Peptitergents (a portmanteau of peptide and detergent) are synthetic peptides designed to be lipophilic on one side and hydrophilic on the other upon folding to an α-helical conformation and were designed to solubilize integral membrane proteins in aqueous solution.[1] They can be considered a sub-class of amphipols and are based on earlier fundamental explorations of amphiphilic secondary structures[2]
^Schafmeister, CE; Miercke, LJ; Stroud, RM (29 October 1993). "Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins". Science. 262 (5134): 734–8. doi:10.1126/science.8235592. PMID 8235592.
peptitergents, portmanteau, peptide, detergent, synthetic, peptides, designed, lipophilic, side, hydrophilic, other, upon, folding, helical, conformation, were, designed, solubilize, integral, membrane, proteins, aqueous, solution, they, considered, class, amp. Peptitergents a portmanteau of peptide and detergent are synthetic peptides designed to be lipophilic on one side and hydrophilic on the other upon folding to an a helical conformation and were designed to solubilize integral membrane proteins in aqueous solution 1 They can be considered a sub class of amphipols and are based on earlier fundamental explorations of amphiphilic secondary structures 2 See also editAmphipolsReferences edit Schafmeister CE Miercke LJ Stroud RM 29 October 1993 Structure at 2 5 A of a designed peptide that maintains solubility of membrane proteins Science 262 5134 734 8 doi 10 1126 science 8235592 PMID 8235592 Kaiser ET Kezdy FJ 20 January 1984 Amphiphilic secondary structure design of peptide hormones Science 223 4633 249 55 Bibcode 1984Sci 223 249K doi 10 1126 science 6322295 PMID 6322295 nbsp This article about an organic compound is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Peptitergents amp oldid 1084625059, wikipedia, wiki, book, books, library,
