Rafael Radi is an Uruguayan biochemist and biomedical scientist that has extensively worked to elucidate molecular mechanisms by which free radicals, oxidants and nitric oxide participate in human pathologies. In particular, he has made relevant contributions to unravel how the signal transducing free radical nitric oxide can evolve into toxic species via the formation of secondary nitric oxide-derived oxidants. His work has characterized reactions of oxidizing species with biological targets, the role of mitochondrial dysfunction is the alterations of cellular redox homeostasis and the impact of these biochemical processes in disease states. He has studied the actions of synthetic compounds in redox-based therapeutics, including in cardiovascular and neurodegenerative diseases. This work has also contributed to understand the redox biology of host cell interactions with intracellular pathogens and the impact in the control of infectious diseases. His seminal paper related to the biochemical actions of peroxynitrite, a potent oxidant and nucleophile formed secondary to the diffusion-controlled reaction of nitric oxide with superoxide radicals together with Joe S. Beckman, Kent Bush and Bruce A. Freeman in 1991 has been selected as a JBC Classics due to its influence in the field.
Bruce. A Freeman and Joe S. Beckman (University of Alabama at Birmingham)
Radi is currently Professor and Chairman at the Departamento de Bioquímica, Facultad de Medicina and Director of Centro de Investigaciones Biomédicas (CEINBIO) at Universidad de la República, Montevideo, Uruguay. He is categorized at the highest level of the National Research System of Uruguay.
Radi started studies at Universidad de la República in 1981 and became an MD (General Medicine) in 1988 and PhD (Biochemistry) in 1991. He performed postdoctoral studies at the University of Alabama at Birmingham. Upon his return to Uruguay, he became tenured in the Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay and evolved through all the academic positions until becoming Professor and Chairman in 2006. In 2004 he founded the Centro de Investigaciones Biomédicas (CEINBIO) at Universidad de la República, being his Director. He has adjunct appointments at the Universidad de Buenos Aires, University of Alabama at Birmingham, University of Pittsburgh and Vanderbilt University. He has extensively visited and lectured at universities and research centers worldwide and has been scientific advisor of several research institutions. He has trained over 30 PhDs and MD. PhDs in Uruguay.
In April 2020, Radi was appointed a member of the GACH, an advisory committee created by President Luis Lacalle Pou to define methods and studies to advise the government regarding the COVID-19 pandemic in Uruguay. He shared the group with Fernando Paganini, the mathematician, electrical engineer, and academic from the Latin American Academy of Sciences; and Dr. Henry Cohen, President of the National Academy of Medicine and awarded as a Master by the World Gastroenterology Organisation in 2019.[1]
Awards and honorsedit
Radi has received numerous awards and recognition for his work. He is the first Uruguayan to be elected as International Member of the US National Academy of Sciences.[2] Also, in 2024 he has been appointed as a member of the The Pontifical Academy of Sciences, this academy "has its roots in the Academy of the Lynxes (Accademia dei Lincei) which was founded in Rome in 1603 as the first exclusively scientific academy in the world". Other relevant awards and honours include, Howard Medical Institute[3] Alumni, Alexander Von Humboldt Senior Award,[4] Discovery Award of the Society for Redox Biology and Medicine,[5] Guggenheim Fellow, Fulbright Fellow,[6] Morosoli Prize of Science and Technology, Leloir Prize for International Scientific Cooperation, Doctor Honoris Causa, Universidad de Buenos Aires,[7] Argentina; Premio México de Ciencia y Tecnología.[8] He is a founding member and current president of the Academia Nacional de Ciencias del Uruguay,[9] member of the Academia Nacional de Medicina del Uruguay, and foreign member of the Argentinian,[10] Brazilian,[11] Latin American and Developing World (TWAS) Academy of Sciences. He is a former president of the Society for Redox Biology and Medicine and former president of the Society for Free Radical Research International.[12] Doctor Honoris Causa de la Universidad Autónoma de Madrid[13]
Referencesedit
^ElPais (18 April 2020). "Lacalle Pou anuncia el equipo que planificará "la nueva normalidad"". Diario EL PAIS Uruguay (in Spanish). Retrieved 2020-04-18.
Wikiquote has quotations related to Rafael Alberto Radi Isola.
January 01, 1970
rafael, radi, uruguayan, biochemist, biomedical, scientist, that, extensively, worked, elucidate, molecular, mechanisms, which, free, radicals, oxidants, nitric, oxide, participate, human, pathologies, particular, made, relevant, contributions, unravel, signal. Rafael Radi is an Uruguayan biochemist and biomedical scientist that has extensively worked to elucidate molecular mechanisms by which free radicals oxidants and nitric oxide participate in human pathologies In particular he has made relevant contributions to unravel how the signal transducing free radical nitric oxide can evolve into toxic species via the formation of secondary nitric oxide derived oxidants His work has characterized reactions of oxidizing species with biological targets the role of mitochondrial dysfunction is the alterations of cellular redox homeostasis and the impact of these biochemical processes in disease states He has studied the actions of synthetic compounds in redox based therapeutics including in cardiovascular and neurodegenerative diseases This work has also contributed to understand the redox biology of host cell interactions with intracellular pathogens and the impact in the control of infectious diseases His seminal paper related to the biochemical actions of peroxynitrite a potent oxidant and nucleophile formed secondary to the diffusion controlled reaction of nitric oxide with superoxide radicals together with Joe S Beckman Kent Bush and Bruce A Freeman in 1991 has been selected as a JBC Classics due to its influence in the field Rafael RadiBorn 1963 05 07 May 7 1963 age 61 Montevideo UruguayCitizenshipUruguay ItalyAlma materUniversidad de la Republica MD 1988 PhD 1991 AwardsForeign Associate of the US National Academy of Sciences Howard Hughes Medical Institute HHMI Alumni Alexander Von Humboldt Senior Award Discovery Award The Society for Redox Biology and Medicine Premio Mexico 2016Scientific careerFieldsbiochemistry biomedical sciencesInstitutionsUniversidad de la Republica Montevideo UruguayDoctoral advisorEugenio ProdanovOther academic advisorsBruce A Freeman and Joe S Beckman University of Alabama at Birmingham Radi is currently Professor and Chairman at the Departamento de Bioquimica Facultad de Medicina and Director of Centro de Investigaciones Biomedicas CEINBIO at Universidad de la Republica Montevideo Uruguay He is categorized at the highest level of the National Research System of Uruguay Contents 1 Academic career 2 Awards and honors 3 References 3 1 Sources 4 External linksAcademic career editRadi started studies at Universidad de la Republica in 1981 and became an MD General Medicine in 1988 and PhD Biochemistry in 1991 He performed postdoctoral studies at the University of Alabama at Birmingham Upon his return to Uruguay he became tenured in the Departamento de Bioquimica Facultad de Medicina Universidad de la Republica Montevideo Uruguay and evolved through all the academic positions until becoming Professor and Chairman in 2006 In 2004 he founded the Centro de Investigaciones Biomedicas CEINBIO at Universidad de la Republica being his Director He has adjunct appointments at the Universidad de Buenos Aires University of Alabama at Birmingham University of Pittsburgh and Vanderbilt University He has extensively visited and lectured at universities and research centers worldwide and has been scientific advisor of several research institutions He has trained over 30 PhDs and MD PhDs in Uruguay In April 2020 Radi was appointed a member of the GACH an advisory committee created by President Luis Lacalle Pou to define methods and studies to advise the government regarding the COVID 19 pandemic in Uruguay He shared the group with Fernando Paganini the mathematician electrical engineer and academic from the Latin American Academy of Sciences and Dr Henry Cohen President of the National Academy of Medicine and awarded as a Master by the World Gastroenterology Organisation in 2019 1 Awards and honors editRadi has received numerous awards and recognition for his work He is the first Uruguayan to be elected as International Member of the US National Academy of Sciences 2 Also in 2024 he has been appointed as a member of the The Pontifical Academy of Sciences this academy has its roots in the Academy of the Lynxes Accademia dei Lincei which was founded in Rome in 1603 as the first exclusively scientific academy in the world Other relevant awards and honours include Howard Medical Institute 3 Alumni Alexander Von Humboldt Senior Award 4 Discovery Award of the Society for Redox Biology and Medicine 5 Guggenheim Fellow Fulbright Fellow 6 Morosoli Prize of Science and Technology Leloir Prize for International Scientific Cooperation Doctor Honoris Causa Universidad de Buenos Aires 7 Argentina Premio Mexico de Ciencia y Tecnologia 8 He is a founding member and current president of the Academia Nacional de Ciencias del Uruguay 9 member of the Academia Nacional de Medicina del Uruguay and foreign member of the Argentinian 10 Brazilian 11 Latin American and Developing World TWAS Academy of Sciences He is a former president of the Society for Redox Biology and Medicine and former president of the Society for Free Radical Research International 12 Doctor Honoris Causa de la Universidad Autonoma de Madrid 13 References edit ElPais 18 April 2020 Lacalle Pou anuncia el equipo que planificara la nueva normalidad Diario EL PAIS Uruguay in Spanish Retrieved 2020 04 18 Member directory NAS HHMI alumni rafael radi Humbold fundation alumni award SFRBM senior awards GF Fulbright fellow Honoris causa UBA PDF Premio MX ANCIU miembro fundador ANCEFN miembro ABC miembro SFRR Executive La UAM inviste como doctor honoris causa al bioquimico uruguayo Rafael Radi www uam es in Spanish Retrieved 2022 10 23 Sources edit http www jbc org content 290 52 30726 extract ANCiU ademia Nacional de Ciencias del Uruguay http ceinbio udelar edu uy index php es http www bioquimica fmed edu uy Integrantes 20English 20G5 html http www hhmi org scientists rafael radi http www sfrr org SFRRIExecutive RafaelRadi php http www sfrbm org sections resources senior awards https www humboldt foundation de web alumni award htmlExternal links edit nbsp Wikiquote has quotations related to Rafael Alberto Radi Isola Retrieved from https en wikipedia org w index php title Rafael Radi amp oldid 1222800397, wikipedia, wiki, book, books, library,
