Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000174444 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032399 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^Bagni C, Mariottini P, Annesi F, Amaldi F (Feb 1994). "Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein". Biochim Biophys Acta. 1216 (3): 475–8. doi:10.1016/0167-4781(93)90017-8. PMID 8268230.
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Chan YL, Olvera J, Wool IG (1995). "The primary structures of rat ribosomal proteins L4 and L41". Biochem. Biophys. Res. Commun. 214 (3): 810–8. doi:10.1006/bbrc.1995.2359. PMID 7575549.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Twiss JL, Smith DS, Chang B, Shooter EM (2000). "Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration". Neurobiol. Dis. 7 (4): 416–28. doi:10.1006/nbdi.2000.0293. PMID 10964612. S2CID 5734400.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC125346. PMID 11823430.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC155282. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.
ribosomal, protein, protein, that, humans, encoded, rpl4, gene, rpl4available, structurespdbortholog, search, pdbe, rcsblist, codes4ug0, 4v6x, 5aj0, 4ujd, 5a8l, 4d67, 4d5y, 4uje, 4ujcidentifiersaliasesrpl4, ribosomal, protein, l4external, idsomim, 180479, 1915. 60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene 5 6 7 RPL4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UG0 4V6X 5AJ0 4UJD 5A8L 4D67 4D5Y 4UJE 4UJCIdentifiersAliasesRPL4 L4 Ribosomal protein L4External IDsOMIM 180479 MGI 1915141 HomoloGene 748 GeneCards RPL4Gene location Human Chr Chromosome 15 human 1 Band15q22 31Start66 498 015 bp 1 End66 524 532 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 CStart64 080 657 bp 2 End64 085 948 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inembryoganglionic eminencevulvasmooth muscle tissuesuperficial temporal arterycaput epididymisstromal cell of endometriumurinary bladderislet of Langerhanscorpus epididymisTop expressed inovaryganglionic eminenceuterusurinary bladdermorulazone of skinthymusmirroradrenal glandislet of LangerhansMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding structural constituent of ribosome RNA bindingCellular componentcytoplasm cytosol ribosome membrane focal adhesion nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus rough endoplasmic reticulum ribonucleoprotein complexBiological processprotein biosynthesis viral transcription SRP dependent cotranslational protein targeting to membrane translational initiation nuclear transcribed mRNA catabolic process nonsense mediated decay rRNA processing cytoplasmic translationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez612467891EnsemblENSG00000174444ENSMUSG00000032399UniProtP36578Q9D8E6RefSeq mRNA NM 000968NM 024212RefSeq protein NP 000959NP 077174Location UCSC Chr 15 66 5 66 52 MbChr 9 64 08 64 09 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseRibosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 60S subunit The protein belongs to the L4E family of ribosomal proteins It is located in the cytoplasm As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome 7 References Edit a b c GRCh38 Ensembl release 89 ENSG00000174444 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032399 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kenmochi N Kawaguchi T Rozen S Davis E Goodman N Hudson TJ Tanaka T Page DC Aug 1998 A map of 75 human ribosomal protein genes Genome Res 8 5 509 23 doi 10 1101 gr 8 5 509 PMID 9582194 Bagni C Mariottini P Annesi F Amaldi F Feb 1994 Human ribosomal protein L4 cloning and sequencing of the cDNA and primary structure of the protein Biochim Biophys Acta 1216 3 475 8 doi 10 1016 0167 4781 93 90017 8 PMID 8268230 a b Entrez Gene RPL4 ribosomal protein L4 Further reading EditWool IG Chan YL Gluck A 1996 Structure and evolution of mammalian ribosomal proteins Biochem Cell Biol 73 11 12 933 47 doi 10 1139 o95 101 PMID 8722009 Chan YL Olvera J Wool IG 1995 The primary structures of rat ribosomal proteins L4 and L41 Biochem Biophys Res Commun 214 3 810 8 doi 10 1006 bbrc 1995 2359 PMID 7575549 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Twiss JL Smith DS Chang B Shooter EM 2000 Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration Neurobiol Dis 7 4 416 28 doi 10 1006 nbdi 2000 0293 PMID 10964612 S2CID 5734400 Uechi T Tanaka T Kenmochi N 2001 A complete map of the human ribosomal protein genes assignment of 80 genes to the cytogenetic map and implications for human disorders Genomics 72 3 223 30 doi 10 1006 geno 2000 6470 PMID 11401437 Andersen JS Lyon CE Fox AH et al 2002 Directed proteomic analysis of the human nucleolus Curr Biol 12 1 1 11 doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Jakel S Mingot JM Schwarzmaier P et al 2002 Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains EMBO J 21 3 377 86 doi 10 1093 emboj 21 3 377 PMC 125346 PMID 11823430 Yoshihama M Uechi T Asakawa S et al 2002 The human ribosomal protein genes sequencing and comparative analysis of 73 genes Genome Res 12 3 379 90 doi 10 1101 gr 214202 PMC 155282 PMID 11875025 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Lehner B Semple JI Brown SE et al 2004 Analysis of a high throughput yeast two hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region Genomics 83 1 153 67 doi 10 1016 S0888 7543 03 00235 0 PMID 14667819 Bouwmeester T Bauch A Ruffner H et al 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Tu LC Yan X Hood L Lin B 2007 Proteomics analysis of the interactome of N myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells Mol Cell Proteomics 6 4 575 88 doi 10 1074 mcp M600249 MCP200 PMID 17220478 This article on a gene on human chromosome 15 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 60S ribosomal protein L4 amp oldid 1171081324, wikipedia, wiki, book, books, 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