03.
March 03, 2023
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This article may be expanded with text translated from the corresponding article in German March 2016 Click show for important translation instructions Machine translation like DeepL or Google Translate is a useful starting point for translations but translators must revise errors as necessary and confirm that the translation is accurate rather than simply copy pasting machine translated text into the English Wikipedia Consider adding a topic to this template there are already 9 746 articles in the main category and specifying topic will aid in categorization Do not translate text that appears unreliable or low quality If possible verify the text with references provided in the foreign language article You must provide copyright attribution in the edit summary accompanying your translation by providing an interlanguage link to the source of your translation A model attribution edit summary is Content in this edit is translated from the existing German Wikipedia article at de Ruth Sonntag Nussenzweig see its history for attribution You should also add the template Translated de Ruth Sonntag Nussenzweig to the talk page For more guidance see Wikipedia Translation Ruth Sonntag Nussenzweig 20 June 1928 1 April 2018 1 was an Austrian Brazilian immunologist specializing in the development of malaria vaccines In a career spanning over 60 years she was primarily affiliated with New York University NYU She served as C V Starr Professor of Medical and Molecular Parasitology at Langone Medical Center Research Professor at the NYU Department of Pathology and finally Professor Emerita of Microbiology and Pathology at the NYU Department of Microbiology 2 Contents 1 Biography 2 Research work 3 Major publications 4 Awards 5 ReferencesBiography EditDr Nussenzweig was born Ruth Sonntag in Vienna Austria to a secular Jewish family in which both of her parents were physicians 3 In 1939 after the Anschluss the Sonntags fled to Sao Paulo Brazil While attending the University of Sao Paulo School of Medicine she became involved in leftist politics and met Victor Nussenzweig her future husband and lifelong research partner 4 After receiving her M D Nussenzweig moved to Paris for a research fellowship In 1963 she did further graduate work at the NYU laboratory of immunologist Zoltan ovary In 1965 the Nussenzweigs returned to Sao Paulo and found that working conditions had become untenable since the 1964 military coup many of their friends and colleagues had been jailed by the regime and Victor was singled out for questioning by the School s new military administration Through the intervention of Baruj Benacerraf both Nussenzweigs obtained Assistant Professorships at NYU and moved permanently to the United States Dr Nussenzweig returned briefly to Brazil to defend her doctoral thesis earning her Ph D from the University of Sao Paulo in 1968 4 Dr Nussenzweig s family includes multiple people who have made significant contributions to research and academia including husband Victor Professor Emeritus at the NYU School of Medicine son Michel C Nussenzweig Professor of Medicine at The Rockefeller University daughter Sonia Nussenzweig Hotimsky Professor of Anthropology at the Foundation School of Sociology and Politics in Sao Paulo and son Andre Nussenzweig Distinguished Investigator at the National Institutes of Health 5 Research work EditIn 1967 Dr Nussenzweig demonstrated that mice could acquire immunity to the Plasmodium berghei parasite She did so by exposing the mice to P berghei sporozoites that had been inactivated by X ray irradiation 6 Major publications EditHuang Jing Li Xiangming Coelho Dos Reis Jordana G A Zhang Min Mitchell Robert Nogueira Raquel Tayar Tsao Tiffany Noe Amy R Ayala Ramses Sahi Vincent Gutierrez Gabriel M Nussenzweig Victor Wilson James M Nardin Elizabeth H Nussenzweig Ruth S Tsuji Moriya Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria Journal of Immunological Methods 2015 Sep 42 50 Teixeira Lais H Tararam Cibele A Lasaro Marcio O Camacho Ariane G A Ersching Jonatan Leal Monica T Herrera Socrates Bruna Romero Oscar Soares Irene S Nussenzweig Ruth S Ertl Hildegund C J Nussenzweig Victor Rodrigues Mauricio M Immunogenicity of a Prime Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents Infection and Immunity 2014 Feb 82 2 793 807 Mishra Satish Nussenzweig Ruth S Nussenzweig Victor Antibodies to Plasmodium circumsporozoite protein CSP inhibit sporozoite s cell traversal activity Journal of Immunological Methods 2012 Mar 377 1 2 47 52 Camacho Ariane Guglielmi Ariza Teixeira Lais Helena Bargieri Daniel Youssef Boscardin Silvia Beatriz Soares Irene da Silva Nussenzweig Ruth Sonntag Nussenzweig Victor Rodrigues Mauricio Martins TLR5 dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium Memorias do Instituto Oswaldo Cruz 2011 Aug 106 Suppl 1 167 171 Mishra Satish Rai Urvashi Shiratsuchi Takayuki Li Xiangming Vanloubbeeck Yannick Cohen Joe Nussenzweig Ruth S Winzeler Elizabeth A Tsuji Moriya Nussenzweig Victor Identification of non CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites Vaccine 2011 Oct 6 29 43 7335 7342Awards EditPaul Ehrlich and Ludwig Darmstaedter Prize 1985 Carlos J Finlay Prize for Microbiology Cuba 1985 Albert B Sabin Gold Medal 2008 Warren Alpert Foundation Prize 2015 National Order of Scientific Merit Brazil References Edit Ruth Nussenzweig precursora no estudo da vacina contra a malaria morre aos 89 Folha de Sao Paulo 2018 04 02 Retrieved 2018 04 03 Ruth S Nussenzweig NYU Langone Health Retrieved 11 October 2017 Genzlinger Neil 12 April 2018 Ruth Nussenzweig Who Pursued Malaria Vaccine Dies at 89 The New York Times p A29 Retrieved 16 April 2018 a b Catanzaro Michele A Fresh Start Back in Brazil at 85 Science Retrieved 2018 04 03 A Fresh Start Back in Brazil at 85 Science AAAS 2013 06 25 Retrieved 2017 02 14 Nussenzweig Ruth J Vanderberg H Most C Orton 14 October 1967 Protective Immunity produced by the Injection of X irradiated Sporozoites of Plasmodium berghei Nature 216 5111 160 162 Bibcode 1967Natur 216 160N doi 10 1038 216160a0 PMID 6057225 S2CID 4283134 Retrieved 2016 03 03 Retrieved from https en wikipedia org w index php title Ruth Sonntag Nussenzweig amp oldid 1112749906, wikipedia, wiki, book, books, library,
