ROSA26 is a locus used for constitutive, ubiquitous gene expression in mice.[1] It was first isolated in 1991[2] by the group of Philippe Soriano in a gene-trap mutagenesis screen of embryonic stem cells (ESCs). Over 800 knock-in lines have been created based on the ROSA26 locus according to the MGI database.[3] The human homolog of the ROSA26 locus has been identified.[4] ROSA stands for Reverse Orientation Splice Acceptor, named after the lentivirus genetrap vector.[5]
^Friedrich, G; Soriano, P (1991). "Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice". Genes & Development. 5 (9): 1513–23. doi:10.1101/gad.5.9.1513. PMID 1653172.
^"Gt(ROSA)26Sor MGI Mouse Gene Detail - MGI:104735 - gene trap ROSA 26, Philippe Soriano". www.informatics.jax.org. Retrieved 2023-09-30.
^Irion, Stefan; Luche, Hervé; Gadue, Paul; Fehling, Hans Joerg; Kennedy, Marion; Keller, Gordon (2007). "Identification and targeting of the ROSA26 locus in human embryonic stem cells". Nature Biotechnology. 25 (12): 1477–82. doi:10.1038/nbt1362. PMID 18037879. S2CID 10292785.
^Friedrich, G.; Soriano, P. (September 1991). "Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice". Genes & Development. 5 (9): 1513–1523. doi:10.1101/gad.5.9.1513. ISSN 0890-9369. PMID 1653172.
April 12, 2024
rosa26, locus, used, constitutive, ubiquitous, gene, expression, mice, first, isolated, 1991, group, philippe, soriano, gene, trap, mutagenesis, screen, embryonic, stem, cells, escs, over, knock, lines, have, been, created, based, locus, according, database, h. ROSA26 is a locus used for constitutive ubiquitous gene expression in mice 1 It was first isolated in 1991 2 by the group of Philippe Soriano in a gene trap mutagenesis screen of embryonic stem cells ESCs Over 800 knock in lines have been created based on the ROSA26 locus according to the MGI database 3 The human homolog of the ROSA26 locus has been identified 4 ROSA stands for Reverse Orientation Splice Acceptor named after the lentivirus genetrap vector 5 References edit rosa26 Retrieved 8 January 2013 Friedrich G Soriano P 1991 Promoter traps in embryonic stem cells A genetic screen to identify and mutate developmental genes in mice Genes amp Development 5 9 1513 23 doi 10 1101 gad 5 9 1513 PMID 1653172 Gt ROSA 26Sor MGI Mouse Gene Detail MGI 104735 gene trap ROSA 26 Philippe Soriano www informatics jax org Retrieved 2023 09 30 Irion Stefan Luche Herve Gadue Paul Fehling Hans Joerg Kennedy Marion Keller Gordon 2007 Identification and targeting of the ROSA26 locus in human embryonic stem cells Nature Biotechnology 25 12 1477 82 doi 10 1038 nbt1362 PMID 18037879 S2CID 10292785 Friedrich G Soriano P September 1991 Promoter traps in embryonic stem cells a genetic screen to identify and mutate developmental genes in mice Genes amp Development 5 9 1513 1523 doi 10 1101 gad 5 9 1513 ISSN 0890 9369 PMID 1653172 Retrieved from https en wikipedia org w index php title ROSA26 amp oldid 1177879645, wikipedia, wiki, book, books, library,
