Robin HollidayFRSFAA (6 November 1932 – 9 April 2014) was a British molecular biologist.[1] Holliday described a mechanism of DNA-strand exchange that attempted to explain gene-conversion events that occur during meiosis in fungi. That model first proposed in 1964 and is now known as the Holliday Junction.[2][3]
Holliday held a B.A. in Natural Sciences and a PhD in genetics from Cambridge University. He was a Fellow of the Royal Society, a Fellow Australian Academy of Science (FAA), a member of the European Molecular Biology Organization, a Foreign Fellow of the Indian National Science Academy, and held the 1987 Lord Cohen Medal for Gerontological research. He was formerly the Head of the Genetics Division, National Institute for Medical Research, (Medical Research Council), Mill Hill, London, UK, and prior to his death was a retired Chief Research Scientist, CSIRO Division of BioMolecular Engineering, Sydney, Australia.
Epigenetic researchedit
In 1975 he suggested that DNA methylation could be an important mechanism for the control of gene expression in higher organisms, and this has now become documented as a basic epigenetic mechanism in normal and also cancer cells. In 1988 he moved to a Commonwealth Scientific and Industrial Research Organisation CSIRO laboratory in Sydney, Australia, where he continued to study ageing, and his book Understanding Ageing was published in 1995. He was a biogerontologist and mentored several successful biogerontologists, including Suresh Rattan, editor-in-chief of the journal Biogerontology. The main focus of his experimental work was the epigenetic control of gene expression by DNA methylation in CHO cells. These experiments provide direct evidence that DNA methylation is a primary cause of gene silencing in mammalian cells.
Publicationsedit
Holliday was the author of numerous books, including;
The Science of Human Progress, Oxford University Press, Oxford, 1981;
Genes, Proteins and Cellular Aging, Van Nostrand Reinhold, New York, 1986
Understanding Aging, Cambridge University Press, Cambridge England, 1995
Slaves and Saviours, Blackwall Books, Sydney, 2000
Aging: The Paradox of Life: Why We Age, Springer, Dordrecht, 2007
Origins & Outcomes: An Autobiography, Longueville, Sydney, 2008.
Selected historical survey articles in scientific journals by Holliday:
A different kind of inheritance. Scientific American, 260, 60–73 (1989).
The history of the DNA heteroduplex. BioEssays, 12, 133–142 (1990).
Twenty years of ageing research at the Mill Hill laboratories. Experimental Gerontology 37, 851–857 (2002)
Early studies on recombination and DNA repair in Ustilago maydis. DNA Repair, 3, 671–682 (2004)
Epigenetics: a historical overview. Epigenetics, 1, 76–80 (2006).
Selected edited publications and proceedings:
Genes, Proteins and Cellular Ageing (Benchmark Papers in Genetics). Holliday, R (editor). van Nostrand Reinhold, New York (1986). Selected facsimile reprints of 30 scientific papers by various authors, with an Introduction, Comments and Epilogue by the editor.
Towards Prolongation of the Healthy Lifespan. Holliday, R., D. Harman, and M. Meydani (eds). Annals N.Y. Acad. Sci. 854 (1998). Proceedings of the 7th Congress of the International Association of Biomedical Gerontology, Adelaide, Australia (1997).
Evolution of Adaptation by Natural Selection. Holliday, R., J. Maynard Smith (eds). The Royal Society, London (1979). Proceedings of a Discussion Meeting of the Royal Society, London, organised by the Editors, in December 1978.
DNA Methylation and Gene Regulation. Holliday, R., M. Monk and J.E. Pugh (eds). The Royal Society, London (1990). Proceedings of a Discussion Meeting of the Royal Society, London, organised by the Editors, in February 1989
Ageing: Science, Medicine and Society. Phil. Trans. Roy. Soc B, 352, 1761–1920 (1997). Holliday, R., J. Grimley Evans, T.B.L. Kirkwood, P. Laslett, and L. Tyler (eds). Proceedings of a Discussion Meeting of the Royal Society, London, organised by the Editors, in May 1997.
^. NIMR News. National Institute of Medical Research. 14 April 2014. Archived from the original on 16 April 2014.
^ The double life of Holliday junctions Cell Research (2010) 20:611–613. doi: 10.1038/cr.2010.73; published online 25 May 2010
^Tom Kirkwood (20 May 2014). "Robin Holliday obituary | Science". The Guardian. Retrieved 20 May 2014.
External linksedit
January 01, 1970
robin, holliday, november, 1932, april, 2014, british, molecular, biologist, holliday, described, mechanism, strand, exchange, that, attempted, explain, gene, conversion, events, that, occur, during, meiosis, fungi, that, model, first, proposed, 1964, known, h. Robin Holliday FRS FAA 6 November 1932 9 April 2014 was a British molecular biologist 1 Holliday described a mechanism of DNA strand exchange that attempted to explain gene conversion events that occur during meiosis in fungi That model first proposed in 1964 and is now known as the Holliday Junction 2 3 Robin HollidayBorn 1932 11 06 6 November 1932Died9 April 2014 2014 04 09 aged 81 NationalityBritishOccupationMolecular biologistKnown forHolliday junctionContents 1 Education and employment 2 Epigenetic research 3 Publications 4 See also 5 References 6 External linksEducation and employment editHolliday held a B A in Natural Sciences and a PhD in genetics from Cambridge University He was a Fellow of the Royal Society a Fellow Australian Academy of Science FAA a member of the European Molecular Biology Organization a Foreign Fellow of the Indian National Science Academy and held the 1987 Lord Cohen Medal for Gerontological research He was formerly the Head of the Genetics Division National Institute for Medical Research Medical Research Council Mill Hill London UK and prior to his death was a retired Chief Research Scientist CSIRO Division of BioMolecular Engineering Sydney Australia Epigenetic research editIn 1975 he suggested that DNA methylation could be an important mechanism for the control of gene expression in higher organisms and this has now become documented as a basic epigenetic mechanism in normal and also cancer cells In 1988 he moved to a Commonwealth Scientific and Industrial Research Organisation CSIRO laboratory in Sydney Australia where he continued to study ageing and his book Understanding Ageing was published in 1995 He was a biogerontologist and mentored several successful biogerontologists including Suresh Rattan editor in chief of the journal Biogerontology The main focus of his experimental work was the epigenetic control of gene expression by DNA methylation in CHO cells These experiments provide direct evidence that DNA methylation is a primary cause of gene silencing in mammalian cells Publications editHolliday was the author of numerous books including The Science of Human Progress Oxford University Press Oxford 1981 Genes Proteins and Cellular Aging Van Nostrand Reinhold New York 1986 Understanding Aging Cambridge University Press Cambridge England 1995 Slaves and Saviours Blackwall Books Sydney 2000 Aging The Paradox of Life Why We Age Springer Dordrecht 2007 Origins amp Outcomes An Autobiography Longueville Sydney 2008 Selected historical survey articles in scientific journals by Holliday A different kind of inheritance Scientific American 260 60 73 1989 The history of the DNA heteroduplex BioEssays 12 133 142 1990 Twenty years of ageing research at the Mill Hill laboratories Experimental Gerontology 37 851 857 2002 Early studies on recombination and DNA repair in Ustilago maydis DNA Repair 3 671 682 2004 Epigenetics a historical overview Epigenetics 1 76 80 2006 Selected edited publications and proceedings Genes Proteins and Cellular Ageing Benchmark Papers in Genetics Holliday R editor van Nostrand Reinhold New York 1986 Selected facsimile reprints of 30 scientific papers by various authors with an Introduction Comments and Epilogue by the editor Towards Prolongation of the Healthy Lifespan Holliday R D Harman and M Meydani eds Annals N Y Acad Sci 854 1998 Proceedings of the 7th Congress of the International Association of Biomedical Gerontology Adelaide Australia 1997 Evolution of Adaptation by Natural Selection Holliday R J Maynard Smith eds The Royal Society London 1979 Proceedings of a Discussion Meeting of the Royal Society London organised by the Editors in December 1978 DNA Methylation and Gene Regulation Holliday R M Monk and J E Pugh eds The Royal Society London 1990 Proceedings of a Discussion Meeting of the Royal Society London organised by the Editors in February 1989 Ageing Science Medicine and Society Phil Trans Roy Soc B 352 1761 1920 1997 Holliday R J Grimley Evans T B L Kirkwood P Laslett and L Tyler eds Proceedings of a Discussion Meeting of the Royal Society London organised by the Editors in May 1997 See also editHolliday junctionReferences edit Robin Holliday 1932 2014 NIMR News National Institute of Medical Research 14 April 2014 Archived from the original on 16 April 2014 The double life of Holliday junctions Cell Research 2010 20 611 613 doi 10 1038 cr 2010 73 published online 25 May 2010 Tom Kirkwood 20 May 2014 Robin Holliday obituary Science The Guardian Retrieved 20 May 2014 External links editRobin Holliday s website via Archive org Retrieved from https en wikipedia org w index php title Robin Holliday amp oldid 1131195276, wikipedia, wiki, book, books, library,
