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Wikipedia

RGS5

March 14, 2024

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[5][6]

RGS5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5, regulator of G protein signaling 5
External IDsOMIM: 603276 MGI: 1098434 HomoloGene: 2682 GeneCards: RGS5
Orthologs
SpeciesHumanMouse
Entrez

8490

19737

Ensembl

ENSG00000143248

ENSMUSG00000026678

UniProt

O15539

O08850

RefSeq (mRNA)

NM_001195303
NM_001254748
NM_001254749
NM_003617
NM_025226

NM_009063
NM_001313705

RefSeq (protein)

NP_001182232
NP_001241677
NP_001241678
NP_003608
NP_003608.1

NP_001300634
NP_033089

Location (UCSC)Chr 1: 163.11 – 163.32 MbChr 1: 169.48 – 169.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[6]

Interactions edit

RGS5 has been shown to interact with GNAO1,[7][8] GNAI2[7][8] and GNAI3.[7][8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143248 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026678 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. doi:10.1007/s100380050071. PMID 9747037.
  6. ^ a b "Entrez Gene: RGS5 regulator of G-protein signalling 5".
  7. ^ a b c Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. UNITED STATES. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
  8. ^ a b c Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. England. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.

Further reading edit

  • Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
  • Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. doi:10.1038/12867. PMID 10471929. S2CID 26981462.
  • Adams LD, Geary RL, McManus B, Schwartz SM (2000). "A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media" (PDF). Circ. Res. 87 (7): 623–31. doi:10.1161/01.res.87.7.623. PMID 11009569. S2CID 2390642.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Zhou J, Moroi K, Nishiyama M, et al. (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. PMID 11253162.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Morris DW, Rodgers A, McGhee KA, et al. (2005). "Confirming RGS4 as a susceptibility gene for schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50–3. doi:10.1002/ajmg.b.20109. PMID 14755443. S2CID 45411595.
  • Berger M, Bergers G, Arnold B, et al. (2005). "Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization". Blood. 105 (3): 1094–101. doi:10.1182/blood-2004-06-2315. PMID 15459006.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Liang Y, Li C, Guzman VM, et al. (2005). "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues". FEBS J. 272 (3): 791–9. doi:10.1111/j.1742-4658.2004.04516.x. PMID 15670159. S2CID 13519368.
  • Adams LD, Geary RL, Li J, et al. (2006). "Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap". Arterioscler. Thromb. Vasc. Biol. 26 (2): 319–25. doi:10.1161/01.ATV.0000196647.45718.d6. PMID 16293795. S2CID 14434603.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Rhee KH, Nam KH, Lee WH, et al. (2007). "Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-". Protein Pept. Lett. 13 (9): 945–9. doi:10.2174/092986606778256225. PMID 17100651.
  • Bodenstein J, Sunahara RK, Neubig RR (2007). "N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells". Mol. Pharmacol. 71 (4): 1040–50. doi:10.1124/mol.106.029397. PMID 17220356. S2CID 11212754.
  • Yang Z, Gaudio S, Song W, et al. (2007). "Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5)". Cell. Physiol. Biochem. 20 (5): 303–10. doi:10.1159/000107516. PMID 17762159.
 

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

March 14, 2024
rgs5, regulator, protein, signaling, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2crpidentifiersaliases, mst092, mst106, mst129, mstp032, mstp092, mstp106, mstp129, regulator, protein, signaling, regulat. Regulator of G protein signaling 5 is a protein that in humans is encoded by the RGS5 gene 5 6 RGS5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2CRPIdentifiersAliasesRGS5 MST092 MST106 MST129 MSTP032 MSTP092 MSTP106 MSTP129 regulator of G protein signaling 5 regulator of G protein signaling 5External IDsOMIM 603276 MGI 1098434 HomoloGene 2682 GeneCards RGS5Gene location Human Chr Chromosome 1 human 1 Band1q23 3Start163 111 121 bp 1 End163 321 791 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H2 3 1 76 84 cMStart169 483 070 bp 2 End169 523 382 bp 2 RNA expression patternBgeeHumanMouse ortholog n aTop expressed inbody of femurankleolfactory epitheliumdigastric musclesternocleidomastoid muscletemporal muscletriceps brachii musclevastus lateralis muscleright ventricleintercostal muscleBioGPSMore reference expression dataGene ontologyMolecular functionGTPase activator activity GTPase activityCellular componentplasma membrane membrane cytoplasm cytosolBiological processnegative regulation of signal transduction regulation of G protein coupled receptor signaling pathway positive regulation of GTPase activity G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez849019737EnsemblENSG00000143248ENSMUSG00000026678UniProtO15539O08850RefSeq mRNA NM 001195303NM 001254748NM 001254749NM 003617NM 025226NM 009063NM 001313705RefSeq protein NP 001182232NP 001241677NP 001241678NP 003608NP 003608 1NP 001300634NP 033089Location UCSC Chr 1 163 11 163 32 MbChr 1 169 48 169 52 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe regulator of G protein signaling RGS proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL 10 of Caenorhabditis elegans Multiple genes homologous to SST2 are present in higher eukaryotes RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators 6 Interactions editRGS5 has been shown to interact with GNAO1 7 8 GNAI2 7 8 and GNAI3 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000143248 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026678 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Seki N Sugano S Suzuki Y Nakagawara A Ohira M Muramatsu M Saito T Hori T October 1998 Isolation tissue expression and chromosomal assignment of human RGS5 a novel G protein signaling regulator gene J Hum Genet 43 3 202 5 doi 10 1007 s100380050071 PMID 9747037 a b Entrez Gene RGS5 regulator of G protein signalling 5 a b c Chen C Zheng B Han J Lin S C March 1997 Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast J Biol Chem UNITED STATES 272 13 8679 85 doi 10 1074 jbc 272 13 8679 ISSN 0021 9258 PMID 9079700 a b c Zhou J Moroi K Nishiyama M Usui H Seki N Ishida J Fukamizu A Kimura S February 2001 Characterization of RGS5 in regulation of G protein coupled receptor signaling Life Sci England 68 13 1457 69 doi 10 1016 S0024 3205 01 00939 0 ISSN 0024 3205 PMID 11253162 Further reading editChen C Zheng B Han J Lin SC 1997 Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast J Biol Chem 272 13 8679 85 doi 10 1074 jbc 272 13 8679 PMID 9079700 Cismowski MJ Takesono A Ma C et al 1999 Genetic screens in yeast to identify mammalian nonreceptor modulators of G protein signaling Nat Biotechnol 17 9 878 83 doi 10 1038 12867 PMID 10471929 S2CID 26981462 Adams LD Geary RL McManus B Schwartz SM 2000 A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes all in aortic media PDF Circ Res 87 7 623 31 doi 10 1161 01 res 87 7 623 PMID 11009569 S2CID 2390642 Hartley JL Temple GF Brasch MA 2001 DNA cloning using in vitro site specific recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Wiemann S Weil B Wellenreuther R et al 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Zhou J Moroi K Nishiyama M et al 2001 Characterization of RGS5 in regulation of G protein coupled receptor signaling Life Sci 68 13 1457 69 doi 10 1016 S0024 3205 01 00939 0 PMID 11253162 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Morris DW Rodgers A McGhee KA et al 2005 Confirming RGS4 as a susceptibility gene for schizophrenia Am J Med Genet B Neuropsychiatr Genet 125 1 50 3 doi 10 1002 ajmg b 20109 PMID 14755443 S2CID 45411595 Berger M Bergers G Arnold B et al 2005 Regulator of G protein signaling 5 induction in pericytes coincides with active vessel remodeling during neovascularization Blood 105 3 1094 101 doi 10 1182 blood 2004 06 2315 PMID 15459006 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Wiemann S Arlt D Huber W et al 2004 From ORFeome to biology a functional genomics pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Liang Y Li C Guzman VM et al 2005 Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues FEBS J 272 3 791 9 doi 10 1111 j 1742 4658 2004 04516 x PMID 15670159 S2CID 13519368 Adams LD Geary RL Li J et al 2006 Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap loss of RGS5 distinguishes the cap Arterioscler Thromb Vasc Biol 26 2 319 25 doi 10 1161 01 ATV 0000196647 45718 d6 PMID 16293795 S2CID 14434603 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 Gregory SG Barlow KF McLay KE et al 2006 The DNA sequence and biological annotation of human chromosome 1 Nature 441 7091 315 21 Bibcode 2006Natur 441 315G doi 10 1038 nature04727 PMID 16710414 Rhee KH Nam KH Lee WH et al 2007 Expression purification and preliminary X ray crystallographic analysis of the complex of G alphai3 RGS5 from human with GDP Mg2 AlF4 Protein Pept Lett 13 9 945 9 doi 10 2174 092986606778256225 PMID 17100651 Bodenstein J Sunahara RK Neubig RR 2007 N terminal residues control proteasomal degradation of RGS2 RGS4 and RGS5 in human embryonic kidney 293 cells Mol Pharmacol 71 4 1040 50 doi 10 1124 mol 106 029397 PMID 17220356 S2CID 11212754 Yang Z Gaudio S Song W et al 2007 Evidence for the dimerization of human regulator of G protein signalling 5 RGS5 Cell Physiol Biochem 20 5 303 10 doi 10 1159 000107516 PMID 17762159 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RGS5 amp oldid 1079520460, wikipedia, wiki, book, books, library,

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