Deoxypyridinoline, also called D-Pyrilinks, Pyrilinks-D, or deoxyPYD, is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones.[1] It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity. It is measured in urine tests and is used along with other bone markers such as alkaline phosphatase, osteocalcin, and N-terminal telopeptide to diagnose bone diseases such as postmenopausal osteoporosis, bone metastasis, and Paget's disease, furthermore, it has been useful in monitoring treatments that contain bone-active agents such as estrogens and bisphosphonates. [1]
Certain studies have attempted to generate a standardization of Deoxypyridinoline via an individual molar absorptivity value at acid and neutrality pH. The result was 5160 and 5290 L mol−1 cm−1 respectively.[2]
ReferencesEdit
^ abRubinacci, A; Melzi, R; Zampino, M; Soldarini, A; Villa, I (1999). "Total and free deoxypyridinoline after acute osteoclast activity inhibition". Clinical Chemistry. 45 (9): 1510–6. doi:10.1093/clinchem/45.9.1510. PMID 10471654.
^Robins, SP; Duncan, A; Wilson, N; Evans, BJ (1996). "Standardization of pyridinium crosslinks, pyridinoline and deoxypyridinoline, for use as biochemical markers of collagen degradation". Clinical Chemistry. 42 (10): 1621–6. doi:10.1093/clinchem/42.10.1621. PMID 8855145.
October 22, 2023
deoxypyridinoline, also, called, pyrilinks, pyrilinks, deoxypyd, pyridinium, cross, links, that, provide, structural, stiffness, type, collagen, found, bones, excreted, unmetabolized, urine, specific, marker, bone, resorption, osteoclastic, activity, measured,. Deoxypyridinoline also called D Pyrilinks Pyrilinks D or deoxyPYD is one of two pyridinium cross links that provide structural stiffness to type I collagen found in bones 1 It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity It is measured in urine tests and is used along with other bone markers such as alkaline phosphatase osteocalcin and N terminal telopeptide to diagnose bone diseases such as postmenopausal osteoporosis bone metastasis and Paget s disease furthermore it has been useful in monitoring treatments that contain bone active agents such as estrogens and bisphosphonates 1 Deoxypyridinoline NamesSystematic IUPAC name 2R 6 3 3S 3 Amino 3 carboxypropyl 4 2S 2 amino 3 carboxyethyl 5 hydroxypyridin 1 ium 1 yl hexanoateIdentifiersCAS Number 83462 55 9 YChemSpider 94801PubChem CID 105071UNII GXI9WV7IP9 YCompTox Dashboard EPA DTXSID701009105PropertiesChemical formula C 18H 28N 4O 7Molar mass 412 43752 g mol 1Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox references Certain studies have attempted to generate a standardization of Deoxypyridinoline via an individual molar absorptivity value at acid and neutrality pH The result was 5160 and 5290 L mol 1 cm 1 respectively 2 References Edit a b Rubinacci A Melzi R Zampino M Soldarini A Villa I 1999 Total and free deoxypyridinoline after acute osteoclast activity inhibition Clinical Chemistry 45 9 1510 6 doi 10 1093 clinchem 45 9 1510 PMID 10471654 Robins SP Duncan A Wilson N Evans BJ 1996 Standardization of pyridinium crosslinks pyridinoline and deoxypyridinoline for use as biochemical markers of collagen degradation Clinical Chemistry 42 10 1621 6 doi 10 1093 clinchem 42 10 1621 PMID 8855145 Retrieved from https en wikipedia org w index php title Deoxypyridinoline amp oldid 1175814585, wikipedia, wiki, book, books, library,
