Redondoviruses (members of the Redondoviridae) are a family of human-associated DNA viruses.[2] Their name derives from the inferred circular structure of the viral genome (“redondo” means round in Spanish). Redondoviruses have been identified in DNA sequence based surveys of samples from humans, primarily samples from the oral cavity and upper airway.[3][4][5]
The family Redondoviridae is divided into two species, Brisavirus and Vientovirus.[1][5] The names derive from the words for breeze and wind in Spanish (“brisa” and “viento”), denoting the association with the human airway. Multiple strains have been proposed on the basis of viral genome structure.[citation needed]
The redondoviruses are members of the Circular Rep-Containing Single Stranded (CRESS) DNA Virus group.[7]
Class: Arfiviricetes[8] (Ar from arginine; fi from finger; describes a feature of the Rep protein conserved among viruses in this class)
Order: Recrevirales[8] (Re from redondoviruses; cre from CRESS)
Genomeedit
The redondovirus genome is circular, and by analogy to other CRESS viruses likely single stranded. Genomes range in size from about 3.0 to 3.1 kilobases. The genome encodes three inferred proteins:[citation needed]
A Cap protein that likely self-assembles to yield icosahedral particles.
An ORF3 protein of unknown function. ORF3 is entirely encoded within the Cap coding region in a different reading frame.
Epidemiologyedit
Distributionedit
Redondovirus genomes have been reported primarily from human samples surveyed using metagenomic DNA sequencing. They have been found primarily in oral and airway specimens.[4][5]In some human populations, oral samples can show up to 80% Redondovirus positivity.[10]
Analysis of a variety of human-derived sample types showed a strong positive correlation of Redondovirus DNA and DNA of the oral amoeba Entamoeba gingivalis. Follow up studies showed that a xenic culture containing Entamoeba gingivalis and feeder bacteria was also positive for redondovirus DNA and RNA. Analysis using intracellular cross linking (Hi-C) showed crosslinking of redondovirus DNA to Entamoeba DNA, supporting Entamoeba gingivalis as the host.[11][12]
Disease associationsedit
It is unknown whether redondoviruses cause human disease. Some CRESS viruses are known pathogens, such as porcine circovirus type 2[13]
Redondoviruses have been reported associated with periodontitis. In one study, the levels fell with successful treatment.[5] Abundance of redondovirus genomes has also been found to be high in some intensive care unit patients, and in patients with severe COVID-19.[14] At present the basis of these disease associations is unclear.[1][5]
^Abbas A, Taylor LJ, Collman RG, Bushman FD, ICTV Report Consortium (January 2021). "ICTV Virus Taxonomy Profile: Redondoviridae". The Journal of General Virology. 102 (1). doi:10.1099/jgv.0.001526. PMC8116785. PMID 33258767.
^Noell K, Kolls JK (May 2019). "Further Defining the Human Virome using NGS: Identification of Redondoviridae". Cell Host & Microbe. 25 (5): 634–635. doi:10.1016/j.chom.2019.04.010. PMC6849504. PMID 31071291.
^ abCui L, Wu B, Zhu X, Guo X, Ge Y, Zhao K, Qi X, Shi Z, Zhu F, Sun L, Zhou M (November 2017). "Identification and genetic characterization of a novel circular single-stranded DNA virus in a human upper respiratory tract sample". Archives of Virology. 162 (11): 3305–3312. doi:10.1007/s00705-017-3481-3. ISSN 0304-8608. PMID 28707271. S2CID 9239411.
^ abcdefAbbas AA, Taylor LJ, Dothard MI, Leiby JS, Fitzgerald AS, Khatib LA, Collman RG, Bushman FD (August 2019). "Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness". Cell Host & Microbe. 26 (2): 719–729.e4. doi:10.1016/j.chom.2019.07.015. PMC6510254. PMID 31071295.
^Abbas AA, Taylor LJ, Collman RG, Bushman FD (14 October 2019). "Create one new family (Redondoviridae) for circular, Rep-encoding DNA viruses". International Committee on Taxonomy of Viruses (ICTV). Retrieved 25 February 2020.[dead link]
^Zhao L, Rosario K, Breitbart M, Duffy S (2019), "Eukaryotic Circular Rep-Encoding Single-Stranded DNA (CRESS DNA) Viruses: Ubiquitous Viruses With Small Genomes and a Diverse Host Range", Advances in Virus Research, Elsevier, 103: 71–133, doi:10.1016/bs.aivir.2018.10.001, ISBN978-0-12-817722-8, PMID 30635078, S2CID 58636379
^ abcWalker PJ. "2019.012D.A.v1.Cressdnaviricota" (XLSX). International Committee on Taxonomy of Viruses (ICTV). Retrieved 25 February 2020. CressdnaviricotaArfiviricetesRecreviralesRedondoviridae[dead link]
^Krupovic M, Varsani A, Kuhn J, Kazlauskas D, Breitbart M, Delwart E, Rosario K, Yutin N, Wolf YI, Harrach B, Zerbini FM, Dolja VV, Koonin EV (2019). . ICTV Taxonomy Proposal 2019.012D.A.v1.Cressdnaviricota. Archived from the original on February 12, 2020.{{cite web}}: CS1 maint: multiple names: authors list (link)
^Taylor LJ, Dothard MI, Rubel MA, Allen AA, Hwang Y, Roche AM, Graham-Wooten J, Fitzgerald AS, Khatib LA, Ranciaro A, Thompson SR, Beggs WR, Campbell MC, Mokone GG, Mpoloka SW, Fokunang C, Njamnshi AK, Mbunwe E, Woldemeskel D, Belay G, Nyambo T, Tishkoff SA, Collman RG, Bushman FD (October 2021). "Redondovirus Diversity and Evolution on Global, Individual, and Molecular Scales". J Virol. 95 (21): e0081721. doi:10.1128/JVI.00817-21. PMC8513488. PMID 34406857.
^Keeler E, Merenstein C, Reddy S, Taylor L, Cobian-Guemes A, Zankharia U, Collman R, Bushman F (December 1, 2022). "Widespread, human-associated redondoviruses infect the commensal protozoan Entamoeba gingivalis". Cell Host and Microbe. 31 (1): 58–68.e5. doi:10.1016/j.chom.2022.11.002. PMC9969835. PMID 36459997. S2CID 254179614.
^Kinsella C, Deijs M, Becker C, Broekhuizen P, van Gool T, Bart A, Schaefer A, van der Hoek L (September 16, 2022). "Host prediction for disease-associated gastrointestinal cressdnaviruses". Virus Evol. 8 (2): veac087. doi:10.1093/ve/veac087. PMC9615429. PMID 36325032.
^Meng X (January 2013). "Porcine Circovirus Type 2 (PCV2): Pathogenesis and Interaction with the Immune System". Annual Review of Animal Biosciences. 1 (1): 43–64. doi:10.1146/annurev-animal-031412-103720. ISSN 2165-8102. PMID 25387012.
^Merenstein C, Liang G, Whiteside SA, Cobián-Güemes AG, Merlino MS, Taylor LJ, Glascock A, Bittinger K, Tanes C, Graham-Wooten J, Khatib LA, Fitzgerald AS, Reddy S, Baxter AE, Giles JR, Oldridge DA, Meyer NJ, Wherry EJ, McGinniss JE, Bushman FD, Collman RG (August 2021). "Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome". mBio. 12 (4): e0177721. doi:10.1128/mBio.01777-21. PMC8406335. PMID 34399607.
External linksedit
Data related to Redondoviridae at Wikispecies
ICTV Report:Redondoviridae
February 27, 2024
redondoviridae, redondoviruses, members, family, human, associated, viruses, their, name, derives, from, inferred, circular, structure, viral, genome, redondo, means, round, spanish, redondoviruses, have, been, identified, sequence, based, surveys, samples, fr. Redondoviruses members of the Redondoviridae are a family of human associated DNA viruses 2 Their name derives from the inferred circular structure of the viral genome redondo means round in Spanish Redondoviruses have been identified in DNA sequence based surveys of samples from humans primarily samples from the oral cavity and upper airway 3 4 5 RedondoviridaeVirus classification unranked VirusRealm MonodnaviriaKingdom ShotokuviraePhylum CressdnaviricotaClass ArfiviricetesOrder RecreviralesFamily RedondoviridaeGenus and species 1 Torbevirus Vientovirus Brisavirus Redondoviridae genome mapContents 1 Virology 1 1 Taxonomy 1 2 Classification 1 3 Genome 2 Epidemiology 2 1 Distribution 2 2 Disease associations 3 References 4 External linksVirology editTaxonomy edit Redondoviruses are assigned to a new family by the International Committee on Taxonomy of Viruses ICTV the Redondoviridae 1 5 6 Classification edit The family Redondoviridae is divided into two species Brisavirus and Vientovirus 1 5 The names derive from the words for breeze and wind in Spanish brisa and viento denoting the association with the human airway Multiple strains have been proposed on the basis of viral genome structure citation needed The redondoviruses are members of the Circular Rep Containing Single Stranded CRESS DNA Virus group 7 Phylum Cressdnaviricota 8 9 Class Arfiviricetes 8 Ar from arginine fi from finger describes a feature of the Rep protein conserved among viruses in this class Order Recrevirales 8 Re from redondoviruses cre from CRESS Genome edit The redondovirus genome is circular and by analogy to other CRESS viruses likely single stranded Genomes range in size from about 3 0 to 3 1 kilobases The genome encodes three inferred proteins citation needed A Rep protein that likely initiates rolling circle DNA replication A Cap protein that likely self assembles to yield icosahedral particles An ORF3 protein of unknown function ORF3 is entirely encoded within the Cap coding region in a different reading frame Epidemiology editDistribution edit Redondovirus genomes have been reported primarily from human samples surveyed using metagenomic DNA sequencing They have been found primarily in oral and airway specimens 4 5 In some human populations oral samples can show up to 80 Redondovirus positivity 10 Analysis of a variety of human derived sample types showed a strong positive correlation of Redondovirus DNA and DNA of the oral amoeba Entamoeba gingivalis Follow up studies showed that a xenic culture containing Entamoeba gingivalis and feeder bacteria was also positive for redondovirus DNA and RNA Analysis using intracellular cross linking Hi C showed crosslinking of redondovirus DNA to Entamoeba DNA supporting Entamoeba gingivalis as the host 11 12 Disease associations edit It is unknown whether redondoviruses cause human disease Some CRESS viruses are known pathogens such as porcine circovirus type 2 13 Redondoviruses have been reported associated with periodontitis In one study the levels fell with successful treatment 5 Abundance of redondovirus genomes has also been found to be high in some intensive care unit patients and in patients with severe COVID 19 14 At present the basis of these disease associations is unclear 1 5 References edit a b c d ICTV Report Redondoviridae Abbas A Taylor LJ Collman RG Bushman FD ICTV Report Consortium January 2021 ICTV Virus Taxonomy Profile Redondoviridae The Journal of General Virology 102 1 doi 10 1099 jgv 0 001526 PMC 8116785 PMID 33258767 Noell K Kolls JK May 2019 Further Defining the Human Virome using NGS Identification of Redondoviridae Cell Host amp Microbe 25 5 634 635 doi 10 1016 j chom 2019 04 010 PMC 6849504 PMID 31071291 a b Cui L Wu B Zhu X Guo X Ge Y Zhao K Qi X Shi Z Zhu F Sun L Zhou M November 2017 Identification and genetic characterization of a novel circular single stranded DNA virus in a human upper respiratory tract sample Archives of Virology 162 11 3305 3312 doi 10 1007 s00705 017 3481 3 ISSN 0304 8608 PMID 28707271 S2CID 9239411 a b c d e f Abbas AA Taylor LJ Dothard MI Leiby JS Fitzgerald AS Khatib LA Collman RG Bushman FD August 2019 Redondoviridae a Family of Small Circular DNA Viruses of the Human Oro Respiratory Tract Associated with Periodontitis and Critical Illness Cell Host amp Microbe 26 2 719 729 e4 doi 10 1016 j chom 2019 07 015 PMC 6510254 PMID 31071295 Abbas AA Taylor LJ Collman RG Bushman FD 14 October 2019 Create one new family Redondoviridae for circular Rep encoding DNA viruses International Committee on Taxonomy of Viruses ICTV Retrieved 25 February 2020 dead link Zhao L Rosario K Breitbart M Duffy S 2019 Eukaryotic Circular Rep Encoding Single Stranded DNA CRESS DNA Viruses Ubiquitous Viruses With Small Genomes and a Diverse Host Range Advances in Virus Research Elsevier 103 71 133 doi 10 1016 bs aivir 2018 10 001 ISBN 978 0 12 817722 8 PMID 30635078 S2CID 58636379 a b c Walker PJ 2019 012D A v1 Cressdnaviricota XLSX International Committee on Taxonomy of Viruses ICTV Retrieved 25 February 2020 Cressdnaviricota Arfiviricetes Recrevirales Redondoviridae dead link Krupovic M Varsani A Kuhn J Kazlauskas D Breitbart M Delwart E Rosario K Yutin N Wolf YI Harrach B Zerbini FM Dolja VV Koonin EV 2019 Create 1 new phylum Cressdnaviricota including 2 classes and 6 orders for classification of CRESS DNA viruses ICTV Taxonomy Proposal 2019 012D A v1 Cressdnaviricota Archived from the original on February 12 2020 a href Template Cite web html title Template Cite web cite web a CS1 maint multiple names authors list link Taylor LJ Dothard MI Rubel MA Allen AA Hwang Y Roche AM Graham Wooten J Fitzgerald AS Khatib LA Ranciaro A Thompson SR Beggs WR Campbell MC Mokone GG Mpoloka SW Fokunang C Njamnshi AK Mbunwe E Woldemeskel D Belay G Nyambo T Tishkoff SA Collman RG Bushman FD October 2021 Redondovirus Diversity and Evolution on Global Individual and Molecular Scales J Virol 95 21 e0081721 doi 10 1128 JVI 00817 21 PMC 8513488 PMID 34406857 Keeler E Merenstein C Reddy S Taylor L Cobian Guemes A Zankharia U Collman R Bushman F December 1 2022 Widespread human associated redondoviruses infect the commensal protozoan Entamoeba gingivalis Cell Host and Microbe 31 1 58 68 e5 doi 10 1016 j chom 2022 11 002 PMC 9969835 PMID 36459997 S2CID 254179614 Kinsella C Deijs M Becker C Broekhuizen P van Gool T Bart A Schaefer A van der Hoek L September 16 2022 Host prediction for disease associated gastrointestinal cressdnaviruses Virus Evol 8 2 veac087 doi 10 1093 ve veac087 PMC 9615429 PMID 36325032 Meng X January 2013 Porcine Circovirus Type 2 PCV2 Pathogenesis and Interaction with the Immune System Annual Review of Animal Biosciences 1 1 43 64 doi 10 1146 annurev animal 031412 103720 ISSN 2165 8102 PMID 25387012 Merenstein C Liang G Whiteside SA Cobian Guemes AG Merlino MS Taylor LJ Glascock A Bittinger K Tanes C Graham Wooten J Khatib LA Fitzgerald AS Reddy S Baxter AE Giles JR Oldridge DA Meyer NJ Wherry EJ McGinniss JE Bushman FD Collman RG August 2021 Signatures of COVID 19 Severity and Immune Response in the Respiratory Tract Microbiome mBio 12 4 e0177721 doi 10 1128 mBio 01777 21 PMC 8406335 PMID 34399607 External links edit nbsp Data related to Redondoviridae at Wikispecies ICTV Report Redondoviridae Retrieved from https en wikipedia org w index php title Redondoviridae amp oldid 1197177647, wikipedia, wiki, book, books, library,
