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Robin Allshire

December 07, 2023

Robin Campbell Allshire (born 19 May 1960) FRS FRSE FMedSci[3][4][5] is Professor of Chromosome Biology[6] at University of Edinburgh and a Wellcome Trust Principal Research Fellow.[7][1] His research group at the Wellcome Trust Centre for Cell Biology[8] focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division.[9]

Robin Allshire

FRS FRSE
Robin Allshire in 2019
Born
Robin Campbell Allshire

1960 (age 62–63)
Alma materTrinity College Dublin (BSc)
University of Edinburgh (PhD)
Scientific career
FieldsEpigenetics
Heterochromatin
Chromatin
Centromere
Kinetochore[1]
InstitutionsUniversity of Edinburgh
Cold Spring Harbor Laboratory
ThesisConstruction and analysis of vectors based on bovine papilloma virus (1985)
Doctoral advisorChris Bostock
Edwin Southern[2]
Other academic advisorsNicholas Hastie
Websiteallshirelab.com

Early life and education edit

Allshire grew up in the fishing village of Howth, Co Dublin 1960–1978.[citation needed] His parents were Arthur Gordon Allshire (1925-2012) who was a Pharmacist and Freda Margaret (née Schmutz; 1933–2014).[10][11] He was awarded his Bachelor of Arts degree in Genetics by Trinity College Dublin, in 1981[citation needed] where he was motivated by the inspirational teaching of David McConnell and colleagues at the Dept of Genetics to undertake post-graduate studies.[12] He subsequently joined the Medical Research Council (MRC) Mammalian Genome Unit at the University of Edinburgh where he obtained his PhD in 1985[2] under the guidance of Chris Bostock and Edwin Southern investigating the use of bovine papillomavirus as a chassis for mammalian artificial chromosome construction.[2]

Career and research edit

In 1985 Allshire joined Nicholas Hastie's research group at the MRC Human Genetics Unit, Edinburgh (formerly MRC Clinical and Population Cytogentics Unit) as a postdoctoral researcher where he discovered that mammalian telomeres are composed of simple repetitive sequences similar to those of unicellular eukaryotes[13] and that telomere length in blood cells shorten with age and are further eroded in cancerous cells.[14] This work resulted from following the fate of fission yeast (Schizosaccharomyces pombe) telomeres after introdroducing fission yeast chromosomes into mouse cell in collaboration with Peter Fantes.[15] In 1989 he took a position as an independent visiting scientist at Cold Spring Harbor Laboratory (CSHL) for 18 months before joining the MRC Human Genetics Unit as a junior group leader. While at CSHL he decided to switch his focus to investigating chromosomal elements in the genetically tractable fission yeast.[16] At the MRC HGU, Edinburgh (1990 - 2002), and subsequently at the Wellome Trust Centre for Cell Biology, University of Edinburgh (2002–present), he discovered that genes are silenced when placed within fission yeast centromeres[17][18] and telomeres,[19] and then utilised this gene silencing to gain fundamental insights into the processes of chromosome segregation,[20][21][22] and heterochromatin[23][24][25][26] and kinetochore CENP-A chromatin[27][28][29][30][31][32] establishment[33][34] and maintenance.[35][36][37] He is particularly interested in the epigenetic mechanisms that allow the persistence of specialised chromatin domains through multiple cell divisions and meiosis.[38] He has investigated how RNA interference (RNAi) mediates heterochromatin formation[39][40][41] and shown that splicing factors contribute to heterochromatin integrity via siRNA generation and RNAi.[42][43] He has provided insight into how transcription and resulting non-coding RNA might influence the assembly of specialised CENP-A chromatin[44][45][46][47] and demonstrated that some acts of lncRNA transcription are responsive to environmental stimuli and regulate neighbouring genes by transcriptional interference.[48][49] Recently using fission yeast his team discovered an epigenetic mechanism that allows fungi to develop resistance to antifungal drugs without alterations to their DNA.[50] This finding is important for understanding how pathogenic fungi become resistant to the limited number of available antifungal agents in both clinical and agricultural arenas.

Awards and honours edit

Allshire was elected a Fellow of the Royal Society of Edinburgh in 2005,[51] a Fellow of the Royal Society (FRS) in 2011 [4] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2020.[5]

References edit

  1. ^ a b Robin Allshire publications indexed by Google Scholar  
  2. ^ a b c Allshire, Robin Campbell (1985). Construction and analysis of vectors based on bovine papilloma virus (PhD thesis). University of Edinburgh. hdl:1842/11176. OCLC 606010479. EThOS uk.bl.ethos.355979.  
  3. ^ "Professor Robin Campbell Allshire FRS, FRSE". rse.org.uk. 24 August 2020.
  4. ^ a b Anon (2011). "Professor Robin Allshire FRS". royalsociety.org. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- at the Wayback Machine (archived 2016-11-11)
  5. ^ a b "Professor Robin Allshire | the Academy of Medical Sciences". Academy of Medical Sciences.
  6. ^ "Allshire lab members".
  7. ^ "Principal Research Fellowships: people we've funded". wellcome.ac.uk. Wellcome Trust.
  8. ^ "Wellcome Centre for Cell Biology - Wellcome Centre for Cell Biology". University of Edinburgh.
  9. ^ "Wellcome Trust lab".
  10. ^ "ALLSHIRE, Arthur : Death notice - Irish Times Family Notices". The Irish Times.
  11. ^ "ALLSHIRE, Freda Margaret : Death notice - Irish Times Family Notices". The Irish Times.
  12. ^ "EPIGENETICS AND SPECIALIZED CHROMATIN".
  13. ^ Allshire, Robin C; Gosden, John R; Cross, Sally H; Cranston, Gwen; Rout, Derek; Sugawara, Neal; Szostak, Jack W; Fantes, Peter A; Hastie, Nicholas D (1988). "Telomeric repeat from T. Thermophila cross hybridizes with human telomeres". Nature. 332 (6165): 656–9. Bibcode:1988Natur.332..656A. doi:10.1038/332656a0. PMID 2833706. S2CID 4352376.
  14. ^ Hastie, Nicholas D; Dempster, Maureen; Dunlop, Malcolm G; Thompson, Alastair M; Green, Daryll K; Allshire, Robin C (1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346 (6287): 866–8. Bibcode:1990Natur.346..866H. doi:10.1038/346866a0. PMID 2392154. S2CID 4258451.
  15. ^ Allshire, R. C; Cranston, G; Gosden, J. R; Maule, J. C; Hastie, N. D; Fantes, P. A (1987). "A fission yeast chromosome can replicate autonomously in mouse cells". Cell. 50 (3): 391–403. doi:10.1016/0092-8674(87)90493-4. PMID 3475186. S2CID 2193386.
  16. ^ Allshire, R. C (1990). "Introduction of large linear minichromosomes into Schizosaccharomyces pombe by an improved transformation procedure". Proceedings of the National Academy of Sciences of the United States of America. 87 (11): 4043–7. Bibcode:1990PNAS...87.4043A. doi:10.1073/pnas.87.11.4043. PMC 54043. PMID 2349217.
  17. ^ Allshire, R. C; Javerzat, J. P; Redhead, N. J; Cranston, G (1994). "Position effect variegation at fission yeast centromeres". Cell. 76 (1): 157–69. doi:10.1016/0092-8674(94)90180-5. PMID 8287474. S2CID 42369473.
  18. ^ Allshire, R. C; Nimmo, E. R; Ekwall, K; Javerzat, J. P; Cranston, G (1995). "Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation". Genes & Development. 9 (2): 218–33. doi:10.1101/gad.9.2.218. PMID 7851795.
  19. ^ Nimmo, E. R; Cranston, G; Allshire, R. C (1994). "Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes". The EMBO Journal. 13 (16): 3801–11. doi:10.1002/j.1460-2075.1994.tb06691.x. PMC 395293. PMID 8070408.
  20. ^ Nimmo, Elaine R; Pidoux, Alison L; Perry, Paul E; Allshire, Robin C (1998). "Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe". Nature. 392 (6678): 825–8. Bibcode:1998Natur.392..825N. doi:10.1038/33941. PMID 9572142. S2CID 4412433.
  21. ^ Pidoux, A. L; Uzawa, S; Perry, P. E; Cande, W. Z; Allshire, R. C (2000). "Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast". Journal of Cell Science. 113 Pt 23 (23): 4177–91. doi:10.1242/jcs.113.23.4177. PMID 11069763.
  22. ^ Bernard, P; Maure, J. F; Partridge, J. F; Genier, S; Javerzat, J. P; Allshire, R. C (2001). "Requirement of Heterochromatin for Cohesion at Centromeres". Science. 294 (5551): 2539–42. Bibcode:2001Sci...294.2539B. doi:10.1126/science.1064027. PMID 11598266. S2CID 31166180.
  23. ^ Ekwall, K; Javerzat, J. P; Lorentz, A; Schmidt, H; Cranston, G; Allshire, R (1995). "The chromodomain protein Swi6: A key component at fission yeast centromeres". Science. 269 (5229): 1429–31. Bibcode:1995Sci...269.1429E. doi:10.1126/science.7660126. PMID 7660126. S2CID 38678389.
  24. ^ Ekwall, K; Olsson, T; Turner, B. M; Cranston, G; Allshire, R. C (1997). "Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres". Cell. 91 (7): 1021–32. doi:10.1016/S0092-8674(00)80492-4. PMID 9428524.
  25. ^ Bannister, Andrew J; Zegerman, Philip; Partridge, Janet F; Miska, Eric A; Thomas, Jean O; Allshire, Robin C; Kouzarides, Tony (2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain". Nature. 410 (6824): 120–4. Bibcode:2001Natur.410..120B. doi:10.1038/35065138. PMID 11242054. S2CID 4334447.
  26. ^ Partridge, J. F; Scott, K. S; Bannister, A. J; Kouzarides, T; Allshire, R. C (2002). "Cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site". Current Biology. 12 (19): 1652–60. doi:10.1016/S0960-9822(02)01177-6. PMID 12361567.
  27. ^ Pidoux, Alison L; Richardson, William; Allshire, Robin C (2003). "Sim4". The Journal of Cell Biology. 161 (2): 295–307. doi:10.1083/jcb.200212110. PMC 2172903. PMID 12719471.
  28. ^ Castillo, A. G; Mellone, B. G; Partridge, J. F; Richardson, W; Hamilton, G. L; Allshire, R. C; Pidoux, A. L (2007). "Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4". PLOS Genetics. 3 (7): e121. doi:10.1371/journal.pgen.0030121. PMC 1934396. PMID 17677001.
  29. ^ Dunleavy, Elaine M; Pidoux, Alison L; Monet, Marie; Bonilla, Carolina; Richardson, William; Hamilton, Georgina L; Ekwall, Karl; McLaughlin, Paul J; Allshire, Robin C (2007). "A NASP (N1/N2)-Related Protein, Sim3, Binds CENP-A and is Required for Its Deposition at Fission Yeast Centromeres". Molecular Cell. 28 (6): 1029–44. doi:10.1016/j.molcel.2007.10.010. PMC 2193228. PMID 18158900.
  30. ^ Pidoux, Alison L; Choi, Eun Shik; Abbott, Johanna K.R; Liu, Xingkun; Kagansky, Alexander; Castillo, Araceli G; Hamilton, Georgina L; Richardson, William; Rappsilber, Juri; He, Xiangwei; Allshire, Robin C (2009). "Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin". Molecular Cell. 33 (3): 299–311. doi:10.1016/j.molcel.2009.01.019. PMC 2697330. PMID 19217404.
  31. ^ Sanchez-Pulido, Luis; Pidoux, Alison L; Ponting, Chris P; Allshire, Robin C (2009). "Common Ancestry of the CENP-A Chaperones Scm3 and HJURP". Cell. 137 (7): 1173–4. doi:10.1016/j.cell.2009.06.010. PMC 4397584. PMID 19563746.
  32. ^ Subramanian, L; Toda, N. R. T; Rappsilber, J; Allshire, R. C (2014). "Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly". Open Biology. 4 (4): 140043. doi:10.1098/rsob.140043. PMC 4043117. PMID 24789708.
  33. ^ Folco, H. D; Pidoux, A. L; Urano, T; Allshire, R. C (2008). "Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres". Science. 319 (5859): 94–7. Bibcode:2008Sci...319...94F. doi:10.1126/science.1150944. PMC 2586718. PMID 18174443.
  34. ^ Kagansky, A; Folco, H. D; Almeida, R; Pidoux, A. L; Boukaba, A; Simmer, F; Urano, T; Hamilton, G. L; Allshire, R. C (2009). "Synthetic Heterochromatin Bypasses RNAi and Centromeric Repeats to Establish Functional Centromeres". Science. 324 (5935): 1716–9. Bibcode:2009Sci...324.1716K. doi:10.1126/science.1172026. PMC 2949999. PMID 19556509.
  35. ^ Partridge, J. F; Borgstrøm, B; Allshire, R. C (2000). "Distinct protein interaction domains and protein spreading in a complex centromere". Genes & Development. 14 (7): 783–91. doi:10.1101/gad.14.7.783. PMC 316498. PMID 10766735.
  36. ^ Trewick, Sarah C; Minc, Elsa; Antonelli, Richard; Urano, Takeshi; Allshire, Robin C (2007). "The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin". The EMBO Journal. 26 (22): 4670–82. doi:10.1038/sj.emboj.7601892. PMC 2048757. PMID 17948055.
  37. ^ Buscaino, Alessia; Lejeune, Erwan; Audergon, Pauline; Hamilton, Georgina; Pidoux, Alison; Allshire, Robin C (2013). "Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance". The EMBO Journal. 32 (9): 1250–64. doi:10.1038/emboj.2013.72. PMC 3642681. PMID 23572080.
  38. ^ Audergon, P. N. C. B; Catania, S; Kagansky, A; Tong, P; Shukla, M; Pidoux, A. L; Allshire, R. C (2015). "Restricted epigenetic inheritance of H3K9 methylation". Science. 348 (6230): 132–5. Bibcode:2015Sci...348..132A. doi:10.1126/science.1260638. PMC 4397586. PMID 25838386.
  39. ^ Simmer, Femke; Buscaino, Alessia; Kos-Braun, Isabelle C; Kagansky, Alexander; Boukaba, Abdelhalim; Urano, Takeshi; Kerr, Alastair R W; Allshire, Robin C (2010). "Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast". EMBO Reports. 11 (2): 112–8. doi:10.1038/embor.2009.273. PMC 2828748. PMID 20062003.
  40. ^ Bayne, Elizabeth H; White, Sharon A; Kagansky, Alexander; Bijos, Dominika A; Sanchez-Pulido, Luis; Hoe, Kwang-Lae; Kim, Dong-Uk; Park, Han-Oh; Ponting, Chris P; Rappsilber, Juri; Allshire, Robin C (2010). "Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity". Cell. 140 (5): 666–77. doi:10.1016/j.cell.2010.01.038. PMC 2875855. PMID 20211136.
  41. ^ Buscaino, Alessia; White, Sharon A; Houston, Douglas R; Lejeune, Erwan; Simmer, Femke; De Lima Alves, Flavia; Diyora, Piyush T; Urano, Takeshi; Bayne, Elizabeth H; Rappsilber, Juri; Allshire, Robin C (2012). "Raf1 is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification". PLOS Genetics. 8 (2): e1002499. doi:10.1371/journal.pgen.1002499. PMC 3271066. PMID 22319459.
  42. ^ Bayne, E. H; Portoso, M; Kagansky, A; Kos-Braun, I. C; Urano, T; Ekwall, K; Alves, F; Rappsilber, J; Allshire, R. C (2008). "Splicing Factors Facilitate RNAi-Directed Silencing in Fission Yeast". Science. 322 (5901): 602–6. Bibcode:2008Sci...322..602B. doi:10.1126/science.1164029. PMC 2585287. PMID 18948543.
  43. ^ Bayne, Elizabeth H; Bijos, Dominika A; White, Sharon A; Alves, Flavia de Lima; Rappsilber, Juri; Allshire, Robin C (2014). "A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast". Genome Biology. 15 (10): 481. doi:10.1186/s13059-014-0481-4. PMC 4210515. PMID 25274039.
  44. ^ Choi, Eun Shik; Strålfors, Annelie; Castillo, Araceli G; Durand-Dubief, Mickaël; Ekwall, Karl; Allshire, Robin C (2011). "Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres". Journal of Biological Chemistry. 286 (26): 23600–7. doi:10.1074/jbc.M111.228510. PMC 3123123. PMID 21531710.
  45. ^ Choi, Eun Shik; Strålfors, Annelie; Catania, Sandra; Castillo, Araceli G; Svensson, J. Peter; Pidoux, Alison L; Ekwall, Karl; Allshire, Robin C (2012). "Factors That Promote H3 Chromatin Integrity during Transcription Prevent Promiscuous Deposition of CENP-ACnp1 in Fission Yeast". PLOS Genetics. 8 (9): e1002985. doi:10.1371/journal.pgen.1002985. PMC 3447972. PMID 23028377.
  46. ^ Catania, Sandra; Pidoux, Alison L; Allshire, Robin C (2015). "Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin". PLOS Genetics. 11 (3): e1004986. doi:10.1371/journal.pgen.1004986. PMC 4349457. PMID 25738810.
  47. ^ Shukla M, Manu; Allshire, Robin C (2018). "Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle". Current Biology. 28 (24): 3924–3936. doi:10.1016/j.cub.2018.10.049. PMC 6303189. PMID 30503616.
  48. ^ Ard, Ryan; Tong, Pin; Allshire, Robin C (2014). "Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast". Nature Communications. 5: 5576. Bibcode:2014NatCo...5.5576A. doi:10.1038/ncomms6576. PMC 4255232. PMID 25428589.
  49. ^ Ard, Ryan; Allshire, Robin C (2016). "Transcription-coupled changes to chromatin underpin gene silencing by transcriptional interference". Nucleic Acids Research. 44 (22): 10619–10630. doi:10.1093/nar/gkw801. PMC 5159543. PMID 27613421.
  50. ^ Torres-Garcia, Sito (2020). "Epigenetic gene silencing by heterochromatin primes fungal resistance". Nature. 585 (7825): 453–458. Bibcode:2020Natur.585..453T. doi:10.1038/s41586-020-2706-x. PMC 7116710. PMID 32908306.
  51. ^ "biography". ICG. Retrieved 4 December 2018.
  52. ^ "Genetics Society Medal 2013". Genetics Society. Retrieved 4 December 2018.

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December 07, 2023
robin, allshire, this, biography, living, person, relies, much, references, primary, sources, please, help, adding, secondary, tertiary, sources, contentious, material, about, living, persons, that, unsourced, poorly, sourced, must, removed, immediately, espec. This biography of a living person relies too much on references to primary sources Please help by adding secondary or tertiary sources Contentious material about living persons that is unsourced or poorly sourced must be removed immediately especially if potentially libelous or harmful Find sources Robin Allshire news newspapers books scholar JSTOR July 2018 Learn how and when to remove this template message Robin Campbell Allshire born 19 May 1960 FRS FRSE FMedSci 3 4 5 is Professor of Chromosome Biology 6 at University of Edinburgh and a Wellcome Trust Principal Research Fellow 7 1 His research group at the Wellcome Trust Centre for Cell Biology 8 focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division 9 Robin AllshireFRS FRSERobin Allshire in 2019BornRobin Campbell Allshire1960 age 62 63 Alma materTrinity College Dublin BSc University of Edinburgh PhD Scientific careerFieldsEpigeneticsHeterochromatinChromatinCentromereKinetochore 1 InstitutionsUniversity of EdinburghCold Spring Harbor LaboratoryThesisConstruction and analysis of vectors based on bovine papilloma virus 1985 Doctoral advisorChris BostockEdwin Southern 2 Other academic advisorsNicholas HastieWebsiteallshirelab wbr comContents 1 Early life and education 2 Career and research 2 1 Awards and honours 3 ReferencesEarly life and education editAllshire grew up in the fishing village of Howth Co Dublin 1960 1978 citation needed His parents were Arthur Gordon Allshire 1925 2012 who was a Pharmacist and Freda Margaret nee Schmutz 1933 2014 10 11 He was awarded his Bachelor of Arts degree in Genetics by Trinity College Dublin in 1981 citation needed where he was motivated by the inspirational teaching of David McConnell and colleagues at the Dept of Genetics to undertake post graduate studies 12 He subsequently joined the Medical Research Council MRC Mammalian Genome Unit at the University of Edinburgh where he obtained his PhD in 1985 2 under the guidance of Chris Bostock and Edwin Southern investigating the use of bovine papillomavirus as a chassis for mammalian artificial chromosome construction 2 Career and research editIn 1985 Allshire joined Nicholas Hastie s research group at the MRC Human Genetics Unit Edinburgh formerly MRC Clinical and Population Cytogentics Unit as a postdoctoral researcher where he discovered that mammalian telomeres are composed of simple repetitive sequences similar to those of unicellular eukaryotes 13 and that telomere length in blood cells shorten with age and are further eroded in cancerous cells 14 This work resulted from following the fate of fission yeast Schizosaccharomyces pombe telomeres after introdroducing fission yeast chromosomes into mouse cell in collaboration with Peter Fantes 15 In 1989 he took a position as an independent visiting scientist at Cold Spring Harbor Laboratory CSHL for 18 months before joining the MRC Human Genetics Unit as a junior group leader While at CSHL he decided to switch his focus to investigating chromosomal elements in the genetically tractable fission yeast 16 At the MRC HGU Edinburgh 1990 2002 and subsequently at the Wellome Trust Centre for Cell Biology University of Edinburgh 2002 present he discovered that genes are silenced when placed within fission yeast centromeres 17 18 and telomeres 19 and then utilised this gene silencing to gain fundamental insights into the processes of chromosome segregation 20 21 22 and heterochromatin 23 24 25 26 and kinetochore CENP A chromatin 27 28 29 30 31 32 establishment 33 34 and maintenance 35 36 37 He is particularly interested in the epigenetic mechanisms that allow the persistence of specialised chromatin domains through multiple cell divisions and meiosis 38 He has investigated how RNA interference RNAi mediates heterochromatin formation 39 40 41 and shown that splicing factors contribute to heterochromatin integrity via siRNA generation and RNAi 42 43 He has provided insight into how transcription and resulting non coding RNA might influence the assembly of specialised CENP A chromatin 44 45 46 47 and demonstrated that some acts of lncRNA transcription are responsive to environmental stimuli and regulate neighbouring genes by transcriptional interference 48 49 Recently using fission yeast his team discovered an epigenetic mechanism that allows fungi to develop resistance to antifungal drugs without alterations to their DNA 50 This finding is important for understanding how pathogenic fungi become resistant to the limited number of available antifungal agents in both clinical and agricultural arenas Awards and honours edit Allshire was elected a Fellow of the Royal Society of Edinburgh in 2005 51 a Fellow of the Royal Society FRS in 2011 4 and a Fellow of the Academy of Medical Sciences FMedSci in 2020 5 2013 Genetics Society Medal 52 References edit a b Robin Allshire publications indexed by Google Scholar nbsp a b c Allshire Robin Campbell 1985 Construction and analysis of vectors based on bovine papilloma virus PhD thesis University of Edinburgh hdl 1842 11176 OCLC 606010479 EThOS uk bl ethos 355979 nbsp Professor Robin Campbell Allshire FRS FRSE rse org uk 24 August 2020 a b Anon 2011 Professor Robin Allshire FRS royalsociety org One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies at the Wayback Machine archived 2016 11 11 a b Professor Robin Allshire the Academy of Medical Sciences Academy of Medical Sciences Allshire lab members Principal Research Fellowships people we ve funded wellcome ac uk Wellcome Trust Wellcome Centre for Cell Biology Wellcome Centre for Cell Biology University of Edinburgh Wellcome Trust lab ALLSHIRE Arthur Death notice Irish Times Family Notices The Irish Times ALLSHIRE Freda Margaret Death notice Irish Times Family Notices The Irish Times EPIGENETICS AND SPECIALIZED CHROMATIN Allshire Robin C Gosden John R Cross Sally H Cranston Gwen Rout Derek Sugawara Neal Szostak Jack W Fantes Peter A Hastie Nicholas D 1988 Telomeric repeat from T Thermophila cross hybridizes with human telomeres Nature 332 6165 656 9 Bibcode 1988Natur 332 656A doi 10 1038 332656a0 PMID 2833706 S2CID 4352376 Hastie Nicholas D Dempster Maureen Dunlop Malcolm G Thompson Alastair M Green Daryll K Allshire Robin C 1990 Telomere reduction in human colorectal carcinoma and with ageing Nature 346 6287 866 8 Bibcode 1990Natur 346 866H doi 10 1038 346866a0 PMID 2392154 S2CID 4258451 Allshire R C Cranston G Gosden J R Maule J C Hastie N D Fantes P A 1987 A fission yeast chromosome can replicate autonomously in mouse cells Cell 50 3 391 403 doi 10 1016 0092 8674 87 90493 4 PMID 3475186 S2CID 2193386 Allshire R C 1990 Introduction of large linear minichromosomes into Schizosaccharomyces pombe by an improved transformation procedure Proceedings of the National Academy of Sciences of the United States of America 87 11 4043 7 Bibcode 1990PNAS 87 4043A doi 10 1073 pnas 87 11 4043 PMC 54043 PMID 2349217 Allshire R C Javerzat J P Redhead N J Cranston G 1994 Position effect variegation at fission yeast centromeres Cell 76 1 157 69 doi 10 1016 0092 8674 94 90180 5 PMID 8287474 S2CID 42369473 Allshire R C Nimmo E R Ekwall K Javerzat J P Cranston G 1995 Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation Genes amp Development 9 2 218 33 doi 10 1101 gad 9 2 218 PMID 7851795 Nimmo E R Cranston G Allshire R C 1994 Telomere associated chromosome breakage in fission yeast results in variegated expression of adjacent genes The EMBO Journal 13 16 3801 11 doi 10 1002 j 1460 2075 1994 tb06691 x PMC 395293 PMID 8070408 Nimmo Elaine R Pidoux Alison L Perry Paul E Allshire Robin C 1998 Defective meiosis in telomere silencing mutants of Schizosaccharomyces pombe Nature 392 6678 825 8 Bibcode 1998Natur 392 825N doi 10 1038 33941 PMID 9572142 S2CID 4412433 Pidoux A L Uzawa S Perry P E Cande W Z Allshire R C 2000 Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast Journal of Cell Science 113 Pt 23 23 4177 91 doi 10 1242 jcs 113 23 4177 PMID 11069763 Bernard P Maure J F Partridge J F Genier S Javerzat J P Allshire R C 2001 Requirement of Heterochromatin for Cohesion at Centromeres Science 294 5551 2539 42 Bibcode 2001Sci 294 2539B doi 10 1126 science 1064027 PMID 11598266 S2CID 31166180 Ekwall K Javerzat J P Lorentz A Schmidt H Cranston G Allshire R 1995 The chromodomain protein Swi6 A key component at fission yeast centromeres Science 269 5229 1429 31 Bibcode 1995Sci 269 1429E doi 10 1126 science 7660126 PMID 7660126 S2CID 38678389 Ekwall K Olsson T Turner B M Cranston G Allshire R C 1997 Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres Cell 91 7 1021 32 doi 10 1016 S0092 8674 00 80492 4 PMID 9428524 Bannister Andrew J Zegerman Philip Partridge Janet F Miska Eric A Thomas Jean O Allshire Robin C Kouzarides Tony 2001 Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain Nature 410 6824 120 4 Bibcode 2001Natur 410 120B doi 10 1038 35065138 PMID 11242054 S2CID 4334447 Partridge J F Scott K S Bannister A J Kouzarides T Allshire R C 2002 Cis acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site Current Biology 12 19 1652 60 doi 10 1016 S0960 9822 02 01177 6 PMID 12361567 Pidoux Alison L Richardson William Allshire Robin C 2003 Sim4 The Journal of Cell Biology 161 2 295 307 doi 10 1083 jcb 200212110 PMC 2172903 PMID 12719471 Castillo A G Mellone B G Partridge J F Richardson W Hamilton G L Allshire R C Pidoux A L 2007 Plasticity of fission yeast CENP A chromatin driven by relative levels of histone H3 and H4 PLOS Genetics 3 7 e121 doi 10 1371 journal pgen 0030121 PMC 1934396 PMID 17677001 Dunleavy Elaine M Pidoux Alison L Monet Marie Bonilla Carolina Richardson William Hamilton Georgina L Ekwall Karl McLaughlin Paul J Allshire Robin C 2007 A NASP N1 N2 Related Protein Sim3 Binds CENP A and is Required for Its Deposition at Fission Yeast Centromeres Molecular Cell 28 6 1029 44 doi 10 1016 j molcel 2007 10 010 PMC 2193228 PMID 18158900 Pidoux Alison L Choi Eun Shik Abbott Johanna K R Liu Xingkun Kagansky Alexander Castillo Araceli G Hamilton Georgina L Richardson William Rappsilber Juri He Xiangwei Allshire Robin C 2009 Fission Yeast Scm3 A CENP A Receptor Required for Integrity of Subkinetochore Chromatin Molecular Cell 33 3 299 311 doi 10 1016 j molcel 2009 01 019 PMC 2697330 PMID 19217404 Sanchez Pulido Luis Pidoux Alison L Ponting Chris P Allshire Robin C 2009 Common Ancestry of the CENP A 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secondary small interfering RNA synthesis and silencing in trans in fission yeast EMBO Reports 11 2 112 8 doi 10 1038 embor 2009 273 PMC 2828748 PMID 20062003 Bayne Elizabeth H White Sharon A Kagansky Alexander Bijos Dominika A Sanchez Pulido Luis Hoe Kwang Lae Kim Dong Uk Park Han Oh Ponting Chris P Rappsilber Juri Allshire Robin C 2010 Stc1 A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity Cell 140 5 666 77 doi 10 1016 j cell 2010 01 038 PMC 2875855 PMID 20211136 Buscaino Alessia White Sharon A Houston Douglas R Lejeune Erwan Simmer Femke De Lima Alves Flavia Diyora Piyush T Urano Takeshi Bayne Elizabeth H Rappsilber Juri Allshire Robin C 2012 Raf1 is a DCAF for the Rik1 DDB1 Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification PLOS Genetics 8 2 e1002499 doi 10 1371 journal pgen 1002499 PMC 3271066 PMID 22319459 Bayne E H Portoso M Kagansky A Kos Braun I C Urano T Ekwall K Alves F Rappsilber J Allshire R C 2008 Splicing Factors Facilitate RNAi Directed Silencing in Fission Yeast Science 322 5901 602 6 Bibcode 2008Sci 322 602B doi 10 1126 science 1164029 PMC 2585287 PMID 18948543 Bayne Elizabeth H Bijos Dominika A White Sharon A Alves Flavia de Lima Rappsilber Juri Allshire Robin C 2014 A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast Genome Biology 15 10 481 doi 10 1186 s13059 014 0481 4 PMC 4210515 PMID 25274039 Choi Eun Shik Stralfors Annelie Castillo Araceli G Durand Dubief Mickael Ekwall Karl Allshire Robin C 2011 Identification of Noncoding Transcripts from within CENP A Chromatin at Fission Yeast Centromeres Journal of Biological Chemistry 286 26 23600 7 doi 10 1074 jbc M111 228510 PMC 3123123 PMID 21531710 Choi Eun Shik Stralfors Annelie Catania Sandra Castillo Araceli G Svensson J Peter Pidoux Alison L Ekwall Karl Allshire Robin C 2012 Factors That Promote H3 Chromatin Integrity during Transcription Prevent Promiscuous Deposition of CENP ACnp1 in Fission Yeast PLOS Genetics 8 9 e1002985 doi 10 1371 journal pgen 1002985 PMC 3447972 PMID 23028377 Catania Sandra Pidoux Alison L Allshire Robin C 2015 Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP A Chromatin PLOS Genetics 11 3 e1004986 doi 10 1371 journal pgen 1004986 PMC 4349457 PMID 25738810 Shukla M Manu Allshire Robin C 2018 Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP A Deposition during the Cell Cycle Current Biology 28 24 3924 3936 doi 10 1016 j cub 2018 10 049 PMC 6303189 PMID 30503616 Ard Ryan Tong Pin Allshire Robin C 2014 Long non coding RNA mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast Nature Communications 5 5576 Bibcode 2014NatCo 5 5576A doi 10 1038 ncomms6576 PMC 4255232 PMID 25428589 Ard Ryan Allshire Robin C 2016 Transcription coupled changes to chromatin underpin gene silencing by transcriptional interference Nucleic Acids Research 44 22 10619 10630 doi 10 1093 nar gkw801 PMC 5159543 PMID 27613421 Torres Garcia Sito 2020 Epigenetic gene silencing by heterochromatin primes fungal resistance Nature 585 7825 453 458 Bibcode 2020Natur 585 453T doi 10 1038 s41586 020 2706 x PMC 7116710 PMID 32908306 biography ICG Retrieved 4 December 2018 Genetics Society Medal 2013 Genetics Society Retrieved 4 December 2018 nbsp This article incorporates text available under the CC BY 4 0 license Retrieved from https en wikipedia org w index php title Robin Allshire amp oldid 1188059519, wikipedia, wiki, book, books, library,

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