Ro48-8684 is a water-soluble benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s, which was designed along with Ro48-6791 as an improved replacement for midazolam, but ultimately proved to have little advantages over the parent drug and has not been introduced into clinical practice.[1][2]
^van Gerven JM, Roncari G, Schoemaker RC, Massarella J, Keesmaat P, Kooyman H, et al. (November 1997). "Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects". British Journal of Clinical Pharmacology. 44 (5): 487–93. doi:10.1046/j.1365-2125.1997.t01-1-00613.x. PMC2042863. PMID 9384466.
^Albrecht S, Hering W, Ihmsen H, Schwilden H, Schüttler J (October 1999). "[Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example]". Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 34 (10): 634–7. doi:10.1055/s-1999-213. PMID 10548960.
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ro48, 8684, water, soluble, benzodiazepine, derivative, developed, hoffman, laroche, 1990s, which, designed, along, with, ro48, 6791, improved, replacement, midazolam, ultimately, proved, have, little, advantages, over, parent, drug, been, introduced, into, cl. Ro48 8684 is a water soluble benzodiazepine derivative developed by Hoffman LaRoche in the 1990s which was designed along with Ro48 6791 as an improved replacement for midazolam but ultimately proved to have little advantages over the parent drug and has not been introduced into clinical practice 1 2 Ro48 8684IdentifiersIUPAC name 3 5 dipropylaminomethyloxazol 2 yl 8 fluoro 5 methyl 5 6 dihydro 4H imidazo 1 5 a 1 4 benzodiazepin 6 onePubChem CID9866317ChemSpider8042008Chemical and physical dataFormulaC 22H 26F N 5O 2Molar mass411 472 g mol 13D model JSmol Interactive imageSMILES CCCN CC1 CN C C2 C CN C C3 C4C CC F C3 O C N4C N2 O1 CCCInChI InChI 1S C22H26FN5O2 c1 4 8 27 9 5 2 12 16 11 24 21 30 16 20 19 13 26 3 22 29 17 10 15 23 6 7 18 17 28 19 14 25 20 h6 7 10 11 14H 4 5 8 9 12 13H2 1 3H3Key YKKLHEHNUYCLQQ UHFFFAOYSA N verify See also EditBenzodiazepineReferences Edit van Gerven JM Roncari G Schoemaker RC Massarella J Keesmaat P Kooyman H et al November 1997 Integrated pharmacokinetics and pharmacodynamics of Ro 48 8684 a new benzodiazepine in comparison with midazolam during first administration to healthy male subjects British Journal of Clinical Pharmacology 44 5 487 93 doi 10 1046 j 1365 2125 1997 t01 1 00613 x PMC 2042863 PMID 9384466 Albrecht S Hering W Ihmsen H Schwilden H Schuttler J October 1999 Pharmacokinetic pharmacodynamic modeling in phase II of drug development A comparative study with young and old volunteers with benzdiazepine as an example Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie 34 10 634 7 doi 10 1055 s 1999 213 PMID 10548960 This sedative related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Ro48 8684 amp oldid 1098691412, wikipedia, wiki, book, books, library,
