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Wikipedia

RALGDS

December 15, 2023

Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans.[5][6]

RALGDS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator
External IDsOMIM: 601619 MGI: 107485 HomoloGene: 4562 GeneCards: RALGDS
Orthologs
SpeciesHumanMouse
Entrez

5900

19730

Ensembl

ENSG00000160271

ENSMUSG00000026821

UniProt

Q12967

Q03385

RefSeq (mRNA)

NM_006266
NM_001042368
NM_001271774
NM_001271775
NM_001271776

NM_001145834
NM_001145835
NM_001145836
NM_009058

RefSeq (protein)

NP_001035827
NP_001258703
NP_001258704
NP_001258705
NP_006257

NP_001139306
NP_001139307
NP_001139308
NP_033084

Location (UCSC)Chr 9: 133.1 – 133.15 MbChr 2: 28.4 – 28.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

RALGDS has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160271 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026821 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Hofer F, Fields S, Schneider C, Martin GS (December 1994). "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator". Proc Natl Acad Sci U S A. 91 (23): 11089–93. Bibcode:1994PNAS...9111089H. doi:10.1073/pnas.91.23.11089. PMC 45172. PMID 7972015.
  6. ^ "Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator".
  7. ^ a b Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nat. Cell Biol. 4 (8): 547–55. doi:10.1038/ncb821. PMID 12105416. S2CID 20784208.
  8. ^ a b c d Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
  9. ^ a b Boettner B, Govek EE, Cross J, Van Aelst L (August 2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064–9. Bibcode:2000PNAS...97.9064B. doi:10.1073/pnas.97.16.9064. PMC 16822. PMID 10922060.
  10. ^ a b Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. doi:10.1101/gad.14.8.895. PMC 316541. PMID 10783161.
  11. ^ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
  12. ^ Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (February 1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. doi:10.1074/jbc.272.9.5600. PMID 9038168.
  13. ^ Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (May 1997). "Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras". Cell. 89 (3): 457–67. doi:10.1016/s0092-8674(00)80226-3. PMID 9150145. S2CID 14459536.
  14. ^ Stang S, Bottorff D, Stone JC (June 1997). "Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells". Mol. Cell. Biol. 17 (6): 3047–55. doi:10.1128/MCB.17.6.3047. PMC 232157. PMID 9154803.
  15. ^ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (November 1997). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
  16. ^ Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (October 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616. S2CID 40024826.
  17. ^ a b Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (March 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Further reading edit

  • Spaargaren M, Bischoff JR (1995). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
  • Albright CF, Giddings BW, Liu J, Vito M, Weinberg RA (1993). "Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase". EMBO J. 12 (1): 339–47. doi:10.1002/j.1460-2075.1993.tb05662.x. PMC 413211. PMID 8094051.
  • Urano T, Emkey R, Feig LA (1996). "Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation". EMBO J. 15 (4): 810–6. doi:10.1002/j.1460-2075.1996.tb00416.x. PMC 450279. PMID 8631302.
  • Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. doi:10.1074/jbc.272.9.5600. PMID 9038168.
  • Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018.
  • Geyer M, Herrmann C, Wohlgemuth S, Wittinghofer A, Kalbitzer HR (1997). "Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling". Nat. Struct. Biol. 4 (9): 694–9. doi:10.1038/nsb0997-694. hdl:11858/00-001M-0000-0024-AF7E-E. PMID 9302994. S2CID 3189922.
  • Humphrey D, Kwiatkowska J, Henske EP, Haines JL, Halley D, van Slegtenhorst M, Kwiatkowski DJ (1997). "Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1". Ann. Hum. Genet. 61 (Pt 4): 299–305. doi:10.1046/j.1469-1809.1997.6140299.x. PMID 9365783. S2CID 20453717.
  • Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (1998). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
  • Shirouzu M, Morinaka K, Koyama S, Hu CD, Hori-Tamura N, Okada T, Kariya K, Kataoka T, Kikuchi A, Yokoyama S (1998). "Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS". J. Biol. Chem. 273 (13): 7737–42. doi:10.1074/jbc.273.13.7737. PMID 9516482.
  • Okada S, Matsuda M, Anafi M, Pawson T, Pessin JE (1998). "Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes". EMBO J. 17 (9): 2554–65. doi:10.1093/emboj/17.9.2554. PMC 1170597. PMID 9564038.
  • Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
  • Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616. S2CID 40024826.
  • Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
  • Zheng Q, Yu L, Zhao Y, Sun X, Dai F, Hu P, Fu Q, Geng Z (2000). "[Refined chromosome assignment of human novel H-RalGDS gene on chromosome 9q34.1 by using radiation hybrid genebridge 4 panel]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 17 (1): 1–5. PMID 10653898.
  • Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Zheng Q, Yu L, Zhao Y, Zhang H, Fu Q, Mao N, Hu P, Geng Z, Zhao S (2001). "Structure characterization of human RalGDS gene, and the identification of its novel variant". Mol. Biol. Rep. 27 (4): 209–16. doi:10.1023/A:1011043122220. PMID 11455956. S2CID 7866224.
  • Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, Kelley GG, Der CJ (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
  • Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene. 21 (6): 937–46. doi:10.1038/sj.onc.1205144. PMID 11840339.
  • Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA (2002). "PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism". EMBO J. 21 (6): 1327–38. doi:10.1093/emboj/21.6.1327. PMC 125928. PMID 11889038.

December 15, 2023
ralgds, guanine, nucleotide, dissociation, stimulator, protein, that, encoded, gene, humans, available, structurespdbortholog, search, pdbe, rcsblist, codes1rax, 2b3a, 2rgf, 3kh0identifiersaliases, rgds, ralgef, guanine, nucleotide, dissociation, stimulatorext. Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans 5 6 RALGDSAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1RAX 2B3A 2RGF 3KH0IdentifiersAliasesRALGDS RGDS RGF RalGEF ral guanine nucleotide dissociation stimulatorExternal IDsOMIM 601619 MGI 107485 HomoloGene 4562 GeneCards RALGDSGene location Human Chr Chromosome 9 human 1 Band9q34 13 q34 2Start133 097 720 bp 1 End133 149 334 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 A3Start28 403 137 bp 2 End28 443 093 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpituitary glandanterior pituitaryskin of abdomensubstantia nigraamygdalacaudate nucleushippocampus properputamencorpus callosumnucleus accumbensTop expressed inentorhinal cortexspermatidsuperior frontal gyruslipspermatocytecerebellar cortexlensankle jointneural tubeseminiferous tubuleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding guanyl nucleotide exchange factor activity GTPase regulator activityCellular componentcytosol brush border cytoplasm nucleusBiological processsmall GTPase mediated signal transduction Ras protein signal transduction signal transduction regulation of catalytic activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez590019730EnsemblENSG00000160271ENSMUSG00000026821UniProtQ12967Q03385RefSeq mRNA NM 006266NM 001042368NM 001271774NM 001271775NM 001271776NM 001145834NM 001145835NM 001145836NM 009058RefSeq protein NP 001035827NP 001258703NP 001258704NP 001258705NP 006257NP 001139306NP 001139307NP 001139308NP 033084Location UCSC Chr 9 133 1 133 15 MbChr 2 28 4 28 44 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editRALGDS has been shown to interact with Arrestin beta 1 7 Arrestin beta 2 7 HRAS 5 8 9 10 11 12 13 14 KRAS 8 10 MRAS 15 16 RAP1A 9 17 RAP2A 17 RAPGEF2 8 and RRAS 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000160271 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026821 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Hofer F Fields S Schneider C Martin GS December 1994 Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator Proc Natl Acad Sci U S A 91 23 11089 93 Bibcode 1994PNAS 9111089H doi 10 1073 pnas 91 23 11089 PMC 45172 PMID 7972015 Entrez Gene RALGDS ral guanine nucleotide dissociation stimulator a b Bhattacharya M Anborgh PH Babwah AV Dale LB Dobransky T Benovic JL Feldman RD Verdi JM Rylett RJ Ferguson SS August 2002 Beta arrestins regulate a Ral GDS Ral effector pathway that mediates cytoskeletal reorganization Nat Cell Biol 4 8 547 55 doi 10 1038 ncb821 PMID 12105416 S2CID 20784208 a b c d Spaargaren M Bischoff JR December 1994 Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R ras H ras K ras and Rap Proc Natl Acad Sci U S A 91 26 12609 13 Bibcode 1994PNAS 9112609S doi 10 1073 pnas 91 26 12609 PMC 45488 PMID 7809086 a b Boettner B Govek EE Cross J Van Aelst L August 2000 The junctional multidomain protein AF 6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin Proc Natl Acad Sci U S A 97 16 9064 9 Bibcode 2000PNAS 97 9064B doi 10 1073 pnas 97 16 9064 PMC 16822 PMID 10922060 a b Li W Han M Guan KL April 2000 The leucine rich repeat protein SUR 8 enhances MAP kinase activation and forms a complex with Ras and Raf Genes Dev 14 8 895 900 doi 10 1101 gad 14 8 895 PMC 316541 PMID 10783161 Mitin NY Ramocki MB Zullo AJ Der CJ Konieczny SF Taparowsky EJ May 2004 Identification and characterization of rain a novel Ras interacting protein with a unique subcellular localization J Biol Chem 279 21 22353 61 doi 10 1074 jbc M312867200 PMID 15031288 Miller MJ Prigent S Kupperman E Rioux L Park SH Feramisco JR White MA Rutkowski JL Meinkoth JL February 1997 RalGDS functions in Ras and cAMP mediated growth stimulation J Biol Chem 272 9 5600 5 doi 10 1074 jbc 272 9 5600 PMID 9038168 Rodriguez Viciana P Warne PH Khwaja A Marte BM Pappin D Das P Waterfield MD Ridley A Downward J May 1997 Role of phosphoinositide 3 OH kinase in cell transformation and control of the actin cytoskeleton by Ras Cell 89 3 457 67 doi 10 1016 s0092 8674 00 80226 3 PMID 9150145 S2CID 14459536 Stang S Bottorff D Stone JC June 1997 Interaction of activated Ras with Raf 1 alone may be sufficient for transformation of rat2 cells Mol Cell Biol 17 6 3047 55 doi 10 1128 MCB 17 6 3047 PMC 232157 PMID 9154803 Kimmelman A Tolkacheva T Lorenzi MV Osada M Chan AM November 1997 Identification and characterization of R ras3 a novel member of the RAS gene family with a non ubiquitous pattern of tissue distribution Oncogene 15 22 2675 85 doi 10 1038 sj onc 1201674 PMID 9400994 Ehrhardt GR Leslie KB Lee F Wieler JS Schrader JW October 1999 M Ras a widely expressed 29 kD homologue of p21 Ras expression of a constitutively active mutant results in factor independent growth of an interleukin 3 dependent cell line Blood 94 7 2433 44 doi 10 1182 blood V94 7 2433 419k31 2433 2444 PMID 10498616 S2CID 40024826 a b Nancy V Wolthuis RM de Tand MF Janoueix Lerosey I Bos JL de Gunzburg J March 1999 Identification and characterization of potential effector molecules of the Ras related GTPase Rap2 J Biol Chem 274 13 8737 45 doi 10 1074 jbc 274 13 8737 PMID 10085114 Further reading editSpaargaren M Bischoff JR 1995 Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R ras H ras K ras and Rap Proc Natl Acad Sci U S A 91 26 12609 13 Bibcode 1994PNAS 9112609S doi 10 1073 pnas 91 26 12609 PMC 45488 PMID 7809086 Albright CF Giddings BW Liu J Vito M Weinberg RA 1993 Characterization of a guanine nucleotide dissociation stimulator for a ras related GTPase EMBO J 12 1 339 47 doi 10 1002 j 1460 2075 1993 tb05662 x PMC 413211 PMID 8094051 Urano T Emkey R Feig LA 1996 Ral GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation EMBO J 15 4 810 6 doi 10 1002 j 1460 2075 1996 tb00416 x PMC 450279 PMID 8631302 Miller MJ Prigent S Kupperman E Rioux L Park SH Feramisco JR White MA Rutkowski JL Meinkoth JL 1997 RalGDS functions in Ras and cAMP mediated growth stimulation J Biol Chem 272 9 5600 5 doi 10 1074 jbc 272 9 5600 PMID 9038168 Fukunaga R Hunter T 1997 MNK1 a new MAP kinase activated protein kinase isolated by a novel expression screening method for identifying protein kinase substrates EMBO J 16 8 1921 33 doi 10 1093 emboj 16 8 1921 PMC 1169795 PMID 9155018 Geyer M Herrmann C Wohlgemuth S Wittinghofer A Kalbitzer HR 1997 Structure of the Ras binding domain of RalGEF and implications for Ras binding and signalling Nat Struct Biol 4 9 694 9 doi 10 1038 nsb0997 694 hdl 11858 00 001M 0000 0024 AF7E E PMID 9302994 S2CID 3189922 Humphrey D Kwiatkowska J Henske EP Haines JL Halley D van Slegtenhorst M Kwiatkowski DJ 1997 Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1 Ann Hum Genet 61 Pt 4 299 305 doi 10 1046 j 1469 1809 1997 6140299 x PMID 9365783 S2CID 20453717 Kimmelman A Tolkacheva T Lorenzi MV Osada M Chan AM 1998 Identification and characterization of R ras3 a novel member of the RAS gene family with a non ubiquitous pattern of tissue distribution Oncogene 15 22 2675 85 doi 10 1038 sj onc 1201674 PMID 9400994 Shirouzu M Morinaka K Koyama S Hu CD Hori Tamura N Okada T Kariya K Kataoka T Kikuchi A Yokoyama S 1998 Interactions of the amino acid residue at position 31 of the c Ha Ras protein with Raf 1 and RalGDS J Biol Chem 273 13 7737 42 doi 10 1074 jbc 273 13 7737 PMID 9516482 Okada S Matsuda M Anafi M Pawson T Pessin JE 1998 Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2 SOS and CrkII C3G complexes EMBO J 17 9 2554 65 doi 10 1093 emboj 17 9 2554 PMC 1170597 PMID 9564038 Nancy V Wolthuis RM de Tand MF Janoueix Lerosey I Bos JL de Gunzburg J 1999 Identification and characterization of potential effector molecules of the Ras related GTPase Rap2 J Biol Chem 274 13 8737 45 doi 10 1074 jbc 274 13 8737 PMID 10085114 Ehrhardt GR Leslie KB Lee F Wieler JS Schrader JW 1999 M Ras a widely expressed 29 kD homologue of p21 Ras expression of a constitutively active mutant results in factor independent growth of an interleukin 3 dependent cell line Blood 94 7 2433 44 doi 10 1182 blood V94 7 2433 419k31 2433 2444 PMID 10498616 S2CID 40024826 Shao H Kadono Okuda K Finlin BS Andres DA 1999 Biochemical characterization of the Ras related GTPases Rit and Rin Arch Biochem Biophys 371 2 207 19 doi 10 1006 abbi 1999 1448 PMID 10545207 Zheng Q Yu L Zhao Y Sun X Dai F Hu P Fu Q Geng Z 2000 Refined chromosome assignment of human novel H RalGDS gene on chromosome 9q34 1 by using radiation hybrid genebridge 4 panel Zhonghua Yi Xue Yi Chuan Xue Za Zhi 17 1 1 5 PMID 10653898 Nagase T Kikuno R Ishikawa KI Hirosawa M Ohara O 2000 Prediction of the coding sequences of unidentified human genes XVI The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro DNA Res 7 1 65 73 doi 10 1093 dnares 7 1 65 PMID 10718198 Zheng Q Yu L Zhao Y Zhang H Fu Q Mao N Hu P Geng Z Zhao S 2001 Structure characterization of human RalGDS gene and the identification of its novel variant Mol Biol Rep 27 4 209 16 doi 10 1023 A 1011043122220 PMID 11455956 S2CID 7866224 Murphy GA Graham SM Morita S Reks SE Rogers Graham K Vojtek A Kelley GG Der CJ 2002 Involvement of phosphatidylinositol 3 kinase but not RalGDS in TC21 R Ras2 mediated transformation J Biol Chem 277 12 9966 75 doi 10 1074 jbc M109059200 PMID 11788587 Ramirez de Molina A Penalva V Lucas L Lacal JC 2002 Regulation of choline kinase activity by Ras proteins involves Ral GDS and PI3K Oncogene 21 6 937 46 doi 10 1038 sj onc 1205144 PMID 11840339 Tian X Rusanescu G Hou W Schaffhausen B Feig LA 2002 PDK1 mediates growth factor induced Ral GEF activation by a kinase independent mechanism EMBO J 21 6 1327 38 doi 10 1093 emboj 21 6 1327 PMC 125928 PMID 11889038 Retrieved from https en wikipedia org w index php title RALGDS amp oldid 1188156389, wikipedia, wiki, book, books, library,

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