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Wikipedia

RHOJ

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.[5][6]

RHOJ
Identifiers
AliasesRHOJ, ARHJ, RASL7B, TC10B, TCL, ras homolog family member J
External IDsOMIM: 607653 MGI: 1931551 HomoloGene: 56894 GeneCards: RHOJ
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020663

NM_023275

RefSeq (protein)

NP_065714
NP_065714.1

NP_075764

Location (UCSC)Chr 14: 63.2 – 63.29 MbChr 12: 75.36 – 75.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM][6]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126785 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046768 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 and Ccdc42". J Biol Chem. 275 (46): 36457–64. doi:10.1074/jbc.M003487200. PMID 10967094.
  6. ^ a b "Entrez Gene: RHOJ ras homolog gene family, member J".

Further reading edit

  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Lett. 579 (5): 1039–46. doi:10.1016/j.febslet.2005.01.006. PMID 15710388. S2CID 36721405.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology". FEBS Lett. 572 (1–3): 159–66. doi:10.1016/j.febslet.2004.06.095. PMID 15304341. S2CID 9107914.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • de Toledo M, Senic-Matuglia F, Salamero J, et al. (2004). "The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway". Mol. Biol. Cell. 14 (12): 4846–56. doi:10.1091/mbc.E03-04-0254. PMC 284789. PMID 12960428.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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For the television series see The Real Housewives of Jersey For the television series see The Real Housewives of Johannesburg Rho related GTP binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene 5 6 RHOJIdentifiersAliasesRHOJ ARHJ RASL7B TC10B TCL ras homolog family member JExternal IDsOMIM 607653 MGI 1931551 HomoloGene 56894 GeneCards RHOJGene location Human Chr Chromosome 14 human 1 Band14q23 2Start63 204 114 bp 1 End63 293 508 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 12 C3Start75 355 096 bp 2 End75 448 230 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nervesmooth muscle tissuegallbladderleft uterine tubeupper lobe of left lungendothelial celllower lobe of lungvisceral pleurasubcutaneous adipose tissueganglionic eminenceTop expressed insemi lunar valveaortic valvebelly cordascending aortaexternal carotid arteryinternal carotid arteryciliary bodyparotid glandirisright lung lobeMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotide binding GTP binding protein binding GTPase activity protein kinase bindingCellular componentcytosol plasma membrane extracellular exosome membrane intracellular anatomical structure cytoplasm cell cortex cell projectionBiological processregulation of small GTPase mediated signal transduction retina vasculature morphogenesis in camera type eye actin cytoskeleton organization Rho protein signal transduction regulation of cell shape small GTPase mediated signal transduction angiogenesis endocytosis actin filament organization establishment or maintenance of cell polarity regulation of endothelial cell migration cell projection assembly regulation of actin cytoskeleton organization positive regulation of cell migration involved in sprouting angiogenesis regulation of sprouting angiogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5738180837EnsemblENSG00000126785ENSMUSG00000046768UniProtQ9H4E5Q9ER71RefSeq mRNA NM 020663NM 023275RefSeq protein NP 065714NP 065714 1NP 075764Location UCSC Chr 14 63 2 63 29 MbChr 12 75 36 75 45 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse ARHJ belongs to the Rho family of small GTP binding proteins Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes such as cell proliferation and motility and the establishment of cell polarity They are also involved in pathophysiologic process such as cell transformation and metastasis supplied by OMIM 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000126785 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000046768 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Vignal E De Toledo M Comunale F Ladopoulou A Gauthier Rouviere C Blangy A Fort P Dec 2000 Characterization of TCL a new GTPase of the rho family related to TC10 and Ccdc42 J Biol Chem 275 46 36457 64 doi 10 1074 jbc M003487200 PMID 10967094 a b Entrez Gene RHOJ ras homolog gene family member J Further reading editBarrios Rodiles M Brown KR Ozdamar B et al 2005 High throughput mapping of a dynamic signaling network in mammalian cells Science 307 5715 1621 5 Bibcode 2005Sci 307 1621B doi 10 1126 science 1105776 PMID 15761153 S2CID 39457788 Nishikimi A Meller N Uekawa N et al 2005 Zizimin2 a novel DOCK180 related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes FEBS Lett 579 5 1039 46 doi 10 1016 j febslet 2005 01 006 PMID 15710388 S2CID 36721405 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ruusala A Aspenstrom P 2004 Isolation and characterisation of DOCK8 a member of the DOCK180 related regulators of cell morphology FEBS Lett 572 1 3 159 66 doi 10 1016 j febslet 2004 06 095 PMID 15304341 S2CID 9107914 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 de Toledo M Senic Matuglia F Salamero J et al 2004 The GTP GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway Mol Biol Cell 14 12 4846 56 doi 10 1091 mbc E03 04 0254 PMC 284789 PMID 12960428 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 nbsp This article on a gene on human chromosome 14 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RHOJ amp oldid 1184134037, wikipedia, wiki, book, books, library,

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