Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000198918 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000079641 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Otsuka S, Tanaka M, Saito S, Yoshimoto K, Itakura M (Sep 1996). "Molecular cloning of a cDNA encoding human ribosomal protein L39". Biochim Biophys Acta. 1308 (2): 119–21. doi:10.1016/0167-4781(96)00106-6. PMID 8764829.
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC155282. PMID 11875025.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Tsui SK, Lee SM, Fung KP, et al. (1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem. Mol. Biol. Int. 40 (3): 611–6. doi:10.1080/15216549600201203. PMID 8908372. S2CID 7909023.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.
ribosomal, protein, protein, that, humans, encoded, rpl39, gene, rpl39available, structurespdbortholog, search, pdbe, rcsblist, codes4ug0, 4v6x, 5aj0, 3j92, 4ujc, 3j7p, 4uje, 3j7q, 3j7r, 4d67, 4ujd, 4v5z, 4d5y, 3j7oidentifiersaliasesrpl39, rpl39p42, rpl39, 180. 60S ribosomal protein L39 is a protein that in humans is encoded by the RPL39 gene 5 6 RPL39Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UG0 4V6X 5AJ0 3J92 4UJC 3J7P 4UJE 3J7Q 3J7R 4D67 4UJD 4V5Z 4D5Y 3J7OIdentifiersAliasesRPL39 L39 RPL39P42 RPL39 23 1806 ribosomal protein L39External IDsOMIM 300899 MGI 1914498 HomoloGene 133571 GeneCards RPL39Gene location Human Chr X chromosome human 1 BandXq24Start119 786 504 bp 1 End119 791 630 bp 1 Gene location Mouse Chr X chromosome mouse 2 BandX X A3 3Start36 346 173 bp 2 End36 349 055 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceendometriumskin of abdomensubcutaneous adipose tissuelymph nodespleenright adrenal glandrectumright uterine tubevaginaTop expressed inyolk sacganglionic eminencelipesophagusuterusduodenumurinary bladderjejunumbone marrowneural tubeMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionRNA binding structural constituent of ribosomeCellular componentribosome cytosol intracellular anatomical structure extracellular space cytosolic large ribosomal subunit polysomal ribosomeBiological processSRP dependent cotranslational protein targeting to membrane innate immune response in mucosa viral transcription nuclear transcribed mRNA catabolic process nonsense mediated decay translational initiation protein biosynthesis rRNA processing antimicrobial humoral immune response mediated by antimicrobial peptide cytoplasmic translationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez617067248EnsemblENSG00000198918ENSMUSG00000079641UniProtP62891P62892RefSeq mRNA NM 001000NM 026055RefSeq protein NP 000991NP 080331Location UCSC Chr X 119 79 119 79 MbChr X 36 35 36 35 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseRibosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 60S subunit The protein belongs to the S39E family of ribosomal proteins It is located in the cytoplasm In rat the protein is the smallest and one of the most basic proteins of the ribosome This gene is co transcribed with the U69 small nucleolar RNA gene which is located in its second intron As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000198918 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000079641 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Otsuka S Tanaka M Saito S Yoshimoto K Itakura M Sep 1996 Molecular cloning of a cDNA encoding human ribosomal protein L39 Biochim Biophys Acta 1308 2 119 21 doi 10 1016 0167 4781 96 00106 6 PMID 8764829 a b Entrez Gene RPL39 ribosomal protein L39 Further reading editWool IG Chan YL Gluck A 1996 Structure and evolution of mammalian ribosomal proteins Biochem Cell Biol 73 11 12 933 47 doi 10 1139 o95 101 PMID 8722009 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Yoshihama M Uechi T Asakawa S et al 2002 The Human Ribosomal Protein Genes Sequencing and Comparative Analysis of 73 Genes Genome Res 12 3 379 90 doi 10 1101 gr 214202 PMC 155282 PMID 11875025 Uechi T Tanaka T Kenmochi N 2001 A complete map of the human ribosomal protein genes assignment of 80 genes to the cytogenetic map and implications for human disorders Genomics 72 3 223 30 doi 10 1006 geno 2000 6470 PMID 11401437 Tsui SK Lee SM Fung KP et al 1997 Primary structures and sequence analysis of human ribosomal proteins L39 and S27 Biochem Mol Biol Int 40 3 611 6 doi 10 1080 15216549600201203 PMID 8908372 S2CID 7909023 Kato S Sekine S Oh SW et al 1995 Construction of a human full length cDNA bank Gene 150 2 243 50 doi 10 1016 0378 1119 94 90433 2 PMID 7821789 nbsp This article on a gene on the human X chromosome and or its associated protein is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 60S ribosomal protein L39 amp oldid 1174950546, wikipedia, wiki, book, books, library,
