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Wikipedia

RFC2

April 08, 2024

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.[5][6][7]

RFC2
Identifiers
AliasesRFC2, RFC40, replication factor C subunit 2
External IDsOMIM: 600404 MGI: 1341868 HomoloGene: 6885 GeneCards: RFC2
Orthologs
SpeciesHumanMouse
Entrez

5982

19718

Ensembl

ENSG00000049541

ENSMUSG00000023104

UniProt

P35250
Q75MT5

Q9WUK4

RefSeq (mRNA)

NM_001278791
NM_001278792
NM_001278793
NM_002914
NM_181471

NM_020022

RefSeq (protein)

NP_064406

Location (UCSC)Chr 7: 74.23 – 74.25 MbChr 5: 134.61 – 134.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.[7]

Interactions edit

RFC2 has been shown to interact with BRD4,[8] CHTF18,[9][10] PCNA,[11][12][13] RFC4[11][14] and RFC5.[11][14]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000049541 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023104 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen M, Pan ZQ, Hurwitz J (Apr 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2516–20. Bibcode:1992PNAS...89.2516C. doi:10.1073/pnas.89.7.2516. PMC 48692. PMID 1313560.
  6. ^ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.
  7. ^ a b "Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa".
  8. ^ Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Molecular and Cellular Biology. 22 (18): 6509–20. doi:10.1128/MCB.22.18.6509-6520.2002. PMC 135621. PMID 12192049.
  9. ^ Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  10. ^ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  11. ^ a b c Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". The Journal of Biological Chemistry. 272 (30): 18974–81. doi:10.1074/jbc.272.30.18974. PMID 9228079.
  12. ^ Pan ZQ, Chen M, Hurwitz J (Jan 1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis". Proceedings of the National Academy of Sciences of the United States of America. 90 (1): 6–10. Bibcode:1993PNAS...90....6P. doi:10.1073/pnas.90.1.6. PMC 45588. PMID 8093561.
  13. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  14. ^ a b Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). "ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11607–12. Bibcode:1998PNAS...9511607C. doi:10.1073/pnas.95.20.11607. PMC 21688. PMID 9751713.

Further reading edit

  • Pan ZQ, Chen M, Hurwitz J (Jan 1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis". Proceedings of the National Academy of Sciences of the United States of America. 90 (1): 6–10. Bibcode:1993PNAS...90....6P. doi:10.1073/pnas.90.1.6. PMC 45588. PMID 8093561.
  • Peoples R, Perez-Jurado L, Wang YK, Kaplan P, Francke U (Jun 1996). "The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion". American Journal of Human Genetics. 58 (6): 1370–3. PMC 1915059. PMID 8651315.
  • Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). "In vitro reconstitution of human replication factor C from its five subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (13): 6521–6. Bibcode:1996PNAS...93.6521U. doi:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
  • Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Sep 1996). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.
  • Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (Apr 1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Molecular and Cellular Biology. 17 (4): 1817–23. doi:10.1128/MCB.17.4.1817. PMC 232028. PMID 9121429.
  • Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". The Journal of Biological Chemistry. 272 (30): 18974–81. doi:10.1074/jbc.272.30.18974. PMID 9228079.
  • Ellison V, Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". The Journal of Biological Chemistry. 273 (10): 5979–87. doi:10.1074/jbc.273.10.5979. PMID 9488738.
  • Zhang G, Gibbs E, Kelman Z, O'Donnell M, Hurwitz J (Mar 1999). "Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 1869–74. Bibcode:1999PNAS...96.1869Z. doi:10.1073/pnas.96.5.1869. PMC 26703. PMID 10051561.
  • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (Apr 2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes & Development. 14 (8): 927–39. doi:10.1101/gad.14.8.927. PMC 316544. PMID 10783165.
  • Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF (Oct 2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23". Mammalian Genome. 11 (10): 890–8. doi:10.1007/s003350010166. PMID 11003705. S2CID 8575994.
  • Griffith JD, Lindsey-Boltz LA, Sancar A (May 2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". The Journal of Biological Chemistry. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025.
  • Nieborowska-Skorska M, Hoser G, Kossev P, Wasik MA, Skorski T (Jun 2002). "Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis". Blood. 99 (12): 4531–9. doi:10.1182/blood.V99.12.4531. PMID 12036885.
  • Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  • Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Molecular and Cellular Biology. 22 (18): 6509–20. doi:10.1128/MCB.22.18.6509-6520.2002. PMC 135621. PMID 12192049.
  • Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  • Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.

April 08, 2024
rfc2, replication, factor, subunit, protein, that, humans, encoded, gene, identifiersaliases, rfc40, replication, factor, subunit, 2external, idsomim, 600404, 1341868, homologene, 6885, genecards, gene, location, human, chromosome, human, band7q11, 23start74, . Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene 5 6 7 RFC2IdentifiersAliasesRFC2 RFC40 replication factor C subunit 2External IDsOMIM 600404 MGI 1341868 HomoloGene 6885 GeneCards RFC2Gene location Human Chr Chromosome 7 human 1 Band7q11 23Start74 231 499 bp 1 End74 254 458 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 G2 5 74 68 cMStart134 610 220 bp 2 End134 630 659 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencemonocyteskin of abdomengastrocnemius musclestromal cell of endometriumbloodright lobe of liverrectumprefrontal cortexislet of LangerhansTop expressed inspermatidspermatocyteseminiferous tubuleabdominal walldermisthymusmaxillary prominencespleenprimitive streakyolk sacMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding DNA binding single stranded DNA helicase activity protein binding enzyme binding ATP binding DNA clamp loader activityCellular componentDNA replication factor C complex Ctf18 RFC like complex nucleoplasm nucleusBiological processnucleotide excision repair DNA gap filling error free translesion synthesis error prone translesion synthesis DNA replication positive regulation of DNA directed DNA polymerase activity translesion synthesis transcription coupled nucleotide excision repair nucleotide excision repair DNA incision nucleotide excision repair DNA incision 5 to lesion DNA repair telomere maintenance via semi conservative replication DNA dependent DNA replication regulation of signal transduction by p53 class mediatorSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez598219718EnsemblENSG00000049541ENSMUSG00000023104UniProtP35250Q75MT5Q9WUK4RefSeq mRNA NM 001278791NM 001278792NM 001278793NM 002914NM 181471NM 020022RefSeq protein NP 001265720NP 001265721NP 001265722NP 002905NP 852136NP 002905 2NP 064406Location UCSC Chr 7 74 23 74 25 MbChr 5 134 61 134 63 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThe elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen PCNA and replication factor C RFC RFC also called activator 1 is a protein complex consisting of five distinct subunits of 145 40 38 37 and 36 5 kD This gene encodes the 40 kD subunit which has been shown to be responsible for binding ATP Deletion of this gene has been associated with Williams syndrome Alternatively spliced transcript variants encoding distinct isoforms have been described 7 Interactions editRFC2 has been shown to interact with BRD4 8 CHTF18 9 10 PCNA 11 12 13 RFC4 11 14 and RFC5 11 14 References edit a b c GRCh38 Ensembl release 89 ENSG00000049541 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000023104 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chen M Pan ZQ Hurwitz J Apr 1992 Sequence and expression in Escherichia coli of the 40 kDa subunit of activator 1 replication factor C of HeLa cells Proceedings of the National Academy of Sciences of the United States of America 89 7 2516 20 Bibcode 1992PNAS 89 2516C doi 10 1073 pnas 89 7 2516 PMC 48692 PMID 1313560 Okumura K Nogami M Taguchi H Dean FB Chen M Pan ZQ Hurwitz J Shiratori A Murakami Y Ozawa K Jan 1995 Assignment of the 36 5 kDa RFC5 37 kDa RFC4 38 kDa RFC3 and 40 kDa RFC2 subunit genes of human replication factor C to chromosome bands 12q24 2 q24 3 3q27 13q12 3 q13 and 7q11 23 Genomics 25 1 274 8 doi 10 1016 0888 7543 95 80135 9 PMID 7774928 a b Entrez Gene RFC2 replication factor C activator 1 2 40kDa Maruyama T Farina A Dey A Cheong J Bermudez VP Tamura T Sciortino S Shuman J Hurwitz J Ozato K Sep 2002 A Mammalian bromodomain protein brd4 interacts with replication factor C and inhibits progression to S phase Molecular and Cellular Biology 22 18 6509 20 doi 10 1128 MCB 22 18 6509 6520 2002 PMC 135621 PMID 12192049 Bermudez VP Maniwa Y Tappin I Ozato K Yokomori K Hurwitz J Sep 2003 The alternative Ctf18 Dcc1 Ctf8 replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA Proceedings of the National Academy of Sciences of the United States of America 100 18 10237 42 Bibcode 2003PNAS 10010237B doi 10 1073 pnas 1434308100 PMC 193545 PMID 12930902 Merkle CJ Karnitz LM Henry Sanchez JT Chen J Aug 2003 Cloning and characterization of hCTF18 hCTF8 and hDCC1 Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment The Journal of Biological Chemistry 278 32 30051 6 doi 10 1074 jbc M211591200 PMID 12766176 a b c Cai J Gibbs E Uhlmann F Phillips B Yao N O Donnell M Hurwitz J Jul 1997 A complex consisting of human replication factor C p40 p37 and p36 subunits is a DNA dependent ATPase and an intermediate in the assembly of the holoenzyme The Journal of Biological Chemistry 272 30 18974 81 doi 10 1074 jbc 272 30 18974 PMID 9228079 Pan ZQ Chen M Hurwitz J Jan 1993 The subunits of activator 1 replication factor C carry out multiple functions essential for proliferating cell nuclear antigen dependent DNA synthesis Proceedings of the National Academy of Sciences of the United States of America 90 1 6 10 Bibcode 1993PNAS 90 6P doi 10 1073 pnas 90 1 6 PMC 45588 PMID 8093561 Ohta S Shiomi Y Sugimoto K Obuse C Tsurimoto T Oct 2002 A proteomics approach to identify proliferating cell nuclear antigen PCNA binding proteins in human cell lysates Identification of the human CHL12 RFCs2 5 complex as a novel PCNA binding protein The Journal of Biological Chemistry 277 43 40362 7 doi 10 1074 jbc M206194200 PMID 12171929 a b Cai J Yao N Gibbs E Finkelstein J Phillips B O Donnell M Hurwitz J Sep 1998 ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits Proceedings of the National Academy of Sciences of the United States of America 95 20 11607 12 Bibcode 1998PNAS 9511607C doi 10 1073 pnas 95 20 11607 PMC 21688 PMID 9751713 Further reading editPan ZQ Chen M Hurwitz J Jan 1993 The subunits of activator 1 replication factor C carry out multiple functions essential for proliferating cell nuclear antigen dependent DNA synthesis Proceedings of the National Academy of Sciences of the United States of America 90 1 6 10 Bibcode 1993PNAS 90 6P doi 10 1073 pnas 90 1 6 PMC 45588 PMID 8093561 Peoples R Perez Jurado L Wang YK Kaplan P Francke U Jun 1996 The gene for replication factor C subunit 2 RFC2 is within the 7q11 23 Williams syndrome deletion American Journal of Human Genetics 58 6 1370 3 PMC 1915059 PMID 8651315 Uhlmann F Cai J Flores Rozas H Dean FB Finkelstein J O Donnell M Hurwitz J Jun 1996 In vitro reconstitution of human replication factor C from its five subunits Proceedings of the National Academy of Sciences of the United States of America 93 13 6521 6 Bibcode 1996PNAS 93 6521U doi 10 1073 pnas 93 13 6521 PMC 39056 PMID 8692848 Osborne LR Martindale D Scherer SW Shi XM Huizenga J Heng HH Costa T Pober B Lew L Brinkman J Rommens J Koop B Tsui LC Sep 1996 Identification of genes from a 500 kb region at 7q11 23 that is commonly deleted in Williams syndrome patients Genomics 36 2 328 36 doi 10 1006 geno 1996 0469 PMID 8812460 Cujec TP Cho H Maldonado E Meyer J Reinberg D Peterlin BM Apr 1997 The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme Molecular and Cellular Biology 17 4 1817 23 doi 10 1128 MCB 17 4 1817 PMC 232028 PMID 9121429 Cai J Gibbs E Uhlmann F Phillips B Yao N O Donnell M Hurwitz J Jul 1997 A complex consisting of human replication factor C p40 p37 and p36 subunits is a DNA dependent ATPase and an intermediate in the assembly of the holoenzyme The Journal of Biological Chemistry 272 30 18974 81 doi 10 1074 jbc 272 30 18974 PMID 9228079 Ellison V Stillman B Mar 1998 Reconstitution of recombinant human replication factor C RFC and identification of an RFC subcomplex possessing DNA dependent ATPase activity The Journal of Biological Chemistry 273 10 5979 87 doi 10 1074 jbc 273 10 5979 PMID 9488738 Zhang G Gibbs E Kelman Z O Donnell M Hurwitz J Mar 1999 Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen Proceedings of the National Academy of Sciences of the United States of America 96 5 1869 74 Bibcode 1999PNAS 96 1869Z doi 10 1073 pnas 96 5 1869 PMC 26703 PMID 10051561 Wang Y Cortez D Yazdi P Neff N Elledge SJ Qin J Apr 2000 BASC a super complex of BRCA1 associated proteins involved in the recognition and repair of aberrant DNA structures Genes amp Development 14 8 927 39 doi 10 1101 gad 14 8 927 PMC 316544 PMID 10783165 Martindale DW Wilson MD Wang D Burke RD Chen X Duronio V Koop BF Oct 2000 Comparative genomic sequence analysis of the Williams syndrome region LIMK1 RFC2 of human chromosome 7q11 23 Mammalian Genome 11 10 890 8 doi 10 1007 s003350010166 PMID 11003705 S2CID 8575994 Griffith JD Lindsey Boltz LA Sancar A May 2002 Structures of the human Rad17 replication factor C and checkpoint Rad 9 1 1 complexes visualized by glycerol spray low voltage microscopy The Journal of Biological Chemistry 277 18 15233 6 doi 10 1074 jbc C200129200 PMID 11907025 Nieborowska Skorska M Hoser G Kossev P Wasik MA Skorski T Jun 2002 Complementary functions of the antiapoptotic protein A1 and serine threonine kinase pim 1 in the BCR ABL mediated leukemogenesis Blood 99 12 4531 9 doi 10 1182 blood V99 12 4531 PMID 12036885 Ohta S Shiomi Y Sugimoto K Obuse C Tsurimoto T Oct 2002 A proteomics approach to identify proliferating cell nuclear antigen PCNA binding proteins in human cell lysates Identification of the human CHL12 RFCs2 5 complex as a novel PCNA binding protein The Journal of Biological Chemistry 277 43 40362 7 doi 10 1074 jbc M206194200 PMID 12171929 Maruyama T Farina A Dey A Cheong J Bermudez VP Tamura T Sciortino S Shuman J Hurwitz J Ozato K Sep 2002 A Mammalian bromodomain protein brd4 interacts with replication factor C and inhibits progression to S phase Molecular and Cellular Biology 22 18 6509 20 doi 10 1128 MCB 22 18 6509 6520 2002 PMC 135621 PMID 12192049 Merkle CJ Karnitz LM Henry Sanchez JT Chen J Aug 2003 Cloning and characterization of hCTF18 hCTF8 and hDCC1 Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment The Journal of Biological Chemistry 278 32 30051 6 doi 10 1074 jbc M211591200 PMID 12766176 Bermudez VP Maniwa Y Tappin I Ozato K Yokomori K Hurwitz J Sep 2003 The alternative Ctf18 Dcc1 Ctf8 replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA Proceedings of the National Academy of Sciences of the United States of America 100 18 10237 42 Bibcode 2003PNAS 10010237B doi 10 1073 pnas 1434308100 PMC 193545 PMID 12930902 Retrieved from https en wikipedia org w index php title RFC2 amp oldid 1170205267, wikipedia, wiki, book, books, library,

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