Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).
The cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets.[1] PVPP is a highly cross-linked version of PVP, making it insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets.
It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced.[2] One such commercial product is called Polyclar. PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.[3]
^(PDF). Archived from the original (PDF) on 2015-09-06. Retrieved 2017-05-19.
February 16, 2024
polyvinylpolypyrrolidone, polyvinyl, polypyrrolidone, pvpp, crospovidone, crospolividone, e1202, highly, cross, linked, modification, polyvinylpyrrolidone, namesiupac, name, ethenylpyrrolidin, oneother, names, polyvinyl, polypyrrolidone, crospovidone, crospoli. Polyvinylpolypyrrolidone polyvinyl polypyrrolidone PVPP crospovidone crospolividone or E1202 is a highly cross linked modification of polyvinylpyrrolidone PVP Polyvinylpolypyrrolidone NamesIUPAC name 1 ethenylpyrrolidin 2 oneOther names Polyvinyl polypyrrolidone crospovidone crospolividone E1202 Kollidon CLIdentifiersCAS Number 25249 54 1Abbreviations PVPPChemSpider noneECHA InfoCard 100 110 608E number E1202 additional chemicals PharmacologyATC code A07BC03 WHO Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox references The cross linked form of PVP is used as a disintegrant see also excipients in pharmaceutical tablets 1 PVPP is a highly cross linked version of PVP making it insoluble in water though it still absorbs water and swells very rapidly generating a swelling force This property makes it useful as a disintegrant in tablets PVPP can be used as a drug taken as a tablet or suspension to absorb compounds so called endotoxins that cause diarrhea Cf bone char charcoal It is also used as a fining to extract impurities via agglomeration followed by filtration It is used in winemaking Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced 2 One such commercial product is called Polyclar PVPP forms bonds similar to peptidic bonds in protein especially like proline residues and that is why it can precipitate tannins the same way as proteins do 3 PVPP has E number code E1202 and is used as a stabiliser See also editPolyethylene glycol polyvinyl alcoholReferences edit Povidones Copovidones and Crospovidones for Pharmaceutical Products BASF Pharma Retrieved 2022 06 11 Microsoft Word G0294 doc dead link A Novel Stabilization of Beer with Polyclar Brewbrite Mustafa Rehmanji Chandra Gopal and Andrew Mola MBAA TQ vol 39 no 1 2002 pp 24 28 PDF Archived from the original PDF on 2015 09 06 Retrieved 2017 05 19 Retrieved from https en wikipedia org w index php title Polyvinylpolypyrrolidone amp oldid 1092644319, wikipedia, wiki, book, books, library,
