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Potassium canrenoate

February 20, 2024

Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium,[1] the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.[2] Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body.[3][4]

Potassium canrenoate
Clinical data
Other namesSC-14266
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Intravenous
ATC code
Pharmacokinetic data
MetabolismHepatic
ExcretionRenal and fecal
Identifiers
  • potassium 3-[(8R,9S,10R,13S,14S,17R)-
    17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,
    11,12,14,15,16-octahydro-1H-cyclopenta[a]
    phenanthren-17-yl]propanoate
CAS Number
  • 2181-04-6 N
PubChem CID
  • 23671691
DrugBank
  • DB09015 N
ChemSpider
  • 570975 Y
UNII
  • M671F9NLEA
ChEMBL
  • ChEMBL1371200 N
CompTox Dashboard (EPA)
  • DTXSID2045602
ECHA InfoCard100.016.868
Chemical and physical data
FormulaC22H29KO4
Molar mass396.568 g·mol−1
3D model (JSmol)
  • Interactive image
  • [K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C
  • InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1 Y
  • Key:JTZQCHFUGHIPDF-RYVBEKKQSA-M Y
 NY (what is this?)  (verify)

Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous)[4][5] as opposed to oral administration.[6]

In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.

See also edit

References edit

  1. ^ Selye H (17 April 2013). Hormones and Resistance: Part 1 and. Springer Science & Business Media. pp. 186–. ISBN 978-3-642-65192-2.
  2. ^ Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991). Dictionary of Steroids. CRC Press. pp. 656–. ISBN 978-0-412-27060-4.
  3. ^ Burger A, Wolff ME (1996). Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents. Wiley. ISBN 978-0-471-57557-3.
  4. ^ a b Waldmann C, Soni N, Rhodes A (27 November 2008). "Diurectics and the Critical Ill". Oxford Desk Reference: Critical Care. OUP Oxford. pp. 187–. ISBN 978-0-19-922958-1.
  5. ^ Santambrogio R, Barabino M, Opocher E (21 June 2017). "Non-resection: Radiofrequency Ablation, Cryo, Microwave". In Bonjer HJ (ed.). Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES). Springer. pp. 136–. ISBN 978-3-319-43196-3.
  6. ^ Kolkhof P, Bärfacker L (July 2017). "30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development". The Journal of Endocrinology. 234 (1): T125–T140. doi:10.1530/JOE-16-0600. PMC 5488394. PMID 28634268.
 

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

February 20, 2024
potassium, canrenoate, canrenoate, potassium, usan, brand, names, venactone, soldactone, also, known, aldadiene, kalium, potassium, salt, canrenoic, acid, aldosterone, antagonist, spirolactone, group, like, spironolactone, prodrug, metabolized, active, canreno. Potassium canrenoate INN JAN or canrenoate potassium USAN brand names Venactone Soldactone also known as aldadiene kalium 1 the potassium salt of canrenoic acid is an aldosterone antagonist of the spirolactone group 2 Like spironolactone it is a prodrug and is metabolized to active canrenone in the body 3 4 Potassium canrenoateClinical dataOther namesSC 14266AHFS Drugs comInternational Drug NamesRoutes ofadministrationIntravenousATC codeC03DA02 WHO Pharmacokinetic dataMetabolismHepaticExcretionRenal and fecalIdentifiersIUPAC name potassium 3 8R 9S 10R 13S 14S 17R 17 hydroxy 10 13 dimethyl 3 oxo 2 8 9 11 12 14 15 16 octahydro 1H cyclopenta a phenanthren 17 yl propanoateCAS Number2181 04 6 NPubChem CID23671691DrugBankDB09015 NChemSpider570975 YUNIIM671F9NLEAChEMBLChEMBL1371200 NCompTox Dashboard EPA DTXSID2045602ECHA InfoCard100 016 868Chemical and physical dataFormulaC 22H 29K O 4Molar mass396 568 g mol 13D model JSmol Interactive imageSMILES K O C O CC C 3 O CC C H 2 C H 4 C C C1 C C O CC C 1 C H 4CC C 23C CInChI InChI 1S C22H30O4 K c1 20 9 5 15 23 13 14 20 3 4 16 17 20 6 10 21 2 18 16 7 11 22 21 26 12 8 19 24 25 h3 4 13 16 18 26H 5 12H2 1 2H3 H 24 25 q 1 p 1 t16 17 18 20 21 22 m1 s1 YKey JTZQCHFUGHIPDF RYVBEKKQSA M Y N Y what is this verify Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration specifically intravenous 4 5 as opposed to oral administration 6 In the UK it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring See also editCanrenoic acid CanrenoneReferences edit Selye H 17 April 2013 Hormones and Resistance Part 1 and Springer Science amp Business Media pp 186 ISBN 978 3 642 65192 2 Hill RA Makin HL Kirk DN Murphy GM 23 May 1991 Dictionary of Steroids CRC Press pp 656 ISBN 978 0 412 27060 4 Burger A Wolff ME 1996 Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents Wiley ISBN 978 0 471 57557 3 a b Waldmann C Soni N Rhodes A 27 November 2008 Diurectics and the Critical Ill Oxford Desk Reference Critical Care OUP Oxford pp 187 ISBN 978 0 19 922958 1 Santambrogio R Barabino M Opocher E 21 June 2017 Non resection Radiofrequency Ablation Cryo Microwave In Bonjer HJ ed Surgical Principles of Minimally Invasive Procedures Manual of the European Association of Endoscopic Surgery EAES Springer pp 136 ISBN 978 3 319 43196 3 Kolkhof P Barfacker L July 2017 30 YEARS OF THE MINERALOCORTICOID RECEPTOR Mineralocorticoid receptor antagonists 60 years of research and development The Journal of Endocrinology 234 1 T125 T140 doi 10 1530 JOE 16 0600 PMC 5488394 PMID 28634268 nbsp This drug article relating to the cardiovascular system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Potassium canrenoate amp oldid 1187574409, wikipedia, wiki, book, books, library,

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