Pyridinoline, also known as Hydroxylysylpyridinoline, is a fluorescent cross-linking compound of collagen fibers. Crosslinks in collagen and elastin are derived from lysyl and hydroxylysyl residues,[1] a process catalyzed by lysyl oxidase. Fujimoto and colleagues first described the isolation and characterization of a fluorescent material in bovine Achilles tendon collagen and termed it pyridinoline.[2] It is reported to be present in collagen of bone and cartilage, but is absent in collagen of skin. It is not present in newly synthesized collagen and is formed from aldimine cross-links during maturation of collagen fibers.[3]
Pyridinoline and deoxypyridinoline were found to be released into the blood during bone degradation and rapidly excreted in the urine. In a preliminary study, both these compounds were proposed as a marker for metastaticbone tumor in patients with prostate cancer.[4]
References
^Gallop PM, Blumenfeld OO, Seifter S (1972). "Structure and metabolism of connective tissue proteins". Annual Review of Biochemistry. 41 (1): 617–72. doi:10.1146/annurev.bi.41.070172.003153. PMID 4343456.
^Fujimoto D, Akiba K, Nakamura N (June 1977). "Isolation and characterization of a fluorescent material in bovine achilles tendon collagen". Biochemical and Biophysical Research Communications. 76 (4): 1124–9. doi:10.1016/0006-291X(77)90972-X. PMID 901463.]
^Uchiyama A, Inoue T, Fujimoto D (December 1981). "Synthesis of pyridinoline during in vitro aging of bone collagen". Journal of Biochemistry. 90 (6): 1795–8. doi:10.1093/oxfordjournals.jbchem.a133657. PMID 7334012.
^Samma S, Kagebayashi Y, Yasukawa M, et al. (February 1997). "Sequential changes of urinary pyridinoline and deoxypyridinoline as markers of metastatic bone tumor in patients with prostate cancer: a preliminary study". Japanese Journal of Clinical Oncology. 27 (1): 26–30. doi:10.1093/jjco/27.1.26. PMID 9070337.
March 06, 2023
pyridinoline, also, known, hydroxylysylpyridinoline, fluorescent, cross, linking, compound, collagen, fibers, crosslinks, collagen, elastin, derived, from, lysyl, hydroxylysyl, residues, process, catalyzed, lysyl, oxidase, fujimoto, colleagues, first, describe. Pyridinoline also known as Hydroxylysylpyridinoline is a fluorescent cross linking compound of collagen fibers Crosslinks in collagen and elastin are derived from lysyl and hydroxylysyl residues 1 a process catalyzed by lysyl oxidase Fujimoto and colleagues first described the isolation and characterization of a fluorescent material in bovine Achilles tendon collagen and termed it pyridinoline 2 It is reported to be present in collagen of bone and cartilage but is absent in collagen of skin It is not present in newly synthesized collagen and is formed from aldimine cross links during maturation of collagen fibers 3 Pyridinoline IdentifiersCAS Number 63800 01 1ChemSpider 94798PubChem CID 105068CompTox Dashboard EPA DTXSID00980373PropertiesChemical formula C 18H 28N 4O 8Molar mass 428 43692 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox references Pyridinoline and deoxypyridinoline were found to be released into the blood during bone degradation and rapidly excreted in the urine In a preliminary study both these compounds were proposed as a marker for metastatic bone tumor in patients with prostate cancer 4 References Edit Gallop PM Blumenfeld OO Seifter S 1972 Structure and metabolism of connective tissue proteins Annual Review of Biochemistry 41 1 617 72 doi 10 1146 annurev bi 41 070172 003153 PMID 4343456 Fujimoto D Akiba K Nakamura N June 1977 Isolation and characterization of a fluorescent material in bovine achilles tendon collagen Biochemical and Biophysical Research Communications 76 4 1124 9 doi 10 1016 0006 291X 77 90972 X PMID 901463 Uchiyama A Inoue T Fujimoto D December 1981 Synthesis of pyridinoline during in vitro aging of bone collagen Journal of Biochemistry 90 6 1795 8 doi 10 1093 oxfordjournals jbchem a133657 PMID 7334012 Samma S Kagebayashi Y Yasukawa M et al February 1997 Sequential changes of urinary pyridinoline and deoxypyridinoline as markers of metastatic bone tumor in patients with prostate cancer a preliminary study Japanese Journal of Clinical Oncology 27 1 26 30 doi 10 1093 jjco 27 1 26 PMID 9070337 Retrieved from https en wikipedia org w index php title Pyridinoline amp oldid 1102332433, wikipedia, wiki, book, books, library,
