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Rowena Green Matthews

January 01, 1970

Rowena Green Matthews, born in 1938,[1] is the G. Robert Greenberg Distinguished University professor emeritus at the University of Michigan, Ann Arbor.[2] Her research focuses on the role of organic cofactors as partners of enzymes catalyzing difficult biochemical reactions, especially folic acid and cobalamin (vitamin B12). Among other honors, she was elected to the National Academy of Sciences in 2002 and the Institute of Medicine in 2004.[2]

Rowena Green Matthews
Born
Rowena Green

1938 (age 85–86)
Cambridge, England
Alma materUniversity of Michigan
Known forStudies of cobalamin and folic acid
Awards
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Michigan
Doctoral advisorVincent Massey

Early life and education edit

Matthews was born in Cambridge, England while her father, biochemist David E. Green, was on sabbatical there.[3]: xxi  Matthews earned her B.A. in biology summa cum laude from Radcliffe College in 1960.[4] As an undergraduate, and for three years thereafter, she worked with George Wald studying a new intermediate in the bleaching of the visual pigment rhodopsin that temporally coincided with initiation of visual excitation.[5] She then attended graduate school in biophysics at the University of Michigan, with dissertation research in the laboratory of Vincent Massey. She received her Ph.D. in 1969.[6]

Academic career edit

After finishing her Ph.D., Matthews remained at the University of Michigan as a postdoctoral fellow in the laboratory of Charles Williams in the department of Biological Chemistry and Assistant Research Scientist in the Biophysics Research Division in 1978. She was promoted to Associate Professor in 1981 became a full professor in 1986, and became the G. Robert Greenberg Distinguished University Professor in 1995.[2][6][7] In 2002, she assumed the position of Senior Research Professor and Charter Faculty Member of the Life Sciences Institute.[8] She retired in 2007, assuming professor emeritus status.[6]

Awards edit

She received numerous recognitions and honors during her career, the Repligen award given by the ACS (2001),[9] election to the National Academy of Sciences (2002),[10] the American Academy of Microbiology (2002),[2] the Institute of Medicine (2004),[11] the American Academy of Arts and Sciences (2005), and the American Philosophical Society (2009).[12][13] She received the William C. Rose Award given by the American Society for Biochemistry and Molecular Biology in 2000 and the Repligen Corporation Award in Chemistry of Biological Processes given by the American Chemical Society in 2001.[2]

She was the Frederick Gowland Hopkins Lecturer at 12th International Conference of Pteridines and Folates in 2001, an honor she particularly appreciated because her father had worked with Hopkins.[3] She serves on the Medical Advisory Board of the Howard Hughes Medical Institute,[14] and has served on the Council of the National Academy of Sciences.[15]

The University of Michigan hosts a professorship honoring Matthews; since 2009 James Bardwell has held the Rowena G. Matthews Collegiate Professorship.[16]

Research edit

Dr. Matthew's research focused on one-carbon metabolism, with particular emphasis on the enzymes that catalyze the de novo generation of methyl groups: methionine synthase, a B-12 dependent enzyme in humans, and methylenetetrahydrofolate reductase.[17][18] Her collaboration with geneticist Rima Rozen at McGill University led to the cloning of human methylenetetrahydrofolate reductase and the characterization of the C677T polymorphism associated with hyperhomocysteinemia in humans.[19][20] The polymorphism can lead to a high amount of homocysteine in the bloodstream. High concentrations of homocysteine in the plasma can increase the risk for cardiovascular diseases and the use of folic acid have been shown to decrease the amounts in humans.[21] In collaboration with Prof. Martha Ludwig they elucidated the first X-ray structure of vitamin B12 bound to a protein, cobalamin-dependent methionine synthase.[20][22]

Selected publications edit

  • A love affair with vitamins (2009)[23]
  • Cobalamin- and corrinoid-dependent enzymes[24]
  • Cobalamin-dependent and cobamide-dependent methyltransferases (2008)[25]

Personal life edit

Matthews is the eldest daughter of biochemist David E. Green and the aunt of United States Senator Tammy Baldwin.[26]

References edit

  1. ^ "Rowena Green Matthews from Ann Arbor, Michigan | VoterRecords.com". voterrecords.com. Retrieved 2019-09-26.
  2. ^ a b c d e "Rowena Matthews, Ph.D." University of Michigan, Ann Arbor. 2014-08-13. Retrieved 3 August 2016.
  3. ^ a b Shane, Barry (2002). Milstein, Sheldon; Kapatos, Gregory; Levine, Robert A.; Shane, Barry (eds.). Chemistry and Biology of Pteridines and Folates Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. Boston, MA: Springer US. ISBN 9781461509455.
  4. ^ "Tangs for the memories | Michigan Today". michigantoday.umich.edu. 20 September 2017. Retrieved 2019-09-26.
  5. ^ Matthews, Rowena G.; Ruth Hubbard; Paul K. Brown; George Wald (1963). "Tautomeric forms of metarhodopsin". Journal of General Physiology. 47 (2): 215–240. doi:10.1085/jgp.47.2.215. PMC 2195338. PMID 14080814.
  6. ^ a b c "Rowena Matthews". University of Michigan Faculty History Project. Retrieved 3 August 2016.
  7. ^ "Memoir | Faculty History Project". www.lib.umich.edu. Retrieved 2019-09-26.
  8. ^ "Emeritus Faculty". Life Sciences Institute. 2018-03-23. Retrieved 2019-09-26.
  9. ^ "Repligen Corporation Award in Chemistry of Biological Processes" (PDF). The Repligen Award.
  10. ^ Matthews, Rowena. "Rowena Matthews-National Academy of Sciences".
  11. ^ Matthews, Rowena. "Directory: IOM Member-Rowena G. Matthews, Ph.D." Global directory. Archived from the original on 2013-08-15.
  12. ^ "American Philosophical Society Honors HHMI Scientists and Board Members". HHMI News. 7 May 2009. Retrieved 7 August 2016.
  13. ^ "Dr. Rowena G. Matthews". American Philosophical Society Member History. Retrieved 7 August 2016.
  14. ^ "Medical Advisory Board". Howard Hughes Medical Institute. Retrieved 25 March 2015.
  15. ^ "Leadership and Governance". National Academy of Sciences. Retrieved 25 March 2015.
  16. ^ "Lab Members". Bardwell Lab. Retrieved 3 August 2016.
  17. ^ Koutmos, Markos; Datta, Supratim; Pattridge, Katherine A.; Smith, Janet L.; Matthews, Rowena G. (2009-11-03). "Insights into the reactivation of cobalamin-dependent methionine synthase". Proceedings of the National Academy of Sciences of the United States of America. 106 (44): 18527–18532. Bibcode:2009PNAS..10618527K. doi:10.1073/pnas.0906132106. ISSN 1091-6490. PMC 2765455. PMID 19846791.
  18. ^ Hondorp, Elise R.; Matthews, Rowena G. (May 2009). "Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli". Journal of Bacteriology. 191 (10): 3407–3410. doi:10.1128/JB.01722-08. ISSN 1098-5530. PMC 2687158. PMID 19286805.
  19. ^ Yamada, K.; Chen, Z.; Rozen, R.; Matthews, R. G. (2001-12-11). "Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase". Proceedings of the National Academy of Sciences. 98 (26): 14853–14858. Bibcode:2001PNAS...9814853Y. doi:10.1073/pnas.261469998. ISSN 0027-8424. PMC 64948. PMID 11742092.
  20. ^ a b Guenther, Brian D.; Sheppard, Christal A.; Tran, Pamela; Rozen, Rima; Matthews, Rowena G.; Ludwig, Martha L. (April 1999). "The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia". Nature Structural Biology. 6 (4): 359–365. doi:10.1038/7594. ISSN 1545-9985. PMID 10201405. S2CID 23529857.
  21. ^ "Active Emeritus". Biological Chemistry. 2014-08-13. Retrieved 2019-09-26.
  22. ^ Multiple sources:
    • Drennan, C. L.; Matthews, R. G.; Ludwig, M. L. (December 1994). "Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes". Current Opinion in Structural Biology. 4 (6): 919–929. doi:10.1016/0959-440X(94)90275-5. hdl:2027.42/31943. ISSN 0959-440X. PMID 7712296.
    • Ludwig, Martha L.; Matthews, Rowena G. (1997). "Structure-Based Perspectives on B12-Dependent Enzymes". Annual Review of Biochemistry. 66 (1): 269–313. doi:10.1146/annurev.biochem.66.1.269. PMID 9242908.
    • Guenther, B. D.; Sheppard, C. A.; Tran, P.; Rozen, R.; Matthews, R. G.; Ludwig, M. L. (1999). "The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia". Nat. Struct. Mol. Biol. 6: 359–365. doi:10.2210/pdb1b5t/pdb.
  23. ^ Matthews, Rowena G. (2009-09-25). "A love affair with vitamins". The Journal of Biological Chemistry. 284 (39): 26217–26228. doi:10.1074/jbc.X109.041178. ISSN 1083-351X. PMC 2785309. PMID 19596855.
  24. ^ Matthews, R. G. (2009). "Cobalamin- and corrinoid-dependent enzymes". Metal Ions in Life Sciences. 6: 53–114. doi:10.1515/9783110436587-006. ISBN 978-3-11-044279-3. PMC 3120101. PMID 20877792.
  25. ^ Matthews, Rowena G.; Koutmos, Markos; Datta, Supratim (December 2008). "Cobalamin-dependent and cobamide-dependent methyltransferases". Current Opinion in Structural Biology. 18 (6): 658–666. doi:10.1016/j.sbi.2008.11.005. ISSN 1879-033X. PMC 2639622. PMID 19059104.
  26. ^ Beinert, Helmut; Stumpf, Paul K.; Wakil, Salih J. (2004). "David Ezra Green". Biographical Memoirs. 84. National Academies Press: 112–44. PMID 15484418.

External links edit

  • National Academy of Sciences InterViews podcast with Rowena Matthews

January 01, 1970
rowena, green, matthews, born, 1938, robert, greenberg, distinguished, university, professor, emeritus, university, michigan, arbor, research, focuses, role, organic, cofactors, partners, enzymes, catalyzing, difficult, biochemical, reactions, especially, foli. Rowena Green Matthews born in 1938 1 is the G Robert Greenberg Distinguished University professor emeritus at the University of Michigan Ann Arbor 2 Her research focuses on the role of organic cofactors as partners of enzymes catalyzing difficult biochemical reactions especially folic acid and cobalamin vitamin B12 Among other honors she was elected to the National Academy of Sciences in 2002 and the Institute of Medicine in 2004 2 Rowena Green MatthewsBornRowena Green1938 age 85 86 Cambridge EnglandAlma materUniversity of MichiganKnown forStudies of cobalamin and folic acidAwardsNational Academy of Sciences 2002 American Academy of Microbiology 2002 Institute of Medicine 2004 American Academy of Arts and Sciences 2005 American Philosophical Society 2009 Scientific careerFieldsBiochemistryInstitutionsUniversity of MichiganDoctoral advisorVincent Massey Contents 1 Early life and education 2 Academic career 3 Awards 4 Research 5 Selected publications 6 Personal life 7 References 8 External linksEarly life and education editMatthews was born in Cambridge England while her father biochemist David E Green was on sabbatical there 3 xxi Matthews earned her B A in biology summa cum laude from Radcliffe College in 1960 4 As an undergraduate and for three years thereafter she worked with George Wald studying a new intermediate in the bleaching of the visual pigment rhodopsin that temporally coincided with initiation of visual excitation 5 She then attended graduate school in biophysics at the University of Michigan with dissertation research in the laboratory of Vincent Massey She received her Ph D in 1969 6 Academic career editAfter finishing her Ph D Matthews remained at the University of Michigan as a postdoctoral fellow in the laboratory of Charles Williams in the department of Biological Chemistry and Assistant Research Scientist in the Biophysics Research Division in 1978 She was promoted to Associate Professor in 1981 became a full professor in 1986 and became the G Robert Greenberg Distinguished University Professor in 1995 2 6 7 In 2002 she assumed the position of Senior Research Professor and Charter Faculty Member of the Life Sciences Institute 8 She retired in 2007 assuming professor emeritus status 6 Awards editShe received numerous recognitions and honors during her career the Repligen award given by the ACS 2001 9 election to the National Academy of Sciences 2002 10 the American Academy of Microbiology 2002 2 the Institute of Medicine 2004 11 the American Academy of Arts and Sciences 2005 and the American Philosophical Society 2009 12 13 She received the William C Rose Award given by the American Society for Biochemistry and Molecular Biology in 2000 and the Repligen Corporation Award in Chemistry of Biological Processes given by the American Chemical Society in 2001 2 She was the Frederick Gowland Hopkins Lecturer at 12th International Conference of Pteridines and Folates in 2001 an honor she particularly appreciated because her father had worked with Hopkins 3 She serves on the Medical Advisory Board of the Howard Hughes Medical Institute 14 and has served on the Council of the National Academy of Sciences 15 The University of Michigan hosts a professorship honoring Matthews since 2009 James Bardwell has held the Rowena G Matthews Collegiate Professorship 16 Research editDr Matthew s research focused on one carbon metabolism with particular emphasis on the enzymes that catalyze the de novo generation of methyl groups methionine synthase a B 12 dependent enzyme in humans and methylenetetrahydrofolate reductase 17 18 Her collaboration with geneticist Rima Rozen at McGill University led to the cloning of human methylenetetrahydrofolate reductase and the characterization of the C677T polymorphism associated with hyperhomocysteinemia in humans 19 20 The polymorphism can lead to a high amount of homocysteine in the bloodstream High concentrations of homocysteine in the plasma can increase the risk for cardiovascular diseases and the use of folic acid have been shown to decrease the amounts in humans 21 In collaboration with Prof Martha Ludwig they elucidated the first X ray structure of vitamin B12 bound to a protein cobalamin dependent methionine synthase 20 22 Selected publications editA love affair with vitamins 2009 23 Cobalamin and corrinoid dependent enzymes 24 Cobalamin dependent and cobamide dependent methyltransferases 2008 25 Personal life editMatthews is the eldest daughter of biochemist David E Green and the aunt of United States Senator Tammy Baldwin 26 References edit Rowena Green Matthews from Ann Arbor Michigan VoterRecords com voterrecords com Retrieved 2019 09 26 a b c d e Rowena Matthews Ph D University of Michigan Ann Arbor 2014 08 13 Retrieved 3 August 2016 a b Shane Barry 2002 Milstein Sheldon Kapatos Gregory Levine Robert A Shane Barry eds Chemistry and Biology of Pteridines and Folates Proceedings of the 12th International Symposium on Pteridines and Folates National Institutes of Health Bethesda Maryland June 17 22 2001 Boston MA Springer US ISBN 9781461509455 Tangs for the memories Michigan Today michigantoday umich edu 20 September 2017 Retrieved 2019 09 26 Matthews Rowena G Ruth Hubbard Paul K Brown George Wald 1963 Tautomeric forms of metarhodopsin Journal of General Physiology 47 2 215 240 doi 10 1085 jgp 47 2 215 PMC 2195338 PMID 14080814 a b c Rowena Matthews University of Michigan Faculty History Project Retrieved 3 August 2016 Memoir Faculty History Project www lib umich edu Retrieved 2019 09 26 Emeritus Faculty Life Sciences Institute 2018 03 23 Retrieved 2019 09 26 Repligen Corporation Award in Chemistry of Biological Processes PDF The Repligen Award Matthews Rowena Rowena Matthews National Academy of Sciences Matthews Rowena Directory IOM Member Rowena G Matthews Ph D Global directory Archived from the original on 2013 08 15 American Philosophical Society Honors HHMI Scientists and Board Members HHMI News 7 May 2009 Retrieved 7 August 2016 Dr Rowena G Matthews American Philosophical Society Member History Retrieved 7 August 2016 Medical Advisory Board Howard Hughes Medical Institute Retrieved 25 March 2015 Leadership and Governance National Academy of Sciences Retrieved 25 March 2015 Lab Members Bardwell Lab Retrieved 3 August 2016 Koutmos Markos Datta Supratim Pattridge Katherine A Smith Janet L Matthews Rowena G 2009 11 03 Insights into the reactivation of cobalamin dependent methionine synthase Proceedings of the National Academy of Sciences of the United States of America 106 44 18527 18532 Bibcode 2009PNAS 10618527K doi 10 1073 pnas 0906132106 ISSN 1091 6490 PMC 2765455 PMID 19846791 Hondorp Elise R Matthews Rowena G May 2009 Oxidation of cysteine 645 of cobalamin independent methionine synthase causes a methionine limitation in Escherichia coli Journal of Bacteriology 191 10 3407 3410 doi 10 1128 JB 01722 08 ISSN 1098 5530 PMC 2687158 PMID 19286805 Yamada K Chen Z Rozen R Matthews R G 2001 12 11 Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase Proceedings of the National Academy of Sciences 98 26 14853 14858 Bibcode 2001PNAS 9814853Y doi 10 1073 pnas 261469998 ISSN 0027 8424 PMC 64948 PMID 11742092 a b Guenther Brian D Sheppard Christal A Tran Pamela Rozen Rima Matthews Rowena G Ludwig Martha L April 1999 The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia Nature Structural Biology 6 4 359 365 doi 10 1038 7594 ISSN 1545 9985 PMID 10201405 S2CID 23529857 Active Emeritus Biological Chemistry 2014 08 13 Retrieved 2019 09 26 Multiple sources Drennan C L Matthews R G Ludwig M L December 1994 Cobalamin dependent methionine synthase the structure of a methylcobalamin binding fragment and implications for other B12 dependent enzymes Current Opinion in Structural Biology 4 6 919 929 doi 10 1016 0959 440X 94 90275 5 hdl 2027 42 31943 ISSN 0959 440X PMID 7712296 Ludwig Martha L Matthews Rowena G 1997 Structure Based Perspectives on B12 Dependent Enzymes Annual Review of Biochemistry 66 1 269 313 doi 10 1146 annurev biochem 66 1 269 PMID 9242908 Guenther B D Sheppard C A Tran P Rozen R Matthews R G Ludwig M L 1999 The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia Nat Struct Mol Biol 6 359 365 doi 10 2210 pdb1b5t pdb Matthews Rowena G 2009 09 25 A love affair with vitamins The Journal of Biological Chemistry 284 39 26217 26228 doi 10 1074 jbc X109 041178 ISSN 1083 351X PMC 2785309 PMID 19596855 Matthews R G 2009 Cobalamin and corrinoid dependent enzymes Metal Ions in Life Sciences 6 53 114 doi 10 1515 9783110436587 006 ISBN 978 3 11 044279 3 PMC 3120101 PMID 20877792 Matthews Rowena G Koutmos Markos Datta Supratim December 2008 Cobalamin dependent and cobamide dependent methyltransferases Current Opinion in Structural Biology 18 6 658 666 doi 10 1016 j sbi 2008 11 005 ISSN 1879 033X PMC 2639622 PMID 19059104 Beinert Helmut Stumpf Paul K Wakil Salih J 2004 David Ezra Green Biographical Memoirs 84 National Academies Press 112 44 PMID 15484418 External links editNational Academy of Sciences InterViews podcast with Rowena Matthews Retrieved from https en wikipedia org w index php title Rowena Green Matthews amp oldid 1217661583, wikipedia, wiki, book, books, library,

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