Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly(I:C)) is an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.[1]
Poly I:C is known to interact with toll-like receptor 3 (TLR3), which is expressed at the endosomal membrane of B-cells, macrophages and dendritic cells. Poly I:C is structurally similar to double-stranded RNA, which is present in some viruses and is a "natural" stimulant of TLR3. Thus, Poly I:C can be considered a syntheticanalog of double-stranded RNA and is a common tool for scientific research on the immune system.[2]
Poly I:C has been shown to activate schizophrenia-like behavior in the offspring of pregnant mice, which can be accompanied by decreased GABAergic transmission in the dentate gyrus.[3]
Optimization of physicochemical properties of poly I:C has led to generation of derivatives that have increased stability in body fluids (such as polyICLC), or reduced toxicity through reduced stability in body fluids (such as poly I:C12U).[4]
Referencesedit
^Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN (October 2004). "The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 287 (4): R759–R766. doi:10.1152/ajpregu.00293.2004. PMID 15205185. S2CID 24028101.
^Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, et al. (November 2015). "TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia". CNS Neuroscience & Therapeutics. 21 (11): 905–913. doi:10.1111/cns.12469. PMC4638223. PMID 26494128.
^Xia Y, Zhang Z, Lin W, Yan J, Zhu C, Yin D, et al. (October 2020). "Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus". Neuropsychopharmacology. 45 (11): 1896–1908. doi:10.1038/s41386-020-0743-7. PMC7608378. PMID 32599605.
^Naumann K, Wehner R, Schwarze A, Petzold C, Schmitz M, Rohayem J (2013-12-02). "Activation of dendritic cells by the novel Toll-like receptor 3 agonist RGC100". Clinical & Developmental Immunology. 2013: 283649. doi:10.1155/2013/283649. PMC3878805. PMID 24454470.
polyinosinic, polycytidylic, acid, usually, abbreviated, poly, poly, immunostimulant, used, form, sodium, salt, simulate, viral, infections, sodium, saltclinical, dataatc, codel03ax07, identifiersiupac, name, poly, amino, oxopyrimidin, dihydroxyoxolan, methyl,. Polyinosinic polycytidylic acid usually abbreviated poly I C or poly I C is an immunostimulant It is used in the form of its sodium salt to simulate viral infections 1 Polyinosinic polycytidylic acid sodium saltClinical dataATC codeL03AX07 WHO IdentifiersIUPAC name poly 2R 3S 4R 5R 5 4 amino 2 oxopyrimidin 1 yl 3 4 dihydroxyoxolan 2 yl methyl dihydrogen phosphate CAS Number24939 03 5 YPubChem CID32744ChemSpidernoneUNII3R630IWW5IO84C90HH2L YCompTox Dashboard EPA DTXSID90947819Chemical and physical dataFormula C10H10N4NaO7P x C9H11N3NaO7P x N Y what is this verify Poly I C is known to interact with toll like receptor 3 TLR3 which is expressed at the endosomal membrane of B cells macrophages and dendritic cells Poly I C is structurally similar to double stranded RNA which is present in some viruses and is a natural stimulant of TLR3 Thus Poly I C can be considered a synthetic analog of double stranded RNA and is a common tool for scientific research on the immune system 2 Poly I C has been shown to activate schizophrenia like behavior in the offspring of pregnant mice which can be accompanied by decreased GABAergic transmission in the dentate gyrus 3 Chemistry editPoly I C is a mismatched double stranded RNA with one strand being a polymer of inosinic acid the other a polymer of cytidylic acid Variants editOptimization of physicochemical properties of poly I C has led to generation of derivatives that have increased stability in body fluids such as polyICLC or reduced toxicity through reduced stability in body fluids such as poly I C12U 4 References edit Fortier ME Kent S Ashdown H Poole S Boksa P Luheshi GN October 2004 The viral mimic polyinosinic polycytidylic acid induces fever in rats via an interleukin 1 dependent mechanism American Journal of Physiology Regulatory Integrative and Comparative Physiology 287 4 R759 R766 doi 10 1152 ajpregu 00293 2004 PMID 15205185 S2CID 24028101 Li Y Xu XL Zhao D Pan LN Huang CW Guo LJ et al November 2015 TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia CNS Neuroscience amp Therapeutics 21 11 905 913 doi 10 1111 cns 12469 PMC 4638223 PMID 26494128 Xia Y Zhang Z Lin W Yan J Zhu C Yin D et al October 2020 Modulating microglia activation prevents maternal immune activation induced schizophrenia relevant behavior phenotypes via arginase 1 in the dentate gyrus Neuropsychopharmacology 45 11 1896 1908 doi 10 1038 s41386 020 0743 7 PMC 7608378 PMID 32599605 Naumann K Wehner R Schwarze A Petzold C Schmitz M Rohayem J 2013 12 02 Activation of dendritic cells by the novel Toll like receptor 3 agonist RGC100 Clinical amp Developmental Immunology 2013 283649 doi 10 1155 2013 283649 PMC 3878805 PMID 24454470 Portal nbsp Biology nbsp This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Polyinosinic polycytidylic acid amp oldid 1212525152, wikipedia, wiki, book, books, library,
