The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[7]
^ abcGRCh38: Ensembl release 89: ENSG00000123091 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028557 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (December 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
^Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC310876. PMID 10810093.
^Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC2657574. PMID 19131965.
^Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
Further readingedit
Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia. 8 (8): 689–95. doi:10.1593/neo.06469. PMC1601945. PMID 16925951.
Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC1221394. PMID 11042109.
Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. doi:10.1016/S0002-9440(10)64176-4. PMC1850689. PMID 12107109.
Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta. 1639 (2): 104–12. doi:10.1016/j.bbadis.2003.07.001. PMID 14559117.
Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer. 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMC2394340. PMID 14562029.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC442148. PMID 15231748.
Connor MK, Azmi PB, Subramaniam V, Li H, Seth A (2005). "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141. S2CID 24739627.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.
rnf11, ring, finger, protein, protein, that, humans, encoded, gene, identifiersaliases, sid1669, ring, finger, protein, 11external, idsomim, 612598, 1352759, homologene, 32195, genecards, gene, location, human, chromosome, human, band1p32, 3start51, end51, gen. RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene 5 6 7 RNF11IdentifiersAliasesRNF11 SID1669 CGI 123 ring finger protein 11External IDsOMIM 612598 MGI 1352759 HomoloGene 32195 GeneCards RNF11Gene location Human Chr Chromosome 1 human 1 Band1p32 3Start51 236 273 bp 1 End51 273 447 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 C7Start109 308 295 bp 2 End109 341 925 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellprefrontal cortexexternal globus pallidusdorsolateral prefrontal cortexsuperior vestibular nucleusmonocyteBrodmann area 9human penisRegion I of hippocampus properponsTop expressed inbloodventromedial nucleuscingulate gyrussubcutaneous adipose tissueentorhinal cortexsuperior colliculusextensor digitorum longus muscleplantaris muscledorsomedial hypothalamic nucleusprimary motor cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein binding metal ion binding ubiquitin protein transferase activity ubiquitin protein ligase activity zinc ion bindingCellular componentubiquitin ligase complex cytoplasm recycling endosome endosome early endosome extracellular exosome nucleusBiological processubiquitin dependent protein catabolic process protein autoubiquitination proteasome mediated ubiquitin dependent protein catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2699429864EnsemblENSG00000123091ENSMUSG00000028557UniProtQ9Y3C5Q9QYK7RefSeq mRNA NM 014372NM 013876RefSeq protein NP 055187NP 038904Location UCSC Chr 1 51 24 51 27 MbChr 4 109 31 109 34 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 Interactions 4 References 5 Further reading 6 External linksFunction editThe protein encoded by this gene contains a RING H2 finger motif which is known to be important for protein protein interactions The expression of this gene has been shown to be induced by mutant RET proteins MEN2A MEN2B The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia MEN 7 See also editRING finger domainInteractions editRNF11 has been shown to interact with RIPK1 8 and STAMBP 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000123091 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028557 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Seki N Hattori A Hayashi A Kozuma S Sasaki M Suzuki Y Sugano S Muramatsu MA Saito T December 1999 Cloning and expression profile of mouse and human genes Rnf11 RNF11 encoding a novel RING H2 finger protein Biochim Biophys Acta 1489 2 3 421 7 doi 10 1016 s0167 4781 99 00190 6 PMID 10673045 Lai CH Chou CY Ch ang LY Liu CS Lin W August 2000 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics Genome Res 10 5 703 13 doi 10 1101 gr 10 5 703 PMC 310876 PMID 10810093 a b Entrez Gene RNF11 ring finger protein 11 Shembade N Parvatiyar K Harhaj NS Harhaj EW March 2009 The ubiquitin editing enzyme A20 requires RNF11 to downregulate NF kappaB signalling EMBO J 28 5 513 22 doi 10 1038 emboj 2008 285 PMC 2657574 PMID 19131965 Li H Seth A March 2004 An RNF11 Smurf2 complex mediates ubiquitination of the AMSH protein Oncogene 23 10 1801 8 doi 10 1038 sj onc 1207319 PMID 14755250 S2CID 37253372 Further reading editBurger A Amemiya Y Kitching R Seth AK 2006 Novel RING E3 ubiquitin ligases in breast cancer Neoplasia 8 8 689 95 doi 10 1593 neo 06469 PMC 1601945 PMID 16925951 Jolliffe CN Harvey KF Haines BP Parasivam G Kumar S 2000 Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin protein ligase Nedd4 Biochem J 351 Pt 3 3 557 65 doi 10 1042 0264 6021 3510557 PMC 1221394 PMID 11042109 Watanabe T Ichihara M Hashimoto M Shimono K Shimoyama Y Nagasaka T Murakumo Y Murakami H Sugiura H Iwata H Ishiguro N Takahashi M 2002 Characterization of gene expression induced by RET with MEN2A or MEN2B mutation Am J Pathol 161 1 249 56 doi 10 1016 S0002 9440 10 64176 4 PMC 1850689 PMID 12107109 Kitching R Wong MJ Koehler D Burger AM Landberg G Gish G Seth A 2003 The RING H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT type E3 ligases Biochim Biophys Acta 1639 2 104 12 doi 10 1016 j bbadis 2003 07 001 PMID 14559117 Subramaniam V Li H Wong M Kitching R Attisano L Wrana J Zubovits J Burger AM Seth A 2003 The RING H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase Br J Cancer 89 8 1538 44 doi 10 1038 sj bjc 6601301 PMC 2394340 PMID 14562029 Li H Seth A 2004 An RNF11 Smurf2 complex mediates ubiquitination of the AMSH protein Oncogene 23 10 1801 8 doi 10 1038 sj onc 1207319 PMID 14755250 S2CID 37253372 Colland F Jacq X Trouplin V Mougin C Groizeleau C Hamburger A Meil A Wojcik J Legrain P Gauthier JM 2004 Functional proteomics mapping of a human signaling pathway Genome Res 14 7 1324 32 doi 10 1101 gr 2334104 PMC 442148 PMID 15231748 Connor MK Azmi PB Subramaniam V Li H Seth A 2005 Molecular characterization of ring finger protein 11 Mol Cancer Res 3 8 453 61 doi 10 1158 1541 7786 MCR 04 0166 PMID 16123141 S2CID 24739627 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Kimura K Wakamatsu A Suzuki Y Ota T Nishikawa T Yamashita R Yamamoto J Sekine M Tsuritani K Wakaguri H Ishii S Sugiyama T Saito K Isono Y Irie R Kushida N Yoneyama T Otsuka R Kanda K Yokoi T Kondo H Wagatsuma M Murakawa K Ishida S Ishibashi T Takahashi Fujii A Tanase T Nagai K Kikuchi H Nakai K Isogai T Sugano S 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Anderson LR Betarbet R Gearing M Gulcher J Hicks AA Stefansson K Lah JJ Levey AI 2007 PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain J Neuropathol Exp Neurol 66 10 955 64 doi 10 1097 nen 0b013e3181567f17 PMID 17917589 External links editRNF11 protein human at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RNF11 amp oldid 1192436792, wikipedia, wiki, book, books, library,
