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Wikipedia

Pindone

Pindone is an anticoagulant drug[3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

Pindone
Names
Preferred IUPAC name
2-(2,2-Dimethylpropanoyl)-1H-indene-1,3(2H)-dione
Other names
2-Pivaloyl-1,3-indandione
Identifiers
  • 83-26-1 Y
3D model (JSmol)
  • Interactive image
ChemSpider
  • 6476 Y
ECHA InfoCard 100.001.330
KEGG
  • C19141 N
  • 6732
UNII
  • 2KFI1XBH7G Y
  • DTXSID1025930
  • InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 Y
    Key: RZKYEQDPDZUERB-UHFFFAOYSA-N Y
  • InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3
    Key: RZKYEQDPDZUERB-UHFFFAOYAX
  • O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C
Properties
C14H14O3
Molar mass 230.26 g/mol
Appearance Bright-yellow powder[1]
Odor almost none
Density 1.06 g/mL
Melting point 110 °C (230 °F; 383 K)
0.002% (25°C)[1]
Hazards
Lethal dose or concentration (LD, LC):
280 mg/kg (rat, oral)
75 mg/kg (dog, oral)
150 mg/kg (rabbit, oral)[2]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 0.1 mg/m3[1]
REL (Recommended)
TWA 0.1 mg/m3[1]
IDLH (Immediate danger)
100 mg/m3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

See also edit

References edit

  1. ^ a b c d e NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ "Pindone". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  3. ^ Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID 15694595.


pindone, anticoagulant, drug, agricultural, commonly, used, rodenticide, management, rabbit, populations, namespreferred, iupac, name, dimethylpropanoyl, indene, dioneother, names, pivaloyl, indandioneidentifierscas, number, model, jsmol, interactive, imageche. Pindone is an anticoagulant drug 3 for agricultural use It is commonly used as a rodenticide in the management of rat and rabbit populations Pindone NamesPreferred IUPAC name 2 2 2 Dimethylpropanoyl 1H indene 1 3 2H dioneOther names 2 Pivaloyl 1 3 indandioneIdentifiersCAS Number 83 26 1 Y3D model JSmol Interactive imageChemSpider 6476 YECHA InfoCard 100 001 330KEGG C19141 NPubChem CID 6732UNII 2KFI1XBH7G YCompTox Dashboard EPA DTXSID1025930InChI InChI 1S C14H14O3 c1 14 2 3 13 17 10 11 15 8 6 4 5 7 9 8 12 10 16 h4 7 10H 1 3H3 YKey RZKYEQDPDZUERB UHFFFAOYSA N YInChI 1 C14H14O3 c1 14 2 3 13 17 10 11 15 8 6 4 5 7 9 8 12 10 16 h4 7 10H 1 3H3Key RZKYEQDPDZUERB UHFFFAOYAXSMILES O C2c1ccccc1C O C2C O C C C CPropertiesChemical formula C14H14O3Molar mass 230 26 g molAppearance Bright yellow powder 1 Odor almost noneDensity 1 06 g mLMelting point 110 C 230 F 383 K Solubility in water 0 002 25 C 1 HazardsLethal dose or concentration LD LC LD50 median dose 280 mg kg rat oral 75 mg kg dog oral 150 mg kg rabbit oral 2 NIOSH US health exposure limits PEL Permissible TWA 0 1 mg m3 1 REL Recommended TWA 0 1 mg m3 1 IDLH Immediate danger 100 mg m3 1 Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox references It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K dependent clotting factors See also edit1 3 IndandioneReferences edit a b c d e NIOSH Pocket Guide to Chemical Hazards 0516 National Institute for Occupational Safety and Health NIOSH Pindone Immediately Dangerous to Life or Health Concentrations IDLH National Institute for Occupational Safety and Health NIOSH Robinson MH Twigg LE Wheeler SH Martin GR March 2005 Effect of the anticoagulant pindone on the breeding performance and survival of merino sheep Ovis aries Comp Biochem Physiol B 140 3 465 73 doi 10 1016 j cbpc 2004 11 011 PMID 15694595 nbsp This agriculture article is a stub You can help Wikipedia by expanding it vte nbsp This article about a ketone is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Pindone amp oldid 1057048391, wikipedia, wiki, book, books, library,

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