Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000136942 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000062997 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Uechi T, Tanaka T, Kenmochi N (Jun 2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Human RPL35 genome location and RPL35 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P42766 (Human 60S ribosomal protein L35) at the PDBe-KB.
Further readingEdit
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Ou JH, Yen TS, Wang YF, et al. (1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res. 15 (21): 8919–34. doi:10.1093/nar/15.21.8919. PMC306413. PMID 2891103.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
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ribosomal, protein, protein, that, humans, encoded, rpl35, gene, rpl35available, structurespdbortholog, search, pdbe, rcsblist, codes4ug0, 4v6x, 5aj0, 4v5z, 4ujd, 4d67, 4d5y, 4uje, 4ujcidentifiersaliasesrpl35, ribosomal, protein, dba19external, idsomim, 618315. 60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene 5 6 RPL35Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UG0 4V6X 5AJ0 4V5Z 4UJD 4D67 4D5Y 4UJE 4UJCIdentifiersAliasesRPL35 L35 ribosomal protein L35 DBA19External IDsOMIM 618315 MGI 1913739 HomoloGene 31432 GeneCards RPL35Gene location Human Chr Chromosome 9 human 1 Band9q33 3Start124 857 880 bp 1 End124 861 981 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 BStart38 891 592 bp 2 End38 895 636 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomenanterior pituitaryright uterine tubeAchilles tendonbody of pancreascanal of the cervixperiodontal fiberright lobe of thyroid glandlymph nodeleft lobe of thyroid glandTop expressed inurinary bladderovaryneural tubeadrenal glandplacentawhite adipose tissuebone marrowlipmirroruterusMore reference expression dataBioGPSn aGene ontologyMolecular functionmRNA binding RNA binding structural constituent of ribosomeCellular componentcytosol ribosome membrane intracellular anatomical structure nucleolus cytosolic large ribosomal subunitBiological processviral transcription SRP dependent cotranslational protein targeting to membrane maturation of LSU rRNA from tricistronic rRNA transcript SSU rRNA 5 8S rRNA LSU rRNA translational initiation nuclear transcribed mRNA catabolic process nonsense mediated decay rRNA processing protein biosynthesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1122466489EnsemblENSG00000136942ENSMUSG00000062997UniProtP42766Q6ZWV7RefSeq mRNA NM 007209NM 025592RefSeq protein NP 009140NP 079868Location UCSC Chr 9 124 86 124 86 MbChr 2 38 89 38 9 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 External links 4 Further readingFunction EditRibosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 60S subunit The protein belongs to the L29P family of ribosomal proteins It is located in the cytoplasm As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome 6 References Edit a b c GRCh38 Ensembl release 89 ENSG00000136942 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000062997 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Uechi T Tanaka T Kenmochi N Jun 2001 A complete map of the human ribosomal protein genes assignment of 80 genes to the cytogenetic map and implications for human disorders Genomics 72 3 223 30 doi 10 1006 geno 2000 6470 PMID 11401437 a b Entrez Gene RPL35 ribosomal protein L35 External links EditHuman RPL35 genome location and RPL35 gene details page in the UCSC Genome Browser Overview of all the structural information available in the PDB for UniProt P42766 Human 60S ribosomal protein L35 at the PDBe KB Further reading EditWool IG Chan YL Gluck A 1996 Structure and evolution of mammalian ribosomal proteins Biochem Cell Biol 73 11 12 933 47 doi 10 1139 o95 101 PMID 8722009 Ou JH Yen TS Wang YF et al 1988 Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells Nucleic Acids Res 15 21 8919 34 doi 10 1093 nar 15 21 8919 PMC 306413 PMID 2891103 Kato S Sekine S Oh SW et al 1995 Construction of a human full length cDNA bank Gene 150 2 243 50 doi 10 1016 0378 1119 94 90433 2 PMID 7821789 Matoba R Okubo K Hori N et al 1994 The addition of 5 coding information to a 3 directed cDNA library improves analysis of gene expression Gene 146 2 199 207 doi 10 1016 0378 1119 94 90293 3 PMID 8076819 Mammalian Gene Collection Program Team Strausberg R L Feingold E A Grouse L H et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proceedings of the National Academy of Sciences 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Odintsova TI Muller EC Ivanov AV et al 2004 Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing J Protein Chem 22 3 249 58 doi 10 1023 A 1025068419698 PMID 12962325 S2CID 10710245 Bouwmeester T Bauch A Ruffner H et al 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Humphray SJ Oliver K Hunt AR et al 2004 DNA sequence and analysis of human chromosome 9 Nature 429 6990 369 74 Bibcode 2004Natur 429 369H doi 10 1038 nature02465 PMC 2734081 PMID 15164053 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Oh JH Yang JO Hahn Y et al 2006 Transcriptome analysis of human gastric cancer Mamm Genome 16 12 942 54 doi 10 1007 s00335 005 0075 2 PMID 16341674 S2CID 69278 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 This protein related article 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