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Wikipedia

RUNX3

December 15, 2023

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.[5]

RUNX3
Identifiers
AliasesRUNX3, AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3
External IDsOMIM: 600210 MGI: 102672 HomoloGene: 37914 GeneCards: RUNX3
Orthologs
SpeciesHumanMouse
Entrez

864

12399

Ensembl

ENSG00000020633

ENSMUSG00000070691

UniProt

Q13761

Q3U1Q3

RefSeq (mRNA)

NM_001031680
NM_004350
NM_001320672

NM_019732
NM_001369050

RefSeq (protein)

NP_001026850
NP_001307601
NP_004341

NP_062706
NP_001355979

Location (UCSC)Chr 1: 24.9 – 24.97 MbChr 4: 134.85 – 134.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters,[6] and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

In melanocytic cells RUNX3 gene expression may be regulated by MITF.[8]

RUNX3 plays a fundamental role in defense against early tumor formation. In response to growth factors, RUNX3 is acetylated by p300 to complex with bromodomain-containing protein 2 (BRD2; a member of the BET family of transcription co-regulators)[9] and to subsequent transient induction of CDKN1A and ARF.[10] CDKN1A (also known as CIP1 or p21) inhibits the cell cycle, and ARF inhibits MDM2, increasing the stability of the cancer-suppressing gene p53.[10]

The expression of CDKN1A and ARF under wild-type cell cycles is temporary, which results from the RUNX3-BRD2 complex replacing the RUNX3-cyclinD1 complex. However, oncogenic mitogen signals such as KRASG12D cause the RUNX3-BRD2 complex to be maintained continuously, resulting in the continuous expression of p21, ARF, and p53. Therefore, RUNX3 can function as a sensor for unregulated mitogenic signals, and its inactivation can ultimately lead to cancer due to the loss of function as a sensor.[10]

Knockout mouse edit

Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.[11]

The RUNX3 controversy edit

In 2011 serious doubt was cast over the tumor suppressor function of Runx3 originated from the earlier publication by Li and co-workers.[12] On the basis of the original study by Li and co-workers (2002), the majority of later literature citing Li and co-workers (2002) assumed that RUNX3 was expressed in the normal gut epithelium and that it is therefore likely to act as a tumor suppressor in the particular epithelial cancer investigated. Most of this literature used RUNX3 promoter methylation status in various cancers as a proxy for its expression. However, quite many genes are known to be methylated in tumor cell genomes, and the majority of these genes are not expressed in the normal tissue of origin of these cancers. Others used poorly characterized (or fully invalidated) antibodies to detect the RUNX3 protein, or used RT-PCR or validated antibodies and failed to detect RUNX3 in the gut epithelium but still did not question the original finding by Li and co-workers (2002). This facts have recently been discussed in a book by Ülo Maiväli.[13]

Interactions edit

RUNX3 has been shown to interact with TLE1.[14]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000020633 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070691 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y (Sep 1994). "AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization". Genomics. 23 (2): 425–32. doi:10.1006/geno.1994.1519. PMID 7835892.
  6. ^ Levanon D, Eisenstein M, Groner Y (Apr 1998). "Site-directed mutagenesis supports a three-dimensional model of the runt domain". Journal of Molecular Biology. 277 (3): 509–12. doi:10.1006/jmbi.1998.1633. PMID 9533875. S2CID 13139512.
  7. ^ "Entrez Gene: RUNX3 runt-related transcription factor 3".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  9. ^ Lee, You-Soub; Lee, Jung-Won; Jang, Ju-Won; Chi, Xin-Zi; Kim, Jang-Hyun; Li, Ying-Hui; Kim, Min-Kyu; Kim, Da-Mi; Choi, Byeung-Sub; Kim, Eung-Gook; Chung, Jin-Haeng; Lee, Ok-Jun; Lee, You-Mie; Suh, Joo-Won; Chuang, Linda Shyue Huey (2013-11-11). "Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma". Cancer Cell. 24 (5): 603–616. doi:10.1016/j.ccr.2013.10.003. ISSN 1878-3686. PMID 24229708.
  10. ^ a b c Lee, Jung-Won; Kim, Da-Mi; Jang, Ju-Won; Park, Tae-Geun; Song, Soo-Hyun; Lee, You-Soub; Chi, Xin-Zi; Park, Il Yeong; Hyun, Jin-Won; Ito, Yoshiaki; Bae, Suk-Chul (2019-04-23). "RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point". Nature Communications. 10 (1): 1897. doi:10.1038/s41467-019-09810-w. ISSN 2041-1723.
  11. ^ Li QL, Ito K, Sakakura C, Fukamachi H, Inoue Ki, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y (Apr 2002). "Causal relationship between the loss of RUNX3 expression and gastric cancer". Cell. 109 (1): 113–24. doi:10.1016/S0092-8674(02)00690-6. PMID 11955451. S2CID 11362226.
  12. ^ Levanon D, Bernstein Y, Negreanu V, Bone KR, Pozner A, Eilam R, Lotem J, Brenner O, Groner Y (Oct 2011). "Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function". EMBO Mol Med. 3 (10): 593–604. doi:10.1002/emmm.201100168. PMC 3258485. PMID 21786422.
  13. ^ Maiväli, Ülo (2015). Interpreting Biomedical Science. Academic Press. pp. 44–45. ISBN 9780124186897.
  14. ^ Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11590–5. Bibcode:1998PNAS...9511590L. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710.

Further reading edit

  • Vogiatzi P, De Falco G, Claudio PP, Giordano A (Apr 2006). "How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions". Cancer Biology & Therapy. 5 (4): 371–4. doi:10.4161/cbt.5.4.2748. PMID 16627973.
  • Wijmenga C, Speck NA, Dracopoli NC, Hofker MH, Liu P, Collins FS (Apr 1995). "Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter". Genomics. 26 (3): 611–4. doi:10.1016/0888-7543(95)80185-O. PMID 7607690.
  • Bae SC, Takahashi E, Zhang YW, Ogawa E, Shigesada K, Namba Y, Satake M, Ito Y (Jul 1995). "Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain". Gene. 159 (2): 245–8. doi:10.1016/0378-1119(95)00060-J. PMID 7622058.
  • Bae SC, Yamaguchi-Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima H, Shigesada K, Satake M, Ito Y (Mar 1993). "Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1". Oncogene. 8 (3): 809–14. PMID 8437866.
  • Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11590–5. Bibcode:1998PNAS...9511590L. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710.
  • Bangsow C, Rubins N, Glusman G, Bernstein Y, Negreanu V, Goldenberg D, Lotem J, Ben-Asher E, Lancet D, Levanon D, Groner Y (Nov 2001). "The RUNX3 gene--sequence, structure and regulated expression". Gene. 279 (2): 221–32. doi:10.1016/S0378-1119(01)00760-0. PMID 11733147.
  • Waki T, Tamura G, Sato M, Terashima M, Nishizuka S, Motoyama T (Apr 2003). "Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia". Cancer Science. 94 (4): 360–4. doi:10.1111/j.1349-7006.2003.tb01447.x. PMID 12824905. S2CID 22030810.
  • Puig-Kröger A, Sanchez-Elsner T, Ruiz N, Andreu EJ, Prosper F, Jensen UB, Gil J, Erickson P, Drabkin H, Groner Y, Corbi AL (Nov 2003). "RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements". Blood. 102 (9): 3252–61. doi:10.1182/blood-2003-02-0618. hdl:10171/18733. PMID 12855590.
  • Kato N, Tamura G, Fukase M, Shibuya H, Motoyama T (Aug 2003). "Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants". The American Journal of Pathology. 163 (2): 387–91. doi:10.1016/S0002-9440(10)63668-1. PMC 1868235. PMID 12875960.
  • Yang N, Zhang L, Zhang Y, Kazazian HH (Aug 2003). "An important role for RUNX3 in human L1 transcription and retrotransposition". Nucleic Acids Research. 31 (16): 4929–40. doi:10.1093/nar/gkg663. PMC 169909. PMID 12907736.
  • Li QL, Kim HR, Kim WJ, Choi JK, Lee YH, Kim HM, Li LS, Kim H, Chang J, Ito Y, Youl Lee K, Bae SC (Jan 2004). "Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer". Biochemical and Biophysical Research Communications. 314 (1): 223–8. doi:10.1016/j.bbrc.2003.12.079. PMID 14715269.
  • Xiao WH, Liu WW (Feb 2004). "Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma". World Journal of Gastroenterology. 10 (3): 376–80. doi:10.3748/wjg.v10.i3.376. PMC 4724901. PMID 14760761.
  • Oshimo Y, Oue N, Mitani Y, Nakayama H, Kitadai Y, Yoshida K, Ito Y, Chayama K, Yasui W (2004). "Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma". Pathobiology. 71 (3): 137–43. doi:10.1159/000076468. PMID 15051926. S2CID 25618007.
  • Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC (Jul 2004). "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation". The Journal of Biological Chemistry. 279 (28): 29409–17. doi:10.1074/jbc.M313120200. PMID 15138260.
  • Ku JL, Kang SB, Shin YK, Kang HC, Hong SH, Kim IJ, Shin JH, Han IO, Park JG (Sep 2004). "Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines". Oncogene. 23 (40): 6736–42. doi:10.1038/sj.onc.1207731. PMID 15273736. S2CID 28548483.
  • Sakakura C, Hagiwara A, Miyagawa K, Nakashima S, Yoshikawa T, Kin S, Nakase Y, Ito K, Yamagishi H, Yazumi S, Chiba T, Ito Y (Jan 2005). "Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer". International Journal of Cancer. 113 (2): 221–8. doi:10.1002/ijc.20551. PMID 15386419. S2CID 34944735.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

December 15, 2023
runx3, runt, related, transcription, factor, protein, that, humans, encoded, gene, identifiersaliases, aml2, cbfa3, pebp2ac, runt, related, transcription, factor, runx, family, transcription, factor, 3external, idsomim, 600210, 102672, homologene, 37914, genec. Runt related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene 5 RUNX3IdentifiersAliasesRUNX3 AML2 CBFA3 PEBP2aC runt related transcription factor 3 RUNX family transcription factor 3External IDsOMIM 600210 MGI 102672 HomoloGene 37914 GeneCards RUNX3Gene location Human Chr Chromosome 1 human 1 Band1p36 11Start24 899 511 bp 1 End24 965 121 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 D3 4 67 19 cMStart134 847 963 bp 2 End134 905 301 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlymph nodebloodappendixtibiaspleenmonocytebone marrow cellsnipplepylorusparotid glandTop expressed inmembranous bonehuman mandiblespleenclaviclebloodtongueurethramaxillafemale urethramale urethraMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding RNA polymerase II transcription regulatory region sequence specific DNA binding DNA binding transcription factor activity protein binding ATP binding DNA binding transcription factor activity RNA polymerase II specificCellular componentcytoplasm nucleus nucleolus intracellular membrane bounded organelle nucleoplasm cytosol core binding factor complexBiological processperipheral nervous system neuron development regulation of transcription DNA templated chondrocyte differentiation ossification regulation of transcription by RNA polymerase II negative regulation of cell cycle negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription DNA templated positive regulation of transcription DNA templated protein phosphorylation negative regulation of epithelial cell proliferation regulation of cell differentiation response to transforming growth factor beta hemopoiesis negative regulation of CD4 positive alpha beta T cell differentiation positive regulation of CD8 positive alpha beta T cell differentiation neuron differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez86412399EnsemblENSG00000020633ENSMUSG00000070691UniProtQ13761Q3U1Q3RefSeq mRNA NM 001031680NM 004350NM 001320672NM 019732NM 001369050RefSeq protein NP 001026850NP 001307601NP 004341NP 062706NP 001355979Location UCSC Chr 1 24 9 24 97 MbChr 4 134 85 134 91 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Knockout mouse 3 The RUNX3 controversy 4 Interactions 5 See also 6 References 7 Further reading 8 External linksFunction editThis gene encodes a member of the runt domain containing family of transcription factors A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5 YGYGGT 3 found in a number of enhancers and promoters 6 and can either activate or suppress transcription It also interacts with other transcription factors It functions as a tumor suppressor and the gene is frequently deleted or transcriptionally silenced in cancer Multiple transcript variants encoding different isoforms have been found for this gene 7 In melanocytic cells RUNX3 gene expression may be regulated by MITF 8 RUNX3 plays a fundamental role in defense against early tumor formation In response to growth factors RUNX3 is acetylated by p300 to complex with bromodomain containing protein 2 BRD2 a member of the BET family of transcription co regulators 9 and to subsequent transient induction of CDKN1A and ARF 10 CDKN1A also known as CIP1 or p21 inhibits the cell cycle and ARF inhibits MDM2 increasing the stability of the cancer suppressing gene p53 10 The expression of CDKN1A and ARF under wild type cell cycles is temporary which results from the RUNX3 BRD2 complex replacing the RUNX3 cyclinD1 complex However oncogenic mitogen signals such as KRASG12D cause the RUNX3 BRD2 complex to be maintained continuously resulting in the continuous expression of p21 ARF and p53 Therefore RUNX3 can function as a sensor for unregulated mitogenic signals and its inactivation can ultimately lead to cancer due to the loss of function as a sensor 10 Knockout mouse editRunx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells and the cells are resistant to TGF beta stimulation 11 The RUNX3 controversy editIn 2011 serious doubt was cast over the tumor suppressor function of Runx3 originated from the earlier publication by Li and co workers 12 On the basis of the original study by Li and co workers 2002 the majority of later literature citing Li and co workers 2002 assumed that RUNX3 was expressed in the normal gut epithelium and that it is therefore likely to act as a tumor suppressor in the particular epithelial cancer investigated Most of this literature used RUNX3 promoter methylation status in various cancers as a proxy for its expression However quite many genes are known to be methylated in tumor cell genomes and the majority of these genes are not expressed in the normal tissue of origin of these cancers Others used poorly characterized or fully invalidated antibodies to detect the RUNX3 protein or used RT PCR or validated antibodies and failed to detect RUNX3 in the gut epithelium but still did not question the original finding by Li and co workers 2002 This facts have recently been discussed in a book by Ulo Maivali 13 Interactions editRUNX3 has been shown to interact with TLE1 14 See also editCore binding factor RUNX1 RUNX2References edit a b c GRCh38 Ensembl release 89 ENSG00000020633 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000070691 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Levanon D Negreanu V Bernstein Y Bar Am I Avivi L Groner Y Sep 1994 AML1 AML2 and AML3 the human members of the runt domain gene family cDNA structure expression and chromosomal localization Genomics 23 2 425 32 doi 10 1006 geno 1994 1519 PMID 7835892 Levanon D Eisenstein M Groner Y Apr 1998 Site directed mutagenesis supports a three dimensional model of the runt domain Journal of Molecular Biology 277 3 509 12 doi 10 1006 jmbi 1998 1633 PMID 9533875 S2CID 13139512 Entrez Gene RUNX3 runt related transcription factor 3 Hoek KS Schlegel NC Eichhoff OM Widmer DS Praetorius C Einarsson SO Valgeirsdottir S Bergsteinsdottir K Schepsky A Dummer R Steingrimsson E Dec 2008 Novel MITF targets identified using a two step DNA microarray strategy Pigment Cell amp Melanoma Research 21 6 665 76 doi 10 1111 j 1755 148X 2008 00505 x PMID 19067971 Lee You Soub Lee Jung Won Jang Ju Won Chi Xin Zi Kim Jang Hyun Li Ying Hui Kim Min Kyu Kim Da Mi Choi Byeung Sub Kim Eung Gook Chung Jin Haeng Lee Ok Jun Lee You Mie Suh Joo Won Chuang Linda Shyue Huey 2013 11 11 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma Cancer Cell 24 5 603 616 doi 10 1016 j ccr 2013 10 003 ISSN 1878 3686 PMID 24229708 a b c Lee Jung Won Kim Da Mi Jang Ju Won Park Tae Geun Song Soo Hyun Lee You Soub Chi Xin Zi Park Il Yeong Hyun Jin Won Ito Yoshiaki Bae Suk Chul 2019 04 23 RUNX3 regulates cell cycle dependent chromatin dynamics by functioning as a pioneer factor of the restriction point Nature Communications 10 1 1897 doi 10 1038 s41467 019 09810 w ISSN 2041 1723 Li QL Ito K Sakakura C Fukamachi H Inoue Ki Chi XZ Lee KY Nomura S Lee CW Han SB Kim HM Kim WJ Yamamoto H Yamashita N Yano T Ikeda T Itohara S Inazawa J Abe T Hagiwara A Yamagishi H Ooe A Kaneda A Sugimura T Ushijima T Bae SC Ito Y Apr 2002 Causal relationship between the loss of RUNX3 expression and gastric cancer Cell 109 1 113 24 doi 10 1016 S0092 8674 02 00690 6 PMID 11955451 S2CID 11362226 Levanon D Bernstein Y Negreanu V Bone KR Pozner A Eilam R Lotem J Brenner O Groner Y Oct 2011 Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function EMBO Mol Med 3 10 593 604 doi 10 1002 emmm 201100168 PMC 3258485 PMID 21786422 Maivali Ulo 2015 Interpreting Biomedical Science Academic Press pp 44 45 ISBN 9780124186897 Levanon D Goldstein RE Bernstein Y Tang H Goldenberg D Stifani S Paroush Z Groner Y Sep 1998 Transcriptional repression by AML1 and LEF 1 is mediated by the TLE Groucho corepressors Proceedings of the National Academy of Sciences of the United States of America 95 20 11590 5 Bibcode 1998PNAS 9511590L doi 10 1073 pnas 95 20 11590 PMC 21685 PMID 9751710 Further reading editVogiatzi P De Falco G Claudio PP Giordano A Apr 2006 How does the human RUNX3 gene induce apoptosis in gastric cancer Latest data reflections and reactions Cancer Biology amp Therapy 5 4 371 4 doi 10 4161 cbt 5 4 2748 PMID 16627973 Wijmenga C Speck NA Dracopoli NC Hofker MH Liu P Collins FS Apr 1995 Identification of a new murine runt domain containing gene Cbfa3 and localization of the human homolog CBFA3 to chromosome 1p35 pter Genomics 26 3 611 4 doi 10 1016 0888 7543 95 80185 O PMID 7607690 Bae SC Takahashi E Zhang YW Ogawa E Shigesada K Namba Y Satake M Ito Y Jul 1995 Cloning mapping and expression of PEBP2 alpha C a third gene encoding the mammalian Runt domain Gene 159 2 245 8 doi 10 1016 0378 1119 95 00060 J PMID 7622058 Bae SC Yamaguchi Iwai Y Ogawa E Maruyama M Inuzuka M Kagoshima H Shigesada K Satake M Ito Y Mar 1993 Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene AML1 Oncogene 8 3 809 14 PMID 8437866 Levanon D Goldstein RE Bernstein Y Tang H Goldenberg D Stifani S Paroush Z Groner Y Sep 1998 Transcriptional repression by AML1 and LEF 1 is mediated by the TLE Groucho corepressors Proceedings of the National Academy of Sciences of the United States of America 95 20 11590 5 Bibcode 1998PNAS 9511590L doi 10 1073 pnas 95 20 11590 PMC 21685 PMID 9751710 Bangsow C Rubins N Glusman G Bernstein Y Negreanu V Goldenberg D Lotem J Ben Asher E Lancet D Levanon D Groner Y Nov 2001 The RUNX3 gene sequence structure and regulated expression Gene 279 2 221 32 doi 10 1016 S0378 1119 01 00760 0 PMID 11733147 Waki T Tamura G Sato M Terashima M Nishizuka S Motoyama T Apr 2003 Promoter methylation status of DAP kinase and RUNX3 genes in neoplastic and non neoplastic gastric epithelia Cancer Science 94 4 360 4 doi 10 1111 j 1349 7006 2003 tb01447 x PMID 12824905 S2CID 22030810 Puig Kroger A Sanchez Elsner T Ruiz N Andreu EJ Prosper F Jensen UB Gil J Erickson P Drabkin H Groner Y Corbi AL Nov 2003 RUNX AML and C EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements Blood 102 9 3252 61 doi 10 1182 blood 2003 02 0618 hdl 10171 18733 PMID 12855590 Kato N Tamura G Fukase M Shibuya H Motoyama T Aug 2003 Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants The American Journal of Pathology 163 2 387 91 doi 10 1016 S0002 9440 10 63668 1 PMC 1868235 PMID 12875960 Yang N Zhang L Zhang Y Kazazian HH Aug 2003 An important role for RUNX3 in human L1 transcription and retrotransposition Nucleic Acids Research 31 16 4929 40 doi 10 1093 nar gkg663 PMC 169909 PMID 12907736 Li QL Kim HR Kim WJ Choi JK Lee YH Kim HM Li LS Kim H Chang J Ito Y Youl Lee K Bae SC Jan 2004 Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer Biochemical and Biophysical Research Communications 314 1 223 8 doi 10 1016 j bbrc 2003 12 079 PMID 14715269 Xiao WH Liu WW Feb 2004 Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma World Journal of Gastroenterology 10 3 376 80 doi 10 3748 wjg v10 i3 376 PMC 4724901 PMID 14760761 Oshimo Y Oue N Mitani Y Nakayama H Kitadai Y Yoshida K Ito Y Chayama K Yasui W 2004 Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma Pathobiology 71 3 137 43 doi 10 1159 000076468 PMID 15051926 S2CID 25618007 Jin YH Jeon EJ Li QL Lee YH Choi JK Kim WJ Lee KY Bae SC Jul 2004 Transforming growth factor beta stimulates p300 dependent RUNX3 acetylation which inhibits ubiquitination mediated degradation The Journal of Biological Chemistry 279 28 29409 17 doi 10 1074 jbc M313120200 PMID 15138260 Ku JL Kang SB Shin YK Kang HC Hong SH Kim IJ Shin JH Han IO Park JG Sep 2004 Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines Oncogene 23 40 6736 42 doi 10 1038 sj onc 1207731 PMID 15273736 S2CID 28548483 Sakakura C Hagiwara A Miyagawa K Nakashima S Yoshikawa T Kin S Nakase Y Ito K Yamagishi H Yazumi S Chiba T Ito Y Jan 2005 Frequent downregulation of the runt domain transcription factors RUNX1 RUNX3 and their cofactor CBFB in gastric cancer International Journal of Cancer 113 2 221 8 doi 10 1002 ijc 20551 PMID 15386419 S2CID 34944735 External links editRUNX3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title RUNX3 amp oldid 1187162477, wikipedia, wiki, book, books, library,

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