Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPRgene.[5][6]
A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[7] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[8]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000186867 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000058400 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: GPR103 G protein-coupled receptor 103".
^Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
^Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
^Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
Further readingedit
Lee DK, Nguyen T, Lynch KR, et al. (2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Takayasu S, Sakurai T, Iwasaki S, et al. (2006). "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7438–43. Bibcode:2006PNAS..103.7438T. doi:10.1073/pnas.0602371103. PMC1464357. PMID 16648250.
External linksedit
"Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
pyroglutamylated, rfamide, peptide, receptor, also, known, orexigenic, neuropeptide, qrfp, receptor, protein, coupled, receptor, gpr103, protein, that, humans, encoded, qrfpr, gene, qrfpridentifiersaliasesqrfpr, aq27, gpr103, sp9155, pyroglutamylated, rfamide,. Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G protein coupled receptor 103 GPR103 is a protein that in humans is encoded by the QRFPR gene 5 6 QRFPRIdentifiersAliasesQRFPR AQ27 GPR103 SP9155 pyroglutamylated RFamide peptide receptorExternal IDsOMIM 606925 MGI 2677633 HomoloGene 18865 GeneCards QRFPRGene location Human Chr Chromosome 4 human 1 Band4q27Start121 328 642 bp 1 End121 381 059 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 BStart36 233 573 bp 2 End36 276 462 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inrenal cortexleft ventricleprefrontal cortexhypothalamussuperior frontal gyrusbone marrow cellskidneyright adrenal glandBrodmann area 9right coronary arteryTop expressed inventromedial nucleuspiriform cortextemporal lobeolfactory bulbparaventricular nucleus of hypothalamussuperior frontal gyrusatrioventricular valvesuperior colliculusamygdalahippocampus properMore reference expression dataBioGPSn aGene ontologyMolecular functionneuropeptide Y receptor activity peptide binding G protein coupled receptor activity signal transducer activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membraneBiological processcellular response to hormone stimulus neuropeptide signaling pathway signal transduction response to peptide G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez84109229214EnsemblENSG00000186867ENSMUSG00000058400UniProtQ96P65P83861RefSeq mRNA NM 198179NM 198192RefSeq protein NP 937822NP 937835Location UCSC Chr 4 121 33 121 38 MbChr 3 36 23 36 28 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editG protein coupled receptors GPCRs or GPRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins 5 A 26 amino acid RF amide peptide P518 functions as a high affinity ligand of GPR103 Both GPR103 and P518 precursor mRNA exhibited highest expression in brain 7 The 43 amino acid QRFP peptide a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103 Intravenous administration QRFP caused release of aldosterone suggesting that QRFP and GPR103 regulate adrenal function 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000186867 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000058400 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene GPR103 G protein coupled receptor 103 Lee DK Nguyen T Lynch KR Cheng R Vanti WB Arkhitko O Lewis T Evans JF George SR O Dowd BF September 2001 Discovery and mapping of ten novel G protein coupled receptor genes Gene 275 1 83 91 doi 10 1016 S0378 1119 01 00651 5 PMID 11574155 Jiang Y Luo L Gustafson EL Yadav D Laverty M Murgolo N Vassileva G Zeng M Laz TM Behan J Qiu P Wang L Wang S Bayne M Greene J Monsma F Zhang FL July 2003 Identification and characterization of a novel RF amide peptide ligand for orphan G protein coupled receptor SP9155 J Biol Chem 278 30 27652 7 doi 10 1074 jbc M302945200 PMID 12714592 Fukusumi S Yoshida H Fujii R Maruyama M Komatsu H Habata Y Shintani Y Hinuma S Fujino M November 2003 A new peptidic ligand and its receptor regulating adrenal function in rats J Biol Chem 278 47 46387 95 doi 10 1074 jbc M305270200 PMID 12960173 Further reading editLee DK Nguyen T Lynch KR et al 2001 Discovery and mapping of ten novel G protein coupled receptor genes Gene 275 1 83 91 doi 10 1016 S0378 1119 01 00651 5 PMID 11574155 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Jiang Y Luo L Gustafson EL et al 2003 Identification and characterization of a novel RF amide peptide ligand for orphan G protein coupled receptor SP9155 J Biol Chem 278 30 27652 7 doi 10 1074 jbc M302945200 PMID 12714592 Fukusumi S Yoshida H Fujii R et al 2004 A new peptidic ligand and its receptor regulating adrenal function in rats J Biol Chem 278 47 46387 95 doi 10 1074 jbc M305270200 PMID 12960173 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Takayasu S Sakurai T Iwasaki S et al 2006 A neuropeptide ligand of the G protein coupled receptor GPR103 regulates feeding behavioral arousal and blood pressure in mice Proc Natl Acad Sci U S A 103 19 7438 43 Bibcode 2006PNAS 103 7438T doi 10 1073 pnas 0602371103 PMC 1464357 PMID 16648250 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