Roger Unger

Roger H. Unger (March 7, 1924 – August 22, 2020) was an American physician known for his studies of the physiology of pancreatic islets.^[3] In particular the elucidation of the roles of insulin and glucagon in the regulation of normal blood glucose homeostasis and in the pathogenesis of diabetes, and the establishment of glucagon as a hormone. He was the Touchstone/West Distinguished Chair in Diabetes Research at University of Texas Southwestern Medical Center.^[4][5][6]

Roger H. Unger
Born	(1924-03-07)March 7, 1924 New York City^[1]
Died	August 22, 2020(2020-08-22) (aged 96) Dallas, Texas^[1]
Nationality	American
Alma mater	Yale University, Columbia University (MD)
Occupation	Physician
Known for	Studies of the physiology of pancreatic islets, development of the first radioimmunoassay for glucagon
Spouse	Marlise
Children	4 ^[2]
Relatives	Harlow Giles Unger (brother)
Awards	Lilly Award (1964) Banting Medal (1975) Fred Conrad Koch Award (1983) Rolf Luft Award (2014)^[1]

Early life and education

Unger was born March 7, 1924, to parents who were a physician/hematologist and a stay-at-home mother respectively.^[1] He grew up in New York City, attending the Horace Mann School until the age of 15, then the Taft School for the rest of his secondary education. Unger completed his undergraduate studies at Yale University, then his medical degree at Columbia University.^[1]

Medical and research career

Following medical school, Unger worked at New York's Bellevue Hospital. In 1951, he joined the US Public Health Service, where he directed a diabetes detection drive. In 1956, Unger began his research career by joining the faculty of the University of Texas Southwestern Medical Center and the Dallas VA Medical Center.^[1] He turned his attention first to glucagon, then a protein of unknown function known to be secreted by pancreatic islets. With the help of Solomon Berson's lab, Unger's group developed a radioimmunoassay for measuring glucagon levels, which they published in 1959.^[1][7] Over the subsequent decades, Unger's group continued to delve into glucagon's role in controlling blood sugar, as well as how glucagon secretion is regulated. He is known for advocating the "bihormonal hypothesis", that blood sugar is regulated by the opposing actions of insulin and glucagon, and that the disease diabetes is caused both by lack of insulin, and unopposed glucagon.^[1]

In 1986 Unger, Daniel Foster, and J. Denis McGarry founded the Touchstone Diabetes Center at UT Southwestern, which Unger directed from 1987 until 2007.^[1][8]

Roger Unger's research accomplishments were recognized by several honors in his lifetime. He was appointed to the US National Academy of Sciences in 1986, and the American Academy of Arts and Sciences in 1994.^[1]

References

1. Scherer PE, Newgard CB (1 December 2020). "A tribute to Roger H. Unger (1924-2020)". The Journal of Clinical Investigation. 130 (12): 6191–6193. doi:10.1172/JCI145796. PMC 7685714.
2. "Roger H. Unger M.D. Obituary (1924 - 2020) the Dallas Morning News".
3. "Roger Unger, M.D. - Faculty Profile - UT Southwestern".
4. "Roger Unger". utsouthwestern.edu. Retrieved May 13, 2017.
5. "2014 Award". utsouthwestern.edu. Retrieved May 13, 2017.
6. "In Memoriam: Dr. Roger H. Unger, visionary endocrinologist and preeminent authority on diabetes". The University of Texas Southwestern Medical Center. Retrieved 2 September 2020.
7. Unger RH, Eisentraut AM, McCall MS, Keller S, Lanz HC, Madison LL (1959). "Glucagon antibodies and their use for immunoassay for glucagon". Proc Soc Exp Biol Med. 102 (3): 621–3. doi:10.3181/00379727-102-25338. PMID 13840405. S2CID 32765570.
8. Mulder H (December 2020). "Roger H. Unger, 7 March 1924-22 August 2020". Diabetologia. 63 (12): 2497–2498. doi:10.1007/s00125-020-05291-5. PMID 33001230. S2CID 222070899.