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Postcholecystectomy syndrome

January 01, 1970

Postcholecystectomy syndrome (PCS) describes the presence of abdominal symptoms after a cholecystectomy (gallbladder removal).

Postcholecystectomy syndrome
SpecialtyGastroenterology 

Symptoms occur in about 5 to 40 percent of patients who undergo cholecystectomy,[1] and can be transient, persistent or lifelong.[2][3] The chronic condition is diagnosed in approximately 10% of postcholecystectomy cases.

The pain associated with postcholecystectomy syndrome is usually ascribed to either sphincter of Oddi dysfunction or to post-surgical adhesions.[4] A recent 2008 study shows that postcholecystectomy syndrome can be caused by biliary microlithiasis.[5] Approximately 50% of cases are due to biliary causes such as remaining stone, biliary injury, dysmotility and choledococyst. The remaining 50% are due to non-biliary causes. This is because upper abdominal pain and gallstones are both common but are not always related.

Non-biliary causes of PCS may be caused by a functional gastrointestinal disorder, such as functional dyspepsia.[6]

Chronic diarrhea in postcholecystectomy syndrome is a type of bile acid diarrhea (type 3).[3] This can be treated with a bile acid sequestrant like cholestyramine,[3] colestipol[2] or colesevelam,[7] which may be better tolerated.[8]

Presentation edit

Symptoms of postcholecystectomy syndrome may include:[9]

Diagnostics edit

Treatment edit

Some individuals may benefit from diet modification, such as a reduced fat diet, following cholecystectomy. The liver produces bile and the gallbladder acts as reservoir. From the gallbladder, bile enters the intestine in individual portions. In the absence of a gallbladder, bile enters the intestine constantly, but in small quantities. Thus, it may be insufficient for the digestion of fatty foods. Postcholecystectomy syndrome treatment depends on the identified violations that led to it. Typically, the patient is recommended a dietary restriction table with fatty foods, enzyme preparations, antispasmodics, and sometimes cholagogue.[citation needed]

If the pain is caused by biliary microlithiasis, oral ursodeoxycholic acid can alleviate the condition.[5]

A trial of bile acid sequestrant therapy is recommended for bile acid diarrhea.[2][8]

Functional dyspepsia is subdivided into Epigastric Distress Syndrome (EPS) and Post-Prandial Distress Syndrome (PDS).[11] Treatment for EPS and PDS can both include proton pump inhibitors and dopamine antagonists. Tricyclic antidepressants have also been proven effective for nausea, vomiting, early satiety, impaired motility and other related symptoms.[12]

When investigation reveals no abnormalities within the abdominal cavity, the attending physician may consider Anterior cutaneous nerve entrapment syndrome (ACNES) as a possible cause. ACNES may present with pseudovisceral symptoms, including nausea, bloating, diarrhea and early satiety.[13]

References edit

  1. ^ . WebMD. Archived from the original on 2007-07-02. Retrieved 2009-03-07.
  2. ^ a b c Danley T, St Anna L (October 2011). "Postcholecystectomy diarrhea: What relieves it?". The Journal of Family Practice. 60 (10): 632c–d. PMID 21977493.
  3. ^ a b c Sciarretta G, Furno A, Mazzoni M, Malaguti P (December 1992). "Post-cholecystectomy diarrhea: evidence of bile acid malabsorption assessed by SeHCAT test". The American Journal of Gastroenterology. 87 (12): 1852–4. PMID 1449156.
  4. ^ Hyvärinen H, Sipponen P, Silvennoinen E (December 1990). "Intestinal adhesions: an overlooked cause of the postcholecystectomy syndrome". Hepatogastroenterology. 37 (Suppl 2): 58–61. PMID 2083937.
  5. ^ a b Okoro N, Patel A, Goldstein M, Narahari N, Cai Q (July 2008). "Ursodeoxycholic acid treatment for patients with postcholecystectomy pain and bile microlithiasis". Gastrointestinal Endoscopy. 68 (1): 69–74. doi:10.1016/j.gie.2007.09.046. PMID 18577477.
  6. ^ Schmidt M, Søndenaa K, Dumot JA, Rosenblatt S, Hausken T, Ramnefjell M, Njølstad G, Eide GE (28 March 2012). "Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder". World Journal of Gastroenterology. 18 (12): 1365–72. doi:10.3748/wjg.v18.i12.1365. PMC 3319963. PMID 22493550.
  7. ^ Odunsi-Shiyanbade ST, Camilleri M, McKinzie S, et al. (February 2010). "Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function". Clinical Gastroenterology and Hepatology. 8 (2): 159–65. doi:10.1016/j.cgh.2009.10.020. PMC 2822105. PMID 19879973.
  8. ^ a b Mottacki N, Simrén M, Bajor A (2016). "Review article: bile acid diarrhoea - pathogenesis, diagnosis and management". Aliment. Pharmacol. Ther. 43 (8): 884–898. doi:10.1111/apt.13570. PMID 26913381.
  9. ^ nhs.uk, Complications of a gallbladder removal
  10. ^ Lamberts MP, Lugtenberg M, Rovers MM, Roukema AJ, Drenth JP, Westert GP, van Laarhoven CJ (2013). "Persistent and de novo symptoms after cholecystectomy: a systematic review of cholecystectomy effectiveness". Surg Endosc. 27 (3): 709–18. doi:10.1007/s00464-012-2516-9. PMID 23052498. S2CID 206999263.
  11. ^ Shin CM (July 2013). "Overlap between postprandial distress and epigastric pain syndromes in functional dyspepsia: its implications for research and clinical practice (am j gastroenterol 2013;108:767-774)". Journal of Neurogastroenterology and Motility. 19 (3): 409–11. doi:10.5056/jnm.2013.19.3.409. PMC 3714422. PMID 23875111.
  12. ^ Talley NJ, Herrick L, Locke GR (February 2010). "Antidepressants in functional dyspepsia". Expert Review of Gastroenterology & Hepatology. 4 (1): 5–8. doi:10.1586/egh.09.73. PMC 4070655. PMID 20136584.
  13. ^ Suleiman, Saud; Johnston, David E. (August 2001). "The Abdominal Wall: An Overlooked Source of Pain". American Family Physician. 64 (3): 431–438. PMID 11515832.

External links edit

January 01, 1970
postcholecystectomy, syndrome, describes, presence, abdominal, symptoms, after, cholecystectomy, gallbladder, removal, specialtygastroenterology, symptoms, occur, about, percent, patients, undergo, cholecystectomy, transient, persistent, lifelong, chronic, con. Postcholecystectomy syndrome PCS describes the presence of abdominal symptoms after a cholecystectomy gallbladder removal Postcholecystectomy syndromeSpecialtyGastroenterology Symptoms occur in about 5 to 40 percent of patients who undergo cholecystectomy 1 and can be transient persistent or lifelong 2 3 The chronic condition is diagnosed in approximately 10 of postcholecystectomy cases The pain associated with postcholecystectomy syndrome is usually ascribed to either sphincter of Oddi dysfunction or to post surgical adhesions 4 A recent 2008 study shows that postcholecystectomy syndrome can be caused by biliary microlithiasis 5 Approximately 50 of cases are due to biliary causes such as remaining stone biliary injury dysmotility and choledococyst The remaining 50 are due to non biliary causes This is because upper abdominal pain and gallstones are both common but are not always related Non biliary causes of PCS may be caused by a functional gastrointestinal disorder such as functional dyspepsia 6 Chronic diarrhea in postcholecystectomy syndrome is a type of bile acid diarrhea type 3 3 This can be treated with a bile acid sequestrant like cholestyramine 3 colestipol 2 or colesevelam 7 which may be better tolerated 8 Contents 1 Presentation 2 Diagnostics 3 Treatment 4 References 5 External linksPresentation editSymptoms of postcholecystectomy syndrome may include 9 Dyspepsia nausea and vomiting Flatulence bloating and diarrhea Persistent pain in the upper right abdomen 10 Diagnostics editUltrasound of the abdominal cavity General and biochemical blood Intravenous cholangiography Esophagogastroduodenoscopy for examination of the stomach duodenum and the area major duodenal papilla Retrograde cholangiopancreatography Analysis of biliary sludge obtained through endoscopic retrograde cholangiopancreatography ERCP SeHCAT or other test for bile acid diarrheaTreatment editSome individuals may benefit from diet modification such as a reduced fat diet following cholecystectomy The liver produces bile and the gallbladder acts as reservoir From the gallbladder bile enters the intestine in individual portions In the absence of a gallbladder bile enters the intestine constantly but in small quantities Thus it may be insufficient for the digestion of fatty foods Postcholecystectomy syndrome treatment depends on the identified violations that led to it Typically the patient is recommended a dietary restriction table with fatty foods enzyme preparations antispasmodics and sometimes cholagogue citation needed If the pain is caused by biliary microlithiasis oral ursodeoxycholic acid can alleviate the condition 5 A trial of bile acid sequestrant therapy is recommended for bile acid diarrhea 2 8 Functional dyspepsia is subdivided into Epigastric Distress Syndrome EPS and Post Prandial Distress Syndrome PDS 11 Treatment for EPS and PDS can both include proton pump inhibitors and dopamine antagonists Tricyclic antidepressants have also been proven effective for nausea vomiting early satiety impaired motility and other related symptoms 12 When investigation reveals no abnormalities within the abdominal cavity the attending physician may consider Anterior cutaneous nerve entrapment syndrome ACNES as a possible cause ACNES may present with pseudovisceral symptoms including nausea bloating diarrhea and early satiety 13 References edit Postcholecystectomy syndrome WebMD Archived from the original on 2007 07 02 Retrieved 2009 03 07 a b c Danley T St Anna L October 2011 Postcholecystectomy diarrhea What relieves it The Journal of Family Practice 60 10 632c d PMID 21977493 a b c Sciarretta G Furno A Mazzoni M Malaguti P December 1992 Post cholecystectomy diarrhea evidence of bile acid malabsorption assessed by SeHCAT test The American Journal of Gastroenterology 87 12 1852 4 PMID 1449156 Hyvarinen H Sipponen P Silvennoinen E December 1990 Intestinal adhesions an overlooked cause of the postcholecystectomy syndrome Hepatogastroenterology 37 Suppl 2 58 61 PMID 2083937 a b Okoro N Patel A Goldstein M Narahari N Cai Q July 2008 Ursodeoxycholic acid treatment for patients with postcholecystectomy pain and bile microlithiasis Gastrointestinal Endoscopy 68 1 69 74 doi 10 1016 j gie 2007 09 046 PMID 18577477 Schmidt M Sondenaa K Dumot JA Rosenblatt S Hausken T Ramnefjell M Njolstad G Eide GE 28 March 2012 Post cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder World Journal of Gastroenterology 18 12 1365 72 doi 10 3748 wjg v18 i12 1365 PMC 3319963 PMID 22493550 Odunsi Shiyanbade ST Camilleri M McKinzie S et al February 2010 Effects of chenodeoxycholate and a bile acid sequestrant colesevelam on intestinal transit and bowel function Clinical Gastroenterology and Hepatology 8 2 159 65 doi 10 1016 j cgh 2009 10 020 PMC 2822105 PMID 19879973 a b Mottacki N Simren M Bajor A 2016 Review article bile acid diarrhoea pathogenesis diagnosis and management Aliment Pharmacol Ther 43 8 884 898 doi 10 1111 apt 13570 PMID 26913381 nhs uk Complications of a gallbladder removal Lamberts MP Lugtenberg M Rovers MM Roukema AJ Drenth JP Westert GP van Laarhoven CJ 2013 Persistent and de novo symptoms after cholecystectomy a systematic review of cholecystectomy effectiveness Surg Endosc 27 3 709 18 doi 10 1007 s00464 012 2516 9 PMID 23052498 S2CID 206999263 Shin CM July 2013 Overlap between postprandial distress and epigastric pain syndromes in functional dyspepsia its implications for research and clinical practice am j gastroenterol 2013 108 767 774 Journal of Neurogastroenterology and Motility 19 3 409 11 doi 10 5056 jnm 2013 19 3 409 PMC 3714422 PMID 23875111 Talley NJ Herrick L Locke GR February 2010 Antidepressants in functional dyspepsia Expert Review of Gastroenterology amp Hepatology 4 1 5 8 doi 10 1586 egh 09 73 PMC 4070655 PMID 20136584 Suleiman Saud Johnston David E August 2001 The Abdominal Wall An Overlooked Source of Pain American Family Physician 64 3 431 438 PMID 11515832 External links edit Retrieved from https en wikipedia org w index php title Postcholecystectomy syndrome amp oldid 1174266745, wikipedia, wiki, book, books, library,

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