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Wikipedia

RANBP3

April 12, 2024

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.[5][6]

RANBP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRANBP3, RAN binding protein 3
External IDsOMIM: 603327 MGI: 1919060 HomoloGene: 136516 GeneCards: RANBP3
Orthologs
SpeciesHumanMouse
Entrez

8498

71810

Ensembl

ENSG00000031823

ENSMUSG00000002372

UniProt

Q9H6Z4

Q9CT10

RefSeq (mRNA)

NM_001300865
NM_003624
NM_007320
NM_007321
NM_007322

NM_001252466
NM_001252467
NM_027933

RefSeq (protein)

NP_001287794
NP_003615
NP_015559
NP_015561

NP_001239395
NP_001239396
NP_082209

Location (UCSC)Chr 19: 5.92 – 5.98 MbChr 17: 56.98 – 57.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Interactions edit

RANBP3 has been shown to interact with RCC1[5][7] and XPO1.[8][9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000031823 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002372 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251. S2CID 28405923.
  6. ^ a b "Entrez Gene: RANBP3 RAN binding protein 3".
  7. ^ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251.
  8. ^ Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735. PMID 11425870.
  9. ^ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322. S2CID 15515037.

Further reading edit

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Lindsay ME, Holaska JM, Welch K, et al. (2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. PMC 2150735. PMID 11425870.
  • Englmeier L, Fornerod M, Bischoff FR, et al. (2002). "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates". EMBO Rep. 2 (10): 926–32. doi:10.1093/embo-reports/kve200. PMC 1084078. PMID 11571268.
  • Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hakata Y, Yamada M, Shida H (2003). "A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein". Mol. Cell. Biol. 23 (23): 8751–61. doi:10.1128/MCB.23.23.8751-8761.2003. PMC 262658. PMID 14612415.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


 

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

April 12, 2024
ranbp3, binding, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2crf, 2y8f, 2y8gidentifiersaliases, binding, protein, 3external, idsomim, 603327, 1919060, homologene, 136516, genecards, gene, locat. Ran binding protein 3 is a protein that in humans is encoded by the RANBP3 gene 5 6 RANBP3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2CRF 2Y8F 2Y8GIdentifiersAliasesRANBP3 RAN binding protein 3External IDsOMIM 603327 MGI 1919060 HomoloGene 136516 GeneCards RANBP3Gene location Human Chr Chromosome 19 human 1 Band19p13 3Start5 916 139 bp 1 End5 978 142 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 DStart56 980 294 bp 2 End57 018 764 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nerveganglionic eminencestromal cell of endometriumgallbladdergastric mucosapopliteal arteryprefrontal cortexright lobe of thyroid glandcanal of the cervixanterior pituitaryTop expressed inspermatocyteyolk sacprimitive streakspermatidsecondary oocyteneural tubesomiteseminiferous tubulesuperior frontal gyrusthymusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionR SMAD binding protein binding GTPase activator activityCellular componentnucleoplasm nucleus cytoplasm centrosome nuclear poreBiological processprotein transport intracellular transport RNA export from nucleus ubiquitin dependent protein catabolic process protein import into nucleus spindle organization positive regulation of GTPase activity positive regulation of mitotic centrosome separation G1 S transition of mitotic cell cycle protein export from nucleusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez849871810EnsemblENSG00000031823ENSMUSG00000002372UniProtQ9H6Z4Q9CT10RefSeq mRNA NM 001300865NM 003624NM 007320NM 007321NM 007322NM 001252466NM 001252467NM 027933RefSeq protein NP 001287794NP 003615NP 015559NP 015561NP 001239395NP 001239396NP 082209Location UCSC Chr 19 5 92 5 98 MbChr 17 56 98 57 02 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm This protein plays a role in nuclear export as part of a heteromeric complex Alternate transcriptional splice variants encoding different isoforms have been characterized 6 Interactions editRANBP3 has been shown to interact with RCC1 5 7 and XPO1 8 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000031823 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000002372 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Mueller L Cordes VC Bischoff FR Ponstingl H July 1998 Human RanBP3 a group of nuclear RanGTP binding proteins FEBS Lett 427 3 330 6 doi 10 1016 S0014 5793 98 00459 1 PMID 9637251 S2CID 28405923 a b Entrez Gene RANBP3 RAN binding protein 3 Nemergut Michael E Lindsay Mark E Brownawell Amy M Macara Ian G May 2002 Ran binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor J Biol Chem 277 20 17385 8 doi 10 1074 jbc C100620200 ISSN 0021 9258 PMID 11932251 Lindsay M E Holaska J M Welch K Paschal B M Macara I G June 2001 Ran binding protein 3 is a cofactor for Crm1 mediated nuclear protein export J Cell Biol 153 7 1391 402 doi 10 1083 jcb 153 7 1391 ISSN 0021 9525 PMC 2150735 PMID 11425870 Lindsay Mark E Plafker Kendra Smith Alicia E Clurman Bruce E Macara Ian G August 2002 Npap60 Nup50 is a tri stable switch that stimulates importin alpha beta mediated nuclear protein import Cell 110 3 349 60 doi 10 1016 S0092 8674 02 00836 X ISSN 0092 8674 PMID 12176322 S2CID 15515037 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Lindsay ME Holaska JM Welch K et al 2001 Ran binding protein 3 is a cofactor for Crm1 mediated nuclear protein export J Cell Biol 153 7 1391 402 doi 10 1083 jcb 153 7 1391 PMC 2150735 PMID 11425870 Englmeier L Fornerod M Bischoff FR et al 2002 RanBP3 influences interactions between CRM1 and its nuclear protein export substrates EMBO Rep 2 10 926 32 doi 10 1093 embo reports kve200 PMC 1084078 PMID 11571268 Nemergut ME Lindsay ME Brownawell AM Macara IG 2002 Ran binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor J Biol Chem 277 20 17385 8 doi 10 1074 jbc C100620200 PMID 11932251 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Hakata Y Yamada M Shida H 2003 A multifunctional domain in human CRM1 exportin 1 mediates RanBP3 binding and multimerization of human T cell leukemia virus type 1 Rex protein Mol Cell Biol 23 23 8751 61 doi 10 1128 MCB 23 23 8751 8761 2003 PMC 262658 PMID 14612415 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Grimwood J Gordon LA Olsen A et al 2004 The DNA sequence and biology of human chromosome 19 Nature 428 6982 529 35 Bibcode 2004Natur 428 529G doi 10 1038 nature02399 PMID 15057824 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RANBP3 amp oldid 1171076904, wikipedia, wiki, book, books, library,

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