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Wikipedia

RUNX1T1

May 06, 2024

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.[5][6][7]

RUNX1T1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, AML1-MTG8, t(8;21)(q22;q22), RUNX1 translocation partner 1, RUNX1 partner transcriptional co-repressor 1
External IDsOMIM: 133435 MGI: 104793 HomoloGene: 3801 GeneCards: RUNX1T1
Orthologs
SpeciesHumanMouse
Entrez

862

12395

Ensembl

ENSG00000079102

ENSMUSG00000006586

UniProt

Q06455

Q61909

RefSeq (mRNA)

NM_001111026
NM_001111027
NM_009822

RefSeq (protein)

NP_001104496
NP_001104497
NP_033952

Location (UCSC)Chr 8: 91.95 – 92.1 MbChr 4: 13.74 – 13.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.[7]

Interactions edit

RUNX1T1 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079102 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006586 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (October 1992). "Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt". Blood. 80 (7): 1825–31. doi:10.1182/blood.V80.7.1825.1825. PMID 1391946.
  6. ^ Calabi F, Cilli V (Dec 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics. 52 (3): 332–341. doi:10.1006/geno.1998.5429. PMID 9790752.
  7. ^ a b "Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)".
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  9. ^ a b Lindberg SR, Olsson A, Persson AM, Olsson I (Dec 2003). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694. S2CID 23106882.
  10. ^ a b Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (September 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. PMID 12242670.
  11. ^ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (Dec 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. PMID 12460926.
  12. ^ McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834. S2CID 25450754.
  13. ^ Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (October 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83. doi:10.1128/mcb.21.19.6470-6483.2001. PMC 99794. PMID 11533236.
  14. ^ a b Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA (January 2001). "Oligomerization of ETO is obligatory for corepressor interaction". Mol. Cell. Biol. 21 (1): 156–63. doi:10.1128/MCB.21.1.156-163.2001. PMC 88789. PMID 11113190.
  15. ^ Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD (June 2004). "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood. 103 (12): 4650–8. doi:10.1182/blood-2003-08-2759. PMID 14982881.
  16. ^ Fukuyama T, Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T (September 2001). "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes". Oncogene. 20 (43): 6225–32. doi:10.1038/sj.onc.1204794. PMID 11593431.
  17. ^ Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (March 2000). "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. doi:10.1128/mcb.20.6.2075-2086.2000. PMC 110824. PMID 10688654.
  18. ^ Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (Dec 2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47. doi:10.1182/blood.V96.12.3939. PMID 11090081.

Further reading edit

  • Ferrara F, Del Vecchio L (2002). "Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity". Haematologica. 87 (3): 306–19. PMID 11869944.
  • Nisson PE, Watkins PC, Sacchi N (1992). "Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells". Cancer Genet. Cytogenet. 63 (2): 81–88. doi:10.1016/0165-4608(92)90384-K. PMID 1423235.
  • Era T, Asou N, Kunisada T, Yamasaki H, Asou H, Kamada N, Nishikawa S, Yamaguchi K, Takatsuki K (1995). "Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells". Genes Chromosomes Cancer. 13 (1): 25–33. doi:10.1002/gcc.2870130105. PMID 7541640. S2CID 41918020.
  • Tighe JE, Calabi F (1994). "Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2". Blood. 84 (7): 2115–21. doi:10.1182/blood.V84.7.2115.2115. PMID 7919324.
  • Erickson PF, Robinson M, Owens G, Drabkin HA (1994). "The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor". Cancer Res. 54 (7): 1782–6. PMID 8137293.
  • Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (1993). "The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript". EMBO J. 12 (7): 2715–21. doi:10.1002/j.1460-2075.1993.tb05933.x. PMC 413521. PMID 8334990.
  • Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M (1993). "Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction". Blood. 82 (4): 1270–6. doi:10.1182/blood.V82.4.1270.1270. PMID 8353289.
  • Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M (1996). "Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia". Genomics. 29 (3): 755–759. doi:10.1006/geno.1995.9941. PMID 8575770.
  • Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA (1996). "ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease". Blood. 88 (5): 1813–23. doi:10.1182/blood.V88.5.1813.1813. PMID 8781439.
  • Wolford JK, Bogardus C, Prochazka M (1998). "Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males". Biochem. Biophys. Res. Commun. 246 (3): 624–626. doi:10.1006/bbrc.1998.8683. PMID 9618262.
  • Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT (1998). "Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells". Oncogene. 16 (20): 2609–2615. doi:10.1038/sj.onc.1201824. PMID 9632137.
  • Wolford JK, Prochazka M (1998). "Structure and expression of the human MTG8/ETO gene". Gene. 212 (1): 103–109. doi:10.1016/S0378-1119(98)00141-3. PMID 9661669.
  • Komori A, Sueoka E, Fujiki H, Ishii M, Kozu T (1999). "Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines". Jpn. J. Cancer Res. 90 (1): 60–8. doi:10.1111/j.1349-7006.1999.tb00666.x. PMC 5925983. PMID 10076566.
  • Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–295. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.
  • Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (2000). "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–2086. doi:10.1128/MCB.20.6.2075-2086.2000. PMC 110824. PMID 10688654.
  • Miyamoto T, Weissman IL, Akashi K (2000). "AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7521–7526. Bibcode:2000PNAS...97.7521M. doi:10.1073/pnas.97.13.7521. PMC 16578. PMID 10861016.
  • Odaka Y, Mally A, Elliott LT, Meyers S (2000). "Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)". Oncogene. 19 (32): 3584–3597. doi:10.1038/sj.onc.1203689. PMID 10951564.
  • Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA (2000). "Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription". J. Cell Biol. 150 (5): 939–948. doi:10.1083/jcb.150.5.939. PMC 2175251. PMID 10973986.

May 06, 2024
runx1t1, protein, cbfa2t1, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1wq6, 2dj8, 2h7b, 2kyg, 2od1, 2odd, 2pp4, 4jolidentifiersaliases, aml1t1, cbfa2t1, mtg8, zmynd2, aml1, mtg8, runx1, translocation, p. Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene 5 6 7 RUNX1T1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1WQ6 2DJ8 2H7B 2KYG 2OD1 2ODD 2PP4 4JOLIdentifiersAliasesRUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2 AML1 MTG8 t 8 21 q22 q22 RUNX1 translocation partner 1 RUNX1 partner transcriptional co repressor 1External IDsOMIM 133435 MGI 104793 HomoloGene 3801 GeneCards RUNX1T1Gene location Human Chr Chromosome 8 human 1 Band8q21 3Start91 954 967 bp 1 End92 103 286 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 A1 4 5 88 cMStart13 743 436 bp 2 End13 893 649 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytesural nerveBrodmann area 23Achilles tendonmiddle temporal gyrusparietal pleuranippleendothelial cellcerebellar vermislactiferous ductTop expressed insecondary oocyteinternal carotid arteryexternal carotid arteryolfactory tubercleascending aortamammillary bodylateral hypothalamustrigeminal ganglionsubiculuminferior colliculusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity DNA binding protein binding transcription corepressor activity metal ion bindingCellular componentnuclear matrix nucleus nucleoplasmBiological processnegative regulation of fat cell differentiation negative regulation of transcription DNA templated regulation of transcription DNA templated generation of precursor metabolites and energy transcription DNA templatedSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez86212395EnsemblENSG00000079102ENSMUSG00000006586UniProtQ06455Q61909RefSeq mRNA NM 001198625NM 001198626NM 001198627NM 001198628NM 001198629NM 001198630NM 001198631NM 001198632NM 001198633NM 001198634NM 001198679NM 004349NM 175634NM 175635NM 175636NM 001395209NM 001111026NM 001111027NM 009822RefSeq protein NP 001185554NP 001185555NP 001185556NP 001185557NP 001185558NP 001185559NP 001185560NP 001185561NP 001185562NP 001185563NP 001185608NP 004340NP 783552NP 783553NP 783554NP 783553 1NP 783554 1NP 001104496NP 001104497NP 033952Location UCSC Chr 8 91 95 92 1 MbChr 4 13 74 13 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThe protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein In acute myeloid leukemia especially in the M2 subtype the t 8 21 q22 q22 translocation is one of the most frequent karyotypic abnormalities The translocation produces a chimeric gene made up of the 5 region of the RUNX1 gene fused to the 3 region of this gene The chimeric protein is thought to associate with the nuclear corepressor histone deacetylase complex to block hematopoietic differentiation Several transcript variants encoding multiple isoforms have been found for this gene 7 Interactions editRUNX1T1 has been shown to interact with CBFA2T2 8 9 10 CBFA2T3 9 10 Calcitriol receptor 11 GFI1 12 Nuclear receptor co repressor 1 13 14 Nuclear receptor co repressor 2 14 15 PRKAR2A 16 and Zinc finger and BTB domain containing protein 16 17 18 References edit a b c GRCh38 Ensembl release 89 ENSG00000079102 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000006586 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Erickson P Gao J Chang KS Look T Whisenant E Raimondi S Lasher R Trujillo J Rowley J Drabkin H October 1992 Identification of breakpoints in t 8 21 acute myelogenous leukemia and isolation of a fusion transcript AML1 ETO with similarity to Drosophila segmentation gene runt Blood 80 7 1825 31 doi 10 1182 blood V80 7 1825 1825 PMID 1391946 Calabi F Cilli V Dec 1998 CBFA2T1 a gene rearranged in human leukemia is a member of a multigene family Genomics 52 3 332 341 doi 10 1006 geno 1998 5429 PMID 9790752 a b Entrez Gene RUNX1T1 runt related transcription factor 1 translocated to 1 cyclin D related Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 a b Lindberg SR Olsson A Persson AM Olsson I Dec 2003 Interactions between the leukaemia associated ETO homologues of nuclear repressor proteins Eur J Haematol 71 6 439 47 doi 10 1046 j 0902 4441 2003 00166 x PMID 14703694 S2CID 23106882 a b Hoogeveen AT Rossetti S Stoyanova V Schonkeren J Fenaroli A Schiaffonati L van Unen L Sacchi N September 2002 The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t 16 21 positive myeloid malignancies Oncogene 21 43 6703 12 doi 10 1038 sj onc 1205882 PMID 12242670 Puccetti E Obradovic D Beissert T Bianchini A Washburn B Chiaradonna F Boehrer S Hoelzer D Ottmann OG Pelicci PG Nervi C Ruthardt M Dec 2002 AML associated translocation products block vitamin D 3 induced differentiation by sequestering the vitamin D 3 receptor Cancer Res 62 23 7050 8 PMID 12460926 McGhee L Bryan J Elliott L Grimes HL Kazanjian A Davis JN Meyers S August 2003 Gfi 1 attaches to the nuclear matrix associates with ETO MTG8 and histone deacetylase proteins and represses transcription using a TSA sensitive mechanism J Cell Biochem 89 5 1005 18 doi 10 1002 jcb 10548 PMID 12874834 S2CID 25450754 Amann JM Nip J Strom DK Lutterbach B Harada H Lenny N Downing JR Meyers S Hiebert SW October 2001 ETO a target of t 8 21 in acute leukemia makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain Mol Cell Biol 21 19 6470 83 doi 10 1128 mcb 21 19 6470 6483 2001 PMC 99794 PMID 11533236 a b Zhang J Hug BA Huang EY Chen CW Gelmetti V Maccarana M Minucci S Pelicci PG Lazar MA January 2001 Oligomerization of ETO is obligatory for corepressor interaction Mol Cell Biol 21 1 156 63 doi 10 1128 MCB 21 1 156 163 2001 PMC 88789 PMID 11113190 Takahashi S McConnell MJ Harigae H Kaku M Sasaki T Melnick AM Licht JD June 2004 The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT Blood 103 12 4650 8 doi 10 1182 blood 2003 08 2759 PMID 14982881 Fukuyama T Sueoka E Sugio Y Otsuka T Niho Y Akagi K Kozu T September 2001 MTG8 proto oncoprotein interacts with the regulatory subunit of type II cyclic AMP dependent protein kinase in lymphocytes Oncogene 20 43 6225 32 doi 10 1038 sj onc 1204794 PMID 11593431 Melnick AM Westendorf JJ Polinger A Carlile GW Arai S Ball HJ Lutterbach B Hiebert SW Licht JD March 2000 The ETO protein disrupted in t 8 21 associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein Mol Cell Biol 20 6 2075 86 doi 10 1128 mcb 20 6 2075 2086 2000 PMC 110824 PMID 10688654 Melnick A Carlile GW McConnell MJ Polinger A Hiebert SW Licht JD Dec 2000 AML 1 ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein Blood 96 12 3939 47 doi 10 1182 blood V96 12 3939 PMID 11090081 Further reading editFerrara F Del Vecchio L 2002 Acute myeloid leukemia with t 8 21 AML1 ETO a distinct biological and clinical entity Haematologica 87 3 306 19 PMID 11869944 Nisson PE Watkins PC Sacchi N 1992 Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t 8 21 leukemic cells Cancer Genet Cytogenet 63 2 81 88 doi 10 1016 0165 4608 92 90384 K PMID 1423235 Era T Asou N Kunisada T Yamasaki H Asou H Kamada N Nishikawa S Yamaguchi K Takatsuki K 1995 Identification of two transcripts of AML1 ETO fused gene in t 8 21 leukemic cells and expression of wild type ETO gene in hematopoietic cells Genes Chromosomes Cancer 13 1 25 33 doi 10 1002 gcc 2870130105 PMID 7541640 S2CID 41918020 Tighe JE Calabi F 1994 Alternative out of frame runt MTG8 transcripts are encoded by the derivative 8 chromosome in the t 8 21 of acute myeloid leukemia M2 Blood 84 7 2115 21 doi 10 1182 blood V84 7 2115 2115 PMID 7919324 Erickson PF Robinson M Owens G Drabkin HA 1994 The ETO portion of acute myeloid leukemia t 8 21 fusion transcript encodes a highly evolutionarily conserved putative transcription factor Cancer Res 54 7 1782 6 PMID 8137293 Miyoshi H Kozu T Shimizu K Enomoto K Maseki N Kaneko Y Kamada N Ohki M 1993 The t 8 21 translocation in acute myeloid leukemia results in production of an AML1 MTG8 fusion transcript EMBO J 12 7 2715 21 doi 10 1002 j 1460 2075 1993 tb05933 x PMC 413521 PMID 8334990 Kozu T Miyoshi H Shimizu K Maseki N Kaneko Y Asou H Kamada N Ohki M 1993 Junctions of the AML1 MTG8 ETO fusion are constant in t 8 21 acute myeloid leukemia detected by reverse transcription polymerase chain reaction Blood 82 4 1270 6 doi 10 1182 blood V82 4 1270 1270 PMID 8353289 Niwa Kawakita M Miyoshi H Gotoh O Matsushima Y Nishimura M Shisa H Ohki M 1996 Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia Genomics 29 3 755 759 doi 10 1006 geno 1995 9941 PMID 8575770 Erickson PF Dessev G Lasher RS Philips G Robinson M Drabkin HA 1996 ETO and AML1 phosphoproteins are expressed in CD34 hematopoietic progenitors implications for t 8 21 leukemogenesis and monitoring residual disease Blood 88 5 1813 23 doi 10 1182 blood V88 5 1813 1813 PMID 8781439 Wolford JK Bogardus C Prochazka M 1998 Polymorphism in the 3 untranslated region of MTG8 is associated with obesity in Pima Indian males Biochem Biophys Res Commun 246 3 624 626 doi 10 1006 bbrc 1998 8683 PMID 9618262 Sacchi N Tamanini F Willemsen R Denis Donini S Campiglio S Hoogeveen AT 1998 Subcellular localization of the oncoprotein MTG8 CDR ETO in neural cells Oncogene 16 20 2609 2615 doi 10 1038 sj onc 1201824 PMID 9632137 Wolford JK Prochazka M 1998 Structure and expression of the human MTG8 ETO gene Gene 212 1 103 109 doi 10 1016 S0378 1119 98 00141 3 PMID 9661669 Komori A Sueoka E Fujiki H Ishii M Kozu T 1999 Association of MTG8 ETO CDR a leukemia related protein with serine threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines Jpn J Cancer Res 90 1 60 8 doi 10 1111 j 1349 7006 1999 tb00666 x PMC 5925983 PMID 10076566 Morohoshi F Mitani S Mitsuhashi N Kitabayashi I Takahashi E Suzuki M Munakata N Ohki M 2000 Structure and expression pattern of a human MTG8 ETO family gene MTGR1 Gene 241 2 287 295 doi 10 1016 S0378 1119 99 00481 3 PMID 10675041 Melnick AM Westendorf JJ Polinger A Carlile GW Arai S Ball HJ Lutterbach B Hiebert SW Licht JD 2000 The ETO protein disrupted in t 8 21 associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein Mol Cell Biol 20 6 2075 2086 doi 10 1128 MCB 20 6 2075 2086 2000 PMC 110824 PMID 10688654 Miyamoto T Weissman IL Akashi K 2000 AML1 ETO expressing nonleukemic stem cells in acute myelogenous leukemia with 8 21 chromosomal translocation Proc Natl Acad Sci U S A 97 13 7521 7526 Bibcode 2000PNAS 97 7521M doi 10 1073 pnas 97 13 7521 PMC 16578 PMID 10861016 Odaka Y Mally A Elliott LT Meyers S 2000 Nuclear import and subnuclear localization of the proto oncoprotein ETO MTG8 Oncogene 19 32 3584 3597 doi 10 1038 sj onc 1203689 PMID 10951564 Wood JD Nucifora FC Duan K Zhang C Wang J Kim Y Schilling G Sacchi N Liu JM Ross CA 2000 Atrophin 1 the dentato rubral and pallido luysian atrophy gene product interacts with ETO MTG8 in the nuclear matrix and represses transcription J Cell Biol 150 5 939 948 doi 10 1083 jcb 150 5 939 PMC 2175251 PMID 10973986 Retrieved from https en wikipedia org w index php title RUNX1T1 amp oldid 1163314497, wikipedia, wiki, book, books, library,

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