RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM][7]
RIT2 has been associated with Parkinson's disease in two large genetic studies.[8][9] An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000152214 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000057455 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lee CH, Della NG, Chew CE, Zack DJ (November 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". The Journal of Neuroscience. 16 (21): 6784–94. doi:10.1523/JNEUROSCI.16-21-06784.1996. PMC6579259. PMID 8824319.
^Wes PD, Yu M, Montell C (November 1996). "RIC, a calmodulin-binding Ras-like GTPase". The EMBO Journal. 15 (21): 5839–48. doi:10.1002/j.1460-2075.1996.tb00971.x. PMC452332. PMID 8918462.
^Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T (March 2012). "Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2". Annals of Neurology. 71 (3): 370–84. doi:10.1002/ana.22687. PMC3354734. PMID 22451204.
^Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, et al. (September 2014). "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease" (PDF). Nature Genetics. 46 (9): 989–93. doi:10.1038/ng.3043. hdl:11858/00-001M-0000-0026-AA42-8. PMC4146673. PMID 25064009.
^Liscovitch N, French L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease". PLOS ONE. 9 (12): e115029. Bibcode:2014PLoSO...9k5029L. doi:10.1371/journal.pone.0115029. PMC4262449. PMID 25493648.
^Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100. S2CID 670567.
Further readingedit
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (November 1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
Hoshino M, Nakamura S (July 2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation". Biochemical and Biophysical Research Communications. 295 (3): 651–6. doi:10.1016/S0006-291X(02)00731-3. PMID 12099688.
Calissano M, Latchman DS (August 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100. S2CID 670567.
Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U (August 2005). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience. 6: 53. doi:10.1186/1471-2202-6-53. PMC1215486. PMID 16122393.
Shi GX, Han J, Andres DA (November 2005). "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation". The Journal of Biological Chemistry. 280 (45): 37599–609. doi:10.1074/jbc.M507364200. PMID 16157584.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.
rit2, binding, protein, rit2, protein, that, humans, encoded, gene, identifiersaliases, riba, roc2, like, without, caax, 2external, idsomim, 609592, 108054, homologene, 2198, genecards, gene, location, human, chromosome, human, band18q12, 3start42, end43, gene. GTP binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene 5 6 7 RIT2IdentifiersAliasesRIT2 RIBA RIN ROC2 Ras like without CAAX 2External IDsOMIM 609592 MGI 108054 HomoloGene 2198 GeneCards RIT2Gene location Human Chr Chromosome 18 human 1 Band18q12 3Start42 743 227 bp 1 End43 115 691 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 18 B1Start31 106 542 bp 2 End31 450 343 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incerebellar cortexcerebellar hemispherecerebellar vermisendothelial cellBrodmann area 9prefrontal cortexnucleus accumbenshypothalamusorbitofrontal cortexcingulate gyrusTop expressed inventral tegmental areadorsal tegmental nucleusdorsomedial hypothalamic nucleusmedial vestibular nucleushabenulasuprachiasmatic nucleusparaventricular nucleus of hypothalamusarcuate nucleusmedian eminencemedial dorsal nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding calmodulin binding identical protein binding GTP binding protein binding semaphorin receptor binding chromatin binding GTPase activity GDP bindingCellular componentmembrane membrane raft plasma membrane nucleus neuron projection cytoplasm cell body dendritic treeBiological processchemical synaptic transmission signal transduction MAPK cascade maintenance of protein location in cell regulation of endocytosis intracellular signal transduction regulation of protein phosphorylation Ras protein signal transduction positive regulation of neuron projection development negative regulation of neuron projection development regulation of Cdc42 protein signal transduction positive regulation of MAPK cascade positive regulation of transcription by RNA polymerase II regulation of calcium mediated signaling small GTPase mediated signal transduction adenylate cyclase activating G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez601419762EnsemblENSG00000152214ENSMUSG00000057455UniProtQ99578P70425RefSeq mRNA NM 002930NM 001272077NM 009065RefSeq protein NP 001259006NP 002921NP 033091Location UCSC Chr 18 42 74 43 12 MbChr 18 31 11 31 45 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse RIN belongs to the RAS HRAS MIM 190020 superfamily of small GTPases Shao et al 1999 supplied by OMIM 7 RIT2 has been associated with Parkinson s disease in two large genetic studies 8 9 An gene expression study of postmortem brain has suggested RIT2 interacts with interferon g signalling 10 Interactions editRIT2 has been shown to interact with POU4F1 11 References edit a b c GRCh38 Ensembl release 89 ENSG00000152214 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000057455 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lee CH Della NG Chew CE Zack DJ November 1996 Rin a neuron specific and calmodulin binding small G protein and Rit define a novel subfamily of ras proteins The Journal of Neuroscience 16 21 6784 94 doi 10 1523 JNEUROSCI 16 21 06784 1996 PMC 6579259 PMID 8824319 Wes PD Yu M Montell C November 1996 RIC a calmodulin binding Ras like GTPase The EMBO Journal 15 21 5839 48 doi 10 1002 j 1460 2075 1996 tb00971 x PMC 452332 PMID 8918462 a b Entrez Gene RIT2 Ras like without CAAX 2 Pankratz N Beecham GW DeStefano AL Dawson TM Doheny KF Factor SA Hamza TH Hung AY Hyman BT Ivinson AJ Krainc D Latourelle JC Clark LN Marder K Martin ER Mayeux R Ross OA Scherzer CR Simon DK Tanner C Vance JM Wszolek ZK Zabetian CP Myers RH Payami H Scott WK Foroud T March 2012 Meta analysis of Parkinson s disease identification of a novel locus RIT2 Annals of Neurology 71 3 370 84 doi 10 1002 ana 22687 PMC 3354734 PMID 22451204 Nalls MA Pankratz N Lill CM Do CB Hernandez DG Saad M et al September 2014 Large scale meta analysis of genome wide association data identifies six new risk loci for Parkinson s disease PDF Nature Genetics 46 9 989 93 doi 10 1038 ng 3043 hdl 11858 00 001M 0000 0026 AA42 8 PMC 4146673 PMID 25064009 Liscovitch N French L 2014 Differential Co Expression between a Synuclein and IFN g Signaling Genes across Development and in Parkinson s Disease PLOS ONE 9 12 e115029 Bibcode 2014PLoSO 9k5029L doi 10 1371 journal pone 0115029 PMC 4262449 PMID 25493648 Calissano M Latchman DS August 2003 Functional interaction between the small GTP binding protein Rin and the N terminal of Brn 3a transcription factor Oncogene 22 35 5408 14 doi 10 1038 sj onc 1206635 PMID 12934100 S2CID 670567 Further reading editShao H Kadono Okuda K Finlin BS Andres DA November 1999 Biochemical characterization of the Ras related GTPases Rit and Rin Archives of Biochemistry and Biophysics 371 2 207 19 doi 10 1006 abbi 1999 1448 PMID 10545207 Hoshino M Nakamura S July 2002 The Ras like small GTP binding protein Rin is activated by growth factor stimulation Biochemical and Biophysical Research Communications 295 3 651 6 doi 10 1016 S0006 291X 02 00731 3 PMID 12099688 Calissano M Latchman DS August 2003 Functional interaction between the small GTP binding protein Rin and the N terminal of Brn 3a transcription factor Oncogene 22 35 5408 14 doi 10 1038 sj onc 1206635 PMID 12934100 S2CID 670567 Hartwig C Veske A Krejcova S Rosenberger G Finckh U August 2005 Plexin B3 promotes neurite outgrowth interacts homophilically and interacts with Rin BMC Neuroscience 6 53 doi 10 1186 1471 2202 6 53 PMC 1215486 PMID 16122393 Shi GX Han J Andres DA November 2005 Rin GTPase couples nerve growth factor signaling to p38 and b Raf ERK pathways to promote neuronal differentiation The Journal of Biological Chemistry 280 45 37599 609 doi 10 1074 jbc M507364200 PMID 16157584 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 nbsp This article on a gene on human chromosome 18 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RIT2 amp oldid 1188052436, wikipedia, wiki, book, books, library,
