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Wikipedia

Protein inhibitor of activated STAT2

April 17, 2024

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.[5][6][7]

PIAS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIAS2, ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, Protein inhibitor of activated STAT2, protein inhibitor of activated STAT 2
External IDsOMIM: 603567 MGI: 1096566 HomoloGene: 20979 GeneCards: PIAS2
Orthologs
SpeciesHumanMouse
Entrez

9063

17344

Ensembl

ENSG00000078043

ENSMUSG00000025423

UniProt

O75928

Q8C5D8

RefSeq (mRNA)

NM_001164167
NM_001164168
NM_001164169
NM_001164170
NM_008602

RefSeq (protein)

NP_001157639
NP_001157640
NP_001157641
NP_001157642
NP_032628

Location (UCSC)Chr 18: 46.8 – 46.92 MbChr 18: 77.15 – 77.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

Protein inhibitor of activated STAT2 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078043 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025423 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–31. Bibcode:1998PNAS...9510626L. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.
  6. ^ Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (September 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech Dev. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. S2CID 11835268.
  7. ^ "Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2".
  8. ^ Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA (December 2000). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. 14 (12): 1986–2000. doi:10.1210/mend.14.12.0569. PMID 11117529.
  9. ^ Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA, Palvimo JJ (February 1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins". J. Biol. Chem. 274 (6): 3700–4. doi:10.1074/jbc.274.6.3700. PMID 9920921.
  10. ^ Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD (2004). "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. 32 (2): 598–610. doi:10.1093/nar/gkh195. PMC 373322. PMID 14752048.
  11. ^ Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (October 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.
  12. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  13. ^ Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (December 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.

Further reading edit

  • Cookson MR (2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. doi:10.1016/S0896-6273(02)01166-2. PMID 12526767. S2CID 14513509.
  • Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA, Palvimo JJ (1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins". J. Biol. Chem. 274 (6): 3700–4. doi:10.1074/jbc.274.6.3700. PMID 9920921.
  • Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.
  • Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. 14 (12): 1986–2000. doi:10.1210/mend.14.12.0569. PMID 11117529.
  • Gross M, Liu B, Tan J, French FS, Carey M, Shuai K (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells". Oncogene. 20 (29): 3880–7. doi:10.1038/sj.onc.1204489. PMID 11439351. S2CID 12895068.
  • Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.
  • Schmidt D, Müller S (2002). "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872–7. Bibcode:2002PNAS...99.2872S. doi:10.1073/pnas.052559499. PMC 122440. PMID 11867732.
  • Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators". J. Biol. Chem. 277 (19): 16993–7001. doi:10.1074/jbc.M109217200. PMID 11877418.
  • Nishida T, Yasuda H (2003). "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription". J. Biol. Chem. 277 (44): 41311–7. doi:10.1074/jbc.M206741200. PMID 12177000.
  • Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I". J. Biol. Chem. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.
  • Tussié-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL (2002). "Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12807–12. Bibcode:2002PNAS...9912807T. doi:10.1073/pnas.192464499. PMC 130541. PMID 12239342.
  • Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H (2003). "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes". J. Biol. Chem. 277 (51): 50131–6. doi:10.1074/jbc.M208319200. PMID 12393906.
  • Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K (2003). "PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4". J. Biol. Chem. 278 (24): 21327–30. doi:10.1074/jbc.C300119200. PMID 12716907.
  • Ohshima T, Shimotohno K (2004). "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4". J. Biol. Chem. 278 (51): 50833–42. doi:10.1074/jbc.M307533200. PMID 14514699.
  • Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.


 

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

April 17, 2024
protein, inhibitor, activated, stat2, sumo, protein, ligase, pias2, enzyme, that, humans, encoded, pias2, gene, pias2available, structurespdbortholog, search, pdbe, rcsblist, codes2asq, 4fo9identifiersaliasespias2, arip3, miz1, piasx, piasx, alpha, piasx, beta. E3 SUMO protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene 5 6 7 PIAS2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2ASQ 4FO9IdentifiersAliasesPIAS2 ARIP3 DIP MIZ MIZ1 PIASX PIASX ALPHA PIASX BETA SIZ2 ZMIZ4 Protein inhibitor of activated STAT2 protein inhibitor of activated STAT 2External IDsOMIM 603567 MGI 1096566 HomoloGene 20979 GeneCards PIAS2Gene location Human Chr Chromosome 18 human 1 Band18q21 1Start46 803 218 bp 1 End46 920 160 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 18 E3Start77 152 904 bp 2 End77 241 496 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermsecondary oocytegastrocnemius musclecerebellar vermisinternal globus pallidusAchilles tendoncorpus callosumponsprefrontal cortexpostcentral gyrusTop expressed inseminiferous tubulespermatidspermatocyteganglionic eminencelensmedial ganglionic eminenceabdominal wallsecondary oocyteneural tubesubstantia nigraMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription coactivator activity zinc ion binding transcription factor binding metal ion binding SUMO ligase activity ligase activity protein binding androgen receptor binding ubiquitin protein ligase binding SUMO transferase activity transferase activityCellular componentPML body nuclear speck nuclear body nucleoplasm nucleusBiological processandrogen receptor signaling pathway regulation of transcription DNA templated regulation of transcription by RNA polymerase II negative regulation of androgen receptor signaling pathway negative regulation of DNA binding transcription factor activity transcription DNA templated positive regulation of transcription DNA templated regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II protein sumoylationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez906317344EnsemblENSG00000078043ENSMUSG00000025423UniProtO75928Q8C5D8RefSeq mRNA NM 004671NM 173206NM 001324046NM 001324047NM 001324048NM 001324049NM 001324051NM 001324052NM 001324053NM 001324054NM 001324055NM 001324057NM 001324058NM 001324059NM 001324060NM 001354033NM 001354034NM 001354035NM 001354036NM 001354037NM 001354038NM 001354039NM 001164167NM 001164168NM 001164169NM 001164170NM 008602RefSeq protein NP 001310975NP 001310976NP 001310977NP 001310978NP 001310980NP 001310981NP 001310982NP 001310983NP 001310984NP 001310986NP 001310987NP 001310988NP 001310989NP 004662NP 775298NP 001340962NP 001340963NP 001340964NP 001340965NP 001340966NP 001340967NP 001340968NP 001157639NP 001157640NP 001157641NP 001157642NP 032628Location UCSC Chr 18 46 8 46 92 MbChr 18 77 15 77 24 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editProtein inhibitor of activated STAT2 has been shown to interact with Androgen receptor 8 9 DNMT3A 10 PARK7 11 and UBE2I 12 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000078043 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025423 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Liu B Liao J Rao X Kushner SA Chung CD Chang DD Shuai K September 1998 Inhibition of Stat1 mediated gene activation by PIAS1 Proc Natl Acad Sci U S A 95 18 10626 31 Bibcode 1998PNAS 9510626L doi 10 1073 pnas 95 18 10626 PMC 27945 PMID 9724754 Wu L Wu H Ma L Sangiorgi F Wu N Bell JR Lyons GE Maxson R September 1997 Miz1 a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA Mech Dev 65 1 2 3 17 doi 10 1016 S0925 4773 97 00032 4 PMID 9256341 S2CID 11835268 Entrez Gene PIAS2 protein inhibitor of activated STAT 2 Kotaja N Aittomaki S Silvennoinen O Palvimo JJ Janne OA December 2000 ARIP3 androgen receptor interacting protein 3 and other PIAS protein inhibitor of activated STAT proteins differ in their ability to modulate steroid receptor dependent transcriptional activation Mol Endocrinol 14 12 1986 2000 doi 10 1210 mend 14 12 0569 PMID 11117529 Moilanen AM Karvonen U Poukka H Yan W Toppari J Janne OA Palvimo JJ February 1999 A testis specific androgen receptor coregulator that belongs to a novel family of nuclear proteins J Biol Chem 274 6 3700 4 doi 10 1074 jbc 274 6 3700 PMID 9920921 Ling Y Sankpal UT Robertson AK McNally JG Karpova T Robertson KD 2004 Modification of de novo DNA methyltransferase 3a Dnmt3a by SUMO 1 modulates its interaction with histone deacetylases HDACs and its capacity to repress transcription Nucleic Acids Res 32 2 598 610 doi 10 1093 nar gkh195 PMC 373322 PMID 14752048 Takahashi K Taira T Niki T Seino C Iguchi Ariga SM Ariga H October 2001 DJ 1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor J Biol Chem 276 40 37556 63 doi 10 1074 jbc M101730200 PMID 11477070 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Lee BH Yoshimatsu K Maeda A Ochiai K Morimatsu M Araki K Ogino M Morikawa S Arikawa J December 2003 Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin like modifier 1 related molecules Virus Res 98 1 83 91 doi 10 1016 j virusres 2003 09 001 PMID 14609633 Further reading editCookson MR 2003 Pathways to Parkinsonism Neuron 37 1 7 10 doi 10 1016 S0896 6273 02 01166 2 PMID 12526767 S2CID 14513509 Moilanen AM Karvonen U Poukka H Yan W Toppari J Janne OA Palvimo JJ 1999 A testis specific androgen receptor coregulator that belongs to a novel family of nuclear proteins J Biol Chem 274 6 3700 4 doi 10 1074 jbc 274 6 3700 PMID 9920921 Minty A Dumont X Kaghad M Caput D 2000 Covalent modification of p73alpha by SUMO 1 Two hybrid screening with p73 identifies novel SUMO 1 interacting proteins and a SUMO 1 interaction motif J Biol Chem 275 46 36316 23 doi 10 1074 jbc M004293200 PMID 10961991 Kotaja N Aittomaki S Silvennoinen O Palvimo JJ Janne OA 2001 ARIP3 androgen receptor interacting protein 3 and other PIAS protein inhibitor of activated STAT proteins differ in their ability to modulate steroid receptor dependent transcriptional activation Mol Endocrinol 14 12 1986 2000 doi 10 1210 mend 14 12 0569 PMID 11117529 Gross M Liu B Tan J French FS Carey M Shuai K 2001 Distinct effects of PIAS proteins on androgen mediated gene activation in prostate cancer cells Oncogene 20 29 3880 7 doi 10 1038 sj onc 1204489 PMID 11439351 S2CID 12895068 Takahashi K Taira T Niki T Seino C Iguchi Ariga SM Ariga H 2001 DJ 1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor J Biol Chem 276 40 37556 63 doi 10 1074 jbc M101730200 PMID 11477070 Schmidt D Muller S 2002 Members of the PIAS family act as SUMO ligases for c Jun and p53 and repress p53 activity Proc Natl Acad Sci U S A 99 5 2872 7 Bibcode 2002PNAS 99 2872S doi 10 1073 pnas 052559499 PMC 122440 PMID 11867732 Tan JA Hall SH Hamil KG Grossman G Petrusz P French FS 2002 Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators J Biol Chem 277 19 16993 7001 doi 10 1074 jbc M109217200 PMID 11877418 Nishida T Yasuda H 2003 PIAS1 and PIASxalpha function as SUMO E3 ligases toward androgen receptor and repress androgen receptor dependent transcription J Biol Chem 277 44 41311 7 doi 10 1074 jbc M206741200 PMID 12177000 Tussie Luna MI Michel B Hakre S Roy AL 2003 The SUMO ubiquitin protein isopeptide ligase family member Miz1 PIASxbeta Siz2 is a transcriptional cofactor for TFII I J Biol Chem 277 45 43185 93 doi 10 1074 jbc M207635200 PMID 12193603 Tussie Luna MI Bayarsaihan D Seto E Ruddle FH Roy AL 2002 Physical and functional interactions of histone deacetylase 3 with TFII I family proteins and PIASxbeta Proc Natl Acad Sci U S A 99 20 12807 12 Bibcode 2002PNAS 9912807T doi 10 1073 pnas 192464499 PMC 130541 PMID 12239342 Miyauchi Y Yogosawa S Honda R Nishida T Yasuda H 2003 Sumoylation of Mdm2 by protein inhibitor of activated STAT PIAS and RanBP2 enzymes J Biol Chem 277 51 50131 6 doi 10 1074 jbc M208319200 PMID 12393906 Arora T Liu B He H Kim J Murphy TL Murphy KM Modlin RL Shuai K 2003 PIASx is a transcriptional co repressor of signal transducer and activator of transcription 4 J Biol Chem 278 24 21327 30 doi 10 1074 jbc C300119200 PMID 12716907 Ohshima T Shimotohno K 2004 Transforming growth factor beta mediated signaling via the p38 MAP kinase pathway activates Smad dependent transcription through SUMO 1 modification of Smad4 J Biol Chem 278 51 50833 42 doi 10 1074 jbc M307533200 PMID 14514699 Lee BH Yoshimatsu K Maeda A Ochiai K Morimatsu M Araki K Ogino M Morikawa S Arikawa J 2004 Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin like modifier 1 related molecules Virus Res 98 1 83 91 doi 10 1016 j virusres 2003 09 001 PMID 14609633 Lehner B Semple JI Brown SE Counsell D Campbell RD Sanderson CM 2004 Analysis of a high throughput yeast two hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region Genomics 83 1 153 67 doi 10 1016 S0888 7543 03 00235 0 PMID 14667819 nbsp This article on a gene on human chromosome 18 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Protein inhibitor of activated STAT2 amp oldid 1191459596, wikipedia, wiki, book, books, library,

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